Average Rating: 2.9 (46 Ratings)

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 Type: Rx Drug

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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 1  Post menopausal symptoms Increased hot flashes. Back pain. Severe hip and pelvic pain. F 56 7 days
0.3-1.5mg 1X D
 2  Perimenopausal symptoms Extreme fatigue, I didnt have the energy to even wash my kods' clothing. My leg muscles became so weak that walking to the end of my very normal driveway made them feel like I was going to collapse. My extrememly thick & shiny hair fell out and became thin & dull. Chest pains any time I got my heart rate above resting. It took care of the mental status changes and hot flashes I was having, but cost me everything else. Totally not worth it. F 44 18 months
.3/1.5mg 1X D
 2  Premenopausal Only day 2 severe headaches, anxiety, moodiness, no appetite and stomach pain, will this go away and after how long of starting this med? Lol I'm ready to kill someone, help! F 49 2 days
1X D
 4  Hot flashes Very tired F 55 0 days
30 1X D
 5  Fatigue Breast tender sometimes cut back on caffeine. Leg cramps drink pickle juice. Feel better than I have in years. I had been on another hormone for 3 years it helped a little. Dr tested me and put me on prempro!! Getting better every day!! Even lost a few pounds!!! Yes!! I've been on this for 3 + months!!! Thanks!!!! 63 0 days
.625-2.5 1X D
 2  Hot flashes due to menapause Weight Gain 8 lbs, increases depression, headache, visual changes Yes- no doubt hot flashes Gone , but the price is too high. Don't recommend. F 57 2 years
.3 mg 1X D
 2  Menopause Bloating, leg cramps, breast tenderness, dark spots on face, weight gain(7 lbs) which is bad because I'm only 5'2. Mood swings, headaches, nausea. At first I didn't know what could be causing all this but after reading reviews, I will stop taking Prempro. I had originally thought it would help with weight loss but not for me. Prempro had the opposite effect. F 54 3 months
2.5 mg 1X D
 3  Complete hysterectomy Headaches, bloating, severe stomach pains, alternating constipation/diarrhea, nausea, dizziness, acne Started taking this 5 days after surgery. Still having brief hot flashes on this medication. Have a follow up appointment with dr next week, going to discuss other options for HRT. Since I have endometriosis I have to very careful about estrogen dominant HRT, and also having my hysterectomy before the age of 50 this is to help keep osteoporosis, heart disease, dementia at bay. But reading about others experiences and this causing breast cancer I want to switch. Maybe even try bioidentical hormones F 43 13 days
 5  Hot flashes due to ovary removal I had my left ovary removed and an ablation that set me into menopause at 42. In the first few days it did make me slightly nauseous and had some leg cramps, moodiness and bloating after several weeks. However, the hot flashes are mostly gone! I will stay on this for as long as possible! F 48 5 years
 5  Osteoporosis Helps me feel normal I stopped a few years ago based on the articles that I was reading. It was a disaster! I had major excema on my hands and feet, I am talking about red peeling skin! I was drying from the inside out! My crotch hurt, forget intercourse I begged my doctor to put me back on it once I figured out what was going on with my body!! F 62 15 years
1X D
 1  Menopausal food allergies, insomnia Red flushing face, nausea, headaches, fast heartbeat / palps Prescribed the lowest dose, Got heart palps within the hour after taking first pill. Racing heart and nausea that day, and headache that evening. It took one day after for the nausea to go away, 2 days for the flushing, and 4 days for the racing heart / palps to go away after taking only one pill. I know this works great for some, but the side effects were terrible for me. F 53 1 days
3mg/1.5 mg
 1  Heavy periods, hot flashes, mood ch I have taken prempro for 15yrs and thought it was a miracle drug. Prempro was advertised to reduce heart failure and osteoporosis. However, after years of taking prempro I have found it is dangerous and poisonous to your body. I have experienced paricardial damage and multiple heart attacks due to Prempro. Prempro gives you a false sense of well being while destroying your heart. Weakness, tiredness, shortness of breathe are common signs of Prempro and can also be an indication it maybe damaging your heart. The benefits of Prempro do not out weight losing a life from heart failure. Prempro should be banned from the market. F 53 15 years
.625 1X D
 3  Hot flashes No hot flashes anymore. I have been on it for a month then my personality started to chance I became moody not depressed but I don't like myself and my husband does not like it. So I wil still go on with it. The most remarkable thing is I have so much energy now and losing weight why would I stop using this med. forgot to say when I first started this med for two weeks I was in pain with my breasts. They became larger and very uncomfortable but after the second week everything calmed down also I lost the eight I gained. It was just about 3lbs F 66 1 months
 4  Severe hot flashes So far slight weight gain. No other side effects. My hot flashes were unbearable and non-stop. Since taking this drug I no longer have them but I am greatly concerned with the possibility of breast cancer. I'm high risk (mother, aunt, grandmother had) and considering getting off the drug. Also, I workout alot and weight gain is not an option I will accept. F 48 2 weeks
.03-1.5 1X D
 3  Sever hot flashes very moody !! Headaches bloating and weight gain, achy joints! But my hot flashes are gone!! Not to sure about this medication yet! F 49 2 weeks
 3  menapause, hot flashes Since March 2015 weight gain 7 lbs,breast enlargement. F 54 3 months
 5  Hot flashes, night sweats etc Slight bloating that went away after a cpl of weeks. I wish I started it sooner. My energy level has returned to normal & I feel more comfortable back to myself. F 52 4 weeks
 5  perimenapause This is out of character for me to leave a comment. Honestly this has been my saving grace, no more hot flashes,anxiety,headaches, hungry horrors, or emotional roller coaster. I'm glad I made my own decesion. Ohh and I have alot more energy. F 55 2 weeks
 4  Hot flashes., sleep issues, sadness Weight gain F 52 5 months
 4  to reduce hot flashes.night swaets F 4 months

PREMPRO  (ESTROGENS, CONJUGATED; MEDROXYPROGESTERONE ACETATE):  This medication contains 2 female hormones: an estrogen (such as conjugated estrogen, estradiol) and a progestin (such as medroxyprogesterone, norethindrone, norgestimate). It is used by women to help reduce symptoms of menopause (such as hot flashes, vaginal dryness). These symptoms are caused by the body making less estrogen. The progestin in this medication helps to reduce the risk of cancer of the uterus which can be caused by using estrogen. Women who have had their uterus removed do not need the progestin and therefore should not use this combination medication. If you are using this medication to treat symptoms only in and around the vagina, products applied directly inside the vagina should be considered before medications that are taken by mouth, absorbed through the skin, or injected. This medication may also be used by women after menopause to prevent bone loss (osteoporosis). However, there are other medications (such as raloxifene, bisphosphonates including alendronate) that are also effective in preventing bone loss and may be safer. These medications should be considered for use before estrogen/progestin treatment.   (Sources: U.S. Centers for Medicare Services, FDA)