Average Rating: 3.4 (584 Ratings)

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 Type: Rx Drug

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on GLUCOPHAGE: Reviews Summary  |  Drug Safety Information

 1  Type 2 Diabetes endometrial lining build-up, fatigue, weakness, depression, suicidal thoughts, emotional highs and lows very extreme. extreme anger and rage. Hair loss, skin itching, loss of taste. I was diagnosed 3 months ago with Type 2 diabetes. He immediately put me on Metformin. Told me there would be stomach effects but they would go away over time. They weren't too bad as long as I took with my first mouthful of food. My blood sugar NEVER came down over 3 month period (he wanted to move me to 1500 mg which he said was standard) instead I quit. I experienced depression, weakness, suicidal thoughts, and then started having problems with my period which my gyno said had nothing to do with this. Then I had to have a biopsy and tests because even though I wasn't having a period my endometrial lining was still building up. Turns out there are studies on this and papers written, but when I told my doctor this she dismissed it. This drug is horrible but the doctors keep pushing it!! F 40 3 months
500 2X D
 3  Lower blood sugar and A1C Nausea, vomiting, low blood sugar, insomnia, headache, diarrhea, stomach pain, achy joints F 27 0 days
500 2X D
 1  diabetes Diarrhea even on low doses and burning in my abdomen, bloating and discomfort. Unable to leave home because of digestive problems. Also lowered my TSH values for thyroid maintenance. It did effectively lower my glucose and A1C but at what cost to my lifestyle. F 78 20 years
1000 mg 2X D
 4  High A1C I've been on Metformin ER 500mg twice a day for two to three years with almost zero negative side effects however my A1C has not gone down very much. I still eat some sweets but I watch my carbs and alcohol consumption. I have never smoked. M 71 2 years
500 mg ER 2X D
 1  Insulin resistance My symptoms while on Metformin included the following: Constant burning across my upper epigastric region, insomnia, severe left leg pain on the lateral upper and lower side of my calf and at times in my left thigh. I also had a horrible weakness in my legs. If I had been sitting at a restaurant in a booth, or in a chair for some time, I had trouble getting up. I felt like a 90-year-old woman (Iím a young 60-year old) when I got up to walk. Near depression and fogginess with lack of motivation to do anything. I had an appendicitis a year ago, and I often wonder if the Metformin caused the inflammation that set off my appendicitis. Now, Iíve only been off the Metformin for 2 days, and the fog has lifted, and I have no more pain in my left leg. The burning in my stomach is gone too. On Metformin I had no joy in my life. So glad I discovered what was causing my pain and lack of joy in my life. Itís like a cloud has been lifted now that Iím not taking Metformin, and F 60 2 years
500 2X D
 1  High blood sugar Nausea vomiting with no warning gas pains Horrible drug. I took it for two years. Did nothing to lower blood glucose and I was always sick from it. Donít take this crap!! M 62 2 years
 2  DM2 Severe, unpredictable diarrhea...even on the ER form. Persistent and unusual taste/odor...not a foul smell...just odd. I was literally living on Imodium (up to 4 a day) when I was taking this medication. It didn't matter what I ate, when I ate, or how much/little I ate...the diarrhea was awful. The only other side effect I had was a constant weird taste/smell in my mouth/nose that was reminiscent of a cross between freshly sawed wood and yeast bread. As soon as I stopped Metformin, this resolved within 2 days....and it returned within 1 day after a trial of restarting Metformin just to see what would happen. The diarrhea resolved within 2 days of stopping Metformin. F 55 8 months
1000mg 2X D
 5  PCOS The only side effect I've had is diarrhea, only on the first day of taking it. I see so many horror stories about this medicine. If you do not want to get violently ill, you have to eat right! This medicine does not tolerate carbs, so every meal has to be limited to a small amount of good carbs (i.e no white carbs). If you eat something bad, it's going to come out in the form of horrible diarrhea and nausea. Take the pill in the middle of your meal to avoid side effects as well. My period arrived in the first 2 days of taking it, I've lost 4 pounds, and my face is clear. I feel much better already! F 28 5 days
500 2x/day
 5  Type 2 Had taken plain Metformin in past with very bad stomach issues. Now am taking Metformin HCL ER (extended release) with almost no issues. F 66 1 years
500 2X D
 1  impaired glucose levels severe allergic reaction to this drug after 20 minutes Thank GOD I'm allergic to this drug, I've seen the vomiting and explosive diarrea it causes. The 'cure' is worse than the illness!!! F 56 1 days
500 1X D
 1  Sugar Explosive diarrhea and or vomiting with NO warning. Often happened in public. I got off it. It got to the point that I was No longer able to leave my house for fear I would get sick and embarrassed. M 59 3 years
 1  insulin resistence Heart palpitations,pain in breast bone,weak,tired, no appetite,pin in left arm going down to left hand and fingers.pain on stomach Made me feel ill from the start but I thought will continue maybe its just my first time but I just got worse F 39 3 months
 1  PCOS Headaches, muscle pains, suicidal thoughts, behavioral changes similar to being high or drunk, loss of love for loved ones, loss of feeling in hands, dizziness, lightheaded. This drug ruined my life. Please, do NOT take Metformin. F 15 2 months
1000MG 3X D
 1  Type 2 diabetes , pcos I had chest pain, diahreha, vomiting and nausea. I also had severe head aches and the medicine didn't help. I've lost my appetite for everything and everything hurts me. This medication has ruined my life F 15 3 months
 4  Diabetes Mellitus M 50 8 years
1000 2X D
 5  Trying to conceive / pcos I got pregnant! I was diagnost with PCOS about 15 years ago. I was using BCP and didn't have a period for about 10 yrs. Went off BCP to try to have a baby, and nothing happened for about 2 yrs. Doc put me on Met to help with ovulation and such. I had sporatic periods, and then just didn't monitor them. I went in for an exray and was asked if I possibly could be pregnant. I said "anything is possible". Nurse came in and told me I was! Turned out I was 3 months along :) That was 4 yrs ago, and our baby boy is 3 yrs old and healthy. If you have PCOS and trying to get pregnant with no success, try this med! I stopped it after finding out I was pregnant, and after I gave birth, my periods have slowly dissapeared again (which is fine with me!) F 35 4 months
500 3X D
 5  insulin resistance I lost 60 lbs on it not even trying. Definitely curbs sweets cravings. Horrible explosive diarrhea with cramping tho. But overall makes my periods 100% regular and on time.. and I conceived. F 24 3 years
 3  Type 2 Diabetes Initially all was good. I have however developed a rash on both legs. I have also lost 20kg's since been diagnosed with type 2 diabetes 3 months ago and started taking Glucophage ! F 38 3 months
 5   I am 28 years old and and was recently diagnosed with PCOS, although I think I've had it for years and years. I started menstrating at 11! I had such severe cramps that I'd stay home from school and in my mid 20's pretty much stopped having a period and started the most devastating acne:( I am not pre-diabetic or really overweight (I always have 10 pounds to lose) but I am taking it to regulate my cycle, possibly clear up my hormonal and cystic acne:( and start to ovulate so one day I can have babies! My fiance is a family physician and was weary about me trying this med because of the side effects but we did some research and found almost definite ways to prevent the gastric and bathroom problems: -Always eat before and a little after taking the med. -Stay away from dairy, carbs (sugar and flour) -Limit your fruits to only a few a day If you stick to this plan you really shouldnt have any drastic side effects:) I have noticed an IMMEDIATE change in appetite and seems it is MUCH easier to eat a healthy diet because the carb cravings are pretty much non-existent!!! Feels like a miracle! I was always always a sugar and carb feen! Felt like it was controlling my life and it was so so difficult to resist junk. I've only been on it 4 days but really feel like its a life changer! Hopefully it sticks around! I will update again giving it more time:) F 28 4 days
500mg 1X D
 5  Pcos/insulin resistance First week it was rough. I adjusted my eating to be more low carb and lost 40 pounds in 3 months. My blood sugar is perfect now. Love it. F 38 2 days

GLUCOPHAGE  (METFORMIN HYDROCHLORIDE):  Metformin is used with a proper diet and exercise program and possibly with other medications to control high blood sugar. It is used in patients with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. Metformin works by helping to restore your body's proper response to the insulin you naturally produce. It also decreases the amount of sugar that your liver makes and that your stomach/intestines absorb.   (Sources: U.S. Centers for Medicare Services, FDA)