Average Rating: 3.0 (196 Ratings)

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 Type: Rx Drug

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on DIFFERIN: Reviews Summary  |  Drug Safety Information

 1  Acne, scarring, dark spot help Burned the hell out of my face, made my face swell and peal and itched like crazy the whole time. I've attempted to use it since and it does the same thing right away. The anti scarring stuff does the same thing. F 38 30 days
? 1X D
 1  Some acne My skin is burning all around my eyes, especially under. The peeling is even pertaining under my eyes and all around my face. My face burns, for the whole day especially if I put makeup on which just looks so bad because of the access of peeling! Do not recommend at all. F 15 4 days
2X D
 2  Acne Area around and between my eyes burn and sting. My skin feels raw. I use the differing gel , wash , and nighttime moisturizer. My forehead acne and jawline acne dried up but my skin around eyes including my eyebrows are peeling. Currently sitting with some ice because it burns so bad . Gave me 1st degree burns. F 17 3 weeks
45 2X D
 1  Daughter acne. Her eyes became real puffy. The next day under her eyelids were peeling. A little bit of burning and plenty of drying of her skin. 13 3 days
1X D
 1  Acne, pores Did not know that Differin would cause a cold sore out break. Do not use Differin on areas that have cold sore breakouts. My problem area was around my mouth and chin. And now I have red, angry skin that itches around my mouth. Flaky, blisters. Terrible. I wish I had a time machine so I could slap myself . After at least two uses I notice dry flaky skin which I read up on line as being normal along with some purging breakouts of massive pimples. I stopped using it after about two weeks. I just can't. I have a gentle cleanser, I have moisturizers but since my face is in this damaged state I can barely stand washing my face. I cannot go another day using it. It's agony. I didn't have sensitive skin before this and now I do. You don't know you were living the good days until they are gone. F 30 2 weeks
1X D
 1  Adult acne My face got extremely sensitive. I wash it hurts, I scratch it hurts, I just couldn't touch my face. Also my acne didn't get any better. Not for everyone F 29 30 days
1X D
 2  Adult acne getting worse I got differin because my acne as an adult is worse than as a teenager, especially now with constant mask use. I am not yet a full week in and I'm regretting my decision. My face literally feels like the skin is burning off. Water on my face hurts, my incredibly gentle cleanser hurts, my face is already dry and flaky. Feels like I've had a chemical peel. F 28 1 weeks
30mg 1X D
 1  acne Differin was absolutely horrible for me. If I could go back in time and not ever use it, I would. I used it for two months and my acne became very severe and cystic. My skin was red, inflamed, peeling, and honestly seemed to have an infection underneath (looked like redness was spreading). Zits would drain green, which was just awful, so I definitely think it caused an infection. I've tried to just stay out of sight and away from people as much as possible because it's so embarrassing. I could be talking to someone and green crap would start bursting out of my face. The redness that spread under the skin would then cause new ones to crop up along the way. I've been trying for a month now to get my skin back (quit using Differin a month ago). Progress is slow. I'm honestly still peeling and still have breakouts. They are better than they were on Differin but I'm nowhere near back to what my skin used to be. (As an aside, I've struggled with breakouts for years but I'd gladly go back to the way my skin used to be if I could ever get healed from the damage caused by Differin). It's HORRIBLE. My method of use was to wash with a gentle cleanser, moisturize and put Differin on top (Dr. Dray's videos on Youtube if you are familiar with her). I have a lot of respect for her and her videos. She's amazing but this product just isn't right for me. F 2 months
 1  Mask-ne Whole face is red and extremely dry. I typically have oily skin but not anymore. I can not add enough moisturizer to my face. I am hoping I can get it back to normal. I used to not have to wear face make up but I will have to for a while probably. I decided to try to product after seeing a Tik Tok on it. I only had mild acne from wearing a mask 24/7. I should have never tried this product. F 24 2 days
1X D
 1  Acne I never had such severe problems with acne like I do now that I wear a mask for much of the day. I decided to try Differin because it was getting out of control. At first, my face was just extremely dry and became flaky. Then, it started itching especially around my jaw line. I just used it again for the 7th time like normally, except this time it started burning. I tried to ignore it and let it dry. I went to put on moisturizer later and it started burning intensely. I now have bright red chemical burn marks on the lower half of my face. I've read this is a common side effect but I can't live with the burning and marks on my face. F 25 7 days
1X D
 3  Adult hormonal acne I am nearing the end of my second month using it and right now my acne is so out of control. I have large deep cysts as well as small bumps under the skin that have begun to pop up recently. I also have dry flakey spots where many of the bumps are. I did plenty of research before starting this so I understand the acne will get worse before it gets better and it could take up to 2-3 months to see results so I'm trying to hang in there but if I don't see improvement soon I'm going to have to stop use. I've also experienced one of my eyes being incredibly watery lately and wonder if its related to the differin. Its not swollen or painful but literally waters all day long. I'm going to avoid the eye area going forward in hopes that will help. F 41 2 months
3% 1X D
 1  Blind pimple on right cheek I used the gel on my cheek for one week and my skin looks and feels burned. Extremely dark red almost like scab but isn't and feels stiff and hurts 5/10 pain. Just called my dermatologist bc I don't know what to do now. F 44 1 weeks
1X D
 1  Cystic acne Redness of the skin, has not gone away 3 years after usage. Still get sun burnt easy and my acne went back to its regular bs after discontinuing the use. Never fully cleared my acne. I look like I'm perm sunburnt on my neck, my face and neck go very red when I am even remotely embarrassed or blush. I'm constantly called a redneck. Acne came back just as strong as before and now I get sunburns very easy even with sunscreen. M 26 2 years
100mg 1X D
 3  To clear my acne and blackheads 1st degree burns on the face. I know it takes a few months to start clearing acne but after only a week of use, I noticed my skin getting very sensitive. It would burn just by touching the skin. Last night, I use it like I normally do and waited about 2 hours before putting moisturizer on. As soon as I put the moisturizer on, it was intense burning. After a minute or so I look at my skin and it was terribly red all over. I just thought it was some irritation so I left it alone. I wake up this morning to find out it burnt my skin, I now have 1st degree burns on my face. Very disappointing. F 19 10 days
30 1X D
 1  Acne w/oily skin Horrible! Why did I try this! I have chemical burns between my eyes, forehead, and both sides of my face. Recently purchased Clinque Repairwear Laser Focus Night Cream for oily skin. I use it day and night and it is helping with the healing but from the looks of it, it will take a while to heal. DO NOT PURCHASE DIFFERIN!! F 62 0 days
? 1X D
 3  To help get rid of my cystic acne My cheeks burning after application like hours after and continues. My skins is extremely dry and flaky It seems to clearing up my acne, I'm just concerned about the intense burning. F 29 3 weeks
1X D
 1  clear tiny zits on forehead and chin my cheeks are burning and bright red even when i put lotion on, my skins peeling around my mouth F 16 0 days
 1  Acne breakouts Severe burning around my nose and mouth, made my skin extremely dry even though my skin type prior to use was oily. F 17 5 days
 1  doctor prescribed for my whiteheads Worse.. Redness... Itchy.... But not any more positive result. F 23 1 months
night only
 2  moderate acne dry skin, eyes swollen shut, inflamed stinging skin, redness, acne don't do it F 18 50 days

DIFFERIN  (ADAPALENE):  This medication is used to treat acne. It may decrease the number and severity of acne pimples and promote quick healing of pimples that do develop. Adapalene belongs to a class of medications called retinoids. It works by affecting the growth of cells and decreasing swelling and inflammation.   (Sources: U.S. Centers for Medicare Services, FDA)