ANAFRANIL Reviews (CLOMIPRAMINE HYDROCHLORIDE)

Average Rating: 3.7 (133 Ratings)

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 ANTIDEPRESSANTS CNS, MISCELLANEOUS

 Type: Rx Drug

  

ANAFRANIL  (CLOMIPRAMINE HYDROCHLORIDE):  Clomipramine is used to treat obsessive compulsive disorder (OCD). It helps decrease persistent/unwanted thoughts (obsessions), and it helps reduce the urge to perform repeated tasks (compulsions such as hand-washing, counting, checking) that interfere with daily living. This medication belongs to a class of medications called tricyclic antidepressants. It works by restoring the balance of certain natural substances (serotonin, among others) in the brain.   FDA Approval Date: 1989-12-29 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on ANAFRANIL: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR ANAFRANILCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  Depression/Anxiety/Depersonalizatio None as yet I have tried Aropax/Zoloft/Luvox/Clonoazepam/Xanax and more recently Cymbalta - most of these with valium, as needed to varying degrees. The side effects of these drugs as well as there inefficacy has led me to try Anafranil - Having only been on this drug for about a week i have felt much better! Less distracted and able to concentrate on uni, and the people i care about. M 6 days
5/13/2009
 5  depression weight gain, sleepiness It changed my life, now I´m a happy person again. It is the best medicine by far. M 31 5 years
1/4/2010
 5  OCD Side-effects as to be expected from a TCA: dry mouth, little sedation (got less after weeks), obstipation and ... no orgasm anymore Life-safer. First time I visited a psychiatrist I was diagnose as bipolar disordered because I decribed my thoughts as "racing" and got a terrible acathisia on SSRI's which he thought to be hypomaniac symptoms. Took me 8 years to get rid of that diagnosis. I'll save you that story. Anafranil made the violent, sexual thoughts, the continuous doubt and need to position things "right" and the need to "confess" so much less. Adding a little risperdal (0.5 mg) made things even better! Symptoms are 60% less and I can have a professional life again! Damn that anorgasmia though ... but it is worth it. I actually don't really understand why TCA have this bad reputation; I personally find them even to be better tolerated than the SSRI's, that for sure. M 32 6 months
1/6/2010
Email
 5   M 53 1 days
10/19/2013
 5  Severe OCD; Depression; Anxiety Side Effects: Fatigue; Constipation; Good sleep; Good sex M 17 10 months
150 mg
11/3/2013
 5  OCD Loss of interest in sex, inorgasmia, impotence Lifesaver for keeping OCD at bay, also stops my insomnia and allows me to wake up at a normal time without feeling groggy all day which I cannot do otherwise. Great feeling of being at peace. M 31 15 years
100mg 1X day
12/27/2013
 5  ocd, anxiety, depression I first took this medicine in 1992 when I was diagnosed with ocd, anxiety and depression. I felt well and lived a wonderful and productive life but when I became pregnant my psychiatrist told me I had to stop taking it as it was not a "safe enough" drug during pregnancy. After, I tried other anti-depressants but they always stopped working after a number of years. Finally, after having reached rock bottom a month ago, I asked my doctor about anafranil and believe it or not, from the first day I took the small dose of 25 mg, I felt a change in my head. I now am happy, healthy and the intrusive thoughts are almost gone and when they do appear, they disappear so fast and the anxiety associated with them is not there. Yes, there are some side-effects but there are with every medication. I would highly recommend this medication to anyone suffering from these illnesses. M 5 weeks
100 mg
3/27/2014
Email
 5  OCD. mood disorder. depression. M 18 1 days
6/22/2014
 5  depression Hypergydrose, tremor, low blood pressure, hypo-salivation. This antidepressant only helped me. M 34 1 years
150
12/6/2014
 5  Ocd M 22 3 weeks
25
2/28/2016
 5  Anxiety, major depression, OCD Constipation, Short term memory loss, hand tremor, weight gain... all minor but much better than not taking the medicine. My Doctor quickly upped the dosage higher and higher. Over 150 mg at one point. I cut it down to 25 mg and kept it that was for many years. Now I have reduced it to 10 mg. Doctors like to increase the dosage but I feel fine now at 10 mg. My Doctor is aware that I cut it back. Anafranil is an old drug but was brand new when I first started. I tried the newer drugs but they don't work for me. Zoloft was terrible. I also tried Citalopram, Wellbutrin and others but for me I seem to do best with Anafranil. What works for one person won't always work for another. Anafranil is a miracle drug for me. M 49 32 years
10 1X day
12/22/2017
Email
 5  Ocd, depression, anxiety No side effects Most effective medication for me M 28 1 years
250-300 mg 1X day
5/26/2021
 5  depression anxiety panic slight constipation seems only one helps very well with my mental problems M 68 2 years
10 mg 1X day
1/7/2023
Email
 4  Panic disorder Sweating, weight gain, loss of libido Works incredibly well for panic disorder but weight gain and loss of libido are severe. M 53 10 years
75mg 1X day
8/24/2020
 4  Anxiety, PTSD Unfortunately some anticholinergic effects are present. Dry mouth at the beginning, but that went away after a few weeks. A feeling of heart burn / reflux that didn't go away. Brain fog / cognitive impairment. This caused sexual dysfunction on a way different level than SSRIs, with almost complete anorgasmia. Also a slight increase in heart rate. Really potent antidepressant, but with a number of annoying side effects. In my experience it packs quite a bit more punch that SSRIs. Go slow with the dosage increases, starting with 10mg for at least two weeks and then move to 25mg. The dosage often prescribed is WAY too high and won't increase effectiveness, but will markedly increase side-effects. Don't recommend going higher than 25mg as you already have very high binding to the serotonin and noradrenalin transporters at this dosage. Drug takes about 4 weeks to show it's full effect, and during that time you may feel worse. M 40 3 months
25 mg 1X day
11/23/2019
Email
 4  Depression, anxiety. Weight gain and bloating It helped M 25 8 months
10
10/26/2016
 4  OCD, Depression dry mouth, sedation, spaced out feeling, minor somnolence, rapid heart beat So far, so good. I have been taking this medication since February 24, 2014, starting at 50 mg titrating up to 150 mg. I consider myself lucky because although I have experienced side effects with Anafranil, they have not been major. I take it at night and sleep like a rock. The sedation quality is good because I have been dealing with anxiety along with the OCD. I am able to shrug off my obsessive thoughts more easily, and I am starting to enjoy life again! M 43 5 weeks
150 mg 1X day
4/3/2014
 4  panic attacks, obsessive thoughts Weight gain, tiredness, sedation. M 20 1 years
100mg
3/9/2014
Email
 4  Excessive/Racing Thoughts/Stress Erectile Dysfunction, tremor(Hand Shaking) this is very good medicines for racing/excessive/speedy thoughts and good for insomnia(anxiety) with 75mg to 100mg--1hs M 34 1 days
75mg 1X day
10/16/2013
Email
 4  Social Anxiety & Paranoia Sweating more (head),dry mouth,sudden movements of hands when sleeping,lower sex drive & Weight Gain Has helped me quite a bit through anxiety M 44 2 years
8/5/2009

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