ANAFRANIL Reviews (CLOMIPRAMINE HYDROCHLORIDE)

Average Rating: 3.7 (133 Ratings)

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 ANTIDEPRESSANTS CNS, MISCELLANEOUS

 Type: Rx Drug

  

ANAFRANIL  (CLOMIPRAMINE HYDROCHLORIDE):  Clomipramine is used to treat obsessive compulsive disorder (OCD). It helps decrease persistent/unwanted thoughts (obsessions), and it helps reduce the urge to perform repeated tasks (compulsions such as hand-washing, counting, checking) that interfere with daily living. This medication belongs to a class of medications called tricyclic antidepressants. It works by restoring the balance of certain natural substances (serotonin, among others) in the brain.   FDA Approval Date: 1989-12-29 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on ANAFRANIL: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR ANAFRANILCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  OCD Loss of interest in sex, inorgasmia, impotence Lifesaver for keeping OCD at bay, also stops my insomnia and allows me to wake up at a normal time without feeling groggy all day which I cannot do otherwise. Great feeling of being at peace. M 31 15 years
100mg 1X day
12/27/2013
 3  OCD Depression Shortness of breath, dizziness, constipation, sweating I want so badly to love this medication as I have given it almost a year. It has minimized obsessive thoughts and made me calmer. The dizziness, constipation and sweating were ok with me but this shortness of breath is a deal-breaker. My doctor loves this medication and keeps insisting that it is my anxiety and not the drug. As each day passes, I am becoming more and more convinced, my shortness of breath is from Anafranil. I believe it is a matter of time before I will be discontinuing it. M 43 10 months
75-150mg 1X day
11/27/2013
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 5  Severe OCD; Depression; Anxiety Side Effects: Fatigue; Constipation; Good sleep; Good sex M 17 10 months
150 mg
11/3/2013
 5   M 53 1 days
10/19/2013
 4  Excessive/Racing Thoughts/Stress Erectile Dysfunction, tremor(Hand Shaking) this is very good medicines for racing/excessive/speedy thoughts and good for insomnia(anxiety) with 75mg to 100mg--1hs M 34 1 days
75mg 1X day
10/16/2013
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 3  OCD Depression Shortness of breath, dizziness, lightheaded. My doctor swears by this results of this drug. I have stayed on it for longer than I would have liked because of my doctors' influence. If i wasn't experiencing shortness of breath regularly, I would be willing to continue it. M 43 5 months
100-125mg 1X day
7/6/2013
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 4  depression, anxiety Sleep disturbance - early morning awakenings, sweating, nervousness, abdominal warmth/tension My mood and energy are much better. In terms of nervousness that I would feel sometimes on Anafranil, what helped was to take it with a good amount of food. Once I got the digestive side effects handled, my agitation was gone. so it seems like my brain was reacting to the stomach problems. Taking it with food at bedtime also helped my sleep. I have experienced significant weight loss - at first because of the stomach issues, but also my urge to overeat has gone down because I feel better mentally. Happy to recommend this drug but the first few weeks are likely to be a tough adjustment for most people. M 31 8 days
10 mg 1X day
5/1/2013
 5  panic disorder, anxiety, dread Dizziness, lower sex drive, inability to orgasm, dullness. M 19 6 weeks
100mg
1/19/2013
 5  OCD Dry Mouth F 41
275 1X day
1/8/2013
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Patient History
 1  OCD-DEPRESSION-PANIC ATTACKS Hallucinations ( visual-auditory and tactile ), insomnia, extreme hot flashes and sweating,very dry mouth, weight gain. After taking Anafranil for only 4 days, I immediately noticed that my depression was getting better, but my OCD got a lot worse and Icouldn't sleep. I would see shadows running on the floor like rats, seeing people that had twisted bodies, dogs etc...hearing people talking about me saying that I had to slap people and if I didn't do it, they would bite me or scratch me. I basically developed all the symptoms of schizophrenia. I didn't do anything right away because I just thought it was real and accepted it. Then people at work noticed and told me that I was staring at things and talking alone. I called my psychiatrist and he immidiately discontinued the treatment, even if it helped my depression. I am now taking Effexor XR 75 mg/day and it is working great ! M 32 2 months
75 MG 1X day
9/20/2012
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 3  ocd constipation , bloating,muscle pains,breast enlargment,diffuculy urination,fatigue and in high doses dry mouth and excessive sweating to me it doesnt work in high doses and made ocd symptoms more severe be careful with the dose very low doses may benifit you and higher make ocd severe.talk with your doctor.i used to take it in 150 mg but after many years i take fluoxetine and low doses of anafranil. M 30 10 years
18,75 mg 1X day
7/20/2012
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 4  OCD/Anxiety Dry Mouth, Difficulty Urinating,Body pain (went away after the first couple months) However exhaustion increased over time along with chest pain/pressure and blood pressure problems. The most effective drug I've ever taken. My OCD felt under control for the first time in 10 years; I felt stable and happy. The side effects were unpleasant but I was willing to undergo anything. However by month 6 I was so exhausted and my heart was so stressed I had to discontinue the meds. Very strong chemical. By day 3 off Anafranil I am back to my old mental state, no control. F 21 6 months
50MG 1X day
7/3/2012
 2  Trichotillomania/OCD dry mouth, spasmodic motions of neck head and hands, orgasmic yawning, extreme weight loss (16 pounds) Anafranil has not worked for me at all. I still pull everyday. As far as side effects, I'm also taking several other medications for ADD/ADHD, so they might not all be valid. However, the spasmodic movements were definitely a result of anafranil; and the movements are SO annoying. I highly recommend not taking it, however everybodys body chemistry is different F 15 6 weeks
50 mg 1X day
5/16/2012
 5  OCD, Depression Dry mouth, constipation F 60 10 years
100mg ?
3/6/2012
 2  OCD I was started on 50MG and was supposed to titrate up to 150MG by week 3. I am still on the 50MG because these side effects wont go away. • Reduced mental focus • Confusion • Zoned out or auto pilot feeling • Lack of visual focus especially in far sighted vision • Dizziness • Increased forgetfulness • Reduced limb sensibility especially in hands • Reduced sex drive • Inability to get or maintain erection • Unable to ejaculate Although I did get the results listed below I would not recommend this drug. • Reduced Irritability • Slight ability to control “obsessive” or “fearful” thoughts during compulsive behavior. • Slight ability to control minor compulsive behaviors. M 26 17 days
50MG 1X day
2/21/2012
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 5  Severe Depression and Anxiety Dry mouth, constipation, nightmares, sweating, muscle pain, yawing, fatigue, hypersomnolence A miracle drug for depression and anxiety when 8 other antidepressants failed. F 42 9 months
100mg 1X day
10/12/2011
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 4  Depression, anxiety Acid reflux, hard to orgasm, severe sweating (head only), tiredness Clomipramine (as it's called here in the UK) has really helped me. It has made me the person I want to be and really helped me face life again. I found I was suffering more acid reflux after taking them so I started to take them at lunchtime with food. The sweating is a problem but not a 'deal breaker' and I take much, much longer to orgasm and when I do it feels somehow different (not bad, just different) so I see why these are prescribed for premature ejaculation. The side effects are OK and I would strongly recommend this medication M 39 8 months
100mg 1X day
9/26/2011
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 4  OCD Lethargic, Nauseous I'm already feeling a great effect, even though it hasn't even reached full strength in my body yet. The only bad thing is that I'm very drowsy, and I can't aim a ball as well as I could before. M 14 17 days
25mg 1X day
7/5/2011
 5  OCD Dry mouth, weight gain, excessive sweating (head), harder to orgasm I was diagnosed with OCD at 13 - hand washing, checking, intrusive thoughts. This drug made my OCD completely disappear. Yes the side effects are not great, but they are not the end of the world. When I had OCD I could not function normally at all, all my time was taken up with my obsessions, I can function normally with these side effects. I have tried coming off the drug many times in the last 13 years but when I do, I get very emotional and depressed and my intrusive thoughts come back. I would recommend this drug to anyone with OCD, the dull headaches and tiredness do go with time, just keep taking it regularly and they will disappear. The side effects I have sited above, however do not seem to disappear. F 26 13 years
75mg 1X day
6/25/2011
 2  Anxiety Awful. It reduced to a degree my anxiety, but also reduced any motivation I had. Had very painful abdominal reflux ( pain 9/10), which pain killers reduced to 7/10, hot burning stomach acid, burping and trapped wind. Belly felt solid like SEVERE colic. Due to long half life, endured this for two days! I would not try this drug again. If I had to I would only take 10mg and stock up with lots of pain relief and antacids. F 50 1 days
25mg 1X O
4/24/2011
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