ANAFRANIL Reviews (CLOMIPRAMINE HYDROCHLORIDE)

Average Rating: 3.7 (133 Ratings)

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 ANTIDEPRESSANTS CNS, MISCELLANEOUS

 Type: Rx Drug

  

ANAFRANIL  (CLOMIPRAMINE HYDROCHLORIDE):  Clomipramine is used to treat obsessive compulsive disorder (OCD). It helps decrease persistent/unwanted thoughts (obsessions), and it helps reduce the urge to perform repeated tasks (compulsions such as hand-washing, counting, checking) that interfere with daily living. This medication belongs to a class of medications called tricyclic antidepressants. It works by restoring the balance of certain natural substances (serotonin, among others) in the brain.   FDA Approval Date: 1989-12-29 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on ANAFRANIL: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR ANAFRANILCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  OCD None-minor constipation M 45
25 1X day
3/18/2010
 5  depression/anxity after the first week no side effects remain worked like magic was very happy with it. M 32 4 months
50mg 1X day
7/18/2010
 5  anxiety panic bad constipation, sleepiness, hungry feeling, dry mouth, dizziness upon standing. Shut down the panic. But side effects and using Phillips all the time made me change. Took six weeks to finally tolerate the side effects to a limited degree M 52 3 years
75 1X day
8/18/2010
 5  OCD, depression, fibromyalgia At first many such as anorgasmia and weight gain and sweating profusely but these have to be lived with sometimes for weeks because it is such an old medication. The good news is that with time these subside and adding 30 min of cardio 4 times per week can really help with the weight as well as the depression. Old medicines sometimes work better than newer ones M 37 5 years
225 mg 1X day
9/6/2010
 5  panic disorder, anxiety, dread Dizziness, lower sex drive, inability to orgasm, dullness. M 19 6 weeks
100mg
1/19/2013
 5  Panic disorder (Severe) Dry mouth, blurred vision, constipation and of course very reduced sex drive This stuff works so much better than anything I have ever been on and I have tried most. Removes completely panic symptoms and greatly reduces anticipatory anxiety - fantastic med if only it didn't kill your libido. I am currently trying different meds, SSRI's - no good for me now on Moclobemide and sex drive back but so is panic! Will be going back on Anafranil ASAP. M 4 years
7/30/2006
 5  ocd, anxiety, depression none I'm mainly trying to take this for anxiety and ocd, so far the drug has cleared my head a lot, everything is so much clearer at 50mg. It has done a little for my anxiety so far, I know doses from 100mg to 250mg are used for ocd, best drug taken I've also taken ssri's, cymbalta,klonopin,herbal remedies,abilfy, nardil and wellbutrin none compare. M 21 7 days
10/22/2008
 5  OCD anxiety My 16 year old son uses this and he has shown literally no side affects at a 50-75Mg. dose. At first his heart raced some but that quickly disappeared. My son has used it now for 1 year. This medicine is an older tricyclic that has a good track record for OCD. We are satisfied but if you use a little anxiety med with it like Ativan it seems to make it really work well.Helps greatly ,his obsessive thoughts M 16 1 years
11/25/2004
 5  Depression, Anxiety Dry Mouth, Anorgasmia I was suffering for about 5months from Depression, Anxiety, Phobia and Intrusive thoughts. I started to feel better 1 day after taking Anafranil (25mg). After 5 weeks, I increased the dose to 50mg daily. I feel much better. My anxiety symptoms and depression are gone, and intrusive thoughts have diminshed immensly. I'd reccomend this to anyone who suffers these symptoms. M 41 8 weeks
6/18/2004
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 5  OCD, Panic Attacks, Anxiety 1st Week: mild twitching, loss of appetite. Week 2 & subsequent: very few side effects other than excessive drymouth when nervous, sweating more when its hot, constipation & anorgasmia This drug is wonderful. The benefits far outweight the side effects. It takes away obsessive thoughts & anxiety without taking away your personality. I started using Anafranil after SSRIs (zoloft) made anxiety & OCD worse. Feel free to contact me. M 25 4 months
9/25/2007
 5  Depersonalization, anxiety, OCD Altered taste perception, difficulty orgasming, reduced sex drive, tiredness Completely removed anxiety symptoms, OCD under control and easy to snap out of when I'm stressed. Complete remission of Depersonalization. M 42 8 months
8/15/2007
 5  OCD Heavy sweating, very mild occasional dizziness Works great for my symptoms. i have now been taking it for about two years. M 45 2 years
1/14/2008
 5  anxiety I've taken 50mg in one dose in the morning for 2 months and have now got a very dry mouth, apart from that it has been very good. This is by far the best med I've tried. M 43 2 months
1/11/2008
 5  Depression, Anxiety, OCD, Paranoia Dry mouth, Lowered libido, Increased sweating during excersize Before Anafranil, my life seemed so chaotic. I was constantly fighting with my parents, struggling to meet demands at school, having friendship troubles due to reluctance to participate in large social groups and crowded events. Also, I would constantly obsess over the way I looked and had an overly cynical outlook/sense of humor, all while feeling guilty for no good reason, and believing that strangers were either critisizing my appearance or annoyed by my prescence. My old life seemed meaningless and it got to the point where all I cared about were a couple friends, any kind of illegal 'upper', and obsessing over my looks and my health. An insane asylum seemed appropriate, as I convinced myself that I was schizophrenic. I would skip class if I was late due to my phobia of being stared at when entering the classroom. I would tense up and begin a negatibe loop of thoughts concerning and obsess for days over what other students were saying about me behind my back (how arrogant of me); M 19 8 days
1/29/2008
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 5  depression, anxiety, obsessions Dry mouth, slight fatigue, some sexual problems I have only been on this medicine for a week and it has been a GODSEND!! After only four days I started feeling better and each day is an improvement on the last. I recomend taking this with huperzine A to counter the anticholinergic effects. This medicine puts zoloft/Prozac/lexapro to shame. The SSRIs have more side effects (don't believe the anti tricyclic marketing) and can barely come close to the fast depression relief anafranil has offered-much less the anxiety and obsession relief. This drug has cured my mind of all doubts, worries, obsessions and paranoia and has left me with clarity to concentrate and happiness to show compassion once again! If your afraid of the side effects, done be, just give it a try and your life as well as those of your loved ones will benefit ! M 7 days
1/28/2008
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 5  OCD Dry mouth, constipation for a couple weeks, lower libido Anafranil has worked the best of all the SRI's I have tried for OCD. I have tried Zoloft, Cymbalta, Lexapro and none made much of a difference, Anafranil is in its own league, it was night and day better than any other med I have tried. The dry mouth is the only real side effect that still bugs me along with occasional night sweats especially on my legs which is funky. Libido is lower and orgasm is more difficult but that isn't all bad! M 27 4 months
4/12/2008
 5  OCD Surprisingly few. A little dry mouth, but only for short periods of time I have tried all SSRIs other than Celexa. They just didn't cut it. Prozac worked well until poop out after 17 yrs. Anafranil was different (better). With my first dose I could tell the difference. Calming. Now up to 150 mgs and loving it. Don't hesitate if you have stubborn OCD. M 58 5 weeks
11/26/2008
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 5  OCD, anxiety, depression difficulty urinating, constipation, dry mouth, decreased libido, difficulty ejaculating, sleepiness Highly effective drug but with many bothersome side effects and a really nasty withdrawal. I would certainly reccomend it to anyone whose symptoms are severe and wants to be relieved no matter the price. M 29 8 months
1/27/2009
 5  ocd anxiety dry mouth sweating not sure if the rest was me or the drug M 54 27 days
2/18/2009
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 5  suicidal depression, anxiety, OCD 25 years experience. Works very well but side effects keep me trying other meds. Yet always a relief to get back to clomipramine (anafranil). Anticholinergic effects include acid reflux leading to scarring of esophagus and inability to swallow many foods without simultaneously drinking lots of warm/hot water, necessitating so far 2 outpatient operations to stretch esophagus. No sexual dysfunction for first 12 years but now severe (depending on dosage, as is libido loss) as I age. Reflux plus dry mouth anticholinergic effect have caused bad tooth decay. Bloating and weight gain. Mental confusion and difficulty urinating on higher doses, i.e., over 100 mg daily sometimes, but at other times fine on 165mg. Constipation, sweating, trembling, imbalance were mainly issues in the earlier years during which I often experienced some borderline serotonin syndrome. Saved my life for sure. I was hospitalized, so they could go straight to 150 mg, and by the 4th day I felt great. Maintains a real sense of well-being. Still have intrusive obsessional thoughts at times, but now I'm almost detached from them and they pass quickly. I keep trying to lower the dose because of side effects, and success depends upon changing life circumstances, seasons and how much anti-anxiety meds I am prescribed. Tricky, but I've done this often enough I don't have to wait to feel suicidal anymore to know I need to increase my dose. I've been on as little as 40 mg daily for 2 months and as much as 200 mg daily when things aren't going well, soon tapering to 150 due to borderline serotonin syndrome. A dose increase like this after falling into depression is like being plucked out of hell into a state of grace, no exaggeration. My average daily dose is 75-90 mg. Also really helps against anxiety and insomnia. Higher doses are the best painkiller ever for my bad back. My generic is APO. Once I filled my Rx at a different pharmacy and sunk into a severe depression. I hadn't noticed the generic was GEN. My shrink said that generic had that reputation. Why don't these dummies tell you these things beforehand? I've also never had a doc tell me about tooth decay from dry-mouth-causing drugs. Drinking water, etc. isn't enough. Dental hygienist says you need a salivary enzyme replacement toothpaste and/or mouthwash, e.g., Biotene. M 62 25 years
3/13/2009
  

ANAFRANIL  (CLOMIPRAMINE HYDROCHLORIDE):  Clomipramine is used to treat obsessive compulsive disorder (OCD). It helps decrease persistent/unwanted thoughts (obsessions), and it helps reduce the urge to perform repeated tasks (compulsions such as hand-washing, counting, checking) that interfere with daily living. This medication belongs to a class of medications called tricyclic antidepressants. It works by restoring the balance of certain natural substances (serotonin, among others) in the brain.   FDA Approval Date: 1989-12-29 (Sources: U.S. Centers for Medicare Services, FDA)

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