Average Rating: 3.7 (130 Ratings)

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 Type: Rx Drug

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on ANAFRANIL: Reviews Summary  |  Drug Safety Information

 5  Ocd, depression, anxiety No side effects Most effective medication for me M 28 1 years
250-300 mg 1X D
 3  Anxiety ocd Headache Muscle soreness Stomachache Bitter taste in mouth Been on 6 antidepressants Non worked Last resort was clomiipramine and it is somewhat better then the others I haven't been on it long enough I guess I start my 10th week today Still getting side effects remaining hopeful I hear it takes time to work for some Best luck to us in need of peace F 16 3 months
50 mg 1X D
 5  OCD and anxiety Flushing They changed my life enabling me to live with OCD pure O I dread to think how I would have managed without them. F 62 40 years
25 MG 1X D
 5  OCD Side effects were gone within the first couple of week. The only annoying is constipation. Much calmer and happier overall. It didn't remove OCD thoughts, but definitely helped with panic reactions and anxious behaviour. F 34 2 days
75 mg 1X D
 1  Somatic OCD Triggered an autoimmune disorder, dangerous lack of concern for self, suicidal ideation, memory loss, brain zaps, seizures, heart damage, began serious self-harming. This medication is the turning point where my life fell apart and everything along with it. The side effects were severe and some have been permanent over 5 years later. I have almost no memory of the time I was on it. I now have a permanent autoimmune disorder that this medication set off that I will spend the rest of my life fighting to keep it from killing me. The skin on my arms is destroyed, have damage to the side of my head and several arteries, and it made my OCD a million times worse. I wish I could sue due to how much this medication ruined my life, if only to pay for the medical bills it caused me to rack up (and continue to rack up). F 25 1 years
1X D
 4  Panic disorder Sweating, weight gain, loss of libido Works incredibly well for panic disorder but weight gain and loss of libido are severe. M 53 10 years
75mg 1X D
 5  Extreme Anxiety, OCD Brain Zapping on and off. Extremely sensitive skin unable to sunbathe burn very easily even when using high factor sun cream. Life changing! Had many problems with SSRIs over the past 10 years I was allergic to everything but Anafranil along side Lamotrigine is a game changer for me and my family. I am much better person and feel so much better than ever before. F 39 2 years
50 MG
 5  Obsessive-Compulsive Disorder Depression, fatigue, tiredness I've tried just about every SSRI available and nothing has ever subsided by OCD the way Anafranil does. I would go as far to call this medication a life-saver. If you're willing to brace some bad depression for the first two months or so of taking it, the effects are very much worth it. F 16 1.5 years
125 MG 1X D
 3  Anxiety Blood pressure fluctuation 70 3 days
 4  Severe OCD Increased thirst, orgasmic dysfunction, orthostatic hypotension, constipation Was on 80mg of Prozac for 25 years and basically OCD symptom-free. Prozac stopped working and was put on 200mg Luvox. Helped a lot with OCD but made me so tired I fell asleep briefly behind the wheel once. Now on max dose of Anafranil for OCD (250mg). Itís lights out for OCD but with really annoying side effects. Itís only been three months but I am thinking of going back to an SSRI like Zoloft and see if that helps with fewer side effects. If not, Iíll probably be on Clomipramime for life. Itís all about trade-offs since no med is perfect I think. 49 3 days
 4  Anxiety, PTSD Unfortunately some anticholinergic effects are present. Dry mouth at the beginning, but that went away after a few weeks. A feeling of heart burn / reflux that didn't go away. Brain fog / cognitive impairment. This caused sexual dysfunction on a way different level than SSRIs, with almost complete anorgasmia. Also a slight increase in heart rate. Really potent antidepressant, but with a number of annoying side effects. In my experience it packs quite a bit more punch that SSRIs. Go slow with the dosage increases, starting with 10mg for at least two weeks and then move to 25mg. The dosage often prescribed is WAY too high and won't increase effectiveness, but will markedly increase side-effects. Don't recommend going higher than 25mg as you already have very high binding to the serotonin and noradrenalin transporters at this dosage. Drug takes about 4 weeks to show it's full effect, and during that time you may feel worse. M 40 3 months
25 mg 1X D
 1  ocd Extreme insomnia,Excessive thirst, M 28 2 days
25 1X D
 4  OCD/dermatillomania, Anxiety, depression Dry mouth, brain zaps, night sweats,sexual dysfunction, tremmors, muscle twitching,insomnia Side effects halted after 6-8 weeks of starting medication as well as with every dosage adjustment. Sexual dysfunction is still an issue a year later F 23 1 years
 2  Depression & OCPD Dry mouth, night sweats, sweating, ringing ears, dry eyes, loss of sex drive M 35 7 weeks
150 mg
 5  Anxiety, major depression, OCD Constipation, Short term memory loss, hand tremor, weight gain... all minor but much better than not taking the medicine. My Doctor quickly upped the dosage higher and higher. Over 150 mg at one point. I cut it down to 25 mg and kept it that was for many years. Now I have reduced it to 10 mg. Doctors like to increase the dosage but I feel fine now at 10 mg. My Doctor is aware that I cut it back. Anafranil is an old drug but was brand new when I first started. I tried the newer drugs but they don't work for me. Zoloft was terrible. I also tried Citalopram, Wellbutrin and others but for me I seem to do best with Anafranil. What works for one person won't always work for another. Anafranil is a miracle drug for me. M 49 32 years
10 1X D
 1  OCD an Depressin Dry mouth, insomnia, pains in joints, burping, terribe constipation, increased depression I did note a slight decrease in my OCD within a day or two, but the side effects such as insomnia made me feel worse and overall I got more depressed. I would rather have my OCD than put up with the terrible side effects. Celexa 20mg controls my depression well, by the way. F 49 5 days
50mg 1X D
 1  Depression and anxiety, thougts Suicide attempts. Aggressive. Teeth pain. Erratic behaviour. Memory loss Tried once before years ago and worked on a low dose, tried again and not helped at all. Still in a state of unreality and another psychiatrist took me off 200mg.He stated he would like me on 10/30max or not at all. I've since had propranolol but I've ceased all meds for time being. Currently got the and social anxiety. No purpose M 37 34 months
 4  Depression, anxiety. Weight gain and bloating It helped M 25 8 months
 5  Ocd M 22 3 weeks
 5  ocd, anxiety, bulimia nausea, acid reflux if I don't eat right after taking it The only med out of 6 or 7 antidepressants I tried for my anxiety/ocd/eating disorder. I take dramamine for if I'm not the driver in the car. I feel SO much better than I have since I was 7 years old. My bulimia is totally gone. F 29 2 years
150 1X D

ANAFRANIL  (CLOMIPRAMINE HYDROCHLORIDE):  Clomipramine is used to treat obsessive compulsive disorder (OCD). It helps decrease persistent/unwanted thoughts (obsessions), and it helps reduce the urge to perform repeated tasks (compulsions such as hand-washing, counting, checking) that interfere with daily living. This medication belongs to a class of medications called tricyclic antidepressants. It works by restoring the balance of certain natural substances (serotonin, among others) in the brain.   (Sources: U.S. Centers for Medicare Services, FDA)