PROMETRIUM Reviews (PROGESTERONE)

Average Rating: 3.1 (568 Ratings)

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 ESTROGENS PROGESTINS

 Type: Rx Drug

  

PROMETRIUM  (PROGESTERONE):  Progesterone is a type of female hormone (progestin). This medication is similar to the progesterone that your body naturally makes and is given to replace the hormone when your body is not making enough of it. In women who are not pregnant and not going through menopause, this medication is used to restore normal menstrual periods that have stopped for several months (amenorrhea). Progesterone is also used as part of combination hormone replacement therapy with estrogens to reduce menopause symptoms (e.g., hot flashes). Progesterone is added to estrogen replacement therapy to reduce the risk of cancer of the uterus. This medication is not for use in children. Progesterone must not be used to test for pregnancy.   FDA Approval Date: 1999-10-15 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on PROMETRIUM: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR PROMETRIUMCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  Menopause Headache when I wake up. Blurry vision even when wearing glasses. Sinus problems. Biggest problem is muscle pain all night and day. Left side of arm, legs and hip. Continually trying to find a comfortable position. F 62 6 weeks
100 mg 1X day
1/6/2024
 1  Peri menopausal Breakthrough bleeding all the time. Always thirsty. Felt angry and very moody. Bloated and farting, stomach feels like its getting period all the time. I was taking the topical estrogen gel and felt so calm and happy on it. Then I had to introduce prometrium which instantly made me feel angry and moody again. F 47 20 days
200mg/day 1X day
9/23/2023
 1  Menopause It was fine at first. After a few weeks I started having horrendous Depression and anxiety. I wanted to cease to live. This was an absolutely horrible experience that I wouldn't wish on anyone. F 54 4 weeks
1X day
9/17/2023
 5  Perimenopausal symptoms Absolutely love it. True, it doesn't agree with a percentage of women, and looks like they've all left a review here. Of course it depends on our individual bodies and hormone balance- but for me, it's been great. I have take it 12-14 days of my cycle for the past three months. I started with 100mg at bedtime and this made me tired and fixed my insomnia. There was some next day sleepiness but that went away in a few days. I found my mood, brain fog and energy were better. Later, I moved to 200 mg. I have to take this in the afternoons because for me it is so energizing. I notice a slight increase in HR with it. But by nighttime sleep is good. Same beneficial effects on mood amd motivation, and it balances the .25 estrogen patch I use. It also decreases my aches and pains. No bloating or sore breasts or weight gain (too much estrogen on its own did that). Still waiting to see if it will eventually help lengthen my cycle back out and decrease heavy periods, but I feel better than I have in years and wish a doctor had given it to me when I first started getting perimenopausal symptoms! You won't know how it agrees with you unless you try it. If you're peri menopausal and don't have an intolerance to it, it can be a godsend. F 45 40 days
200mg 1X day
5/26/2023
 2  Premenopausal Felt like I've been hit by a bus every morning - very irritable; down annoyed,moody.it's awful! I'll try using it topically for a week and if still have these symptoms I'm going to stop. F 53 12 days
100 1X day
3/26/2023
 2  Perimenopause and no more ovulation All listed side affects on the warning label: tension headache, constipation, belching, numb fingers and toes, chest tightness, lack of appetite, intestinal bloating, feeling like I had a football or a hard rock instead of my uterus, both sciatic nerves felt pinched, lower back pain and hips sores, huge cystic acne, dandruff, melasma and black pigmentation on my cheeks and nose. Made my cycle go from 28 before to 21 days the second month, then 18 days, then 14 days. The worst is brain fog and feeling like I lost 50 IQ points in 2 months. I lost my cell 3 times and almost got hit by cars crossing the road 2 times. I am not taking any other HRT and my estrogen levels are still normal. Do not take this if you have ADHD. It will make all your symptoms worts. The only benefit was falling asleep 10 minutes after swallowing the pill the first week. I continued despite the increasing side effects hoping it would get better after 3 months but it did not. I was taking 100 mg right before bed everyday for the whole month. I stopped when I had lost my appetite for life, felt numb all the time, my brain asleep all day, could not get dressed and had very low blood pressure. Made me anemic by increasing the frequency of periods. I have been off of it for 20 days now and still feel foggy and crying for no reason. It seems to take a long time to clear my system. It slowed down my liver and stop my gallbladder from contracting. It stopped everything from contracting: no orgasm, no Only take this if you really need to. If you have side effects, stop or lower the dose. Do not expect the side effects to lessen over time because they will only increase as the hormone accumulate in the body. F 46 75 days
100mg 1X day
1/7/2023
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 1  Peri menopause Horrendous!! Now I'm reading the other reviews it's the same as what I felt! So so depressed and suicidal thoughts: Today was awful and thankfully appt with my doctor and I'm now off it: I tried it orally and vaginally on two sep occasions(most recent vaginally) and not better. Not only did I feel like I was hit by a bus in the mornings, but the depressed thoughts were incredibly severe, hopelessness and suicidal thoughts were prob the worst I've ever felt. Horrible med F 51 12 days
100mg d 1X day
12/16/2022
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 5  Post menopause Love Prometrium, which is micronized bio identical progesterone. Have also started trying touche compounded biest (E2/3) and progesterone, which is also amazing. Great sleep, better mood F 56 2 years
100mg 1X day
9/11/2022
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 1  Perimenopause Anxiety and panic Sweating Frequently urinating I tried this medication twice. I will never touch it again. First time, last month I used it 200mg vaginally at night and after two days I was very depressed. I tried it last night 200mg orally, and after one hour I woke up sweating and in panic. I had all morning full anxiety and I am waiting for it to clear my body. Why is this medication working in few women but not on so many. It’s horrendous! F 45 1 days
200 2X day
8/26/2022
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 1  Low prog in 1st trimester Severe depression, suicidal thoughts, crying, fatigue I have never felt the way I felt taking this medication and I have been through some tough times in my life. The depression and feeling of no longer wanting to be alive were strong. I went against my provider and stopped taking this medication. The moment you feel sad or depressed, stop taking this medication immediately! F 37 14 days
200 1X day
8/1/2022
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 1  Sleep problems from menopause Panic attacks gerd constipation F 52 100 days
100mg 1X day
6/23/2022
 1  Menopause. An awful experience (life threatening). Prior to this I had been on bio-identical hormones for 10 years after peri-menopause left me with no readable levels of estrogen, progesterone nor testerone. Advised that I'd be taking hormones for the rest of my life I chose bio-identical. It worked brilliantly - I'd remained slim, energised and happy and with no side effects whatsoever. Then my doctor suddenly retired and its a 6 month wait (in sth-east Qld, Australia) to get into see anyone who works in bio-identicals. So I opted for an online service in the interim, that replaced the bio-identical troche, with a Prometrium tablet, claiming it to be 'body-identical' yet the side effects are shocking. Its been an awful 3 monrhs. Although the first month of high nighttime anxiety and daytime dizziness has gradually lessened, I still wake every morning feeling like I've been hit by a bus. Groggy tiredness, heaviness, apathy, no energy, no libido, (NIL alcohol while on this because the waves of depression become suicidal), a constant headache and brain fogginess. But the worst side effect is the respiratory struggle, even after the slightest exertion. I'm now 'living' on an asthma spray (20-50puffs every day) and can't go anywhere without it. Some nights I wake hardly breathing. Exercise is out of the question. The prescribing service suggested doubling the estrogel to try to balance it. Now they've had me cut back the Prometrium to every second night. I certainly don't wake feel There is another webite showing reviews of prometrium as all extremely positive. Clearly sponsored. What a shame for those that ready that site for guidance. F 55 3 months
100mg 1X day
5/8/2022
 1  Menopause Skin rash that looked like chicken pox. Red itchy blisters which then changed into smaller itchy spots and by three months were less frequent but still appearing. I did some research and found peanut oil is in the ingredients of Prometrium. I am highly allergic to peanuts!!!! Why anyone would include peanut oil in a drug is beyond me. F 59 90 days
100 1X day
10/13/2021
 1  Menopause - to thin lining Horrible anxiety, panic attacks that I had never experienced before, waking up every hour at night with anxiety, crying, over emotional, loss of appetite, felt I needed to eat every few hours, dizziness and nausea. I couldn’t figure out what was wrong with me. Two trips to Er for them to tell me everything was fine. Thought I was going crazy until I read many reviews of women experiencing the same issues. The one positive thing to come out of taking this was it made me bleed which thinned my lining. F 60 8 weeks
200 1X day
6/18/2021
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 1  Perimenopause Horrendous depression and anxiety. Dizziness, weight gain. Apathy. Chest pain, muscle spasm. Please be careful when using this drug. I didn't know what was wrong with me and had no hope of recovery. The most scary experience ever. F 49 2 months
1X day
5/30/2021
 1  Menopause constant headaches, nausea, constant thirst, frequent urination, bloating, lethargy, depression, brain fog, decreased response to estrogen replacement, dry skin and brown spots on skin. Just awful, this drug actually prevented my body from using the estrogen pills/cream I was using and gave me added horrible side effects. No matter how much estradiol hrt I took I still had low E symptoms. 100mg progesterone for some of us is much too high a dose. Stopped taking prometrium and felt so much better, symptoms mostly resolved, in about a week and my hyperpigmentation is going away. I had endometrial ablation 10 yrs ago so my risk of endometrial cancer is almost zero and the risk of endometrial cancer is the only reason for taking progesterone hrt. Btw progesterone actually increases breast cancer risk and causes hyperpigmentation of skin but doctors don't tell you that. F 56 4 years
100mg 1X day
3/20/2021
 1  PCOS/induce a period About an hour after each pill I feel insanely dizzy and weak. I can't move my eyes or head quickly or I feel like I might fall over. I honestly feel like I'm drunk. My anxiety is at an all time high. I've been thinking my vitamin d was critically low until reading these comments. My hands and feet get numb and I get really cold after taking the pills and I am never cold. Absolutely will never take this again. I only made it to day five and I feel miserable. I've regularly taken other progesterone with no side effects. 0/10 would NEVER recommend. F 34 10 days
200 mg 2X day
3/14/2021
Email
 1  Endometriosis Severe anxiety depression, suicidal thoughts. Should be taken off the market shockingly horrific drug nothing like the bio identical natural progesterone that is compounded that I have always used.. F 50 5 days
1X day
2/6/2021
Email
 3  Post Menopause Extreme lethargy I take a tablet at night which knocks me out but I wake with a headache and nausea and a feeling of extreme tiredness that lasts for most of the day. I am taking it in conjunction with an estrogen gel which has all but got rid of my night sweats. I just hate how tired I always feel now F 57 60 days
100mg 1X day
12/31/2020
 5  On HRT premature ovarian failure I get tired and dizzy sometimes after taking it. Some nights no side effects at all. I also take Vivelle Dot 0.075 twice a week. I take it for the first 12 days of the month. When it does make me dizzy it may last into the next day. It It is worth it to me, my hot flashes were extreme. I had days literally having one an hour. I would turn almost a purple shade. My heart would race then the sweat would drench me, sleep was torture. That has all stopped. I have gained some weight but that may just be my fault. A full glass of water does really help keep the side effects on the lower side. Hormones are crazy. F 44 2 years
200mh 1X day
12/5/2020
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PROMETRIUM  (PROGESTERONE):  Progesterone is a type of female hormone (progestin). This medication is similar to the progesterone that your body naturally makes and is given to replace the hormone when your body is not making enough of it. In women who are not pregnant and not going through menopause, this medication is used to restore normal menstrual periods that have stopped for several months (amenorrhea). Progesterone is also used as part of combination hormone replacement therapy with estrogens to reduce menopause symptoms (e.g., hot flashes). Progesterone is added to estrogen replacement therapy to reduce the risk of cancer of the uterus. This medication is not for use in children. Progesterone must not be used to test for pregnancy.   FDA Approval Date: 1999-10-15 (Sources: U.S. Centers for Medicare Services, FDA)

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