LUPRON DEPOT Reviews (LEUPROLIDE ACETATE)

Average Rating: 3.0 (783 Ratings)

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LUPRON DEPOT  (LEUPROLIDE ACETATE):  Leuprolide is used to treat advanced prostate cancer in men. It is not a cure. Most types of prostate cancer need the male hormone testosterone to grow and spread. Leuprolide works by reducing the amount of testosterone that the body makes. This helps slow or stop the growth of cancer cells and helps relieve symptoms such as painful/difficult urination. Talk to your doctor about the risks and benefits of treatment.   FDA Approval Date: 1989-01-26 (Sources: U.S. Centers for Medicare Services, FDA)

  

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More on LUPRON DEPOT: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR LUPRON DEPOTCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  endo I had nausea,joint pain, hot flashes, night sweats, osteo in my hips and now a permenent disease called fybromialgia. Ladies do not take this shot unless this is the last resort!!!!!!! I have 3 children 9, 6 and 2 and everyday i have to force myself out of bed and i hurts to hug my children..... F 28 2 years
12/22/2009
 4  Endometriosis This time around just pain so far and bloating.... all the endo symptoms arte back. This is my 6th shot the first 5 were 3.25 this one was 7.5mg. #4 and 5 did not do anything at all.. They tell you the first shot everything will get worse well this first shot of 7.5 is def making things worse. My doctor said just three of these then laproscopy. I just wanna get to that i can feel a mass that has gotten bigger esp lately and over the past couple of years and now the pain is more spread out. So we'll see I'll keep you posted but none of the original side effects yet like hot flashes and so on, Shots 1 and 2 were bad for that. Waiting for those to attack me haha. F 25 6 months
11/30/2009
 1  fibroids, heavy periods hot flashes, irritability, extreme itchy skin rashes after 4th dose It is not worth it. I would not recommend this life altering medication to anyone! The side effects are very real and undesirable. F 50 6 months
11/24/2009
 5  Prostrate Cancer Constant urge to urinate; Hot Flashes. Hard to sleep and lost of strenght for sex M 60 6 months
11/16/2009
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 3  endometriosis Hot Flashes, joint pain, memory, concentration, moodiness, dry skin, acne, nausea, weight gain, tiredness. The first injection I had the surge in emotions and hot flashes. I did not have any pain until I was late getting my injection (the third one) and I had heavy bleeding and horrible cramping. Prior to trying the shot I tried birth control and alternative treatment dong quai. I used Estroven to try to help it helped a little during my treatment the hot flashes were not as bad and frequent. I did not use the add back therapy because of epilepsy and the meds I was taking for treatment. I would not recommend this treatment unless absolutely necessary and a last resort. My sex drive was gone and vaginal dryness was the worse. Trying so many products to treat the side effects was rather expensive. I had my last injection a few days ago. I am just glad to be finish last injection early this month and I will not be doing a second round. The hot flashes has been worse like I am sweating bullets. The side effects had a horrible effect on my relationship and my health. I dont want to go through menopause again! At times it also felt like I was still having PMS it probably was the moodiness. I am looking forward to my system going back to that of a 32 year old woman. I just hope they find another way to treat endometriosis. There needs to be more information and treatment available for endometriosis for the sake of all women that have severe endometriosis and pain. This is the first site I have seen that has any current information. F 32 6 months
11/7/2009
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 4  Endometriosis Hot Flashes, FORGETFULNESS I was terrified to take Lupron after reading this website. For the first two weeks after my first shot I kept waiting for the bottom to fall out. Luckily, my symptoms have been minimal. I have an occassional hot flash which only lasts a couple of minutes. The biggest think is memory loss. It's a small price to pay to be free of the pain of endometriosis. I had CHRONIC pelvic pain. It hurt to stand, sit, etc. I'm going in for the second shot tomorrow. I hope my symptoms continue to stay minimal! F 23 6 months
10/26/2009
 2  endo LUPRON WAS THE WORST THING I COULD DO TO MESELF. LACK OF SEX DRIVE & SLEEP. HOT FLASHES, NIGHT SWEATS. UNABLE TO THINK W/O CRYING ABOUT SOMETHING DUMB. FORGETFUL, MOODY, TOTAL WEIGHT GAIN. FEET & HANDS WOULD SWELL UP. TERRIBLE FEELING EVER ! ONLY TO FIND OUT MY ASSET HAD GROWN BACK. F 28 6 months
10/13/2009
 1  endo and in a lot of pain hot flashes, hair loss, acne, water retention, weight gain,lower part of abdominal swelled up, depressed, angry, forgetfull, Ok, so in 1999 I was diagnosed with Endo. Up until then, I though I just had really bad periods. I had 2 laporascopy surgery, and with each surgery the endo was worse everytime, and now I have a lot of scar tissue and the endo is back. the pain never went away and it's so bad to the point where I cry. So, my doctor told me that if I wanna get rid of the pain is to take out my uterus and my left ovary, but that is not an option, we want more kids. Then she decided to put me on the lupron depot shot, every 3 months for 9 months. She told me about some of the side effects, (some), but said they would go away. So, first 3 months, it wasnt as bad, except for the hot flashes and the night sweats which they never went away. The good part was, no period and the pain is gone. Well, my last shot was in March 2009 and ended in June 2009 and as of right now, still no period. The worse part is that all the side effects are back, some are really bad and they are not going away. I started to loose my hair,not able to loose any weight and my belly swelled up (looks like I am pregnant), joint pain, very angry, very depressed, i cry a lot, night sweats, hot flashes, forgetfull sometimes. On top of that, i get so angry, to the point where I cannot control myself and i start crying. I havent had a period in more than a year now, and hope to get it soon and have more kids. Too bad my doctor didnt tell me all this and had to find out on my own. M 32 9 months
10/11/2009
 4  Endometriosis Hot flashes, weight loss, short temper Honestly, I was scared to death to take this medication after reading the horror stories others have experienced. I've only been on the medication for two months (I'm doing the monthly shot for the first three months, and then the three-month short on the fourth month). I'm taking the add-back therapy, plus using Dr. Edward Bach's "Beech" for the mood swings/irritability. The hot flashes are fun sometimes but have decreased since the temperature dropped (I live in the desert). All in all, not as bad as I feared it would be. I'm thrilled I'm not gaining weight, and I hope that this doesn't start happening. F 39 40 days
10/5/2009
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 2  Multiple Fibroids,anemia Muscle aches, joint pain, weakness, some confusion, horrible yeast infections with strong chemical smelling discharge. Had yeast infection of the breast for the first time with same strong odor. Hot flashes, sweating. Brittle hair. Headaches from the first two injections then they went away. Almost lost my job. FYI: www.chemocare.com/bio/lupron_depot.asp I never had a problem with body odor. I had to continually get prescriptions of Diflucan to treat the yeast infections. I found out that the muscle aches and joint pain caused by Lupron is because some medications cause inflammation. Taking anti-inflammatory medicines helps some. I was tired of taking so many medicines, so I went natural. Lemon water with Cayenne pepper. I drank three or more bottles of that every day for about a month and the severe muscle aches and joint pain left. I would just pour it into a water bottle and drink it throughout the day. For some the cayenne pepper might increase your hot flashes, but drinking extra regular water will help. Cayenne pepper is an anti-inflammatory. I don't know if that will flush out the medicine, I doubt it but I know I got relief from pain and stiffness without the other drugs like ibprofen and tylenol types that can also slightly reduce the affects of the Lupron. Either way it helped reduce the side affects and my iron levels increased from the lupron because I didn't have a period at all. That was great! Worst part, I almost lost my job because I was so sick. I was harassed until I told them I was on a chemo drug. Then they backed off after I provided documentation from my doctor. I hated that because it is a personal situation. Lupron is a Chemo therapy drug. Which is ok, except my doctor played down the whole treatment thing. The fibroids did not shrink except one, but not to make a difference. It was worth a shot. F 34 6 months
10/4/2009
 1  preperation for myomectomy Severe hot flashes, night sweats. Severe moods. Inability to function rationally. Severe weight gain. Pretty much became a "crazy person" I was advised to take this medication in preperation for a myomectomy to remove multiple fibroids that ranged from 11cm to about 2cm. The surgeon wanted it to reduce the amount of bleeding during the surgery. I was skeptical about this medication in advance, but chose to trust my surgeon. I have to say, this has been the worst I have ever felt. My injection of 11.25mg Leuprolide in February has cost me a career, my sanity, my figure, and I have yet to determine if I'll ever feel good again. I wanted the myomectomy in hopes to finally have a child at 36 years of age and I still haven't resumed my menses and out of 3 different physicians, none can tell me when I will. Just that I should in 6-9 more months! I have read from a few others on this site that "don't pay attention to these warnings, I took it and it is fine", which worries me. No one should take this medication. The few that MAY not have had the severe reactions that the MAJORITY of us have had, should consider themselves extremely lucky. This medication has cost me a very profitable career in medicine. I know this for a fact because I am still living in this hell. If you are being told by your doctor that you NEED this, definately talk to at LEAST 2 other physicians before having this injected into your system. I am 36 and the doctors that I have went to trying to get relief from my symptoms are unable to do anything but inform me that "I will just have to live with it". Really, get ano F 36 3 months
9/23/2009
 3  Endo. Only day 1 but already very naseaus, crying a bit, hot flashes, fatigued. F 23 1 days
9/18/2009
 5  endometriosis hot flashes around the time the medication is due again. I have also had memory loss and irritableness which I didn't connect to the med until reading this site and learning it could be a side effect. I just thought I was aging quickly. LOL! I have had endometriosis since before my first period at 11. I have had so much pain with my periods (bed ridden for 3 days), prior to my periods and with ovulating. At the time there was nothing to help. Years later tried Depo Lupron and have now been on it for probably 15+ years. With depo lupron I was finally pain free and it has been amazing for me. Tried to go off of it 1X and the cramps came back unbearably so I am on it again. Note: I have been taking it continuously for 15+ years. I have had a bone density test 1X and it was fine. My memory has been bad and getting worse for about 10 years but never connected it but my family has a history of poor memory too! Any one know of statistics for breast ca or ovarian ca, etc for those taking depo lupron for extended periods? F 44 15 years
9/14/2009
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 4  Endometriosis Same as I have read from many other posts: hot flashes, trouble sleeping, "all over" joint and bone pain/sensitivity, headaches, moodiness, WEIGHT GAIN, yeast infections, nausea, chronic fatigue, loss of concentration and memory and a bruise-like feeling at injection area. Sexual side effects were either complete lack of sex drive OR complete addiction to sex which will vary several times throughout a 24 hr period. First diagnosed with Endometriosis at age17 from a Laparoscopy (also revealed ovarian cyst). Put on non-cycling birth control pills at first to suppress the growth of the Endometriosis, but my body DID NOT respond well to thinking it was pregnant. Put on Depo-Provera, still miserable and had frequent E.R. visits for vomiting/constipation/pain. Then I was put on my first 6 month round of Depo-Lupron. Doctor DID inform me of all side effects and their severity. Injection site felt like a bruise for 2-3 days. Months 1-3 were miserable and almost unbearable. When I say miserable I mean I was not able to work or even leave my home hardly ever. I never used to get headaches (I have a caffeine free diet as caffeine exacerbates the Endometriosis), but had some of the worst headaches in my life. Sleep was virtually impossible, for me or my fiancé. Nausea was caused by hot flash severity. But I fought through and months 4-6 were almost pain free. Went back to non-cycling birth control for a second trial. Again, body was sick and useless while thinking it was pregnant. After 6 months had second Laparoscopy which wasn't even close to being as successful as the first was. Given Percocet as pain killer (very strong narcotic). Put on 2nd, 6 month round of Depo-Lupron, again was hard months 1-3 with relief months 4-6. Progesterone prescription helped a lot with the moodiness and hot flashes this time. ALL side effects go away after your off Depo-Lupron EXCEPT the memory problems and b F 22 1 years
9/13/2009
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 3  endometriosis,fibroids, Adenomyosis terrible hot flashes,extreme fatigue,restlesness,depression,aggitated,cold,empty feeling,hair loss,weight gain. has anyone else experienced hair loss. my doctor says its normal to experience alot on these shots and i was put on hormones to help calm me with no success.i am on a nine month regimen with it. and the symptoms got so bad i stopped for two months before the hubby made me go back and finish the therapy. no fun F 27 6 months
9/13/2009
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 5  endometriosis hot flashes, vaginal dryness After add back therapy, I felt better than I have for a long time. F 43 6 months
9/5/2009
 2  Fibroids, Heavy Periods, Anemia Headaches, nausea, vomiting, hot flashes, yeast infections, severe muscle stiffness and pain, joint pain, severe weakness, and exhaustion. First of all I went on a 6 month treatment of Lupron Depot to shrink the fibroids. I am in month 5 and had a follow up done early to check the status. They have remained stable and there is no shrinkage. I have almost lost my job because of the horrible side affects. The only thing I love is not having a period every month. I am disappointed that my doctor did not tell me the truth about all the side effects, because I did ask. What I also was not told was that Lupron Depot is a chemotherapy drug. Even that bit of knowledge would have given me an idea of what might to expect. I did my research first but didn't find that. When I called back to ask the nurse about the side affects, she said that most people don't have them and of course you were going to find all the negative information on the internet. Well, I see why people would post the negative. Not many physicians are owning up to the horrible side effects. I agree going thru this temporary to fix the overall problem. But it looks like in my case it hasn't helped. If any thing I am hoping that perhaps it stopped them from growing more. --Trying to think positive.-- Any how I still have to have surgery, I was hoping that Lupron would have shrunk the fibroids so that I could have smaller incisions and less blood loss. F 34 5 months
8/29/2009
 2  Uteran Fibroids Peiords ceased, mild hot flashes, occasional night sweats, moderate fatigue, moderate joint pain, mild restlessness, mild insomnia, mild depression. My gynocologist prescribed Lupron Depot injections to try to shrink fibroids that were found during a regular exam. The dosage prescribed was 6 monthly 3.75mg injections. I will be receiving the 6th injection in September 2009. A hysterectomy will be scheduled for early November 2009. Unfortunately, the injections did not shrink the fibroids as much as we had hoped (from 20 cm to 16 cm in 4 months). I was expecting the worst in terms of side-effects. I'm very pleased that they have been quite tolerable. F 46 5 months
8/25/2009
 4  Endometriosis MANY Hot flashes, some night sweats, body aches, initial Headaches which got better over time, fatigue I am just about to get my third shot it has helped dramtically with the pain. I had been dealing with it for a long time and it was gradually then quickly getting worse. I had thought cysts and finally found out endo. I was terrified to get this shot due to the side effects but it has been worth it completely. i hope to be able to have more kids in the future so i am taking lupron hoping to decrease the endo for a little bit so that i am able to. My family MD also prescribed prozac which the give for PMDD and it has kept the weight gain and mood aspects under control. my weight has gotten better now it took a bit. It has been worth it. Only fear is getting pregnant on it.... but it has been worth it so far. F 25 2 months
8/14/2009
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 3  ENDOMETIROSIS HOT FLASHES, SEVERE MOOD SWINGS, VERY IRRITABLE, HEADACHES, UNABLE TO FOCUS FORGETFULNESS. NOT SO MUCH INSOMNIA BUT RESTLESSNESS!!!!! I HAD SEVERE PAIN BEFORE THIS SHOT AND NOTHING WOULD HELP. AFTER TAKING THE SHOT I CAN SAY THAT THE PAIN HAS REDUCED DRASTICALLY.SIDE EFFECTS ARE TERRIBLE. I AM A VERY ORGANIZED PERSON, NOW I FEEL LIKE I CAN'T THINK STRAIGHT, I LOSE MY TRAIN OF THOUGHT EASILY AND I AM EASILY DISTRACTED VERY FORGETFUL, IT JUST SUCKS THAT YOU SUFFER IN PAIN THEN WHEN YOU GET THE RELIEF YOU WAITED FOR EVERYTHING ELSE FALLS APART. THE FACT THAT I HAVEN'T HAD A GOOD NIGHTS SLEEP IN 3 MONTHS DOESN'T HELP THE SITUATION ANY EITHER. I HAVE TROUBLE FALLING ASLEEP, STAYING ASLEEP AND MY WATER BILL IS HIGHER BECAUSE OF ALL THE SHOWERS FROM SWEATING SO BAD. AT TIMES I DON'T EVEN WANT TO GET UP AND GO. THE SEVERE PAIN IS GONE BUT I DO HAVE PAIN AND CRAMPS NOW AND THEN THEY JUST SEEM TO PASS OCCASIONALLY WITH ANAPROX FOR THE PAIN. F 27 3 months
8/13/2009

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