DEPAKOTE Reviews (DIVALPROEX SODIUM)

Average Rating: 3.0 (584 Ratings)

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 ANTICONVULSANTS

 Type: Rx Drug

  

DEPAKOTE  (DIVALPROEX SODIUM):  This medication is used to treat seizure disorders, certain psychiatric conditions (manic phase of bipolar disorder), and to prevent migraine headaches. It works by restoring the balance of certain natural substances (neurotransmitters) in the brain.   FDA Approval Date: 1983-03-10 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on DEPAKOTE: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR DEPAKOTECOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  anxiety hair loss good stuff M 39 3 years
250 3X day
7/15/2014
 4  bipolar I In the beginning my appetite increased exponentially, and therefore so did my weight. I also had slight nausea, & I had trouble finding words and had mild brain fog. But after about 2 months those side effects disappeared and now the only side effect is a pretty persistent drowsiness. It's worth it to continue this drug for a few months at least, because it does work. My moods are so much more stable, they don't fluctuate the way they used to and I'm able to experience emotions in between just the black amd white. F 25 4 months
500 mg
7/1/2014
 3  Bi-Polar Lack of ability to concentrate / focus, Depression, Fatigue, some tremors - but most only at start M 43 3 years
2000 mg 1X day
6/3/2014
Email
 1  bipolar Weight gain, drowsiness, slight hair loss M 27 1 years
1500
5/20/2014
 1  Bipolar II rapid cycling Major hand tremors - was embarrassed to even hold objects in public my hands would shake so badly. Total loss of passion for my work as an artist. Literally my drive for life evaporated along with my usual energy and humor. Confusion, memory loss, inability to complete thoughts or sentences (I literally felt myself becoming stupid), major fatigue and lethargy, wandering thoughts - feeling like I'm in a weird trance, brittle hair that just started breaking and falling out. Didn't really gain any weight but did have acid reflux and constipation. No sex drive. I was on Lamictal and Tegretol, ended up in a psych hospital after an episode. I was taken off the Tegretol and put on Depakote. It definitely DID HELP my rapid cycling but turned me into a zombie with terrible side effects that caught up to me. So manic, depressed and crazy or a zombie with no hair?? I'm currently withdrawing from it now but was tapered off in only a week because it affected the Coumadin levels; the blood thinner I had to take after recently ending up in the ER and hospitalized for 10 days after having mini strokes due to a dissected carotid artery with NO EXPLANATION. Depakote? I had migraines every night for two months and went through 3 very decorated doctors before they found the dissection. I could have died. Could I have been that 1% or whatever that could have had a stroke because of this toxic drug that stole a year+ of my life? Withdrawal: flu like symptoms, no energy, tremors, headaches, backach F 29 1 years
1500
3/30/2014
 1  Seizures Weight gain, stomach aches, hairloss. Seizure free now and off meds, but still losing hair after 4.5 months without meds. I was told it would reverse! Never lost the weight. Hyper and memory issues. F 9 10 months
125mg 6X day
3/29/2014
 1  Bipolar Sheer poison, tremors, disturbed sleep, nauseated,hair loss, no improvement. Would like to sure the bastard that prescribed it. Off medicine now, just take klonapin and receive therapy. Feeling relatively good. F 75 3 months
30 3X day
3/21/2014
 2  headache shakey blured vision fell out of bed confussion short of breath chest pain F 58 6 months
2X day
2/6/2014
Email
 5  bipolar I was on depakote er for the majority of my time on the drug. Initial side effects included intense hand shaking, intense sleepiness (I should not have been operating a vehicle, I'm lucky to still be here honestly) and irritability. recently the new doc screwed up and gave me depakote delayed release. There IS a difference. In my experience it has been a good one. I have only taken it for a couple of weeks but my mood has been better than before on the er. my hands have gotten the shakiness back unfortunately. I was glad to be over that. and my chest feels funny sometimes. I talk more now and for me that's really good. I hope I don't have to rely on this medicine forever but for now, it has changed my life for the better F 23 7 months
250mg
11/5/2013
Email
 4  bipolar Much more pleasant mood but it's only been a week. Appetite has increased. It does make me sleepy but not to the point of interfering with daily chores/work F 34 1 weeks
250 mg 3x/
10/12/2013
 3  suspected bipolar Nausea increased appetite weight gain, I felt calmer first few weeks but the last couple of weeks my moods are changing more often but Im having problems to do with work F 50 2 months
750mg
10/9/2013
 1  Calm me down , help me sleep Stayed awake for 2days & nights when first started taken it. I had tremors,loss of appetite,& after 2nd week of being on depakote I started hallucinating and still am after 5months of getting off it.I do not recommend this drug for anyone. F 28 2 weeks
250mg 2xd
9/14/2013
Email
 2  Bipolar disorder Tons of G.I. issues my first month, regardless of my diet or intake. My memory is gone. Depakote sucked my memory out of my brain. The doc says it's ADHD...I disagree. I didn't have a memory "problem" until Depakote entered my body. No weight gain. Make sure you get your blood work done while on this med. In my situation, the con's are worse than the pro's. I took a combo of Remeron and Prozac before Depakote. My wife and I agree that the AD combo was more effective. I wanted off Prozac due to e.d. and anorgasmia. M 30 3 months
1500 MG
8/17/2013
 5  Bipolar NOS At first, I was kind of zombie-ish for 1week. And had a lot more hunger the 1st month and gained weight. After the first month, these side effects went away. After very low level and infrequent bipolarity for most of my life, bipolar NOS with recurring depressions took over my life after being triggered by significant family traumas. I used marijuana to deal with the symptoms. Worked pretty well. But not as well as depakote. I have to say that the vast majority of my dysphoric hypomania symptoms (if not all) have disappeared from taking depakote ER (brand) 250MG 1X/ day after dinner. I really hope it continues to work. My family has noticed the significant positive change as well. I wish I tried this depakote instead of years of antidepressants (which did nothing). I did try abilify which made me extremely anxious. Depakote has really helped me. I didn't expect it and was hopeless that I would ever get better. M 47 4 months
1X day
8/8/2013
 2  bipolar 1 disorder, migraines Extreme nausea, panic attacks, short-term memory loss, 'brain fog,' weight loss. I was prescribed valproic acid during an acute manic episode, since previous treatment with lithium had caused hypothyroidism and kidney problems; although it started to stabilise my mood, I began having panic attacks several times a week, and was frequently too nauseous to eat or would throw up whatever I ate. The gastrointestinal side effects were meant to subside after the first few weeks, but they persisted the entire time I took Depakote, and I lost almost 20 pounds (I was small to begin with, and now weigh less than 100 pounds). I was tired most of the time, had difficulty waking or staying awake, and my grades suffered due to memory problems / fatigue. Ultimately I would not recommend this drug--the detriments outweighed the benefits for me. F 20 6 months
1000 mg 1X day
7/30/2013
 3  Simple, partial seizures Osteoporosis, low free testosterone (from high SHBG levels), mild tremor, mild weight gain (10 lbs.), elevated red blood cell indicies ((e.g. MCV), reduced platelets (although still in normal range) Total seizure control, i.e., zero seizures in 20 years, but significant side-effects from long term use. M 63 20 years
250 MG 4X day
7/24/2013
 1  Seizures 1.short term memory loss and terrible cognitive skills........also my two children had birth defects from depakote......I hate this poisonous drug!!!!!!!!!!!!!!!!!!!!!!! Plz don't take this! F 46 10 years
1000
7/2/2013
Email
 5  Epilepsy Hair loss, cold to hot ( when first started), used to make me drowsy a lot but once dosage was perfected I lost that. WORST SIDE EFFECT IS SHORT TERM MEMORY. Took during college and grades suffered. I cannot remember a persons name unless I ask them multiple times upon meeting. It totally controls my grand mal seizures though so the trade off is worth it!! M 26 10 years
1500 mg
4/28/2013
 5  Migraines Tender breasts, some hair loss, some fatigue, but a really content and mellow feeling, which is a great side effect for me. Some minimal weight gain in the first 2 months (2 kgs), but I workout daily and eat very healthy, so it has gone down again. I slept more with the almost daily migraines and its just hair, and I still have enough, so I am definitely not complaining! The only thing is if I forget to take it, I immediately get a headache. Also, I talk a lot more in my sleep and have more vivid dreams, but my hubby calms me down, so I go right back to sleep. But my quality of life is so much better with this medication and its the only medication I take, so maybe that's why it works better on me than most people here. I'm very happy with it! F 46 4 months
500
3/9/2013
 2  stress related siezures side effects are sleepy constantly, tremors throughout morning, lack of readiness, memory loss, hair loss, appitite hikes, weight loss, irratable.... BUT CONTROLLS SIEZSURES... GO FIGHURE. I HATE THIS PILL F 28 10 years
500mg
12/9/2012

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