DEPAKOTE Reviews (DIVALPROEX SODIUM)

Average Rating: 3.0 (584 Ratings)

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 ANTICONVULSANTS

 Type: Rx Drug

  

DEPAKOTE  (DIVALPROEX SODIUM):  This medication is used to treat seizure disorders, certain psychiatric conditions (manic phase of bipolar disorder), and to prevent migraine headaches. It works by restoring the balance of certain natural substances (neurotransmitters) in the brain.   FDA Approval Date: 1983-03-10 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on DEPAKOTE: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR DEPAKOTECOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  bi polar Weight gain low mood F 42 3 weeks
750mg
6/10/2015
Email
 1  I was depressed about job I wasn't Hair loss head hurts for no reason anxiety attacks sJorgensen disease hysterectomy intestinal problems .I don't know why doctor gave all these drugs I can't even keep a job so muck weight gain I look older. Doctor should not put people on this drug? F 51 8 days
200
5/21/2015
 1  bi polar Insomnia for the first 3 days and then out like a light the next 3 days, I haven't seen the sun in so long. Hair loss weight gain, 10 pounds in 6 days... I srsly don't understand how a drug like this can be prescribed to people. I had some issues at my last job due to anger/anxiety/insacruities but man if I had been on this drug during that time it would have made everything worse. I've lost more hair in the last 6 days than I have due to depression and stress put together in the last year. I'm kind of freaking my self out because I'm not taking another pill of this crap and I'm worried I'll go in to some sort of seizure before my doctors office opens to tell her I'm no longer going to take this medication. I'm a little upset at my doctor because she did not tell me the full side effects of this drug and the issues it could cause me. I haven't been my self, when I lost my job I promised I would clean the house and cook for my husband every day, and I was until I started taking this medication. Now I don't want to leave the bed and I'm having more panic attacks than ever. I'm already over weight and gaining more is not something I would like to do. When I told my doctor I wanted to be put back on metformin for my pcos she just looked at me like I was stupid. My weight, anxiety and my pcos are my problems. Ugh I'm just so pissed, because of depakote I'm sitting here at 5am writing in this. Also if you have someone in your family that has had a bad reaction to this drug it's more than like you will too, they put my dad on it and 6 months later her was in a mental ward getting "dry". Sad thing is it was 100 bucks for 2 F 26 7 days
500 mg
5/15/2015
Email
 3  Anxiety/Bi-Polar Hard to tell if it helps, really. I wet the bed once while taking it. Started to feel very bad physically but better mentally. Make sure to ask for monitored blood work with this medicine. I took it for a month, got off and just got put back on a lower dose with blood work being done periodically. Keep an eye on your urine and energy levels. Libido wasn't effected much. Made me a "zombie" to quote those around me but as far as mood swings, it helps. Double-edged sword M 24 4 weeks
500 2x
5/13/2015
 1  One seizure I had one seizure during a forum. No problems throughout my life otherwise. I may not have another seizure otherwise also. Doctor gave DepaKote along with olimelt and arpizole. Did not stop depakote till my hands started trembling. One month after stopping depakote, I am having severe hair fall since last two months. Seems like I will go bald. I may not have had another seizure anyway. This drug is worse than poison. I was never given another chance and put on this poison.Now with this hair fall I do not feel like socializing Sheer poison. Destroys life of a female. makes her bald F 40 7 weeks
1000mg
4/26/2015
 4  Bi polar depression Low back pain, weight gain 158 to 170, shaking hands F 31 10 days
500
3/30/2015
 1  bipolar disorder Caused problems for me mentally. Was agitated and didn't feel right. F 42 8 months
1000 mg
3/16/2015
 3  Mood swings. To be honest. I don't really know. Pretty good. F 29 4 years
1500
3/15/2015
 2  seizures an migraines 30 lbs weight gain, really bad appetite spikes, hands shake all the time, memory is very bad now, causes upset stomach. It took almost a year for my levels to be in the therapeutic range. It has controlled my seizures but is not working on my migraine anymore. I would not recommend this drug to anyone. F 41 1 years
1000 mg
2/19/2015
 1  Epileptic Constantly sleeping slurred speech mental disorientation weak confused insomnia Stomach bloated severe stomach pain high Ammonia blood levels M 49 6 months
1500mg
2/13/2015
 4  Migraine Some memory loss but mild, short term insomnia, decreased appetite, lowered libido - but this was a big plus. Adding to the dose slowly instead of jumping into the recommended 1000 mg made things easier. The delayed release version was easier to tolerate than ER. Migraine days down from 20+ per month to no more than 5. The side effects are manageable and seem to be improving as I get used to the medication. The first month I had 10 pain days, 7 the second, and now 5, and they weren't as bad. I would highly recommend a slow titration because this is my second try on this drug after a terrible experience when I was immediately placed on the 500 mg and went up to 1000 within weeks. I was totally against trying this again and a few months later I find myself telling my headache specialist Im not going off it unless I have to. I hope this helps others. F 36 3 months
250 3X day
2/12/2015
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 1  Bipolar II First I noticed being sleepy, more depressed, no appetite, urination got more difficult although I drank a lot of water, low back pain ( kidney pains?). Anxiety went through the roof, didn't want to go anywhere, deal with anyone. Suicidal thoughts and plans almost always on mind when awake but no energy to do anything about it. Then came a day I threw a lot of things that were important to me away and that night I woke up looking at my clothes trying to find the blood on them, because I just knew I had killed two people and had to get rid of the evidence. When I didn't find blood, I looked for the rifle I shot them with thinking of getting rid of it or if I had been dreaming, I could give the rifle to someone so I wouldn't shoot these two people like I felt i needed to (In the sane world, I have no reason to harm these two people). It was around this point I realized I didn't own a rifle (or a gun) and that I was having a psychotic breakdown. I'm glad I had some sense left! I called my doctor and stopped the Depakote that day. I would have been hospitalized but have a great therapist who kept an eye on me all day, making me drink tons of water. I slept fine that night other than urinating as though I hadn't for weeks! The next day I felt almost normal just very weak and felt like I'd been through H**l and back! I am surprised this drug hit me this fast...scary too! I don't know how people take this drug but I guess that is why there is a variety of them out there, right? I guess it bothers me a drug that is supposed to help one feel better (have less mood swings) instead has the capability of sending one into a psychotic state (my first and hopefully last). I'd like to see this drug re-researched for its many and potentially severely dangerous side effects! Doctors need to be educated so they can educated their patients also. F 57 4 days
500mg
1/23/2015
 4  Bipolar 2 when lithium caused kidney 140 pound weight gain in 8 yrs How do I ease off of 1500? F 58 4 days
500
1/21/2015
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 2  Bipolar 1, Mood Stabilizer, Anxiety Weight gain( 20 lbs in 8 months ),trouble with memory and putting sentences together. My curly red hair has turned brittle and thin. I have neck and joint pain. I feel lethargic but yet stay up until the middle of the night then pass out from exhaustion. I see black dots when I look from the side of my eyes and sometimes it seems like I am seeing things. Feeling like I can't drive for more than a few minutes without feeling extremely tired like I'll fall asleep at the wheel. I was an undiagnosed bipolar for most of my life (until 8 months ago). This drug seemed like the answer to my prayers. It did stabilize my mood but at what cost? I can't for coherent sentences and often trail off and feel embarrassed around peers. I am very concerned about my appearance and none if my clothes fit now that I am 2 jeans sizes bigger ( who can afford an entire new wardrobe in 8 months? ) I stopped taking it and I told my doctor that I didn't feel comfortable taking Depekote anymore. He supports me and it's been a week cold turkey. Keep in n mind I have no major problems like some people that have posted ( seizures or brain surgery etc ) and I would never try to stop this medicine if that were the case. However I want my control back and my personality back. I want to be me again and not feel like I am just skating by and suddenly 10 years pass and I am 50 lbs overweight,more depressed about that and wondering where my life went. F 35 8 months
500ER 2X
1/17/2015
 5  Bipolar 1 Hand tremors (remedied with Primidone); Memory loss (no remedy); Hair loss (remedied by Bosley for Women). Depakote has been my go-to drug when the lithium just isn't "holding down the fort". Have had to recently restart due to family problems. Depakote is a good drug for mood stabilization, but with side-effects, which really, any drug has. F 53 15 years
1500 1X day
1/5/2015
 4  bipolar Weight gain,no energy,experienced seizure first time ever. Creativity gone. When wellbutrin was added to my regimen, I felt great. Body only likes taking 500mgs. Of depakote. F 50 10 years
1000
12/16/2014
 1  Seizures I have severe hand tremors from this drug. I am. Always writing and it is almost impossible. I can't hold a glass or anything still. Picking up a fork to eat is impossible. I also have weight gain and have been dieting. Doctor lowered dosage from 2,000'to 1500, still terrible. I MUST get off this drug. Don't take it if at all possible. M 68
1500 1X day
12/12/2014
 4  Bipolar Occasionally weird dreams/talk in sleep, short term memory loss, major weight gain My doctor just upped my dosage from 2,250 to 2,500. Seems so high compared to what I'm seeing on here does anyone else take this much!? Reason was I told her I have hard time concentrating F 37 5 years
2,250
12/1/2014
Email
 4  bipolar 1 I had taken Depakote ER for about 6 years asking with lithium. Altogether atv one point I took a 1500mg of Depakote ER and I think 750 or 1000mg of lithium. I was very stable. But hand tremors were extrem. So I eventually was taken off lithium (because I thought i might be pregnant) and stayed on Depakote at the lowest dose of 750mg er... and things were good I was very happy I was not in any danger of getting into manic phases. I don't drink or use drugs in almost 8 years sober. I had a busy job that I loved which looking back I think made a HUGE difference. And had to switch my medication from the ER to the regular because of medication cost. So I took my 750mg 2x day once in the morning and 2 pills at night. I eventually lost my job and became extremely depressed so my dosage was upped. To 1000 mg one the am one in the afternoon 2 in the pm. But lately. I'm tired again my moods are extremely all over the place. I just want to sleep my life away. Im not sure if I'm over medicated or under medicated. I know pills are not magic but I've been really good about being in tune with my body. My dude affects errre different than most I used to have a b&b major sweet tooth but when i started Depakote it took that away...I was happy and sad about it. I do feel like lately I can't think I have headaches all the time and im having trouble processing things at my new job. I also am not really happy at this job. So I plan on reaching out to my Dr. And asking if I can decrease My med F 42 8 years
1000mg
8/29/2014
Email
 3  Bipolar I - manic episode Worked great for mood issues but I have IBS and other stomach problems and it made those a million times worse. I was throwing up and constantly nauseated and had heartburn. I never have side effects other than the same kind with lithium. Onto the next drug.. F 24 3 weeks
1500mg
8/8/2014

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