Average Rating: 2.6 (114 Ratings)

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on NOLVADEX: Reviews Summary  |  Drug Safety Information

 5  prevent breast cancer recurrence At very beginning, felt very tired and fatigued but over time got used to it. No other side effects other than mild hot flashes about 30 minutes after taking it. F 58 8 years
10 2X D
 3  Ovarian cancer No recurrance of cancer! But extreme hot flashes, tired every day. F 50 4 years
 1  ER+ stage-0 cancer, caught on MRI o ER+ cancer cells, stage-0, in-situ contained in one milk duct, right breast, not seen on either mammogram nor ultrasound, but found accidentally on MRI. Had masectomy, plus diep flap. No radiation nor chemo required. Two months after surgery, started Tamoxifen but 3 weeks of using it, developed adverse reaction with hives and swelling and oozing broken skin on neck. Had to go to emergency and given 10mg benedryl and zantac plus betaderm cream to ease condition. Stopped using tamoxifen immediately. Now I am on Femara. It has only been 2 weeks. Drug reaction, if any, is seen after 3-4 weeks, the time allotted for impact on estrogen levels in body. Also I already have had autoimmune disease, psoriasis, for 30 yrs, so I do not know what effects of meds to lower estrogen, like Femara would have on my body. Tamoxifen did not work with me. My concern surrounds having an autoimmune disease like psoriasis, and the impact of Estrogen lowering meds on body. F 57 3 weeks
 3  breast cancer Initially the hot flashes were really hard, to an extreme. My mood began to fluctuate. It felt very much like a "chemical depression." The hot flashes let up in intensity after a few weeks. The mood seems to be stablizing a little, but the thing I am struggling with the most is short term memory loss! F 59 2 months
20MG 1X D
 4  Breast Cancer Invasive Stage 1B I'm not sure. I can't pinpoint anything specific to Tamoxifen (everything can be explained away) but I THINK.. I have lots of joint pain, brain fog and nausea. Had Major Hot Flashes and Night Sweats, which may be tapering off. Overall, for the piece of mind that Tamoxifen may allow me to have extra time with my kids, I take it. I try not to attribute my aches and pains (and there are many) to Tamoxifen but it's possible that it's the culprit to many of them. Back, leg, joint pain. Brain Fog, nausea. I still have to take nausea medications 2-3 mornings per week... no biggie to me though. I went through medical menopause 1 1/2 years ago and they're getting ready to switch me to Arimadex. I hope I handle it well also but if not, I'd easily be persuaded to go back to Tamoxifen. It was bearable for me. F 44 2 years
20 1X D
 4  Breast Cancer Stage II Leg Cramps, Hot flashes. As long as I had a drink of Tonic water ( Quinine) every day or so the leg cramps were manageable. Hot flashes were/are managed by grinning and bearing it. Also keeping a hand fan around helps. Took for 3 (age 51-54) years before switching to Arimidex because my oncologist figured I was post-menopause. (My periods stopped due to Chemo at age 51 so we weren't sure ) The leg cramps were a drag. Now I don't get them. F 56 3 years
1X D
 1  breast cancer 1 days
 3  Breast cancer Cramps legs ,arms,hands,back and lack of energy sometimes lost of conscious like if l am no l olso bad concentration, bone pain, sadness,mood changes,hot flashes,numbness legs and arms. F 46 2 years
20 mg
 5  breast cancer Stage 1c minimal side effects Hardly any side effects for me. Once in awhile my hips will ache. It's worth it to prevent a cancer recurrence. F 46 8 months
20mg 1X D
 2  stage 1a breast cancer in 1 breast Extreme constipation with bleeding and sore rectum, vaginal dryness outside with soreness and bleeding, painful sexual intercourse, ear ache, leg cramps, sore teeth and bones, first time ever low red blood cell count, weight loss. I drink 8-10 glasses of water a day and increased my finer from 35-40 grams/day to 40-50 grams/day to no avail with the constipation. F 46 4 months
 4  Breast Cancer Stage I Grade 3 Hot flashes and night sweats (annoying at worst), weight gain, infrequent bowel movements, increased tinnitus, upper back pain, frequently wake up during the night. The hot flashes may be a result of chemotherapy (Cytoxan) which has stopped my menstrual cycle. I've gained 10lbs and no matter what I try, I can't loose it. I used to have regular bowel movements but now I have to take additional measures. I had slight tinnitus before but now it's noticeably worse. I also have unexplained upper back pain. I take Melatonin to help me get through the night. Overall, other than the upper back pain which may be from something else, my quality of life is pretty good. Currently cancer-free. F 46
20mg 1X D

 1  Breast Cancer In order of negative effect on quality of life: Memory/cognitive/sequencing problems, fatigue, foot and leg cramps, night sweats, short fuse. I'd like to know whether these symptoms and problems will diminish if/when I stop taking Tamoxifen. I feel as if I've aged ten years in less than one. I came up from radiation and then went right back downhill. F 55 9 months
20MG 1X D
 2  breast cancer Hip/knee pain, tendinitis in ankle and shoulder. F 70 10 months
10 MG 1X D
 4  Invasive breast cancer Some memory loss, leg pain and irregular cycle. It's worth it to me. F 42 8 months
20 1X D
 1  Stage IIA Invasive Lobular Only hot flashes at first, then more and more side effects each day, the worst being extreme fatigue, loss of muscle strength, constant stomach problems, constipation, depression/anxiety -- finally to the point that living longer doesn't seem like a big deal if it means living like this. With adjuvant therapy, about 4 women in a thousand will have a recurrence. Without adjuvant therapy, about 8 women in a thousand will have a recurrence. This means that out of 1000 women taking Tamoxifen, Arimidex, etc. 996 women wouldn't have needed it. (10-yr followup) The side effects might be worth it if you're one of the four, but if you're one of the 996... I have no way to know which group I'm in (the 4 or the 996), but I know what the odds-makers would say... F 56 79 days
20 mg 1X D
 1  DCIS INCREASED WEIGHT, BELLY, FLABBY SKIN, BRAIN FOG, BONE SORENESS IN WRISTS FEET AND HANDS, TOTAL LACK OF ENERGY WHICH LED TO DEPRESSION. 2 weeks after stopping tamoxifen i feel like my old self again, cant wait to exercise and get back to LIVING. F 56 160 days
1X D
 1  Breast Cancer I will not take Tamoxifen again. Oncologist is baffled as to why I lost my hearing. There are a lot of articles about Deafness from Tamoxifen. F 73 14 months
20 mg 1X D

 1  Stage 2a node negative breast cance No side effects that I can tell, except making my menstrual period go irregular, which could be from the onset of menopause. Side effects are supposed to be uncommon and I am so sad that these many posts are about very bad side effects. I will quit taking tamoxifen because the 2009 Christopher Li et al study shows that 25% of 5 year tamoxifen takers get a non-ER-positive (a much worse cancer) in the other breast. Endometrial cancer chances are indeed small, 1 in 3000, but 1 in 4 for a contralateral worse cancer is a humongous freaking chance. F 51 4 months
20 1X D
 2  DCIS, Mastectomy Had mastectomy after pre-cancerous cells were found. Experienced memory loss, brain fog (to the point that my teenager said she was really worried for me)loss of concentraton and not much interest in life. After 2 1/2 years, suddenly bled like crazy. Had to be screened for cancer of the endometrial lining. All this was attributed to tamoxifen. Was told to stop taking this to remove the risk. F 49 2.5 years
20 mg 1X D
 4  breast ca hot flashes, weight gain not too bad F 43 1 years
20mg 1X D

NOLVADEX  (TAMOXIFEN CITRATE):  Tamoxifen is used to treat breast cancer. It is also used to reduce the chances of breast cancer in high-risk patients. This medication can block the growth of breast cancer. It works by interfering with the effects of estrogen in the breast tissue.   (Sources: U.S. Centers for Medicare Services, FDA)