IMURAN Reviews (AZATHIOPRINE)

Average Rating: 2.9 (526 Ratings)

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 IMMUNOMODULATORS ANTIMETABOLITES

 Type: Rx Drug

  

IMURAN  (AZATHIOPRINE):  Azathioprine is used to prevent organ rejection in people who have received a kidney transplant. It is usually taken along with other medications to allow your new kidney to function normally. Azathioprine is also used to treat rheumatoid arthritis. In this condition, the body's defense system (immune system) attacks healthy joints. Azathioprine belongs to a class of drugs known as immunosuppressants. It works by weakening the immune system to help your body accept the new kidney as if it were your own (in the case of an organ transplant) or to prevent further damage to your joints (in the case of rheumatoid arthritis). Talk to your doctor about the risks and benefits of azathioprine, especially when used in children and young adults.    (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR IMURANCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  auto immune hepatitis constant discomfort in abdomen, bouts of diarrhea, hair thinning and becoming limp. Psoriasis became much worse! Arthritis better on the whole. I needed to split 75mg dose into three, as it caused severe nausea when taken in one dose.I also take prednisolone 5mgs. F 66 5 months
5/13/2007
 4  hypereosinophilic syndrome Some slight stomach pains. I have been on pred. for about 2 years, and getting significant bone density loss, plus the other usual side effects, so one of my docs suggested imuran. Alternating between 100 and 150mg dosage daily. So far, little effect, but I have managed to reduce my pred. dosage by 1mg. Haven't noticed any additional hives/rash (I have eczema for 13 yrs), or signicant hair loss. Hopefully it can partly replace the function of the prednisone. Best of luck with your conditions. M 26 4 weeks
4/29/2007
 3  Behcet Actually I was placed on three hard medications, Prednison, colchicine and Imuran (1 tablet daily of each, 20mg, 20mg and 100mg respectively. Now, the hard fact is that I am asoospermia ( i.e. No sperm in the ejaculation)although i used to heve over 20million / ml, however, the side effect of those three treatment killed me literaly. sorry for me. I can not elaborate my case more than that, as i am not certain which medication contributed more to my problem. Thank you. (Got to know) M 31 1.5 years
4/25/2007
 3  Behcet Actually I was placed on three hard medications, Prednison, colchicine and Imuran (1 tablet daily of each, 20mg, 20mg and 100mg respectively. Now, the hard fact is that I am asoospermia ( i.e. No sperm in the ejaculation)although i used to have normal sperm count(i.e. over 20million / ml), however, the side effect of this treatment killed me literaly. sorry for me. I can not elaborate my case more than that, as i am not certain which medication contributed more to my problem. Thank you. Got to know) M 31 1.5 years
4/25/2007
 4  autoimmune hepatitis have been on for over 2 years, have extreme joint pain in legs especially the knees, shoulders and hands, also problems sleeping Prefer this to prednisone F 44 2 years
4/19/2007
 2  Crohns Caused acute pancreatitis which needed me to be 999 ambulanced to hospital and given morphine for the pain. Spent days in hospital on drips and was very ill. It works for many but could have killed me. I had the TPMT test prior to taking Azathioprine and it said I would metabolise it normally, but once it is metabolised I could not deal with the chemicals it breaks down into. Be mindful of pain in the stomach region, I had this for a few days before it went acute. If you're thinking of taking this drug remember: it works for lots of people, it just didn't work for me. And I'm sad about that. M 42 2 weeks
4/17/2007
 4  Behcet's/Crohn's colitis Hair loss so far I am taking 20mg pred daily and 100mg Imuran for almost 1 month now and alot of my side effects ie: increased appetite, water retention, night sweats, and waking every few hours to pee are related to the prednisone for sure, but the hair loss is almost definitely related to this Imuran. I have been on pred before and have never lost my hair..maybe gained some where I didn't want it ie face etc. but I am losing more than 100 strands a day now. It started coming out when I was on 75mg and now I am on 100mg :( I hope it will stop falling out and grow back because this drug has been working great for me so far. I won't know for sure if the benefits will last until I can wean off the prednisone, but I am just coming out of a bad flare and 50mg+10mg pred was not bringing me out. So, as they've increased my dose of both the flare waters are fading. I feel great comparatively. I hope I will stay this way once off the pred. I will update later. F 30 8 weeks
4/13/2007
 3  Polymyositis Not sure if they are side effects of the medicine or the disease? Skin rash, insomnia, stomach pain, fatigue, headaches Tried prednisone but got severe headaches. The imuran has regulated my CPK blood levels but has not made any difference in other symptoms. I have had fibromyalgia for 10 years and those symptoms have gotten worse. F 51 5 months
4/5/2007
 3  Autoimmune Hepatitis I have been taking 75 mg for almost three years and experienced very little side effects. My doctor increased my prescription to 150 mg. Since the increase I have been really nauseated and really fatigued. 3 years 75 mg. A couple of weeks 150mg. F 19 3 years
3/26/2007
 5  Crohn's After years of use, I have noticed problems with blood clotting (blood seems thin; I bleed easily - gums, cuticles, etc.) I am also having trouble with chronic anemia and have annual IV iron infusions. I have lots of skin "tags", but no other known growths. Was diagnosed in 1980; begann Imuran in 1986 when it was experimental for Crohn's after my body would no longer tolerate prednisone. I have had two children and took 25 mg of Imuran daily through both pregnacies and nursing. Kids are 11 and 8 and healthy. I have been in total remission since 1991 with only occassional IBS-like symptoms that only last a day or so. Although I worry about long term side effects, Imuran has been a true life-saver for me. I was in bad shape before I started it, in constant pain and totally disabled. I was hospitalized at least twice a year, although I have never had surgery. My quality of life is excellent now, and I am sure Imuran is the reason. I am currently taking 50 mg once a day, and plan to talk to my doctor about cutting back to 25 mg daily. F 44 20 years
3/21/2007
 5  Kidney transplant (1974) Hair loss in beginning,Originally on steroids as well so not sure which drug was responsible. Skin tumors are a real problem on long term therapy. I would not change a thing. I have had a perfectly functioning kidney for 33 years thanks to Imuran. I just deal with the tumors. I am about to become a great grandmother something I would never have seen without the transplant. F 67 33 days
3/17/2007
 3  UC Fever, chills, malaise, head-aches, nausea, muscle aches, liver problems (elevated enzymes). Started at 50 mg's after a major flare-up that landed me in the hospital. Side effects kicked in after going to 100 mg's. My body seemed to go whacko at the higer dose and blood tests showed dangerously high levels of liver enzymes so was taken off and restarted at 25 mg's 3 weeks later. Had some repeat of the side effects, but noticed my colitis improved dramatically again after going back on. Will tough it out and see if it blows out my liver again. Time will tell. M 44 3 months
3/12/2007
 2  Crohn's Severe hair loss, itchy rash like hives everywhere, especially during exercise, feel cold all the time, worse menstrual cramps, always tired -- doctor says hair loss and hives not associated with Imuran, but read on ... I know some of my side effects are also symptoms of Crohn's -- like hair loss and fatigue. But these side effects were worse on higher dose of Imuran, and got less as the dose of Imuran decreased. I am also taking Remicade, that's why I have to take Imuran, but I was on 75 mg of Imuran for 6 months before I started Remicade and it did not help. When I started getting Crohn's cramps again, Dr. increased my Imuran to 100 mg and within a month, I started losing more hair and getting more hives and more stomach cramps. I said I wanted to stop taking Imuran and Dr. said, no, just go down to 50 mg, and guess what -- the hair loss slowed down and I'm actually starting to get hair growing back again, tho still really thin at temples and across forehead. Also, hives are not happening as often -- maybe once a week instead of several times a day. I am considered to be in remission on Remicade and Imuran b/c I started growing and caught up to my intended height from 4' 11" at 13 to 5' 7 F 16 4 years
3/9/2007
 5  Crohn's Severe joint pain in hands, knees, elbows and toes. Muscle aches and chills. Very tired for the first 6 months. I was diagnosed at age 18. Never had surgery. I was scared to take this drug. Finally agreed to try it and have been symptom free for nine months. I am not sure whether the side effects I am experiencing are from long term use of steroids ( Prednisone & Budesnoide ) or from Imuran as I was weaned of steroids at the same time I started Imuran. F 52 13 months
2/21/2007
 3  Crohn's Headaches and abit of nausea at first but no hairloss or anything else that i was warned about Will have to see if it allows me to come off steroids will be taking it along with them for 3 months yet. F 21 3 weeks
2/16/2007
 4  Severe Psoriasis Upset Stomach Gassy, Joint Pain; hands, knees, hips, jaw, ankles. Back Ache. Nothing too bad! I am also on Celebrex; Dr. thinks my joint pain could be due to Psoriatic Arthritis; but I am hoping it is the Imuran! M 25 3 months
2/4/2007
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 5  Sarcoidosis tiredness, skin growths, poor sleep quality - nothing life altering I take 150 mgs a day. Not really which side effects are from the disease or a life well led!!! I need alot of sleep, and get it, but often am still tired. I sleep poorly unless I take Unisom. I also wonder if the fact that I do not easily lose weight is from this medicine. After reading all the other reports I am wondering if the skin growths are from the medicine. The one time I went off the meds my disease flared. All in all - whatever the side effects are it is better then havng my disease destroy my lungs. F 41 7 years
2/3/2007
 1  Ulcerative Colitis 50mg/twice daily - nausea, back and chest pain, very tender stomach, chills/fever of up to 104 degrees, 8-10 welts/bruises on my lower legs, restless sleep, weakness, headaches F 28 6 days
1/27/2007
 5  crohn's i just submitted my rating, but i wanted to add my email address. F 23 4 years
1/26/2007
 5  Crohn's disease imunosuppression, resulting in more infections or illnesses that i may not have otherwise gotten, including shingles. however, imuran completely changed my life with my crohn's. however, imuran completely changed my life with my crohn's. i have a fistula that since being on imuran has decreased in size. I have had crohn's for 13 yrs, and imuran has been the only drug that has helped to control it. i have increased energy levels and formed bowel movements and very minimal bowel pain. before taking imuran, my crohn's was relatively severe. my disease was very extensive and my symptoms included many loose bowel movements daily. bloody stool, much bowel pain and decreased energy level and weight loss. my symptoms are almost non-existant now. F 23 4 years
1/26/2007

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