IMURAN Reviews (AZATHIOPRINE)

Average Rating: 2.9 (526 Ratings)

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 IMMUNOMODULATORS ANTIMETABOLITES

 Type: Rx Drug

  

IMURAN  (AZATHIOPRINE):  Azathioprine is used to prevent organ rejection in people who have received a kidney transplant. It is usually taken along with other medications to allow your new kidney to function normally. Azathioprine is also used to treat rheumatoid arthritis. In this condition, the body's defense system (immune system) attacks healthy joints. Azathioprine belongs to a class of drugs known as immunosuppressants. It works by weakening the immune system to help your body accept the new kidney as if it were your own (in the case of an organ transplant) or to prevent further damage to your joints (in the case of rheumatoid arthritis). Talk to your doctor about the risks and benefits of azathioprine, especially when used in children and young adults.    (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR IMURANCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  RA & Crohn's Disease Low platelet count resulting from pernicious anemia and the combination of these drugs and infection. I was having Remicade infusions while on it and picked up Mono b/c of my low immune system. I wound up being hospitalized, having bone marrow biopsies to rule out lymphoma and then 3 transfusion for having a platelet count of 5. I took 6 months to recover and am already at the point where I am on both drugs again. I am scared to death that I will get sick again. Mostly I'm afraid of it actually being lymphoma next time. I wish there were better drugs out there for me, but there just aren't. F 26 3 years
5/2/2009
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 4  Myasthenia Gravis Fatigue, joint pain (shoulder/arm), insomnia, some hair loss, and liver problems. At 100 mg a day, liver counts are fine (AST/ALT levels). At 150 mg/day, all levels very high. Higher dose was prescribed to lessen my need for prednisone. Also taking Crestor for high cholesterol. M 66 14 months
4/27/2009
 4  Crohns Occaisional "tired" days, some skin tags, mild groin rash. Diagnosed with Crohns @ 48 after years of vague symptoms culminated in total blockage - not fun. Resections 1991 & 2003. 50mg twice daily. Certainly better than the steroids which made me fat and grumpy... Best additional med is Questran Lite (think liquid concrete) which reduces the BM's (2-4 daily which is bliss for Crohns) AND lowers your cholesterol (bummer!) Dr has me on Vit D, B12, Folate and Calcuim supplement to keep bloods OK. Tests every 4 months. Told the authorities all about it and I still have a Class 1 Aviation Medical... M 61 6 years
4/26/2009
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 1  UC acne, fatigue, yellow skin, nausea, hair loss, lowered white blood cell count (had to find this out on my own, my doctor was too stupid to know he was supposed to be watching for this.) My doctor was a moron and had me on a really high dose relative to my age and weight, and I think that's why I had strange side effects like yellowing of the skin. If you have a good doctor who knows what to watch for this is a safe drug. If you have a bad doctor though this is an extremely dangerous drug. M 9 months
4/24/2009
 4  Crohn's Disease No side effects that I'm aware of. My dosage had to be adjusted at the beginning due to my white blood cell count getting low. Also, it hasn't helped to heal my fistulas. Otherwise, quite happy with it. F 34 10 years
4/23/2009
 2  Unknown Auto Immune Disease I don't think any side effects from Imuran. I'm on 100 mg daily. Using to enhance or to lower prednisone dosage(15 mg daily) I have been on Prednisone for almost a year. The only side effects from Pred are insomnia (occasionally) and hot - cold sensitivity to teeth. I really don't think Imuran is helping because I have had to actually increase my prednisone from 10 to 12.5 to 15. Crazy, huh? M 67 2 months
4/23/2009
 1  Crohn's Severe vomiting, lots of hair loss, bad acne, a rash on my face, WARTS, major fatigue, fever. I basically felt like I was dead. Once I got off it, I felt much better, but I don't think a Dr. could burn off the warts because there's so many of them. I hope they go away eventually. F 20
4/14/2009
 1  Ulcerative colitis Skin discoloration, yellow eyes, hair loss, warts, acne, severe nausea, flu-like symptoms, infections...and no positive effect whatsoever...Gee, what a great drug. Never in my life have I felt worse than taking Imuran. Maybe it works for some, but it can also be extremely dangerous to many others. Make sure your doctor knows that. There are some bad, incompetent doctors out there. You can't assume your doctor knows what's going on. The field of gastroenterology is filled with the absolute worst of the medical profession in my experience, greedy people just interested in money, people who have no integrity about doing their job properly, people who care not all if you have good outcomes or not. M
4/2/2009
 5  crohns diease severe neusea, vomiting, fatigue, fevers, After being on high dose of prednisone for many years with little results. While first taking Imuran I was also reducing my prednisone weekly with horrible side effect. And the Imruan together I spent 6 weeks on the lounge with my head in a green bucket I had to dropped out of Uni for one tearm and stop working as a nurse for 10 weeks. But it get better once all the side effects were gone Iam no in 95% remission. I do however still get joint pain and feel fatigued at times. F 46 3 years
3/28/2009
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 2  ulcerative colitis I took Imuran 100mg. per day. A rash appeared on my torso, front and back. These rashes itched terribly. Then the hair fell off of both of my legs. I discontinued taking Imuran. I'm taking Humira in place of the Imuran. The Humira is an injection. M 3 weeks
3/15/2009
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 4  Autoimmune Hepatitis fever, joint pain at higher doses (100 MG/day) none at lower dose (75MG/day) Have been on the medicine for five years and it has controlled my aut hep for the most part. Dr increased dosage last year to 100MG and I started experiencing some bothersome side effects-namely fever and feeling like I am coming down with the flu. Severe joint pain and achy feelings. Dr has lowered me back to 75 and am already feeling better. F 53 5 years
3/13/2009
 5  NSIP, fibrotic So far, so good. Have been on imuran (150 mg) for about 5-6 months for suspected NSIP (along with 20 mg pred). No side effects from the imuran. Prednisone is a different story. I feel better than I've felt in months! Record is 11 hospitalizations since 9/08 and almost 20 since 2/08 for pneumonia/exacerbations. Rarely went more than 20-30 days between hospital stays...usually 2-3 weeks was the average. I broke my record! I've now been pneumonia/exacerbation free for FOUR months! F 57 6 months
3/5/2009
 1  UC Skin discoloration, warts, acne, vomiting, hair loss, fatigue Got much sicker when I took this + other weird side effects. Skin discoloration has never gone away.
3/2/2009
 5  UC Extreme fatigue. mild hair loss at first, very stiff hand,knee and feet joints. lower back pain. nausea for most of day. weak grip in hands.disturbed sleep.eyesight has worsened on third prescription for reading glasses in 12 months. I was prescibed azathioprine in may 2008 after suffering from sever uc for about 7 months. prednisolone could not control it even when administered intravenously in massive doses when I was hospitalized. I found the secret to overcome the fatigue and nausea was by taking the azathioprine after my evening meal instead of in the morning, this way I slept through the symtoms overnight.I have been in remission now for about 6 months. I also take Asacol, 6 tabs daily and alendronic acid once a week . My only other option was surgery as the whole of my colon was affected. So as long as I stay in remission and my regular blood tests are ok I will stay on the drug and will have to live with the stiffness in my joints. I did loose a lot of weight at first but have now returned to my normal weight, but still have a fat stomache which hasn't gone down, I suppose this is due to the steroids I was on for so long. Good luck everyone and do try taking your aza in the evening, it worked for me by stop F 64 10 months
2/21/2009
 5  Ulcerative colitis Rash,some acne This drug combined with asacol has put me in remition I am so thankful for it. F 36 3 months
2/19/2009
 2  Autoimmune hepatitis I was fine when I was taking it with Prednisone (but had major side effects with that).. then took it alone, and had major pain in my body. Went to the ER and was told I had pancreatitis due to the drug! Was immediatly taken off of it. F 30 6 weeks
2/17/2009
 5  Crohn's Disease Thinning hair I have been on Azathioprine (Imuran) for a long time and take 100mg a day. It is the only thing that keeps the Crohn's stable. Have also had Asacol (didn't do anything at all) and Prednisolone (three courses, only the first of which worked) and Metronidazole (keeps the anal abcess at bay) over the years. This drug takes a long time to get in/out of your system, don't expect things to happen overnight. Also, I was advised to not get pregnant while on it. F 41 12 years
2/11/2009
 4  UC Fatigue only. Have had UC for ten years. Well controlled on Asacol until this past year. Went on Imuran 6 months ago. Daily dose is only 50 mg. and have been able to cut back on my Asacol dose to 2400mg. two times a day. Significantly less meds. as I was maxed on Asacol, plus Prednisone, plus Entrocort. Eeek!! So glad to be off steriods, period. Totally normal bowel function now. But do notice I am tired a lot. Find working out more difficult, fatigue much quicker. Presuming it's the Imuran but my physician also blamed it on advancing disease, so could be a little of both. So far have had no problem labs. I am an ICU nurse, take care of the sickest pts. and have not been sicker myself on this med., but am very careful. Overall happy with Imuran. F 44 6 months
2/9/2009
 4  polyarteritis nodosa vasculitus fatigue, joint pain in hands and feet. 50mg twice a day. I much prefer Imuran to the prednisone, but the fatigue is starting to get to me. My rheumatologist wants me to wait a year before we evaluate a lower dose. M 43 9 months
2/6/2009
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 1  Crohn's Lymphoma!! My son was just diagnosed with t-cell non-Hodgkins lymphoma with a guarded prognosis! It was explained this was most likely a result of his 4 year use of 150 mg. of Imuran daily. Worked great on the Crohn's but is it worth the risk? M 19 4 years
2/5/2009
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