DEPO-PROVERA Reviews (MEDROXYPROGESTERONE ACETATE)

Average Rating: 2.1 (2470 Ratings)

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 ESTROGENS PROGESTINS ANTINEOPLASTICS

 Type: Rx Drug

  

DEPO-PROVERA  (MEDROXYPROGESTERONE ACETATE):  This medication is used to treat certain types of cancer (such as uterine cancer, kidney cancer). Medroxyprogesterone is like a natural hormone called progesterone made by the body. It is usually used with or after other treatments (such as radiation, surgery). Medroxyprogesterone may prevent or slow the worsening of the cancer and decrease pain and other symptoms.    (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on DEPO-PROVERA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR DEPO-PROVERACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  birthcontrol severe rashes, vomiting and nausea - Not enough warning bad side effects F 18 2 months
1X O
3/27/2010
 5  can't remember to take pill Bad skin, occasional bloating, random bleeding, increased appetite, frequent urination. The only problem I have with Depo is that the side effects make me feel weird (I have never experienced PMS, so that might be it) and I worry that I am preganant. I've taken pregnancy tests and they have always been negative. Other than that, my side effects are extremely minimal and Depo is the GREATEST alternative EVER to the pill! I was horrible at remembering to take it, and I feel very secure with taking a shot every three months. It's great! F 19 1 years
1X O
3/24/2010
 1  birth control headaches,excessive weight gain,fatigue,nausea,dizziness,pains in chest,heart palpatations,depression,anger i started having this POISON after trying the pill microgynon for two weeks and i was bleeding constant i was given this to stop me bleeding i was told nothing about it apart from it will protect me from pregnancy as i had just gave birth to my son. over the past 2 years i have been going out of my mind im severley paranoid depressed angry. iv been to the doctors with all the side effects OF DEPO and was told it was all in my mind (at the time didnt no it was the depo doing it) i was put on anti depressants .. i feel alone, sad i cry. i used to be happy with the odd pmt like all of us but but now i feel so old my joints ache im so tired .. im glad i found all these pages about depo because this is my 3rd month of being off it still having side effects but i only had 1 period in 2 years..still havnt had one 3months after stopping...I DO NOT RECOMEND DEPO TO ANYBODY. IT HAS RUINED MY LIFE AND I AM JUST HOPING IL STILL BE ABLE TO HAVE MORE KIDS AFTER ITS OUT OF MY SYSTEM!!!!! F 20 2 years
1X AN
3/23/2010
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 1  Birth Control Depression, mood swings, no sex drive, spot for days after sex, weight gain, water retention. This drug should be banned. I went from a normal person to a mad woman. I was happy, sad, angry and insane all within a 5 minute time span. I became suicidal and irrational. When I was able to have sex I spotted for days after. No one wanted to be around me. I gained 30 lbs in a couple months. Post Depo - horrible! I now have anxiety that I have to take meds for, my hormones are not regular and it's been 13 years since I was on this. I've talked with other people who took this injection and several of us are now on anxiety meds and have many of the same hormone and psych issues that were never present until this shot. The people I've seen now who are on it are having all the same problems and also thought they were going crazy. There are cases that this might be justified, but for anyone who wants to maintain their sanity during and after using this drug - DON'T USE IT!!! It's not worth it! F 34 2 years
average 1X O
3/23/2010
 1  Prevent a complicated pregnancy Constant bleeding after 3months and only used depo once. Got it in november 09 and still bleeding and its march 10. It takes too long to wear off and the constant bleeding is uncomfortable. I got pregnant while on the depo F 23 1 days
1X day
3/22/2010
 2  Birth Control No Sex Drive, Bleeding After Sexual Activity, 15lb Weight Gain, Nausea, Headaches, Mood Swings, Depression, Fatigue my sex drive ended the day of the first shot, i instantly felt depressed. my body mimics pregnancy: constant hunger, i hold all my water and at times appear 6-7 months pregnant even though i'm 120lbs. after anything sex [sex, oral, manual] i gush blood for two days. i have intense headaches all the time that aren't relieved by anything. its generally depressing... F 20 7 months
1X O
3/21/2010
 1  birth control nausea,mood swings,stomach pain, horrible cramps,no sex drive,horrible migranes,blurred vision due to the migraines, i swear this shot is going to kill me i got it on the first day of my period and im still on it!ITS been 3 WEEKS im 16 this is really messing with my life im sick all the time my stomach hurts all the time i cry over nothing my headaches are causing me to not focuse on my school work they are so bad i can barely see when i have headache which has been hmm every 20 min for 3 weeks asprin caffine does nothing anymore i got to sleep 4 hours earlier than i used to and i feel like i only got 5 mins of sleep im so depressed and thats not good for me :( F 16 1 months
one shot 1X M
3/19/2010
 4  ovarian cysts and tumors i get head aches but thats normal everything else is great! i find that i do get hungry but you just have to control what you eat and how much you eat! this shot is awesome! i dont hurt anymore and there is NOTHING TO COMPLAIN about! F 17
1X M
3/18/2010
 1  birth control weight gain, depression, moodiness. After stopping: no period at all, despite no other new forms of birth control, for 2 years and counting Started on depo when I was 18. I gained 20lbs in the first few months. I have had no luck loosing it despite exercise and dieting. I also became very depressed and moody (to the point I actually attempted suicide!). I stopped right after anti-depressants did nothing and became a much happier person. What really frightens me is the fact that even though I've been off the shot for 2 years now, I HAVEN'T HAD ONE PERIOD. I DO want kids eventually, so now I'm rather freaked out that this shot may have caused me to be sterile. The lack of periods when I was on it was great, but the side effects aren't worth it. F 23 2.5 years
1X O
3/18/2010
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 1   Spotting before next shot was due, no period, extreme irritability, moodiness, fatigue, extreme weight gain, bloating, abdominal discomfort, skin spotting, no sex drive, depression This shot completely turned my life upside down. When I started the shot last spring, I was 125lbs. Now, one year later, I weigh 180lbs, and it just keeps going up. My sex drive is almost non-existent, and it's killing my relatonship. That combined with the irritability and moodiness is pushing my boyfriend farther and farther away. I find myself snapping at him for things that are so insignificant, it makes me look absolutely crazy. Thats not me. I dont even know who I am anymore. One of the other major things is the fatigue. I am now addicted to caffeine because I never have energy anymore. I will not be going back to for my next shot. F 20 1 years
1X O
3/16/2010
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 1  Prevent pregnancy Weight gain. mood swings, depression, anxiety I used this birth control because my doctor recommended it to me over all other types of birth control. I have now been off of Depo for 8 months and I'm still suffering the side effects of weight gain. I know many will say a medication can't be blamed for excessive weight gain, but Depo is truly an exception. I had never ever experienced any weight issues before Depo and then over a span of nine months I went from 125 lbs to 170 lbs in size perspective 5 to an 11. I do not have a sedentary lifestyle and I have been fighting a long hard battle to try to lose this weight and it's been a challenge (I've only been able so far to lose 10 pounds) I recommend this drug to no one and I hope for those who are already taking this drug to please get off of it, there are other options. I made the switch to Mirena and have been much happier weight is still an issue for me but I no longer have experienced depression or anxiety issues. M 18 1 years
1X O
3/16/2010
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 1  Birth Control Sudden severe headaches, breakthrough bleeding/spotting for 3 weeks, missed period, pre-menstrual bloating, fatigue, extreme weight gain I took 1 dose, but will not continue this method of birth control. F 38 3 months
1X O
3/13/2010
Email
 1  painful periods nausea, diarria, loss of appetite, no sex drive, bleeding non-stop for a month, tired, sad I was debating on getting the second shot because the dr. says my body just needs to get used to the drug and side effects will go away...reading others issues helped me decide no on my next shot. I'd rather have painful periods and end up pregnant than deal with this any longer. F 35 3 months
1X day
3/10/2010
 3  Birth Control Nausea, Moody-ness, tired, headaches, loss of period I had horrible cramping with my period but with the period loss I was starting to feel better. I would occasionally have mood swings, but nothing that I couldn't control if I really wanted too. The shot is said to cause nausea, I did expierence it and found that water made it worse. I called the doctor, and they assured me that water makes nausea worse. Headaches were controlable but often. The worst of the side effects were a week before and after I needed the shot. I would say it was very effective. F 18 1 years
4X AN
3/8/2010
 1  Birth Control While on the shot; major weight gain, loss of period, moodiness, constantly sick, nausea, vomiting, migrane headaches, could not hold food down, joint pain, muscle pain, blurry vision, depression, always tired, and could never get out of bed, Sometime, I would spend days in bed because I was constantly very tied. Eventually, this drug caused me to have a stroke and be a in coma and almost lose my life. After I discontinued; hormonal imbalance, irregular and very heavy periods, trouble taking the weight off, and some muscle pain. When I was 18 years old, my mother through me out of the house because I did poorly in an exam, dropped the course, and change majors. I had no place to go. So I stayed with a guy who I was dating at the time. After a few months, I fell pregnant and he kicked me out. Then I called my great aunt, who called my mother and told her to take me back in and she did. Then I told my mother I was pregnant. In order for be allowed to come home, I had to terminate the pregnancy, agree to never see this guy again, get a part-time job, and go on the depo shot. I agreed because I wanted to get my degree and needed her help. After the first shot, I was starting to feel tired, gained a little weight and my periods became irregular. But after the secong shot, was when the side effects was in full force. I when from being this very athletic, skinny and energetic teenager, to feeling like I was 90 years old. I was on the track team. People thought I was going to be in the Olympics. After the second shot, I became tired, fat, sick all the time and in constant pain. I went to different doctors, trying to find out what was wrong. That was when I found out it was the depo. The next shot was due and I did not go. When my mother found out, she got very angry and threw me out again. However, she let me come home the next day but I had to go to the clinic with her and get the shot. I suffered alot because from then on, my mother would drag me to the clinic to get the shot against my will. F 32 7 years
1X O
3/6/2010
Email
 3  Contraception Weight gain, mood swings, irritability, bloated, madness It is a very effective contraceptive but I'm not sure it's worth the stress - getting fatter, feeling ugly and depressed, not really wanting sex because I feel bloated and unattractive (despite what my boyfriend says). I have had some very light periods but I don't feel like I know my body anymore. I sometimes think I am going mad, I find it harder to be friendly (I'm a bubbly and friendly person normally) and I feel like since I've been taking this drug I'm self-conscious, insecure and uptight, and much more annoyed in general! I hate being so horrible and moody; I am not going to go back for my next injection this month - I want to flush out these hormones and be myself again, and hopefully lose the weight! F 26 9 months
1X day
3/4/2010
 1  birth control It turned me into a different person, angry ALL the time! Definitely my biggest complaint would be the moodiness. I had to withdraw from school and wait for the side effects to pass because I was furious with everyone and all I could focus on were violent, terrible thoughts. I am normally a completely peaceful person! Other side effects included no period (which is the one good thing!), headaches, and bad acne/really greasy hair. I wish this shot would work because not having a period and not having to worry about birth control except once every three months would be great! But after looking over the other comments I don't seem to be alone in having an awful experience with the drug. Another thing to consider when trying this drug is any possible side effects experienced last three months! This drug has put my life on hold while I wait for it to leave my system. F 19
1X O
3/3/2010
 3  birth control Light spotting when close to time for next shot. I have been on depo i think longer than anyone who left a comment. i am 30yrs old and have been on it for 11yrs. i've never experienced any problems with it but now i believe it is causing some of my health issues. i never had weight issued until last year so i think its starting to work against me. i was only around 115 pounds when i started now after 11yrs i'm 150 and pushing it! i find i very hard to lose the weight. my legs hurt when i run and i never thought it had anything to do with the shot until i read someone else's comment. my arms are very weak and shirts are tighter in the arms. i have an appointment this week and am planning to get off the shot and let my body rest. i was told last yr that after 10yrs i need to start taking calcium b/c it could effect my bone density but after reading up on it its not recommended to be on it over 2yrs unless you ABSOLUTELY have no other options due to the "black book warning". i recently had a colonoscopy b/c i was having issues with bowel movement but it came out ok. i have headaches more often than i think is normal and lately i've been very tired and borderline depressed. i dont know for sure if the depo caused all of this but i never had these problems before. weight is sitting mostly on my inner thigh and mid section and i get tired easily when i used to be very energetic:( F 30
1X O
3/1/2010
 1  ovarian cyst It was my hell!! Until I read these comments from other women on the depo I thought I was going crazy! I have had 7 surgeries and lost my left ovary to ovarian cyst. My doctor thought it would be good to start the depo because it would be a great chance with it stopping my periods they wouldnt return. The first shot I felt sick to my stomach and just not myself. Second shot I started to notice the same thing sick to my stomach and just not feeling well. My friends and family commented on my mood swings which I started to notice myself along with horrible back pains, my hair was falling out, acne became horrible, headaches and joint pain. Third shot sent me over the edge! I became so moody for no reason at my boyfriend or anyone who looked at me wrong. I started have anxiety attacks and thinking crazy and crying for no reason. My doctor said it didnt agree with me and started me on anxiety and depression medications. I have lost time at work.. put my family and my boyfriend through hell F 28 3 times
3X O
3/1/2010
Email
 1  birth control Three to four week long periods,spotting every day since shot,worsened depression and mood swings,heightened anxiety,PMS cramps 24-7,bloating,painful gas,headaches,backaches,decreased libido (mentally,at least)lack of physical pleasure from sex,VIOLENT ANGER ISSUES,paranoia,loss of interest in going out or being near people (even on line),did i mention the uncontrollable anger I started taking this when my baby was 4 months old to prevent pregnancy and also, I'd been told it would make my uber painful periods go away. It was supposed to be safe for my age and being a smoker and history of blood clots,depression, and anxiety. I was lied to. This stuff has been toxic to me,I have wanted to die the last three months,and I have everything to live for. I am not me anymore and I am angry because I did some research and the medical establishment just downplayed my fears and assured me the only true possible side effects were loss of a period and weight gain. Maybe for a small segment of women, but it has been a nightmare for me. Instead of a week of cramps and a week of bleeding, I get a month of cramps and mood swings and 3 to 4 weeks of bleeding. Their solution is to keep getting the shots until the periods stop.Never mind my pre existing depression,bipolar,and anxiety have me near a break down when I was doing well postpartum before the depo. My stepmom gripes that they took her off the depo and she loved it,so it does work for some, but for those like me who were ill advised and mislead, this stuff is poisonous. I'm not getting another shot,ever, and I personally think with this many bad side effects it should be taken off the market.At the same time, it has been a life saver for some. The happy medium would be health care providers educating patients THOROUGHLY about what COULD happen with this drug. Even if it only happened to one person. F 37 3 months
1X M
2/27/2010
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