Drug Safety Information for CYTOXAN (Cyclophosphamide)

Adverse Drug Reactions for CYTOXAN* (Cyclophosphamide)

These charts and graphs are based on reports received through the FDA Adverse Event Reporting System (FAERS) program (see below).

Top 20 Adverse Effects Associated with CYTOXAN
(reported in FDA Medwatch/FAERS Reports)

  Side Effect # of FDA Reports
1Febrile neutropenia3681
2Pyrexia*3117
3Neutropenia2964
4Death2481
5Nausea*1837
6Diarrhoea*1814
7Pneumonia1787
8Sepsis1754
9Vomiting*1674
10Thrombocytopenia1660
11Dyspnoea1645
12Anaemia1625
13Infection1412
14Disease progression1375
15White blood cell count decreased1273
16Pancytopenia1266
17Fatigue*1209
18Mucosal inflammation1063
19Hypotension1055
20Drug ineffective1032

* This side effect also appears in "Top 10 Side Effects of CYTOXAN " in the drug's Review Summary based on AskaPatient reviews.

Top 10 Reasons for Taking CYTOXAN
(associated with FDA Medwatch/FAERS Reports)

Reason # of FDA Reports
1Breast cancer*17698
2Multiple myeloma8184
3Diffuse large b-cell lymphoma8158
4Chronic lymphocytic leukaemia6907
5Non-hodgkin's lymphoma6754
6Product used for unknown indication6289
7Acute lymphocytic leukaemia5717
8B-cell lymphoma4519
9Bone marrow conditioning regimen3553
10Lymphoma2802

*Also a top-10 reason in AskaPatient Review Summary.


Types of Adverse Events for CYTOXAN

Total Reports Filed with FDA: 192248


Number of FDA Adverse Event Reports by Patient Age for CYTOXAN

Total Reports Filed with FDA: 192248*


* Reports for drugs with the same active ingredients have been aggregated in this analysis: Cyclophosphamide (Lyophilized cytoxan, Endoxan, Sendoxan, Endoxana, Procytox, Neosar, Cytoxan, Cyclophosphamide)

Charts are based on 192248 reports filed with the FDA between 2004 and June 2015.

Adverse Event Reports are submitted to the FDA by pharmaceutical companies (mandatory reporting is required by manufacturers, distributors, or importers), health care providers such as doctors (voluntary reporting), and by patients themselves (voluntary reporting). More Information on FDA MedWatch (FDA Safety Information and Adverse Event Reporting Program)Voluntary reporting takes place under the FDA's MedWatch program, where health care professionals and consumers submit reports to FDA when they find a problem with a drug, medical device, biologic, or other FDA-regulated product. An adverse event is any undesirable experience or extreme side effect associated with the use of a medical product. Adverse events include: death, life threatening event, hospitalization, disability or permanent damage, congenital anomaly or birth defect, medical product use requiring a surgical or other intervention, or other serious medical situation believed to be caused by the drug.

Click to go back to search results and CYTOXAN Reviews and Review Summary .

Historical Analytics of FDA Adverse Event Reports Provided by Druginformer.com. FDA Drug Safety Information, including safety-related labeling updates, required post-approval safety studies, risk evaluation management strategies (REMS), alerts, and recalls are compiled by AskaPatient.com from the U.S. Food and Drug Administration.