DEPO-PROVERA Reviews (MEDROXYPROGESTERONE ACETATE)

Average Rating: 2.1 (2469 Ratings)

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 ESTROGENS PROGESTINS ANTINEOPLASTICS

 Type: Rx Drug

  

DEPO-PROVERA  (MEDROXYPROGESTERONE ACETATE):  This medication is used to treat certain types of cancer (such as uterine cancer, kidney cancer). Medroxyprogesterone is like a natural hormone called progesterone made by the body. It is usually used with or after other treatments (such as radiation, surgery). Medroxyprogesterone may prevent or slow the worsening of the cancer and decrease pain and other symptoms.    (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on DEPO-PROVERA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR DEPO-PROVERACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Prevent pregnancy Heart palpations, Dizzy, Hot flashes, Anxiety/ Panic attacks, Tingling arms, Leg pain, Back pain, Abdominal pain, Shoulder pain, Months of bleeding I got the shot when I was on my period June 2023 my period stopped shortly after my first shot. At first I had no side effects and no period so I thought "this is great"ť. Then I got my second shot and things went downhill. I got my period in Sept 2023 and it stopped January 2024! I bled light to heavy allll those months with some clotting! I've been to the ER and Urgent care for this weird abdominal pain that I thought was my kidneys or appendix. I've been checked so many times for everything! Even checked my thyroid, kidneys, gallbladder I've checked everything! Blood and urine tests constantly. Got a CT Scan but everything was normal. All my blood tests were normal. All my organs were normal. I've had UTI's and BV so many times. I told my OB about my pain and bleeding and she looked at me and said “well I've never heard of that before”. BS it takes one google search to see so many other women complain about bleeding! I've seen so many doctors about my issues and even one doctor diagnosed me with anxiety and I've never had any mental health issues! I have no history or family history of mental health, cancer, thyroid or anything! Not every woman has a bad experience but this Depo Shot is NOT good! I would NOT recommend! I've been off th F 33 6 months
2 shots 1X M
3/2/2024
Email
 1  Birth control Bleeding non-stop. No sex life with this shot. F 44 15 days
1X day
11/13/2023
 2  For my cysts Dizziness, lots of headaches,weight gain loss of hair F 40 0 days
1X day
9/3/2023
Email
 1  Uterine Fibroids I got the depo-provera injection for the first time 1 month ago (April 28, 2023) and it will be my last. I now have really bad nervousness, anxiety and insomnia. My life has changed since I got the shot. I cannot sleep and I barely eat from the anxiety. I have lost 12 lbs in 1 month. When I try to get some sleep I wake up out of nowhere shaking with severe heart palpitations. I do not recommend this injection at all!!!!! It has ruined my life. I was only told about the weight gain but never any other side effects. I am praying that these side effects go away soon. F 41 3 months
30MG 1X day
5/27/2023
Email

History
 1  To stop pregnancy I didn't realise that this shot strips you of vital vitamins folate and vitamin d which made me so so poorly,, I had mood swings, body aches, not sleeping well, headaches, dizziness, feeling sick,, the list is endless!! I recommend anyone who is on this or just come off to get there vitamin levels checked. I used the depo for years before which I didn't realise until this time that it was what was causing all these issues if I'd have known I'd have never gone back on it!!! Stay clear ladies F 37 3 months
1X day
5/6/2023
 1  Hormone imbalance Anxiety, sadness , painful boobs, hip pain , back pain, muscle pain , headaches, shaking hands & weight loss! My 1st and last injection never ever again! I'm on week 5 of 12 and I cannot wait to get this poison out my body! F 35 3 months
1X O
4/19/2023
 4  To stop pregnancy I was very happy with depo I was on it long term with no periods and not much thoughts as it worked so well. I asked the nurses if I was fine on it and not having periods for so long and they said it was seen as resting my body so I stayed on it. I was then made aware that I should have had a bone scan after two years 7 years later. So I informed my doctor who put me in for a scan to find out my bones have thinned from the injection. I am absolutely gutted and if someone had told me to come off it I would have. I am currently waiting for my body to reset and scared of the periods that will come if they ever come back. I dont really know what to do regarding my bones as its so upsetting and long term I dont know if they will get strong again. This injection is great short term use but please please dont take it for longer than two years. Just get off it. I wish I had stopped after two years and changed I would have stopped if they had told me. Its not worth it. F 27 8 years
1X AN
4/2/2023
Email
 1  Prevent pregnancy I've experienced migraines,fatigue,muscle weakness,scoliosis in my spine, muscle spasms in my entire body, sunken eyes, muscle loss, fainting or passing out anytime F*ck depo shot never get it especially with a hormone imbalance F 22 1 years
1 1X day
2/22/2023
Email
 1  Heavy periods / pregnancy prevention Nausea., dizziness , extreme anxiety / panic attacks. Fatigue, irritability. Nervousness , chest pains , cold hand sweats, vision disturbances, hard to focus , muscle weakness, slight depression. Acne , etc. I have only had 1 shot back in December. I am due for a second shot next month which I WILL NOT be getting. When first getting the shot I only experienced slight nausea. Then I noticed I felt decently ill all the time. I am now going with withdrawals I believe, coming off this is the worst. I have visual disturbances like light and my eyes not being able to really focus on much. I am extremely dizzy every day now. Loss of appetite. I now have extreme anxiety & panic attacks to the point I literally cannot be alone with my son during the day now due to feeling like I'm going to pass out , have a stroke or heart attack. I already have pre existing heart conditions so it really makes my anxiety go through the roof. I haven't had panic attacks like this since high school when I got my first anxiety attack. I am now unable to drive. I feel like I'm so wrapped in with this ans the racing thoughts and anxiety that I'm beginning to feel alone & isolated and like I'm losing connection with my son. I've had so many panic attacks at home that home does rn feel like home anymore. I feel so disconnected from everyone. This is absolutely terrifying and makes me scared I'm going to go crazy. I have just been praying & praying & staying in the word of God and praying over this anxiety. I have absolutely no sex drive. Muscle pain & spasms , h F 24 3 months
1 1X day
2/20/2023
Email
 1  Pregnancy prevention Depo is my greatest regret in life. I have been off it since November 2022 and I thought I would feel better by now (February 2023). But I don't. I have crippling depression. I feel like all the estrogen in my body is depleted and it will never come back. I don't feel beautiful. I feel like I have lost all facial fat. All the feminine features in my face have melted off while I was on depo and I am afraid my face will not be full again. If you are having this symptom please let me know because I feel like I am the only one with sunken eyes and exhaustion! It is depressing and I never smile anymore. I feel like I have no more happiness in life … F 27 1 days
4X AN
2/11/2023
Email
 1  Endometriosis, and pregnancy Vagina dryness, painful intercourse, uterus lining shredded, 3 weeks of bleeding I started Depo-provera in September the 30th 2022 I was going fine until a month in and had my periods For 3 weeks straight and had a continuous pain then realize that I had this long thing that came out of my vagina...i thought I had a miscarriage but I didnt. while I was bleeding/period and it looked like a blood clot but it wasn't. it was my uterus lining that had been shredded and ever since then I have had a very dry vagina. I have had problems having intercourse with my partner as it's been really sore and tight when he inserts it. I have seen the doctor to get onto (ACI -JEL Balance) which lubricanted the inside of my vagina and put acidity back into it because every time I had intercourse with my partner, it would be very sore and cause me to bleed after sex.I would have have to wear a panty liner constantly because of the jelly that came out. I then had a reaction to the panty liners and had to stop wearing them. I had itchy vagina and still dryness. I will never take depo- provera again STAY AWAY FROM IT!!!! it has ruined my sex life and I just want everything to go back to normal again. I've seen a gynecologist and he has put me on the pill as the pill called (levlen) it has estrogen in it which my body was lacking because the dep-provera took that away from me. It is now 6th of Januray 2023 still experience vagina dryness and feeling like my vagina is being ripped open when my partner inserts it still. I am going to wait it out and see what happens. F 31 90 days
1 1X AN
1/5/2023
Email
 1  Endometriosis I went from a ray of sunshine with so much motivation to a couch potatoe with 0 desire to do anything. This shot makes you depressed. My symptoms consist of CRONIC neck and shoulder pain, extreme tiredness, somewhat blurry vision, dizziness, mood swings, crying for no reason, anxiety, a random swollen lymph node in my neck that hurts like heck and overall feeling like I'm dying. I've been to numerous doctors (primary, urgent care and ENT) who say I'm fine and nothing is wrong but I feel awful everyday and they think I'm crazy. Luckily my gyno is amazing and told me to stop taking it and that these symptoms can be side effects of the shot. I can't wait for it to wear off. The only reason why I agreed to take the shot was because I was diagnosed with endometriosis 7 months ago and they said I had to stop periods or I could develop another emdometrioma cyst and potentially lose my other ovary. I REALLY want kids so I agreed to try depo. Never again. I'll take my chances with the pill. If you haven't started it yet, don't! Save yourself. F 26 6 months
2X AN
12/22/2022
Email
 1  Prevent pregnancy Stomach pain, extreme fatigue, hot flashes, waking up in the middle of the night, hair loss, joint pain, sore boobs, brown discharge, bleeding off and on, dizziness, anxious all the time, heart palpitations, neuropathy, no sex drive...I don't know why I took this shot so many times. F 32 9 months
1X M
11/15/2022
 4  To not get pregnant F 34 1 days
1X M
11/1/2022
 1  Endo Relief/Contraceptive Minor weight gain 10-15 lbs, if I remember correctly 1 period after starting depo lasted a few days more than normal and some spotting maybe once or twice in the first year, mood swings I started when I was 16 or 17 as a means to cure painful periods and as a contraceptive. Besides minor changes, it was great, I rarely had cramps and very rarely were they super painful like before. Never had periods, but I did notice a little bloating or mood swings once in awhile, nothing concerning. I loved it and raved about it even knowing others had horror stories from taking it. I knew it worked for me. I once got off of it 4 years ago but only for maybe 6 months and got right back on it, maybe had 2 periods. In January of this year 2022 I was due and decided not to continue and to plan on trying to conceive in the future. The first few months were ok, started having periods, first couple lasted 2 weeks more or less, spotting, very painful, 6 months in, my breasts would get extremely sore and bigger, extreme bloating, took several pregnancy tests. My sex drive I started to notice would fade in and out causing serious problems in my relationship, it was so non existent that when it would come back only then I'd realize how much it comes and goes. I'm extremely irritable off and on, extremely depressed off and on, here we are almost 11 months of discontinuing depo and I am seeing doctors, had my hormone levels checked and they said they were fine. I have sought out counseling. I get extremely emotional and anxiety that makes my heart flutter, panic attacks, lower back aches/cramps, light headed quite frequently, my appetite is next to nothing, I force myself to atleast eat dinner. I am struggling to find answers and a cure to just be normal again. I do have periods every month, this time it has been 5 weeks since the last. If you asked me a year ago I would have highly recommended this, if you ask me now I would do anything for people to have facts and do any research you can. These long term side effects, the random restlessness, the irritability, the mood swings, the stressing over nothing, the depression and anxiety and the effect it puts on your daily life, is NOT worth it. I would give anything to find help right now and how to move forward. I take vitamins, b12, omega, have resorted to cbd for my anxiety, but of dozens of doctors throughout the years none have never told me any one of these things would happen. Look the other way. Depo is not the answer. It is miserable and scary. Reading these threads is all I can do to know that I am not alone. So if your reading this and have similar side effects please reach out, and if your reading this in interest of taking it and made it this far, look at the best interests of your future health, mentally and physically, I beg you. F 29 12 years
1X O
10/27/2022
Email
 1  Prevent pregnancy I have sore breast headaches severe cramps back pain always tired no motivation always sick severe nausea ans feel like passing out a lot and I am always so angry over everything ruined my life don't take it F 18 3 months
1X day
9/7/2022
Email
 1  To prevent pregnancy Extreme weight gain, and extreme moodiness. I stopped getting my period which was nice. The doctors tell you what to expect while taking the shot. But nothing about after you stop. I went through withdraws. I stopped taking it, my last shot was December 2021. I still have not gotten my period and I thought I was dying while going through withdraws. The after effects are not worth the pregnancy prevention. F 21 2 years
30 8X O
7/25/2022
 3  Prevent pregnancy I was on the depo shot for about 3 years and decided to skip my last shot. I am now dealing with what seem to be withdrawl symptoms (headache, body aches, fatigue, shortness of breathe, loss of appetite, feeling of having a viral infection, and as of lately a little bit of nausea) has anyone had anything similar to this when coming off of this shot? F 29 3 years
4X O
7/22/2022
Email
 2  As contraception My doctor should not have left me on this for so long. Started on it at 23, bleeding for 6 weeks on occasions, had to have ultrasound to see what was going on, nothing spotted. Got dexa scan to check bones but thankfully they are ok. Since coming off injection my breasts grew by two cup sizes, my hips widened, this injection is lethal it stilts normal growth. Now breasts riddled with cysts which I have to keep getting checked, risk now dismissing a lump as a cyst and not getting it checked. Sorry I ever went on it. F 48 11 years
1x3monthly 3X O
3/5/2022
Email
 4  Severe cramping with period I've been on depo shot for 6 years and my sex drive have decreased to were I don't want sex often anymore like I use to. I'm always tired, depressed, headaches and moody. I don't know what to do to get it back but I need the shot for my medical issue I have. Someone please help me. F 33 6 years
100 MG 3X M
2/26/2022
Email
  

DEPO-PROVERA  (MEDROXYPROGESTERONE ACETATE):  This medication is used to treat certain types of cancer (such as uterine cancer, kidney cancer). Medroxyprogesterone is like a natural hormone called progesterone made by the body. It is usually used with or after other treatments (such as radiation, surgery). Medroxyprogesterone may prevent or slow the worsening of the cancer and decrease pain and other symptoms.    (Sources: U.S. Centers for Medicare Services, FDA)

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