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Drug Ratings for PLAQUENIL

Average Rating: 3.3 (569 Ratings)


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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)   

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RATING  REASONSIDE EFFECTS FOR PLAQUENILCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
sort down sort up F  M  
 5  RA None It took about 8 weeks for the drug to start working, but it has allowed me to resume a normal life. X-rays show that it has slowed the progression of the disease. I still have occassional flare ups, but it is so much better than before! 53 4 years
8/21/2002

 3  Sjogren's terrilbe itching back of scalp. Recent very red patch across back of neck. Anxiety. Feeling of malaise. Forgetful, I don't know if that problem is from this medication. Can't take too much noise, feel extremely stressed, tired. I have been having what my doctor calls episodic flare up of Sjogren's. I have had itchy scalp for the longest, Rheumo says very likely the medication. I was taking 100mg x2 daily, he told me to cut second dose in half. My itching getting worse, and my scalp itched and burns. Some itching front of scalp, stomach, but the back of scalp is terrible and really red in neck area. The medication has always helped my symptoms, it's depressing that this is happening. Going for blood work. 51 1 years
100/50 2X D
8/1/2011
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 2  MCTD At the end if day two, I experienced the worst diarrhea I think I've ever had. It lasted well into the next day. It was very painful and even burned. I'm taking half the prescribed dose. Also have broken out with little pimples on my face, chest and back. 40 3 days
200mg/day
5/13/2013

 2  For RA - pseudo gout itching! On arms, legs, back, waist. Loss of hair, and thinning of skin, slow weight loss of 15 lbs. I was put on Plaq. for a high RA Factor. (400) and was diagnosed as having RA because of one swollen joint. After a year of plaq. I saw another Rheumatologist at UCLA that emphatically told me I did not have RA but CPPD -- calcium pyrophosphate deposition disease -- also called pseudo gout that can make a joint flare. But I have stayed on plaq because both doctors said it might help my joints, in spite of the itching while my MD here in No Cal and my UCLA MD fight over my DX. So will this hurt me? I really don't like the side effects but don't want another flare up...My RA Factor is creeping up again...Is this working? 72 2 years
1/9/2010
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 1  Mixed connective tissue disease After 2 1/2 weeks on Plaquenil I developed flu-like symptoms, fever, could'nt get out of bed for days and a rash over my entire body. Doctor confirmed an allergy to Plaquenil and put me on a two week course of prednisone. I am so itchy I'm ready to jump out my skin. They said the rash will go away in two weeks. Don't know what I'm going to do next medication wise. 3 weeks
1/26/2009

 1  Lupus like symptoms After taking Plaquenil for 30 days, I developed a severe rash on chest, arms, legs, back. Dr. advised to stop taking Plaquenil, and to clear up rash, take 20mg Prednisone twice daily for 4 days and to also take 4mg Cyproheptadine three times daily for five days. It worked! 30 days
12/8/2008

 5  sjogren's syndrome none After just three days, my fatigue has lessened and I no longer feel mentally sad...it actually has improved my mood and I will start exercising again...beside sjogren's i have hasimoto's thyroiditis so any relief of symptoms are fantastic...so far, so good, I love this medication. F 56 3 days
1/9/2009

 5  RA caused by Joint Hypermobility Initial week horrendous wind, diarrhoea 90% of the time for 1 month. Itchy skin ongoing and bruising very easily. Reduced appetite.Tiredness with some insomnia. 200mg tabs > 2tabs once a day with or after food Consultant prescribed this as I had regular episodes of RA with increasing longevity of attacks. Although blood works came within normal parameters the physical presentation showed the classic clinical signs of RA and after further examination it came to light I was hypermobile in all my joints and this can cause RA. After discussion ( hasn't prescribed for hypermobility cases) and the necessary eye tests, we agreed to trial run for 6 mths but any possible improvement may not be apparent for 12mths. 2 wks into the program and joint swelling started to decrease less painful attack experienced. 2 mths later, hands are almost back to normal with full range of non painful mobility. Slight ache experienced when with hindsight I realise attacks would have occurred. Have not been crippled with swelling nor pain at any point since starting this medication. Lower back pain has decreased but not eradicated - will need to look at improving my posture for this. Would recommend this medicatio F 39 3 months
11/10/2008
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 5  SLE It's been too long to remember. Similar side effects to what everyone describes, hair loss etc. Can't live without it. Felt so much better after many years and tried going down from 400 to 200mg. What a huge mistake. I though I was going to die. Had severe dizziness, numbness and tingeling, dull headache, ringing in ears, fatique,arthritus and joint pain like never before.Why did'nt my Dr. say this might happen. Was I a guenapig??? Relieved to hear this has happened to other. Also I took this through both pregnencies fine. I WILL NEVER GO OFF, unless my vision gets effected. F 42 15 years
11/23/2008
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 5  Scleroderma Stomach cramps Due to the stomach cramps, my Dr. had me start with 1/4 of a tablet and work up from there. I am still in the first week but so far, I am feeling SO MUCH BETTER. My joint pain and fatigue are going away and I am still on 1/4 of a 200 mg tablet. Good luck to everyone and thank you for this site. It was very helpful. F 53
4/29/2008

 5  SLE Diarrhea off and on. Some nausea and gas, but went away after a couple of weeks of continued treatment Started to have hair loss shortly after I took the medicine. Quit taking it. Rheumy said it would be highly rare for it to be from this drug and to start taking it again. 1 week before I started taking it, my hair started falling out again. Finally realized it was a side effect of my SLE, not the drug. The two times I have stopped Plaquenil, I have been hurting so much I'm usually in tears and at the end of my rope when I go see my rheumy. The starting back on the treatment, life gets better again and I feel like I can manage life again. I sleep better on this because my pain is so much better I CAN SLEEP! Something I struggled with for 4 years before I was diagnosed. I'll never go off it again. F 31 4 months
11/13/2008

 5  lupus Took about 3 months for it to start working; about the first month or so I had stomach upset. Thank god for it--it has steadied my lupus and I am not having to be on methotrexate or prednisone or anything else. F 48 4 years
12/28/2007

 5  Sjogren's Syndrome, Fibromyalgia After 8 years, I developed severe thigh pain and muscle weakness. I found I had a very difficult time walking up a stairway on more than one occasion. It was great for improving the fatigue and joint pain of Sjogren's Syndrome, and helped lower my inflammation markers for a long time. I finally had to switch to low doses of Methotrexate three times a week to bring my rising Lupus markers under control. The thigh pain went away. F 58 8 years
3/1/2008
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 5  Lupus In the beginning, stomach upset and could not sleep. I take it every morning and these side effects went away within a couple of weeks. It is a nasty tasting pill so take with juice or something to mask the taste. I began taking Plaquenil in January 2007. I was terrified of the possible side effects with vision so I have yearly eye exams. I used to get constant fevers, mouth sores and pleurisy. Since beginning the Plaquenil, all of this has stopped. I only need 200mg a day because of my weight (130 pounds). I was told the higher the dose, the greater the risk of eye problems. I am very thankful for this drug. F 38 16 months
4/2/2008
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 5  SLE and arthritis Nausea, but the pain is so decreased I will accept nausea in its place for the rest of my life if that is the way it works out. A bit scary about the eyes, however I was assured by my doctor and eye doctor that it is not a common occurence and to just be aware of changes, also my eye doctor has me on a four month routine just to stay on that possibility. I feel soooo much better and seem to be getting my life back! F 54 1.5 months
9/19/2007

 5  SLE Some initial GI upset during the first 2-3 weeks. The first week I had a lot of ringing in my ears about 1/2 hour after taking the plaq but 2 months into it that is no longer happening unless I take it when I am really fatigued. The Plaq has helped so much! I was starting to feel like I would never be normal again. The pain in my hands, shoulders, neck and feet were making it really difficult to function and the fatigue was extreme! At that rate I expected that I would have to quit my job and try to get disability because I was absolutely at the end of my rope. After about 6 weeks on plaq my hands started to improve and I am doing much better. My ability to think and concentrate is much better which is a huge help to my confidence and my sense of well-being. I am still not "normal" but I feel like I function at about 80% of where I was before the lupus and I am hopeful that I will gain some more ground with the plaq over the next couple months. F 30 2 months
5/26/2007

 5  Rheumatoid Arthritis No noticable side effects, but recent increased hair loss which may or may not be attributed to Plaquenil Thank God for this drug. Plaquenil has made a huge difference to my life. Before treatment I was virtually housebound and in severe pain throughout my body with extremely painful feet that left me unable to walk. After 3 to 4 months of 200mg twice daily I saw a vast improvement. I now lead a relatively full and active life with occasional managable flares. F 48 6 years
8/20/2007

 5  UindifferentiatedCTD & Fibromyalgia Initially, in the first two weeks I would develop a severe headache, my nose would run like a tap and from time to time would bleed. Occasionally my vision blurred. All symptoms would last for around an hour and no benefit was noticed for around two months. I found it took about two months to kick in but when it did the results were worth the few side effects I had experienced. Most of my symptoms disappeared almost completely. F 48 3 months
10/22/2007

 5  Palindromic Rheumatism I am now experiencing very itchy skin. I also have some diarrhea. I have been on it for about 4 months (400 mg per day). The itchy skin showed up about a month ago. I see the rheumatologist tomorrow. I'm hoping we can cut down on the amount, as I would like to be able to stay on it, but the itchy skin is driving me crazy. But it is definitely working well for the palindromic rheumatism. In the meantime, I have been cutting down each month by 1/2 pill on the Prednesone. I am down to 1/2 pill, and I have had no more symptoms being on the Plaquenil. F 60 4 months
11/14/2007
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 5  RA none, although my hair has gotten wavy. wonder if it is the medicine or just being post menopausal F 58 3.5 years
10/9/2003

 5  lupus migraine,headaches,acne F 24 2 years
10/14/2003

 5  RA None of note. Has worked very well for me in conjunction with methotrexate. I live a fairly normal life. F 37 15 years
9/24/2002
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 5  UCTD Hair thinning (but this might be part of the disease process). Fifteen months ago I was dragging myself from one day to the next, with severe muscle & joint pains & stiffness, fevers, night sweats, extreme tiredness etc. I had been wrongly diagnosed as having RA and therefore had been on incorrect treatment for 18 months. Sought second opinion, was given the correct diagnosis of UCTD and started on Plaquenil. Within three months my symptoms were improving and by six months I was leading a virtually normal life again. When I forgot to take it for several days (very busy at work), my symptoms returned. I definitely works for me. F 47 15 months
10/1/2002

 5  RA Nausea the first week; after the third week began, diarrhea Pain free after three weeks of 400 mg. in combination with 20 mg. prednisone. F 41 3 weeks
4/2/2003

 5  SLE Pimples on my face, blurry vision I have been taking 400 mg of Plaquenil for the past 15 months. I am experiencing blurry vision when I am reading, but this may be related to my age. Plaquenil has been very helpful to me. F 45 15 months
11/30/2002
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 5  rheumatoid arthritis none , so far When i started taking plaquenil I was in really bad shape. Very stiff, unable to walk, do housework, lift anything etc.I now feel so much better, i am sorry I didn't start taking it two years ago when rheumatolegest first suggested.I strongly recommend trying it early in the treatment of RA. Maybe you wont have damage like I already do in my hands and feet.!I think it has worked for me. So far anyway. F 47 2 months
11/6/2002

 5  RA NIL After one month could cease taking Anti-Inflammatory pills and back to normal exercise again. Taking 400mg daily but will hopefully have this reduced very soon. Make me feel normal again!! F 37 2 months
6/8/2002

 5  Differential is SLE vs. RA I am having some trouble with swallowing, like a marble caught in my throat all the time. However, it may be a coincidence that I started plaquenil at the same time that this symptom started. It could be part of sjogrens, but I have not been actually dx'd with that yet. Morning stiffness is virtually gone, except in my left hip joint. I am a runner and I am back to my usual activity now. It had an effect on me within the first two weeks which I have been told is early. My left hip problem still plagues me like a toothe ache, but for the most part, I can't say enough great things about plaquenil. F 35 8 months
6/25/2002
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 5  uctd when i first started taking the drug 200mg i was in more pain then ever in my upper body. after about 3 months and i have been on this for about 1 1/2 years it is great. I would say my pain is better by 90% the major pain i have is in my feet. F 43 1.5 years
6/30/2002

 5  Mixed Connective Tissue Disease Few side effects exist that I can specifically attribute to Plaquenil but currently having substantial problems with short-term memory and decreased ability to concentrate. Would love to know if other users (especially long-term users) are having similar problems, to determine if Plaquenil is reason. Plaquenil has helped me manage a Lupus-type condition for many years. I have fewer flare-ups and overall have become more stable each year. F 35 10 years
8/27/2002
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 5  autoimmune thyroid I was sleeping excessively and had pretty severe pain throughout my body, particularly in my arms and legs. I'm currently taking 600 mg a day. Except for the occasional flare-up, all symptoms have subsided. I actually feel well-rested after sleeping for eight hours. F 25 2 years
7/8/2002
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 5  UCTD None I have been very satisfied with this medicine. It has helped the muscle and skin pain tremendously. F 27 3 years
10/12/2001

 5  uctd none I believe this drug keep me going fairly well. It's worse without it F 58 9 years
1/14/2002

 5  rheumatoid arthritis No side effects at all. I have been very happy with plaquenil. I take 400mg. per day in addition to an anti-inflammitory. F 47 2 years
2/2/2002
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 5  Inflammatory arthritis, fibromyalgi Gas, gas, gas, dry eyes. Developed allergy in form of all over body rash. This medication was life changing for me until I developed an allergy to it. It started working in 3 weeks, and I felt 10 years younger. I was able to play with my kids, had more energy about everything in life. I hope your result is as good as mine, minus the allergy! F 37 1 months
2/1/2005

 5  RA - Sjogrens Itching, some dark spots on my face, but this could be hormonal. Biggest concern is blurry vision and light sensitivity. Seem to be developing retinal tears, first in one eye and now the other. Eye exams every six month, we'll see. All in all, this drug has positively changed my life. I also take bextra and feel lucky that I don't have many side effects at all. F 43 2 years
3/26/2005
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 5  arthritis None thank god for this drug. I have been on it for 9 years and with out it I would not be able to walk. F 40 9 years
4/21/2005

 5  Lupus I haven't experienced any side effects. This is my second time taking plaquenil/hydroxychloroquine. 200mg 2 times a day. I was first diagnose of lupus in 1995. I went in remission in 2001. I decided to stop taking plaquenil. I had no symptons in the last 4 years. About 2 months ago I start having swelling and pain in my feet. So I started back taking plaquenil. I'm now back feeling great! F 33
4/22/2005

 5  SLE no real side effects I take 200 mg twice a day and this has been a miracle for me. I love it, however recently my doctor changed it to 200 mg once a day and I have started to get headaches and night sweats again. Has anyone else had this experience? F 19 1 years
5/21/2005
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 5  Yes Crazy vivid dreams too. I also feel a little light-headed. F 38 2 days
3/4/2007

 5  RA Crazy vivid dreams! No others. F 26 45 days
2/14/2007

 5  RA None really. I felt a bit more energized and that's why perhaps sometimes have problems sleeping...and sometimes also more vivid dreams. This medication has really worked for me. I was taking Nabumetone for 3 years, but I'd have flair ups and would feel it and also had terrible stomack problems. Now ever since on Plaquenil I feel great. Only on several occasions I felt a little tingling in my fingers, so I knew that if I wasn't on Plaquenil this would be a painful flair up. No itching, or hair loss. This medication makes skin much more sensitive to sunburn, so maybe, if one is not careful, this can cause sunburn, itching, etc... F 40 2 days
4/29/2007

 5  RA None really. I felt a bit more energized and that's why perhaps sometimes have problems sleeping...and sometimes also more vivid dreams. This medication has really worked for me. I was taking Nabumetone for 3 years, but I'd have flair ups and would feel it and also had terrible stomack problems. Now ever since on Plaquenil I feel great. Only on several occasions I felt a little tingling in my fingers, so I knew that if I wasn't on Plaquenil this would be a painful flair up. No itching, or hair loss. This medication makes skin much more sensitive to sunburn, so maybe, if one is not careful, this can cause sunburn, itching, etc... F 40 2 years
4/29/2007

 5  RA F 50 3 years
1/14/2009

 5  RA I haven't had any side effects at all, and I have been taking Plaquenil for 1 1/2 years. It's been very helpful with the pain, which was QUTIE severe when I started taking this, and the pain subsided within 3 weeks of taking it and I still haven't had any flare-ups except for when I occasionally have missed some doses. F 44 1.5 years
2/17/2009
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 5  Lupus After one week, started having increased anxiety, racing heart, back pain and panic attacks about 2 hours after taking pill. Doctors said Plaquenil doesn't cause those side effects so I stopped taking it and all side effects went away. (Was taking 400 mg per day) Started again a week later after all the lupus pain returned at 50mg per day. Cut the 200 mg pill into 4 pieces and take one piece in the morning with breakfast. Works great! No side effects and the arthritis pain, ulcers and rash of lupus are gone too. Maybe some people are really sensitive to it and need a very small dose. F 34 2 months
2/20/2009

 5  Lupus Minor stomach upset the first few weeks, some gas, ringing in the ears, some hair loss but have had major benefits on this med. I've been on plaquenil for 20 years. I see an eye specialist 2x a year. Have never had a problem. I'm on 200mg once daily, taken right after breakfast. My Lupus symptoms have pretty much disappeared while on this med. I still feel some fatigue. Before plaquenil, I could barely function and could not work, had major pain and fatigue. Tried going off my med once to see how I felt. After 3 weeks, I went back on as I felt horrible. Will never try that again! F 52 20 years
2/25/2009
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 5  MCTD (Lupus and RA) during the first 2-3 months, I experienced red bumps all over back (fading, but still there at 4 months), nausea, diarrhea, headaches, bruising, restlessness at night, tiredness (probably from lack of good sleep). Most symptoms subsided after first 2-3 months. Could see the good effects from Plaquenil after about 3 months; My joints and energy-level feel better than they have in several years. For me this is definitely worth going through the 2-3 months of side effects. I still have some red bumps on back, but they have faded a great deal. F 23 4 months
2/25/2009

 5  Connective Tissue Disease/Lupus None I had such bad pain I couldn't walk without my bones cracking. I take plaquenil everyday 200mg. It has truely improved my life. Still pain bothers me every now and then, but I wouldn't be able to go on without this medication. It has helped me ALOT. If I miss taking the pill for a few days, I notice a big difference. F 18
3/23/2009

 5  UCTD with lupus like symptoms A bit of insomnia. I counteract this side effect with amitriptyline. A little gas the first week. The constant chronic pain has been dulled considerably and I'm only three weeks in. Morning stiffness if almost virtually gone. Hair loss was pre-plaquenil and this has not subsided (yet). Thinking seems clearer. I have to say I absolutely love this drug. If it does increase the hair loss that I had already before taking it...I'll wear a wig. It's worth it in comparison to the chronic pain without plaquenil. F 34 3 weeks
3/10/2009

 5  SLE I saw no improvement to extreme fatigue, weakness, body aches, headaches, joint pain until about 5 months after taking Plaquenil. Dose of 400mg a day. I too, tried to discontinue this drug and after 3 weeks I could not get out of bed. My original symptoms were back and felt worse because I had lived without them for several years. Please be very careful with the eye exams. I had some brief episodes of blindness and more indepth testing was done (ERG) and this detected Plaquenil toxicity. I am told it has progressed to 'irreversible' state. If caught before any symptoms can be reversible for most patients. I was very diligent in getting eye exams every 6 months. F 52 15 years
3/17/2009

 5  Sjogrens Blurred vision first two weeks, slight itching on entire body and forgetfulness. Plaquenil has helped me with Sjogrens a tremendous amount. When I went to see the Rheumatologist and he told me I had Sjogrens, I was in denial and didn't want to take the pills. I also have Raynauds, and don't take any meds for this. I was getting worse everyday. I started with one pill in the morning and then accepted what I had and started taking the second pill. Within 3 weeks I noticed a huge difference. I couldn't even swallow my food and would wake up at night with my eyes in pain. I was having severe insomnia for about 1 year and I now sleep through the entire night. My hair looks like it did when I was 20. My skin now has oil in it. Before my hair was dry and my skin was always dry. I'm very happy with plaquenil. I've already seen the eye doctor and plan on seeing her twice a year. I still have minor problems, like my eyes hurting or dry mouth, but compared to how I felt, this is now tolerable. F 47 9 months
3/22/2009
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 5  RA/connective tissue disease/lupus diarrhea, gas, bloating, ringing in my right ear. Since taking plaquenil, decreased swelling in fingers and less pain in all my joints. Am able to work out 4 days a week. Not as fatigued during day as I was prior to taking this medication. Feeling a whole lot better! F 39 2 months
3/31/2009

 5  Inflammatory Arthritis Gas, upset stomach for first week or two This medication has helped me greatly, significantly reducing fatigue and joint pain. F 44 4 years
3/31/2009

 5  Palindrome RA Very sensitive skin and hearing loss Fantastic drug, no more pain, no more swelling, no more piles of pain killer drugs!! F 44 1.5 years
6/15/2008
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 5  Subacute cutaneous lupus No side effects, infact my hot flashes diminished??? Have been taking it x 2 months, my rash within 3 days started fading. I had breast cancer 2 years ago, Stage III, triple negative and had a terrible time with radiation, burned me up. I now know I probably had the beginnings of lupus....wish we had hindsight! F 59 2 months
7/16/2008

 5  Lupus In the beginning, I did have stomach problems and also seemed to have more flare ups, however at the advise of my doctor, I stuck it out for the full 6 months trial and I'm so glad I did! I have not had any, zero,zip - symptoms of lupus at all since then... this is wonderful! I still take 2 tablets a day and for the first time since I was 17, I feel like I'm living a normal life... on occastion, depending on what I've eaten, I may still have some stomach issues but nothing worth complaining about... Plaquenil has been a miracle for me!! F 45 9 months
6/13/2008
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 5  SLE Diarrhea for about a week I've been taking Plaquenil for 3 months now. From the beginning, it stopped my muscle and joint aches. Thank God. It helped me to function more like I use to before I had my first flare up and was diagnosed with SLE 8 months ago. I really thought at one point I would have to stop working and go on disability or something, the aches were too much. My hair has stopped falling out, but it does not grow as it use to. Plaquenil has not yet help me with the butterfly rash I have on my face. I can live with it. It is still early with my usage of it. I hope Plaquenil continues to be a blessing for me. F 40 3 months
6/15/2008

 5  SLE Stomach cramps, diarrhea, and gas, all lasting only about 1 week Started with a blood clot in left leg in Feb 08. Was diagnosed with Lupus Anticoagulation and was put on Coumadin for the rest of my life. Other symptoms began appearing shortly after the clot (TMJ, rashes on arms, joint/muscle pain, hand swelling, fatigue). Was finally diagnosed with SLE in July 08 but it was 5 months of pure hell not knowing what was wrong with me, one symptom after another popping up with no relief in sight. Started Plaquenil last week. Was told it would take about 4 months before seeing any results. However, after less than a week, have already noticed a good amount of decrease in muscle/joint pain and increase in energy level. Like many others on this site, I feel like I've gotten my life back and now have a renewed hope for my future and living with this disease. F 44 5 days
8/20/2008

 5  SLE Some stomach cramping, diarrhea. Symptoms subsided after one week. Even though I've only been on Plaquenil for a little over a week, it has given me my life back. Most of the fatigue and muscle/joint pain is gone. There is still some, but NOTHING compared to what I was feeling a month ago. I hope it lasts. F 44 1.5 weeks
8/26/2008

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