Drug Ratings for PROGESTERONE

Average Rating: 2.3 (403 Ratings)

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ESTROGENS PROGESTINS    INFERTILITY   

  

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RATING  REASONSIDE EFFECTS FOR PROGESTERONECOMMENTSSEXAGEDURATION/
DOSAGE
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 2  Menopause faint feelings, dizzy, vertigo, heavy head, fatigue, tired, numbness arms, pain in hands, low blood pressure, low heart rate, blurry vision, severe hypoglycemia, brain fog, head surges, induces sleep at night, occasional constipation. It seemed fine when I started, age 52, used various types of progesterone, prometrium, creams, bi-est. It was a constant balancing act. This past 1-1/2 year have been on mini-velle est patch from .0375 to .075 now.05. with 50 mg of oral compounded progesterone at bedtime. I used to be very active and now because of the constant fatique, faint feelings and extreme tiredness I am less active. I have suspected the progesterone might be causing the faint feeling. This week I am trying taking 50 mg every other day. So far, the days I don't take progesterone I don't have the strong faint feeling and heavy head when standing so it looks like my body and my brain does not like progesterone. But doc says must take both together. So guess I will have to stop the est patch as well. I went off for a year in 2012 and only had hot flashes, manageable, but new endo doc put me back on hrt and insisted I would be better but it has been a hell year. I am hypothyroid as well and when I started back on hrt my thyroid TSH went high, more hypo, more symptoms. I continued to need increases of synthroid from 125mcg now up to 150mcg plus a couple days of 175mcg. Its been a terrible year and I regret going back to hrt. Its thrown my body out of balance and I know weening off will be difficult as well, just cant live with this almost fainting thing and constant self concern for my body and seeking way too many doctors for answers. The only thing I take is synthroid and hormones and supplements. F 61 8 years
50 mg 1X D
7/7/2014
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 1  Estrogen dominance I added progesterone cream after my dr told me I was estrogen dominant. I had insomnia and thought the pro cream might help. I hadn't changed anything else and I couldn't understand why I had gotten so depressed again. I was still in anti-depressant and had been doing well. About a week after I started pro I started crying, could hardly get out of bed and feeling very depressed again. I started eating a lot and craved many foods and started gaining weight. I began having crippling anxiety: I couldn't function at work and felt like I was having a panic attack (never had one before). I was sleeping better at night but began feeling very sleepy and falling asleep at odd times-at my desk, too sleepy to get out of my car to go in the grocery store without a nap, right there in my car! I stopped the pro and the anxiety decreased over a few days though I often still felt sleepy at odd times. I thought I was taking too much so lowered the dose, then skipped some days. Just used a very tiny amo I thought I was alone with this reaction to progesterone until I found this website. I feel better knowing there are others who have a bad reaction to progesterone. F 56 14 days
2 mg 1X D
6/18/2014

 2  Perimenopause symptoms None initially. I felt increased libido on day three but I don't know if the progesterone was the cause. By day five I felt tired and had an increased appetite. Day 6 and 7 had noticeable gas, loose stool and heart burn - things I NEVER have. I also started to feel depressed. Day 8 - today - I'm done. I feel very depressed and weepy, my stomach hurts and I feel tired, out of it and crabby. I know they say to give it a chance but I don't think I can handle another week of the stomach issues and depression. I was prescribed natural progesterone cream from my Doctor after blood work. The dose was 30mg. The first time I tried it I could not sleep and felt restless and strange. Half a dose did the same thing. I recently tried it again after experiencing several days of very bad headaches due to hormonal fluctuations - at a quarter of the prescribed dose. I know this works for some women, it just doesn't work for me. If my symptoms increase I may try it again. It might not be the right time for me. I think it's worth a try - if you don't like it stop taking it. Next I'm going to try Pregnenolone. F 50 8 days
15 mg 1X D
5/10/2014
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 2  Complete Hysterectomy Heart rate elevated, nervous, hyper feeling, anxiety, kept thinking same things over and over, rapid weight loss, loss of libido, & all sexual functions. I had a complete hysterectomy in 2009. Started Bio-Identical hormones 6 weeks after surgery. Estrogen 0.5/Progesterone 25 mg/Testosterone 1.25 mg 2 times a day. I take the troche under the tongue in the morning and at night, plus 2 50 mg Progesterone capsules at night. I only started the added Progesterone capsules at night 4 months ago because I was having insomnia so this was added to the mix. Up until that point I had NO problems with my hormones, and had great libido, energy, etc. Within the last 2 weeks all of side effects that I mentioned started happening rapidly, couldn't for the life of me figure out what was going on, and I had just had my thyroid hormones checked which were all normal. I then found this site and wow all the same side effects except I have yet to see anyone else with the loss of libido. Upon finding this site I decided to quit taking the extra Progesterone and I will see what happens the next few days. Hopefully this is the problem and I can go back to feeling normal.... F 50 4 months
100 mg 1X D
5/2/2014
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 4  Low progesterone during pregnancy Dizziness, irritability, mood swings, depression, fatigue, loss of appetite, dry mouth F 32 5 weeks
200mg
4/26/2014

 1  Estrogen Dominace Decided to try Twenty to One natural progesterone instead of HRT patches my doctor prescribe for me (big mistakes) on the second day I felt like my insides were on fire for up to 10 minutes at a time, chest pain like a really bad GERD attack, feeling very sad and strange sensation in my left fingers. Decided to stop using the cream and the feelings have eased up a bit. Never again!!! Ladies please stay away from Twenty to One natural progesterone cream F 45 2 days
4/26/2014
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 1   Sever dizziness , headaches , my head was unreal it's like you living out of space ! Numbness in my arms , hands , legs & face . Spend thousand $ on MRI, CT-scan ,blood work. F 33 3 months
100 mg
4/23/2014
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 4  complete hysterectomy When I stopped taking it for a couple weeks I experienced pretty bad depression. I did a saliva test and had only taken .5 mg of estradiol for 11 years after receiving a complete hysterectomy at the age of 45. When I turned 52 I noticed increase in bust size from D-DDD (estradiol imbalance) and about 7 pounds over all. Sleeplessness was always an issue. The saliva test came back with a thorough chart of my hormone levels. They added compounded 50 mg progesterone that I take at night and .5 estradiol (skipping weekends) with 1 mg sublingqual testosterone and 25 mg DHEA in the morning. I feel more rested, definitely more balanced and I'm hoping the addition of the testosterone will bring my weight back down. I've always been very physically active with distance running (up to 50 miles) and hiking so there is no reason for my breasts getting so huge or suddenly putting on padding after being the same for over 30 years. Its my weight I'm hoping to change-so far there has been no change. F 54 14 months
50 MG 1X D
3/13/2014
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 1  Thought I was premenopause I was told to use progesterone cream because of my age- 50- and that "all women" need it at this stage if life. Well, no. I went completely crazy, but it was a slow process. I was told "it get's a little worse before it gets better-- give it at least 3 months" NO!!!!!!!! I experienced escalating symptoms of severe depression, anxiety, irritability, insomnia, adrenal misfiring resulting in a horrible hyped-up feeling, paranoia, nervousness, severe hypoglycemia, mood swings, heart palpitations, irrational thinking, lethargy, indifference, bloat and spotting all month This is how bad it got for me: For the first time in our marriage, my husband considered leaving me. One of my best friends told me she needed to end our friendship too. I became THAT emotionally unstable. I am usually a calm, cool, happy, loving, upbeat person. With the progesterone, I was impossible to live with. This stuff was toxic to me. I regret using it and I regret using it for as long as I did. The day I stopped using it was a huge relief, both physically and mentally. I feel I will need weeks if not months to recover from this experience. Two weeks off and I don't feel like myself yet. When I first researched progesterone cream, I found nothing but glowing, positive information. Progesterone was touted as some miracle cure. Little did I realize those other websites were simply quoting and repeating Dr Lee's propaganda. Later, when I thought I was going insane, I searched for phrases like "progesterone made me crazy" I found a huge number of experiences similar to mine. I feel I lost 5 months of my life and regret using this junk. Please be aware that it's NOT for everyone. F 50 5 months
1/2 tsp 2X D
2/18/2014
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 5  Hysterectomy Only good ones. Calmness and I sleep like a baby. F 54 10 years
200
1/28/2014

 2  Was bf my LO Extreme mood swings, depression, severe headaches, nausea, pregnancy symptoms. F 22 1 days
1/13/2014

 2  pmt,estrogen dominance chronic cough (asthma variant),insomnia,skin redness and spots,fast heartbeat,immune suppression ,hormone imbalance issues. I had a saliva test done which revealed estrogen dominance and low progesterone To remedy the problem I decided to take kokora bio identical progesterone cream.I took this cream for about 12 months,at first the effects were great ,pmt eased and I slept better. However at about the 9th month on this cream I noticed I started to alternate between excess drowsiness and insomnia.At about the 12 month I noticed my skin broke out in spots and I developed excess redness and at around the 12 month also I noticed I developed a chronic cough and irritation in lungs.At around 9 months after I stopped using the cream,I had my hormone levels tested again,they revealed excess progesterone in my body,even 9 months on.Apparently excess progesterone can cling to the fat cells and because of this it can take 2 years to clear this out of the body.My naturopathic doctor does not believe in using hormones either synthetic or natural,and has suggested that progesterone is an immunosuppressant.She stated time and time again shat she has seen elevated levels of progesterone in women who use bio hormone creams.It appears these bio hormone progesterone creams are not as safe as Dr John Lee would have you believe and I am very angry at all the hype,as clearly this has not been researched well enough,no book has ever mentioned the negative side of using progesterone cream.My naturopathic doctor believes that diet ,nutrition and taking care of the adrenal and thyroid gland will remedy hormone imbala F 45 12 months
1/8 tsp 2X D
12/27/2013
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 1  Pms symptoms Severe anxiety, lethargic, flu like symptoms. Ended up in ER three times in one week feeling like I was going to die. Been off 36 hours and still having horrible effects. This drug should be monitored more closely as I really think my hormones are messed up now! Praying this goes away soon as it's awful! F 41 10 days
100mg 1X D
12/16/2013
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 5  hormonal balance Bioidentical progesterone is fine - don't listen to the **ups on this board - they just don't want you to use it. It's great. It balances your hormones, keeps you mentally focused, more energy, no hot flashes, yes there is some weight gain, big deal, like 5-8 lbs, nothing that a little diet and cardio can't fix. Not only has it put me back to my normal self, my skin looks amazing, it's like I'm twenty again! F 44 6 months
100 mg 1X D
12/15/2013
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 1  Estrogen Dominance, Painful Periods Extreme fatigue, falling over when walking, feeling out of body, spacing out, dizzy, painful swollen joints, hallucinations, feel unconnected with life, hair falling out, depression, caused me to halucinate and drank floor cleaner- very scary. fearful of being left by husband, extreme nightmares, unrealistic fears of death, intense crying I would not recommend this to anyone. I didnt realize that this was the cause to all my issues. Once stopping the natural progesterone pill it took months to start to feel somewhat like my self but felt like I had been out of touch with life and missed out on so much while being on this drug. F 36 1 years
300mg 1X D
11/17/2013
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 5  PMDD Tiredness for the first week, was hard to carry on activities F 29 2 weeks
22 mg
9/27/2013
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 1  fibroid/too much estrogen Extreme anxiety, nerve pain, depression, flu like symptoms, muscle pain, faintness, weakness, digestive issues, severe constipation F 31 1 days
50mg
9/4/2013

 1  estrogen dominance In 3 months I've gained 14lbs, breast tenderness, moodiness! I'm very active and its extremely frustrating to put on weight and there is nothing I can do to stop it- I have fat and bloating all over. So, long story short I would not recommend it. I'm more miserable & now fatter than ever...lol!! My cream is compounded so I'm not even sure if the quality is right! I don't know what to do. F 46 4 months
3% 5ml
8/22/2013

 2  perimenopause I became extemely depressed, bloated, puffy around the middle, severe water retention I would not recommend this to anyone F 10 days
2X D
8/15/2013

 1  menopause I have been on biest along with testosterone sublingual for 12 years and did fine. Had a total hysterectomy in 1997. Avoid if possible. In 2011 I started having menopausal symptoms such as hot flashes, insomnia, depression and just not feeling well. Dr upped the estradiol but I still did not feel optimal. Last Sept 2012 I talked with my Dr about tweaking my hormones and we decided to add in progesterone 60mg to my biest. First mistake was to not keep the progesterone separate. I felt bad the first few weeks and then started feeling very good except for breast swelling and tenderness which I could not handle. The progesterone was increased and we kept tweaking my hormones. In the meantime I was having pms symptoms, horrific mood swings, unable to handle stress, muscle pain just to name a few. This past March I felt like I was dying. Had labs drawn. Estradiol was 21! My progesterone was 2.9. What had happened was the progesterone drove my estrogen down and the effects were horrific.Memor F 59 7 months
25-125 1X D
6/9/2013
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 5  Perimenipausal Synthetic progesterone is awful! Women who take synthetic hormones are opening the door to insane side effects! Heart attack & cancer being among just a few... Progesterone is a natural hormone that can be increased by taking natural suppliments that will not cause cancer! It comes from fruits and vegetables and maintaining healthy diet goes a long way. But, if you are anything like me, you might need a suppliment - my body just isn't making enough. Anyway... I began taking ProgonB about a month ago. I did a month long saliva test (twice) & the test determined that I am estrogen dominant, and that I'm in the beginning states of menopause. I have horrible heart palpitations, night sweats, migraines that last three days during ovulation and my cycle... The ProgonB has helped a lot with these symptoms. I can now relax, my headaches are gone for the most part, my sleep is better, my anxiety is less, and my night sweats are better... Some symptoms I still have are hot flashes, nausea, and my heart is still beating rapidly &/or pounding - but it's improved. I'll be seeing a cardiologist just to rule out anything major. But it's important to note the progesterone protects the heart and when it's off balance it can cause high blood pressure and pounding. I see an accupuncturist & sadly, most western doctors are ignorant when it comes to the female body and our hormones. (But they figured out that Viagra thing, didn't they! LOL) Anyway, over time, estro F 39 1 months
ProgonB
6/2/2013

 1  trouble sleeping low sex hormones First off, I had to copy and paste a previous reviewers info because my experience has been so similar. Insomnia, uncontrollable shaking, panic attacks, extreme fatigue, adrenaline rushes, feelings of unreality, extreme anxiety, dehydration, hallucinating, can't stop thinking or doing, can't relax at all, feel high as a kite, tripping(doctor said it can make some people trip! wtf?!)feeling faint leading to the emergency room and hundreds of dollars to see an intergrative doctor.I WAS barely hypothyroid and have spent the last 2 years changing my diet, suppluments, iron, cytomel. This seemed to put me over the edge and I wish I could understand what happened? I took Cortef for a year, weaned off about two months ago, started having insomnia but was able to sleep, I started bioidentical compounded progesterone/ estriol/ saw palmetto( for hair receding) about a month later. I NEVER got the famed best nights sleep ever. It seemed to stimulate me. My skin broke out badly which upset me grea How long does this take to get out of my system? Is there anything I can do to make it get out of mysystem quicker? How did progesterone effect my thyroid? Do I need to reduce or quit my cytomel, Im only taking 12.5 mcg. My $$$ doctor said I coild eventually but Im thinking the progesterone spmade me hyperthyroid? How does progesteone effect adrenals? I WAs able to work out a lot more. I lost 25 lbs in about 2 months and Ive gone down 2 dress sizes. Will I gain the weight back now that Ive stopped it? I pray I can get some sleep on my own soon. I wonder if I shoild go back on Cortef? I tried a stress dose and it made my heart pound terribly. F 44 5 weeks
40 MG 2X D
5/3/2013
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 2  Menopuase symptoms Heart palpitatons even though my blood pressure and pulse stayed normal, hot flashes and night sweats became even worse, sore breasts, horrible nightmares, felt very jittery in the morning yet didn't want to move. At night I rubbed it on my neck which was supposed to help with insomnia. Instead, I could feel my heart beat in my neck right where I applied the cream- very odd. Couldn't make it past using it for just a few days. I used a progesterone cream from the health food store (Source Naturals) in hope that it would treat some of the "35 symptoms of menopause" that I've been experiencing. Sadly, it made those symptoms worse. It gave me gave me the same side effects as when I tried prescription Prometrium progesterone and Divigel for menopause. Women seem to either do really well with progesterone or extremly poorly. I remember taking a high progesterone birth control pill (Lo Ovral) when I was younger and it made me feel depressed. I think my body does not like progesterone in any form. F 50 3 days
1/4 tsp 2X D
4/11/2013

 4  DUB I'm giving this a 4 as I've only been on it for a month. I felt better immediately after starting treatment. No hair loss, no weight gain as if now.. Do have acne, but I had the same thing with progestin. Overall feel better since being on this medication. Pill form. Very light period, and no cramping. F 37 10 days
200mg
4/10/2013
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 1  Heavy Periods MAJOR panick attacks, Heart rate went from 80s to 140 Landed in the ER with a positive D dimer test. DIZZY, Felt like I was going crazy, Chest pains, Hair loss, Fear of dying, ANXIETY. TERRIBLE TERRIBLE drug!!! They need to test people before prescribing a drug that can make you go nutts! KEEO THIS POSION OUT OF YOUR BODY!!!! F 34 30 days
10 1xpd 1X D
3/29/2013
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 1  Post men Hemorrhoids, depression, anxiety, dizziness, nightmares, Dr Katia Meier in Centennial, CO did not recognize my symptoms as related to progesterone. She said no side effects happen with bioidentical. She did not recognize my side effects were from elevated levels of hormones due to other medications and supplements I take, some even prescribed by her. Do not take with drugs, supplements, and foods like grapefruit, which inhibit the CYP3A4 enzyme that clears the drugs metabolized by this enzyme. You will have nasty side effects, and dangerously high levels of hormones. Look up all teas, supplements and medications for CYP3A4 involvement, P450 cytochrome enzyme involvement for potential interactions. F 57 3 months
1X D
3/6/2013
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 2  Estrogen dominance Extreme hair loss to the point of balding, anxiety, heart palpitations,and insomnia I started using this cream to combat estrogen dominance I was experiencing after being on HRT for a year. The cream helped at first but after 3 months the estrogen dominance symptoms got even worse.I upped my dose like suggested by Dr. Lee's to over come the estrogen wake up period and things just got worse. I developed severe insomnia and increased hair loss to the point of noticeable balding. My hair is coming out by the handfuls all day long. When I tried to quit the cream I experienced extreme anxiety and crying spells. I am now slowly weaning myself off it and will never try this again. Still trying to overcome the anxiety and hair loss. I'm happy for those women who have had success using this, I'm just not one of them. F 44 5 months
1/8tsp 2X D
2/12/2013
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 5  total hysterectomy/ Fibrofatigue Had terrible fibro/fatigue after received a flu shot following a hysterectomy in 1995 My ovaries and uterus were ruined by the use of a copper 7 IUD for over 15 years The bioidenticals got me off antidepressants, anti anxiety, morphine. Praise God!!! F 57 8 months
20
2/2/2013

 1  Perimenopause SEVERE heartburn, panic attacks/general anxiety and uneasy, worrisome feelings, feeling faint, headache, knots on my chin after my period, weak and tired all the time, dizziness, oily skin I would NOT recommend ANYBODY use this. I went into this very optimistic and thinking it was really going to help me and I felt great about the 1st 2 weeks I was taking it and after that, I started to gradually feel like CRAP. It helped alot with my moodiness and crankiness during pms, but the other side effects are NOT worth my continuing this medication. I take it in a cream form at night with estrogen cream, that I rub on my forearems. I have had MASSIVE bouts of heartburn, to the point that I feel like im having a heart attack. I have always been bothered with heartburn, but could always control it with prilosec and a restricted diet ( I use NO caffiene, very little chocolate, no carbonated beverages, no booze, dont eat after 7 at night and have done everything that my dr has told me to do to control it), but I have not been able to come close to controling it while on progesterone cream. I also have started to have panic attacks and at times I feel like im going to faint. I also have felt like my airway is being restricted and I cant get a good breath. I got FOUR of the hard knots on my chin that you get before your period, but AFTER my period this time. I bled for 1 1/2 days than stopped for 2 days then bled for 2 more days!!! Talk about aggravated!!! I feel like ive taken a sleeping pill about 30 minutes after I use the cream and I have had really odd/vivid dreams when I take it. Sometimes I wake up and for a few hours I feel almost like a hangover effect...dizzy, weak F 38 3.5 months
50 1X D
1/5/2013
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 4  Perimenopause symptoms Weight gain in the mid-section but nothing else really. The night sweats, fatique, mood swings and cystic acne were almost disabling. My doctor told me it was just normal but I couldn't accept that. Went to an MD who uses holistic approach to treatment. Ran a lot of tests and found the problem was estrogen dominance. Placed on oral progesterone and the results were felt within 2 weeks. I sleep now and don't wake up dripping wet all night! Mood swings are gone, skin cleared up, I have more energy and I actually feel human again. The only bad thing is the weight gain in the belly. I'm athletic and eat right so I'm struggling with that but just being able to sleep again, it's worth it. F 50 30 days
100 MG 1X D
12/19/2012

 1  Low to nonexistent hormones yes all Extreme sleepiness, groggy into the afternoon. Sometimes slept 10 to 12 hours. Started with 100 mg and very vivid, unusual, and hard-to-wake from dreams. Had several very disturbing nightmares. with low dose vivelle dot added, dose of progesterone was upped to 200mg. THE WORST NIGHTMARES AND SEDATION. I MEAN HORRIFIC NIGHTMARES AND SLEEPIN THROUGH 10 or more hours of them. Cannot stop crying and suicidal. This crap is pure poison and I just wish I was dead! I got this in gel cap form from a holistic MD. It's supposed to be bioidentical and cause no side effects. Bull. My MD's practitioner told me only one other person she prescribed to to in "all her many years in practice" has had nightmares. Bull. Practioner took blood to test hormone levels and ave me a Gama drink powder. I just wish I could kill myself right now. I hope I can. F 57 3 months
100 to 200 1X D
12/17/2012

 5  leg and arm tingling and pain I started using OTC progesterone cream at the label dose of 20 mg twice a day. I felt good, but incomplete, relief from my muscle pain. I found that rubbing the cream onto the painful areas really helped a lot! Unfortunately, it seemed like this small dose caused water retention and made me feel really fat. I found a website that talks all about using progesterone cream. They explained that using too little is what causes the water retention and other estrogen dominance symptoms. They recommended using at least 100 mg per day. Since my doc had prescribed 150 mg of oral progesterone (that I had not yet started taking), I figured that dose should be OK. I tried it and my muscles feel NORMAL for the first time in years! When the pain starts to come back, I just put a little more cream on the painful area. I have not gained any more weight with this higher dose and I feel so much better overall. F 44 14 days
100-200 2X D
12/8/2012
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 5  menopausal I was perimenopausal at 38. Also, my hormones were never right after the birth of each child . Symptoms were terrible; doubling-over ovarian pain during ovulation and beyond, hot flashes every 15 mins, no libido and eczema all over my arms & legs. First tried the creams which just didn't work for me. Too up and down with symptoms. Also, it was difficult to keep to a regular schedule with the applications. Finally I came across a place that did bio-identical hormones that are inserted into you every 4-6 months. It is essential to have a blood test before insertion to check your female hormone panel: Estradiol, Testosterone and FSH. Doesn't help too much to check your progesterone through blood testing as it varies so much during the month. Found out my levels were alarmingly low. The estrodial & testosterone are the pellets that are inserted in your backside, with a local first (no kidding!) and the progesterone is taken orally. They don't have a pellet for that, yet. The beauty of the pellets is that they dissolve over 4-6 months and if you are more active a certain time of day (greater blood flow), more of the pellets dissolve into your system. I am very athletic with a high metabolism, hence I have to get the pellets every 5 months. The first few years, it was every 4 months. My life has totally changed for the better. If you do this, make sure to keep copies of your blood test and chart your progress. Take charge of your health and help let the Dr. know what you need. As for periods, you don't have any if you take the progesterone continuously. Btw, I was doing that long before it became popular in Western medicine. I only stop the progesterone if I find my uterine lining starts to build up. Probably about every 6 months. Then restart when my period is completely done. F 50 6 years
200mg 1X D
11/7/2012
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 2  PMS, mood swings, migraines depression, lethargy, heavy bleeding in combination with testosterone I used a blend of bioidentical progesterone and testosterone for two months. At first I felt great on these hormones...energy improved, helped relieve depression and migraines, and I felt I had my life back! The problems began when my second period started while on the hormones. My period was normal but I had unusual depression starting on day 2-3 of my cycle. I felt weird all over! The depression finally eased somewhat and my period ended normally...however, started a second period the day after the first one ended...VERY heavy and I don't ever have heavy periods. At this point in perimenopause I have not had any bleeding like this. I continued to bleed heavy for 3 days as I got off the hormone blend (I felt it was causing the heavy bleeding so decided to discontinue). The whole episode was very terrifying! I was weak and had flu like symtoms. I decided to continue with just progesterone by itself to counteract any estrogen dominance. Experiencing unusual depression, lethargy, dizziness, and sleepiness. I will lower the dose to see what happens. If it continues will discontinue altogether. I would caution those wanting to use bioidentical hormones to proceed carefully. I used them as a last resort and although it was good at first it came back to bite me. Progesterone in excess can cause depression/lethargy because it down regulates available serotonin in the brain. If you use hormone therapy be prepared to constantly tweak the dose and keep a journal! F 42 2 months
1X D
11/4/2012
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 1  tested low DON"T TAKE THIS! YOU WILL BE SORRY! IF AFTER STOPPING THIS MONSTER OF A DRUG, YOU EXPERIENCE SIDE EFFECTS FOR LONGER THAN 18 MONTHS, TRY EMOTIONAL FREEDOM TECHNIQUE. LOOK IT UP ONLINE. IT SAVED ME. F 43 10 weeks
75 1X D
11/2/2012
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 1  tranfered from other boyfriend had higher sex drive at first, then became uninterested in sex due to emotional distress, I have many dizziness, and loss, of apatite and increased blood presser being the fact that myself and my boyfriend had so many negative affects from transfer from a user of this cream ( while have sex repeatedly) leads me to think that is some thing all health men and women who do not need it should avoid contact with. So we are asking our girlfriend to stop using it. F 30 5 days
? 1X D
10/17/2012
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 2  Post Menopausal Osteoporosis I was experiencing bad back pain from osteoporosis, and trouble sleeping. My doctor put me on bioidentical estrogen, progesterone, and testosterone creams. Within a week, I began experiencing major bloating, fat deposits began, and have not stopped. Despite a clean diet, exercise, etc. I have gained 25 pounds since starting the creams. I have severe estrogen dominance, despite using products that certify no xeno-estrogens. I have been taking DIM for over a year, but still have the symptoms of estrogen dominance. I would love to get off of this cream, if I could find a solution for my bones. So far, nothing has helped, as my bone density is not getting much better from these creams. F 64 1 years
1/4 tsp 1x
10/6/2012
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 1  Peri-menopause/Fibroids EXTREME DIZZINESS, DEPRESSION, INSOMNIA, ANGER, MOODINESS!! I AM POSTING TODAY IN HOPES THAT I CAN HELP SOMEONE WHO IS SUFFERING FROM DIZZINESS DUE TO PROGESTERONE CREAM!!!!!!!!!! I WAS TOLD THAT PROGESTERONE CREAM COULDN'T MAKE ME DIZZY, BUT THEY ARE WRONG AND HERES WHY.... AFTER STOPPING THE CREAM MY DIZZINESS WENT ON FOR 9 WEEKS... FOUND OUT THAT ITS BECAUSE THE CREAM THAT I USED WAS CHEAPLY MADE WITH AN OIL COSMETIC BASE,, RATHER THAN THE MORE EXPENSIVE LIPOSOMAL COMPOUNDS!!! SO BECAUSE OF THIS THE CREAM GOT STUCK IN MY FAT TISSUE CAUSING FLUID RETENTION IN THE BODY, AS WELL AS FLUID RETENTION IN THE INNER EAR, CAUSING VERTIGO AND DIZZINESS...EVEN AFTER THE CREAM WAS STOPPED IT WAS STILL BEING RELEASED INTO THE BLOOD STREAM.. SO HERES WHAT YOU NEED TO DO; YOU NEED TO FLUSH YOUR SYSTEM WITH LOTS OF WATER, ABOUT 2 LITERS A DAY AS WELL AS NOT USING ANY BODY LOTION OR BODY OIL BECAUSE ANY PRODUCTS WILL FURTHER TRAP IN THE PROGESTERONE CREAM. ALSO YOU NEED TO TAKE HOT SHOWERS, SO THAT YOU CAN SWEAT AND DRAW OUT THE CREAM WITH THE HEAT AND HUMIDITY..., THEN VIGOROUSLY MASSAGE YOUR SKIN TO WAKE UP TOXINS WHICH ALLOWS THEM TO BE EXCRETED!! THIS WILL MAKE YOU DIZZIER AT FIRST BUT ONLY FOR A SHORT TIME. ITS YOUR ONLY HOPE OF GETTING THE STUFF OUT! ALSO TAKE A GOOD MULTI VITAMIN AND LOTS OF C. OH OH AND YOU MUST HAVE A VERY LOW SALT DIET WHILE THIS IS GOING ON TO AVOID ANYMORE FLIUD RETENTION ISSUES IN THE HEAD AND BODY!! GOOD LUCK AND PLEASE DO NOT BE SCARED ANYMORE, THERE IS A SOLUTION!!! I AM DOING IT WITH SUCCESS AS WE SPEAK!!! F 42 10 days
200-400mg 3X D
10/6/2012
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 1  TOOK PRO-GEST AS PERI-MEOPAUSAL SEVERE VOMITING, CHEST PAINS, LEG CRAMPS AND LEG PAINS, SEVERE STOUMACH PAINS, NUMBNESS DOWN RIGHT ARM I rubbed a small pea sized amount twice into me over a two day period and suffered severe vomiting, shaking, chest pains, numbness in my hands and arm, leg cramps and leg aches, it took over two days to get over such a small amount that I rubbed in, I was taking this Pro-gest as I have peri-menopausal and was willing to try anything, I advise not to take this as I nearly ended up in hospital F 44 2 days
1 1X D
9/26/2012
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 5  Menstrual migraines If i take more than one, i get sleepy. A small price to pay. This medicine has literally given me my life back after over 30 years of debilitating migraines thay made me close to considering suicide. Do be sure that you get the compounded kind from a wellness pharmacy, NOT the Prometrium or generic equivalant as they are not the same. I take 100 mg morning and evening every day, except for when i feel a migraine coming on, then i take one every two hours or so till the headache is gone. I cannot comment on how it works for other sysmptoms, but for mine i can honestly say it changed my life! F 50 6 years
100mg
9/5/2012

 1  to balance estrogen Insomnia, uncontrollable shaking, panic attacks, extreme fatigue, adrenaline rushes, feelings of unreality, nausea, dehydration, walking sideways, feeling faint leading to the emergency room and hundreds of dollars worth of tests and still doctors told me to switch to sublingual tablets which made me think I was dieing! .Why is anyone allowed to manufacture a product that doctors clearly don't understand the extreme danger of this drug. The doctors don't have a clue about how long this poison can stay in your system and disrupt all of your adrenals. I don't think I will or ever want to use any progesterone again. I have never experience anything like this. Don't put this on your skin because nobody knows how long it will be in your system! F 58 1 years
50 - 80 1X D
8/24/2012
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 1  total hysterectomy hormone balance Severe depression/anxiety, constant crying, diarrhea, worse acne with extremely oily skin and hair, dizziness, loss of balance, severe fluid retention ankles/hands, severe lower backache and abdominal bloating with reflux. At first very drowsy, then very anxious with suicidal thoughts and inability to think clearly. I only went on the natural progesterone gel because though I'd had a total hyst, I thought I shouldn't be on unopposed estradiol, even though I'm only on a 0.0125mg/day patch (a VERY low dose), but I have a history of MDD/anxiety disorder and I was unaware of that being a contraindication to using progsterone. F 57 2 weeks
5mg 1X D
8/20/2012
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 1  Estrogen dominance/Facial hair Severe anxiety, panic attacks, depression, tremors,shaking, muscle twitching, lost 20 pounds in six weeks, mental confusion, paranoia,joint pain , insomnia. Bio-identical progesterone. After first application on progesterone cream i should have stopped.My muscles started to ache the next day i even had to wear a brace on one ankle to be able to work all day it was that bad. I broke out with acne, had bloated stomach and i was feeling drunk during the last few days of application. I had severe anxiety, cried all the time, i seriously though i was going to go into a mental institution i felt like i was going crazy. I almost lost my job, my boyfriend and all my friends believed i was making it all up. I found a great dr who listens to me and looked at me like why in the world would you ever take that. I had gone to a hormone dr who prescribed me progesterone cream, thyroid pill, adrenal rebuilder, b-12 shots its all BS! do not take this i regret ever putting this into my body. I am so thankful for this website i had to read it every morning to help myself not go crazy. My dr prescribed me xanex to help the anxiety i take melitonin at night to sleep. please god let the symptoms end soon. do not poison yourself. F 24 3 months
10mg 1X D
8/14/2012
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 1  Estrogen Dominance Irritable, depressed, confused, very tired, sleeping 14 hours straight, hunger out of control, fatigued, flare up of fibromyalgia, angry, impatient, bad cramps and ovary sensitivity, pelvic and back pain constant, muscle fatigue I was given Progesterone through a woman doctor from BodyLogics. Wow, I really feel stupid as Biologics is an idea of physicians angry at insurance companies and wanting to make a lot of money without earning it! I have to date spent $600 on supplements and bioidentical hormones. I spent $575 on a consult that was to be an hour long and was 40 minutes. Never did I speak or discuss my symptoms or concerns during my "consult." The whole focus was selling me prescriptions and supplements. One prescription was an weekly injection of B12. She only asked if I had an issue with needles. I said no. When I pick up the prescription and try to take it, I had to use YouTube to figure out how to inject myself. I eventually had to call the pharmacist twice because the B12 was not coming out of the vile. The woman looked at my lab results, started throwing one supplement bottle after another at me, gave me prescription hormones (testosterone daily, progesterone daily, estriol daily, DHEA, and thyroid) and then took out her calculator to give me prices on everything she was selling me from her office and the consult. This was $1110.57 just to get out of my first appointment. Her office is located in a financial building in which no one knew of her in the building and no directory was in the building to guide me. I spent 45 minutes in the building running around looking for her. By the time I found her office, I was exhausted and just wanted to give up. I waited in t F 51 14 days
100 mg 1X D
8/2/2012
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 2  Peri-Menopause/Low estrogen Doctor prescribed Vivelle estrogen patch (.5 mg) with compounded progesterone to offset. Started estrogen first for a few days. Hot flashes stopped, clarity of thoughts returned, felt depression subside. After starting progesterone, I started getting severely depressed, I'm so sleepy and fatigued I can't function. My thoughts are very foggy - I feel like a zombie. My progesterone is a cream which is compounded, as I can't take prometrium or the compounded progesterone pills - they cause digestive issues and confusion. This cream is a little easier as I've decided to adjust the amount of cream I'm using for a few days. I was using it full strength, but I felt so bad that I can't do much. I used half strength last night. I feel only slightly better - still feeling very foggy headed and fatigued. I'm going to talk to my doctor about cycling this so that I don't have to feel this bad all the time. F 47 10 days
75 mg 1X D
7/7/2012
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 1  Estrogen Dominence/PMDD ANGER, Irritability, depression, sore breasts, acne, spotting. I can't believe it took me 3 months to figure out that the progesterone cream was ruining my life. I kept reading forums saying that all of those side effects were because my hormones were finally evening out. EFF THAT! I waited, like a dummy, for 3 months and everything got wayyyy worse. The only thing that made it better was getting off of it!! And it's been a few months and my body is still working on getting back to normal. After that experience, I'll take PMS or PMDD over severe depression, anger etc., any day!! M 26 3 months
30 MG 1X D
7/5/2012
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 3  balance out estrogen therapy Severe bloating, stomach pain, gas Two weeks ago started with the pill form then switched to cream due to severe bloating and stomach pain. Cream still causes the side effects just not as severe. Waiting to see if side effects will disappear after time. F 54 2 weeks
80Mg crea 1X D
6/16/2012

 1  estrogen dominance Instant weight gain and bloating. My stomach began to swell and bloat I could not button my pants. It was supposed to ease my estrogen dominance but seemed to do the opposite. I has prescribed the cream by my doctor which I had filled at a compounding pharmacy. F 43 4 days
6/14/2012
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 1  menopausal symptoms Rapid weight gain in mid section and thighs. Loss of memory. Dizziness. Total anhedonia: lack of feeling for anything. Bloating. Fear and dread all the time. Fatigue that made it difficult for me to function. Sore and aching feet. The naturopath said it was good for me and i was desperate because of the severe hot flashes. I was skeptical but went on the cream anyway. This was not a good choice for me. I feel fortunate that after 5 weeks i noticed these symptoms as being related to the use of the creme and nothing else. I stopped taking it and i feel inuitively, that the creme was bad for me. I can not recommend it and hope to find relief through diet and exercise. Spread the word to other women so that they might be spared this violation and poisening of their bodies! F 50 6 weeks
20
6/13/2012
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 1  Perimenopause Weight gain in midsection; Cystic acne on chin; Breast Enlargement I think women really need to do the research before taking this...best to be your own advocate! I was placed on bioidentical progesterone cream for two weeks out of the month. All of a sudden, started to get cystic acne breakouts on chin..painful to say the least! Once I backed off the cream, the acne subsided. Weight went up in my midsection, despite strict diet and exercise. Breast cup size increased. In fact, I have read that too much progesterone can cause these things to happen...especially if there is too much of it in relation to estrogen. I think it is so easy to throw around terms like "estrogen dominance" these days and then think that progesterone cream is the answer for weight loss. After my personal experience with it, progesterone turned out to equal weight gain for me. F 43 2 months
50mg 1X D
6/7/2012

 4  estrogen dominance (EDom) EDOM - Clean out xenoestrogen first (research DIMpro, MACA, etc for the liver, then get it off your skin/out of your home/food, have your water tested - your liver can't clean toxins that come in thru the skin/transdermally)- adding Prog to an estrogen saturated body will only exasperate EDOM symptoms, as prog creates good estrogen (and testosterone) (EDOM + MORE estrogen=horrible side effects). Prog is fantastic when xenoestrogens are eliminated (to the best of our ability). Prog is fantastic if you mimic nature. Too much of anything will produce side effects, right? VIT D is crucial as well (have your personal levels tested - you can OD on VIT D, but suffer without optimal levels = tricky) F 43
cyclical 1X D
5/2/2012
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History
 5  Estrogen dominance, irregular periods No bad "side-effects" - this stuff is wonderful! BEFORE taking bio-identical progesterone, I had bad PMS, irregular periods, facial hair, hair-loss, and weight gain, and adult acne. AFTER taking progesterone, I sleep easily, skin clearing up already, losing bloat, and energy levels are amazing. I will definitely keep taking this cream! F 39 7 days
30mg/day
5/1/2012

 1  yes Pain in the head in different areas; dizziness and confused; unable to focus thoughts. I will never let a Dr. give me this again! Never F 53 5 days
200 1X D
4/30/2012
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 1  Perimenopause, irregular periods EXTREME anxiety and nervousness to the point of shaking. Heart racing, sweating, bad, vivid dreams and extreme insomnia. Hot flashes and feet sweating. I started "natural" progesterone cream after complaining to my gyno about longer periods that were getting closer together, along with fatigue, breast tenderness, facial hair, weight gain, etc. I started this cream at about 10-20 mg twice per day and then lowered it to a small pea size amount twice per day, because it was making me feel so bad. I want to note that, for some odd reason, I did have a few hours here and there where I felt extremely calm, but that never lasted on this med. Instead of the lower dose making the symptoms back off, they continued to get worse, almost like every dose was just adding to the last one. I felt like I overdosed on poison. I stopped the medication the following Wednesday after a night of no sleep and waking up in a TOTAL PANIC STATE. That was yesterday morning and today I feel about 50%-75% better, although still a little shaky and nervous. Going to start acupuncture for perimenopause, which is what I should have done from the start. Total crap this stuff. Please spare yourself the horrible experience and find another way to treat your symptoms. Sorry to the other women reading this who are experiencing this as well :( You will get better, I already did just by stopping it. As much as I thought this was going to be an easy miracle cure, my body did not like it at all and sure told me so! F 42 6 days
10-20mg 2X D
4/27/2012

 1  hormonal imbalance/menopause Headache, hot flashes day and night, insomnia, lack of focus, anger Was on Prometrium a few days with horrible side effects. Tried cream for close to 5 years under holistic MD. Saliva progesteron to 12,000; should be 200. Everything worse. Nearly crazy with Hot flashes. Dr can't figure it out. Never AGAIN.Beware! I too wonder how long to get these out of system. F 62
20 1X D
3/19/2012
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 1  PeriMenopause/PMS/PMDD No side effects at first, worked well. Over time, I believe I have gained weight(25#) that I now cannot seem to lose. My uterus is enlarged too. I feel about 3-4 months pregnant. Don't know if it's from the progesterone cream, I'm starting to suspect it is. I had terrible estrogen dominance issues. I had blood sugar problems, horrible anxiety, breast tingling (felt like milk letdown) constantly. I truly feel that this stuff helped at first. I think something changed along the way. I began to gain weight - seems like anywhere I put the cream (arms, inner thighs and mostly around my abdomen. I always used the smallest amounts. I judged by the size of the dot on my hand. I'm bummed because I want to keep using it but can't stand how fat I'm getting from it. I use compounded bio identical progesterone. My doctor prescribed an amount that was way too high so I found the amount that worked for me. I have read that using the Crinone gel vaginally avoids your skin becoming saturated and unable to absorb the progesterone. I'm trying to find out more information about that as an alternative. I thought about using the cream I have vaginally, but I'm nervous to try that. If any of this sounds familiar to anybody and you have come up with a good alternative, please email me. I'm afraid all my old symptoms are knocking on my door. F 43 3 years
varied 1X D
3/19/2012
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 1  For PMS Symptom Relief Depression, crying, insomnia, anxiety. I started taking progesterone cream to help moderate PMS symptoms (irritability/depression). Three days ago I started using Source Naturals Progesterone Cream, 500 mg per ounce. I only used 1/4 teaspoon once per day, which is about 20 mg. I used it in the morning only. By the afternoon of the first day I was feeling horrible, depressed, completely off. I thought I was just having a "bad day". I slept badly that night. I used it again the next day, and I felt very tired and depressed all day. I could barely sleep last night, which I don't normally have a problem with, and woke up with anxiety this morning. I don't have anxiety problems. I'm stopping this today. I didn't realize that there were so many possible side effects until I found this and other web pages detailing the possible side effects. F 37 2 days
20 1X D
2/29/2012

 5  Estrogen Dominance/PMS/Migraine Premenstrual breast pain disappeared during month one and has been gone for the last two months. PMS swelling is reduced. Skin where the cream is applied has experienced a very noticeable reduction in lines. The only negative side effect has been a slight increase in heart rate that feels similiar to too much caffeine on the two or three days leading into my period. My premenstural migraine was shorter and less severe last month. I feel much better already. I have noticed a very positive improvement in a short time. F 43 2 months
20mg 2X D
2/22/2012
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 1  hives, cysts, IBS I took Dr. Lees bioidentical progesterone cream. I felt great the first 2 days then on the 3rd day my breasts were swollen, i felt anxious and got weird thoughts, my hives broke out worse than ever. Its been 3 days since I have taken this medication and I still have nervosness, my hives are horrible and I itch severely at night and feel tightness in my shoulder blades. This is horrible. I would not recommend taking this without a doctors guidance. F 45 3 days
30mg 1X D
2/22/2012

 1  pre menopause symtoms weight gain, depression, mood swings, night sweats, anxiety I stopped about five days ago and am already feeling better. I work out daily 1.5 hours minimum cardio and weights, pilates. I believe this is helping to get the toxins out more quickly as others have said it takes a longer time. was also taking a mix of black kolash and wild yam. I will never self medicate on herbal remedies again! very glad I found this blog... F 55 1 days
2X D
2/10/2012
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