IMIPRAMINE HYDROCHLORIDE Reviews (IMIPRAMINE HYDROCHLORIDE)

Average Rating: 3.5 (106 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

IMIPRAMINE HCL  (IMIPRAMINE HYDROCHLORIDE):  This medication is used to treat depression. It is also used with other therapies for the treatment of nighttime bed-wetting (enuresis) in children. Using this medication to treat depression may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living. Imipramine can help your child control nighttime bed-wetting. Imipramine belongs to a class of medications called tricyclic antidepressants. It works by restoring the balance of certain natural substances (neurotransmitters such as norepinephrine) in the brain. For bed-wetting, this medication may work by blocking the effect of a certain natural substance (acetylcholine) on the bladder.   FDA Approval Date: 1990-06-05 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by Gender with females listed first (reviews with no gender reported listed before females).

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on IMIPRAMINE HYDROCHLORIDE: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR IMIPRAMINE HYDRCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  depression waking up after a few hours. I was on 25mg of elavil (amitryptaline) and I was having recurring negative mood swings. The psychiatrist gave me 10mg imipramine, the smallest dose available, and said I could take up to 3 a day. At first I wasn't that happy with it, but now that I'm up to 3 a day it seems pretty good. I work 2nd shift and I find that I'm sleeping less on the imipramine which is good because I can get up earlier and get more done during the day. I like the fact that they are only 10mg because if I'm feeling blue at work I can take one without it effecting my performance. I'm beginning to make a habit of that though, and it may be because I was a substance abuser and the idea of that appeals to someone with an addictive personality. There is some loss of libido which concerns me but I'm not in a relationship so I'll cross that bridge when I come to it. 56 24 days
11/13/2006
 2  Depression/agitation Horrible constipation and extreme rage. Ended up threatening and screaming at my family. Wanted to die and spent hours crying and coming up with creative ways to kill myself. I've never experienced such extreme mood swings in my life. My family was actually afraid of me. Don't just take different meds because your doctor suggests it. Do your research first. I feel like a guinea pig. 37 2 months
100 MG
2/27/2017
 5  major depression, agoraphobia Dry mouth and eyes, constipation,weight gain. I have taken it for 29 years, but site was not allowing me to indicate that from "smartphone". I was housebound before I started it. I had drowsiness at first, (at a higher dose, 125 mg), but that went away. Craving for carbs also eventually went away. Since I went on imipramine, I have held down jobs, gone to school. I would never want to go back to the life I had before taking it. F 56 10 years
50 mg
9/15/2014
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 5  panic attacks/depression dry mouth and elevated pulse This wonder drug has made all the difference in my life. Began taking it for panic attacks and got immediate relief even though it was supposed to take time to start working. Didn't realize I had been depressed until it made me feel like a new person. About 8 years ago I tried weaning off but found that I needed 75 mg. to feel normal and have emotional buoyancy . So I quickly went back from 50 mg to 75. Over the last year I went from 75 mg down to 25 mg. Felt fine at 25 mg for two months. 25 mg is not supposed to be therapeutic but it IS for me and other people who have left comments! My doctor encouraged me to go off completely--probably because of the myth of 25 mg being nonclinical-- but the insomnia and ever decreasing energy is intolerable. My symptoms including the age of onset followed a grandfather's pattern to a T. Should have known that I needed to be on it for life. Am now looking for a new doctor. F 53 20 days
150 to 25 1X day
10/2/2014
 5  I was 15 yrs old 9th and 10th grade I was sleepy alot, but that was my norm, i love sleeping. Never really ate, I dont remeber dry mouth, great mood, mostly happy. I went from a F DC student to A B student. I took myself off becuase My Sifu said if I want it, then I will achieve it. So I achieved an extra belt in nun chunks in 1 months. I was proud. But then hello I started not paying attention, not reading and failing. I was not interested in the material. I just daydreaming . Now I need it for work. I cant even do my routine 2 days the same. Im inconsistent and I really try. I loved it. It does wonders if you truly can not concentrate and that is real dx you cant. F 38 18 months
30mg
10/21/2019
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 5  Depression So so so much sweating! I sweat when it's the dead of winter and freezing outside! Crazy side effect! It's helped a lot but I wish it didn't have excessive sweating as a side effect. I hope it goes away, it's awful. I sweat like I've spent hours at the gym, just going to the store for a brief period. F 32 4 months
100 mg 1X day
2/11/2022
 5  Depression, anxiety, eating disorde dry mouth, constipation, fast heart beat, developed some speech problems which got better when lowered dosage to 125mg, no sex drive, I found imipramine to be one of the many tried anti-depressants that worked. I was once on 300mg a day through some bad times but have been on 150mg since 2003 and now for the last month am on 125mg. Found i developed speech problems and would say the wrong words and clutter my speech. This has improved now i am on 125mg. Having headaches tho and some down moments but determined to not increase dose again. Trying to get past the withdrawral symptons. F 28 6 days
2/19/2008
 5  Migraines dry mouth, funny taste in my mouth I have been taking this medication every day for 18 years. I was experiencing extreme visual problems such as temporary blindness, double vision, etc... and had been through tons of doctors, procedures, tests... Tofranil was prescribed to me for what they suspected was migraines in the occipital lobe of my brain, although I never experienced headaches. I got better immediately and have been maintained on 75mg a day since. I was young, in graduate school and thought I was loosing my mind. This medicine saved my life. One strange thing I noticed right away. I get a very funny taste in my mouth if I am late taking a dose or miss a dose. Now I take the PM brand so it does not happen near as much. F 43 18 years
3/19/2008
 5  depression and anxiety dry mouth, slow urination in the morning Nine years ago I was prescribed zoloft first then celexa. Both had side effects that I couldn't tolerate. A friend told me about Tofranil and that it helped her more than anything. I asked my doctor and he told me it is one of the older tricylic meds but was usually effective. I took 50 mgs. of imipramine hcl (generic Tofranil) daily for about 8 years and tried to go off. After a couple of months, I began to have extreme anxiety. I'm back on imipramine 75 mgs a day and plan to continue as long as necessary-maybe for life. Dry mouth is a small price to pay for feeling normal. I believe doctors try the more expensive meds first because imipramine hcl is very inexpensive. F 54 9 years
12/5/2008
 5  Panic Disorder Dry mouth I was having severe panic attacks and this medication saved my life. It worked very well for me. I took it for about 3 years after my divorce. Since then I only need it when in a very stressful situation. F 61 25 years
12/9/2008
 5  Panic Attacks/Agoraphobia Dry Mouth, Constipation, hand tremors, weight gain, sleepiness, irregular heartbeat. Side effects stayed with me the entire time I was on drug. After suffering with totally dibilitating and constant panic attacks and agoraphobia for several years, imipramine incredibly helped to a point I could get out of the house and work again. But, after 5 years I had a life threatening cardiac reaction and was immediately taken off of it, leaving me totally dibilitated again. Nothing since has helped like this drug did. Too bad it had the side effects it had. F 32 5 years
1/28/2009
 5  Mild Depression I'll have five minutes of dry mouth; doesn't matter. I had been on 25mg a day for a few weeks and had a scary episode with urinary blockage. Then after I took it for a couple of months where I felt happy, I suddenly stopped and was hit with a Major panic attack. I am now taking 10mg and may stop. I Hate taking drugs. I feel like I'm chained to them. But it really works great for me, even in very low doses. I guess I should just live with mild depression and get little enjoyment from anything. F 62 14 days
10/25/2006
 5  Bladder Problems none to my knowledge Greatly helped with daytime and nightime wetness when I was younger. Eventually, I grew out of the problem, but this medicine helped me a great deal. F 17 7 years
7/3/2006
 5  depression, unable to fall asleep involuntary noticeable muscle twitching, difficulty urinating,hot flashes, dry mouth, inability to speak occsionally (feels like my tongue quits working) Has helped my depression a great deal. I also take Welbutrin daily F 45 3 weeks
9/30/2005
 5  depression, unable to fall asleep involuntary noticeable muscle twitching, difficulty urinating,hot flashes, dry mouth, inability to speak occsionally (feels like my tongue quits working), exteme craving for sweets, 10 lb weight gain Has helped my depression a great deal. I also take Welbutrin daily F 45 3 weeks
9/30/2005
 5  anxiety & high blood pressure none... It really helps!...sometimes I try to do without after every 2 years...I want to be a puritan...but I truly feel normal and best...I sleep well with no panic attacks! Old med...with no side affects with me! F 42 5 years
4/27/2006
 5  Panic Disorder drowsiness, dry mouth and fast heart rate This drug restored the quality of my life. I take 50mg at night. I was always a confident independent high achiever-I developed panic disorder literally over night. I was completely disabled by it. Forget the mind over matter stuff, i tried all the therapy going -this disease is a biological imbalance hence the instant "cure" thanks to imipramine. Within days of starting it, I was back to normal.The side effects sre nothing compared to constant debilitating panic attacks. I tried Prozac for 2 days and it made my panic disorder 100 times worse-nightmare. Imipramine saved me from a living hell. F 41 10 years
3/14/2007
 5  anxiety or panic blurred vision; dry mouth only at first; possible weight gain of 25 lbs. I only take 10mg at bedtime but if I miss 2 doses I have a major panic attack. Hate being on a drug. Stops all panic/anxiety when I take it. F 60 2 years
6/26/2004
 5  Depression Dry mouth, some blurred vision. My doctor says Tofranil-PM is the most balanced anti-depressant on the market, and its been available for like 40 years or something! Anyway, it acts on both serotonin and norepinephrine, which Effexor XR says it does, but doesn't. Anyhow, Tofranil-PM has changed my life. Everyone with depression should try it. F 44 1 years
2/26/2003
 5  Major Depression Dry mouth, constipation, urinary hesitancy F 48 5 years
2/28/2003
  

IMIPRAMINE HCL  (IMIPRAMINE HYDROCHLORIDE):  This medication is used to treat depression. It is also used with other therapies for the treatment of nighttime bed-wetting (enuresis) in children. Using this medication to treat depression may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living. Imipramine can help your child control nighttime bed-wetting. Imipramine belongs to a class of medications called tricyclic antidepressants. It works by restoring the balance of certain natural substances (neurotransmitters such as norepinephrine) in the brain. For bed-wetting, this medication may work by blocking the effect of a certain natural substance (acetylcholine) on the bladder.   FDA Approval Date: 1990-06-05 (Sources: U.S. Centers for Medicare Services, FDA)

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