Drug Ratings for METHOTREXATE SODIUMAverage Rating: 3.4 (359 Ratings)
Compare METHOTREXATE SODIUM with similar: |
Results are sorted by Gender with males listed first Key to Ratings: 1=LOW (I would not recommend taking this medicine.) |
| RATING | REASON | SIDE EFFECTS FOR METHOTREXATE SO | COMMENTS | SEX | AGE | DURATION/ DOSAGE | DATE ADDED |
  | F M | | | | |||
| 5 | Rheumatoid Arthritis | Feel ill 3/4 of the time, nausea, dry mouth | M | 54 | 1.75 years | 4/23/2001 | 5 | RA | I am writing this for my husband. He has had mouth sores from the start. | The methotrexate was working wonder for the first month. Now though since he has started taking the Remicade with it he has been exhausted to the point of being able to sleep all day or just falling asleep unexpectedly through out the day,headaches but the biggest thing is leg fatigue and weakness with muscle pain. | M | 33 | 2 months 2.5mg 1X W | 3/17/2010 | 5 | Psoriatic Arthritis & Psoriasis | 15mg Methotrexate (MTX) / week, tablet form. A few hours after taking MTX I get extremely drowsy, so now I time it just before bed with a cup of milky hot chocolate. Sometimes the following morning I wake up with a thumping head-ache, but by mid-day the head-ache is gone, I feel groggy though (bit like jet-lag). I'm used to it now, after being on it for six years. I still have to go for monthly blood tests so that my local Hospital can monitor my Liver function. My hair pre-maturely has gone grey :-( this is definitely due to MTX because my brother who is older than me still has pigment in his hair ! But I can dye it so no big deal. I feel as though I'm a little more emotional / less patient ? but that might just be old age creeping up on me. Sometimes it takes a long time for my blood to clot if I cut myself during shaving but I've got used to that now and I'm more careful. Sometimes I take the odd 5mg tablet of Folic acid but can't say that I really notice the difference. Since being | Its a horrible thing to have to take and its a life sentance but if you weigh up the pros & cons my experience is that its worth taking the risk. For me, its meant having an almost normal quality of life and has made the management of the two incurable diseases bearable. Ohh and by the way, it has NOT affected my fertility at all ! | M | 39 | 7 years | 2/7/2006 | 5 | Psoriatic Arthritis & Psoriasis | 15mg Methotrexate (MTX) / week, tablet form. A few hours after taking MTX I get extremely drowsy, so now I time it just before bed with a cup of milky hot chocolate. Sometimes the following morning I wake up with a thumping head-ache, but by mid-day the head-ache is gone, I feel groggy though (bit like jet-lag). I'm used to it now, after being on it for seven years. I still have to go for monthly blood tests so that my local Hospital can monitor my Liver function. My hair pre-maturely has gone grey :-( this is definitely due to MTX because my brother who is older than me still has pigment in his hair ! But I can dye it so no big deal. I feel as though I'm a little more emotional / less patient ? but that might just be old age creeping up on me. Sometimes it takes a long time for my blood to clot if I cut myself during shaving but I've got used to that now and I'm more careful. Sometimes I take the odd 5mg tablet of Folic acid but can't say that I really notice the difference. | Since being on MTX my un-stable skin psoriasis is now very well behaved and I only have a few small patches left which I treat topically with Exorex lotion (yellow, banana based coal tar). A Huge improvement and my quality of life is 10x better ! My Psoriatic Arthrtis (PA) only effects a few of my toes and I can't help feeling that going on MTX when I did stopped the PA dead in its tracks and no new joints (thank God) have been affected since I've been on MTX. So I guess you could say I'm a happy bunny. Its a horrible thing to have to take and its a life sentance but if you weigh up the pros & cons my experience is that its worth taking the risk. For me, its meant having an almost normal quality of life and has made the management of the two incurable diseases bearable. Ohh and by the way, it has NOT affected my fertility at all ! | M | 39 | 7 years | 2/7/2006 | 5 | RA | Loss of sex drive nausea tiredness | Before i took this drug i could not walk for the pain it has helped me get my life back | M | 39 | 1 years | 4/20/2006 | 5 | RA | Loss of sex drive nausea tiredness | Before i took this drug i could not walk for the pain it has helped me get my life back | M | 39 | 1 years | 4/20/2006 | 5 | RA | I have had no noticeable side effects from my dosage of 15 mg once weekly. | It has made a significant improvement in my RA. I have not had any serious disease progression since I started taking it. I supplement the methotrexate with an anti-inflammatory as needed - usually a couple of times a week - depending on my physical activity level. | M | 61 | 3 years | 10/13/2007 | 5 | Palmoplanter psoriasis | Fatigue for few days after each dose. Loss of sex drive. Some hair loss (patches) | This has been a wonder drug for me as every previous attempt to control the condition has failed. Almost complete remission of psoriasis and therefore the side effects are worthwhile. Had a recent bout of flu that lasted a month - was this extended period a side effect? My doctor thought it may be but can't be sure. | M | 48 | 1 years | 3/8/2007 | 5 | R A | none | best thing ever I feal great I have my life back | M | 18 months | 5/7/2006 | 5 | RA | I feel competely fatigue most of the time. This may be due to the RA. I usually feel worse day after taking it. I normally take 15mg a week. I also take 5mg of Predisone daily,200mg celebrex daily,Inbrel injection once a week, & folic acid. My mouth gets dry, may have a sore once in a while. I generally have not feeling well feeling, you know what I mean. I play golf at least 4 times a week. Without Methotrexate I couldn't do this. As I write this I have had to stop the drug, because of some lung problems. Pulmonary Fibrosis. I will be off methotrexate for 2 months & then repete test on my lungs. | Methrotrexate has done wonders for me. I was able to hold down my full time job. I still had RA flare ups, but they usually would just last a day. I did have to get off drug once because of liver test came back bad. That cleared up next test. | M | 66 | 13 years | 7/12/2006 | 5 | Psoriatic Arthiritis | None apart from raise liver thingys. | I take Meth and Enbrel and it is a miracle combinaiton. My Psoriatic patches dissapear back into the woodwork, and the pain is gone like a wild goose in winter! | M | 70 | 2 years | 7/25/2005 | 5 | psororiatic arthritus | none the arthritus started diminishing in the first week after 20 years of pain ,short term memory loss is there but as i am in my seventies this goes with the territory.after 20 years of severe pain i think M is great and i am only into my third week | it started working for me within three weeks, only time will tell what the long term situatin will be, the specialist reckons three months time i should be ok | M | 74 | 21 days | 10/9/2006 | 5 | Rheumatoid Arthritis | Vomiting, Nausea, Anorexia | Ive lost about 10 Kilos taking this stuff. Makes me feel sick and has killed my appetite but it works really well plus it kicks in fast (about 3 weeks). I can put up with the side effect because it works so well. | M | 48 | 16 months | 11/23/2004 | 5 | psoriatic arthritis | I have taken 7.5 mgs (three 2.5 mg pills, one each Monday AM, PM & Tuesday AM) with meals each week for 18 years. A few times, I did increase it for one week to 4 pills. Slight reduction of sex drive. Slightly more tired. | This has been the magic bullet for me. I had lost over twenty joints in my toes, fingers, etc. that were totally locked and methotrexate restored all of them but one. I have blood tests periodically to monitor liver functions, but they are OK. | M | 59 | 16 years | 8/24/2004 | 5 | asymmetric psoriatic arthritis | None | 15 mg/wk. I think the rest of you are hysterical. Perhaps you are reading these web forums waay too much | M | 41 | 90 days | 1/13/2004 | 5 | rhuematoid arthritis | bowel disturbance | M | 33 | 4 months | 5/11/2003 | 5 | rhuematoid arthritis | Some bowel disturbance...some hair loss...that's all,, till now. | at first 15 mg now i am on 7.5 mg..i become nearly a normal person,,,it is great till now...i take antioxidants,folic acid,and multivitamins,drink more than 3 litters of water per day..may be i can avoid any side effects in the future. | M | 33 | 4 months | 5/11/2003 | 5 | Rheumatoid Arthritis | EXTREME tiredness, almost complete loss of energy. Sore gums periodically (every few weeks). Involuntary twitching of arms and legs at night. Recently extreme depression (may not be related). | This has completely subdued my RA, although I still need painkillers due to damaged wrist joints. I can't get any doctors to acknowledge that this drug causes tiredness - yet look at other's comments! | M | 54 | 4 years | 5/29/2003 | 5 | reactive arthritis | whenever I stop being positive fatigue seems to hit me hard; occasional loss ot appetite, unexplained wretching (although this was put down to 'a virus') | it worked where everything else didn't | M | 33 | 18 months | 1/13/2003 | 5 | psoriatic arthritis | Take 15mg on Saturday mornings with food and coffee. Take folic acid every day along with hydrocodone and other stuff. Sometimes, Saturdays can be a little seasicky, but nothing to worry about. | If you are just starting on this drug, hang in there. I was hurt pretty badly with psoriais and p.a. About two months after I started taking Methotrexate, the psoriasis started to retreat. Pain is still there from PA in great quantity, but after first seven years of taking Methotrexate, I am virtually free of skin psoriasis and I had it all just about everywhere. Great stuff! Hang in there. | M | 66 | 12 years | 5/4/2005 | 5 | For RA | None | I took 6 pills per week for about 6 mos.(beginning in April of 2007). I also took prednisone (5mg daily) for about a month. In October I started to ween off methotrexate, each 6 weeks I take one less pill. Now I'm taking 1 pill and in July 0 pills. Doing great with very little or no pain. | M | 65 | 13 months | 5/5/2008 | 5 | Ulcerative Colitis | Been taking METHOTREXATE for 6 years - had bad nausea for the first couple of years, now only occasionally. A bit of hair loss at first, now OK. Worth persevering. | Before taking METHOTREXATE I was in hospital for a week or two every couple of years. It has been a 'wonder drug' for me. The additional benefit is I no longer have problems with asthma, used to have to use oxygen during the Winter now no symptoms at all. I take 15mg once a week. | M | 61 | 6 years | 9/16/2008 | 5 | Ankylosing Spondylitis | No side effects experienced. Tolerated the drug very well. | Worked perfectly. Didn't experience any side effects (except the occasional mouth ulcer). But, I've always been pretty good at tolerating drugs. | M | 21 | 2 years | 9/23/2009 | 5 | Psoriatic Arthritis | occasional lethargy, poor concentration, loss of appetite, some depression. | I have been on methotrexate for 4 years now, I started on 40mg a week orally and now I take 10 mg per week. This drug has literally saved my life, before taking it my skin was like sandpaper and my joints were so swollen I could barely walk and was in constant pain physically and emotionally. Within three months my skin was clear and I was back exercising. I now play sport three times per week, run and lift weights........the side effects for me are bearable and are worth it. | M | 30 | 4 years | 10/11/2009 | 4 | Psoriasis and Psoriatic Arthritis | Extreme (well pretty bad anyway) nausea and extreme fatigue about 1-2 days after treatment day. I take 20 mg/week orally. I get bad nausea for about 4-5 days and extreme fatigue about 1-2 days after the treatment day. | I don't really like this medication. It does seem reasonably effective at helping my p and pa. It is very reasonably priced, but I worry about effects on my liver. The side effects such as nausea and fatigue are definitely adversely affecting my lifestyle and general outlook on life. I guess individuals need to weigh up the advantage versus the disadvantage for this (and every) medication. | M | 44 | 10 weeks | 9/9/2009 | 4 | Psoriac Arthritus | Nausea, Diziness (lack of balance), Tiredness | 7.5mg, side effects kicked in after about 5 weeks. Has helped the PA but feel rubbish for a couple of days after taking. The loss of balance is very disconcerting. Also on Folic Acid 3 days after. Only on it 3 months so far so will wait and see... | M | 45 | 3 months | 6/17/2009 | 4 | Psoriatic Arthritis | none | Had no notable side effects but also had zero effect on my arthritis (up to max dose of 20mg/Week). My regular blood tests have always been fine. I am now on MTX + Humira (which works very well) and am lead to believe that the MTX decreases the chances of my developing resistance to Humira and improves its effectiveness but I have no way of confirming this. | M | 2.5 years | 7/11/2009 | 4 | RA | Nausea, severe headaches, tiredness | Initially I got morning sickness the day after I had taken my 10mg dose. After a few months I started tio get powerful headaches the evening and day after I take the MTX. Side effects go away if I stop taking for a week, but the headaches now just seem to be getting worse. I am looking at going to injected MTX, as I am losing every weekend to tyhe side effects of this drug. | M | 49 | 9 months | 9/14/2009 | 4 | Rheumatoid Arthritis | If any they are very subtle. Been taking it the entire 2 years after the symptoms set in. Maybe nausea, lower energy. Take 12.5mg weekly only. Was taking 1mg folic acid, but stopped around a year or so ago, as blood tests showed fine without. | I am getting ready to start a ween off the methotrexate by dropping 2.5mg (1pill) per week or three until down to 3 pills 7.5mg. That is how I found this site, I was looking for best known method for weening from methotrexate and if it is a bad idea. If I have no affect following the ween for a year, doctor will consider remission as posibility. I pray, we can cure for all of us. Able to do everything I want, have what I think is a tendon issue very close to the RA pain, but is topical as far as I can tell, following activity sometimes. Just played 2hrs of football and biked 12miles and I am spent. I love it!! I just hope I am not hurting myself. We'll see tomorrow?!? When it hit me 2years ago, I was afraid I would be bed ridden for life as it hurt to do everything, I mean everything and was almost at a full stop. Started treatment within 2months of it showing up. In retrospect I had one of the worst flu type illnesses or virus in my life, 2 months or so before I was in pain. | M | 42 | 2 years | 1/1/2010 | 4 | RA | Have been taking MTX for 2 years. I take 12.5 as a weekly shot and have had no side effects after the initial few weeks. Shots are easy and worth considering. | I have a mild case of RA and feel fine. Unfortunately, I've started getting bone erotions so will be starting Remicade in addition to MTX. I can't go higher on MTX because of liver problems with higher dosages. | M | 65 | 2 years | 3/17/2009 | 4 | Severe RA | Nausia for 24 hours after weekly injection, but nausia is intermittent, only occuring about once a month. | My RA was bad, went from superman to vegetable in <12 months. Needed my 14 year old son to help me stand up, had to have walker to get around. Pain moved from joint to joint with no pattern. Occasionally when both hands would flare, needed help in the bathroom. In other words it sucked. Started MTX injections at .2ml for 6 weeks with no affect. Went to different Dr. and she said I should be taking 8mg. I went home and interpreted 8mg. as .8ml MISTAKE, I found out later that 1ml = 25mg, therefore .8ml = 22.5mg, almost 3x more than I was supposed to. But guess what..... The RA got 90% better. I got my life back, and am not embarrassed because I don't hobble in to work from the parking lot. As an ex air force pilot, I wasn't ready for pasture, so the intermittent nausia is OK. Don't anticipate bad side effects based on other's, it is an individual response, not a sure thing. | M | 43 | 1 years | 7/10/2008 | 4 | RA | dry throat, slight cough, and my memory seems to be slower (might just be age). also i get an ear infection that keeps coming back. nothing too serious. i take 15mg a week with 5mg folic acid one day before and one day after | took a few months to work but reduced my symtoms from being nearly crippled to some stiffness in the morning and the occasional twinge. i hope it doesn't fuck my liver and i can stay on it for years. | M | 59 | 18 months | 1/14/2005 | 4 | Rheumatoid arthritis | nausea/bloating/unsettled gut/diarrhoea for a day or two after taking. Also mouth sensitivity/ulcers, feeling low and often very tired (this could be the RA),dizzyness. | MTX has brought about a big reduction in joint inflammation although the stiffness and discomfort remain to some extent (I also take tramadol and diclofenac) | M | 57 | 9 months | 7/16/2007 | 4 | R A (HLAB27 Positive) | I am only on a low dose (7.5mg per week)but still developed breathing problems after 3 weeks on MTX. The medication was discontinued for 6 weeks and the respiratory problem cleared up. I've now been on MTX again for 30 weeks and the main side effects are extreme tiredness, scalp soreness and a slight cough. The dose is due to be increased to 10mg / week next month. | I have had 2 flare ups of RA whilst on MTX, but no problems with Scleritis which was a serious problem before starting the medication. I feel uneasy about taking MTX because I am aware of the possible side effects. I work in the NHS in the UK so (fortunately) can contact a Rheumatology nurse relatively quickly if problems with the medication seem to be setting in. | M | 62 | 9 months | 8/7/2007 | 4 | CIDP | Feel very nauseous the night I take it. Wake up feeling stunned but by the next day I'm fine. Haven't noticed any hair problems. | I take 5mg twice a week. This medication has helped me a lot. The progressive numbness in my arms and legs has subsided and seems to be stabilized. | M | 22 | 5 months | 11/3/2007 | 4 | spondyloarthropathy | fatigue, heartburn, slight nausea, hair loss | Helpful drug, much better than the joint pain and immobility. Taking 12.5mg per week plus 50mg injection of Enbrel. Together, these two drugs are a miracle. **I only take the drugs during flare ups (once or twice a year) as opposed to every single day. | M | 37 | 10 years | 2/24/2008 | 4 | pyoderma gangrenosum | For the first 2-3 days after dose: fatigue, nausea, low mood, lowered sex drive. After that, none. | I take 50 mg per week (yes, 50) as my condition is difficult to treat. It has made a tremendous difference, but side effects are a problem at this dose. | M | 38 | 1 years | 2/12/2008 | 4 | Psoriasis | Developed pains in my arms and legs the day after taking the tablets. I had no other problems with them and the weekly blood tests were fine. I was taking 25mg weekly for 6 weeks, reducing to 20mg for 8 weeks and then to 15mg for 8 weeks. It has cleared up my psoriasis completely | M | 31 | 22 weeks | 12/3/2003 | 4 | RA | M | 46 | 2 days | 6/24/2004 | 4 | RA | M | 46 | 2 days | 6/24/2004 | 4 | RA | Some tiredness usually one or two days after I take my it but hasn't really been too bad. | I have been on 10 to 15 mg. of methotrexate for approximately two years. It has help some, but I also take embrel shots twice a week and the combination has done really good together. | M | 46 | 2 days | 6/24/2004 | 4 | chron's disease | None | This medication gave me some control over this terrible disease. My quality of life improved substantially after I started taking this and other medications. I take it subcutaneously, 25 mg/week. | M | 2 years | 5/14/2004 | 4 | RA | I had been taking 15mg orally once a week for about three months and all I have noticed is the occasional stomach upset. I also take a Folic Acid supplement which alleviates any side effects. | Am now on 20mg per week which I inject and have noticed occasional dizziness and am lethargic about 5 hours after injection. Increase in doseage has helped with my RA. | M | 50 | 4 months | 10/17/2003 | 4 | Psoriatic Arthritis | Slight nausea the day after taking it, mood swings, anger management issues. Dry cough. | M | 54 | 18 months | 4/17/2006 | 4 | ankylosing spondylitis | Like many people I experience fatigue and nausea for a day or two after my weekly dose and I do believe it has an influence on my memory. Apthous mouth ulcers occurred frequently in the first year. | It has made a big difference to my general quality of life and well being. It has helped me to take control of my condition especially when the pain and stiffnes were intolerable. Yes it has potentially severe side effects, but they can be prevented if careful monitoring is done regularly. I have also found that approaching these conditions holistically is the best approach ie. Exercise, eat well and try to laugh at least weekly | M | 29 | 3 years | 7/1/2006 | 4 | RA | I am extremely tired the day after my once per week 25 mg injection. I also experience memory loss, and the foggy head syndrome described by others. | This drug has allowed me to function semi-normally after being bedridden. | M | 32 | 6 days | 7/4/2006 | 4 | Psoriatic Arthiritis | Fatique, Memory loss, lack of concentration, and headaches. It's like I have a fog over my brain sometimes... the type you encounter with lack of sleep. It's hard to wrap my brain around thoughts and projects, like I did before I started taking it... by the way this is the first time i have seen this website. My doctor keeps telling me that memory loss isn't one of the symptoms. But these symptoms are undeniable!!! | M | 31 | 1 years | 11/15/2005 | 4 | PA | Nausea, Feeling Unwell (10mg weekly), Reduced dose to 7.5 mg weekly with 2 days instead of 5 feeling unwell. Fatigue, nausea. Also experienced a DVT last year which may or may not have been a result of the drug/health condition? Have overwhelming feeling of numbness in legs/lumbar region, walking as if on sponge cake. Cannot run or do excessive exercise as this exasperates my condition. Additional care because I am on Warfarin due to DVT. | Not sure about this drug, could say that I'm concerned about the long term effect on internal organs. Had to insist on a lower dose from 10mg weekly to 7.5mg weekly due to increased nausea and generally feeling un well. Similar to having eaten something which makes you want to lie down all the time to help with the problem of fatigue and nausea. | M | 47 | 18 months | 10/11/2005 | 4 | Psoriatic Arthritis & Psoriasis | 15mg Methotrexate (MTX) / week, tablet form. A few hours after taking MTX I get extremely drowsy, so now I time it just before bed with a cup of milky hot chocolate. Sometimes the following morning I wake up with a thumping head-ache, but by mid-day the head-ache is gone, I feel groggy though (bit like jet-lag). I'm used to it now, after being on it for six years. I still have to go for monthly blood tests so that my local Hospital can monitor my Liver function. My hair pre-maturely has gone grey :-( this is definitely due to MTX because my brother who is older than me still has pigment in his hair ! But I can dye it so no big deal. I feel as though I'm a little more emotional / less patient ? but that might just be old age creeping up on me. Sometimes it takes a long time for my blood to clot if I cut myself during shaving but I've got used to that now and I'm more careful. Sometimes I take the odd 5mg tablet of Folic acid but can't say that I really notice the difference. Since being | Its a horrible thing to have to take and its a life sentance but if you weigh up the pros & cons my experience is that its worth taking the risk. For me, its meant having an almost normal quality of life and has made the management of the two incurable diseases bearable. | M | 39 | 7 years | 2/7/2006 | 4 | Ankylosing spondilitis | Oral - Nausea and vomiting, bleeding ulcers, mouth sores if not taken with folic acid suppliments, occasional leg and arm ulcers, tooth deterioration. With the injectable I don't get the vomiting or stomach ulcers but I still get nausea for the first day or so after the shot and the other side effects apply to the injectable as well. Also unable to take any NSAIDS or COX-2 inhibitors without raising my liver enzymes and upping my blood pressure so I am limited to small doses of Tylenol and opiates to control my pain. | This rating applies for me only when used with a TNF blocker/remover such as Enbrel, Remicade, or Humira. By itself it doesn't work nearly as well and would rate a 2. | M | 38 | 12 years | 1/10/2006 | 4 | Psoriasis, PA | Mouth sores are not fun. I find that acitic foods help trigger them on top of MTX. I have had some consistent high liver reading, my Rhumy keeps track of that monthly. A few minor, minor PA flares, nothing like not being able to walk, or tie shoes like before. Some difficulty with memory, time and sensory perception, find it difficult to summon the right words sometimes, a problem I never used to have. Makes my Sundays (day after I take the 3 2-pill doeses) a bit slow and tired. | My Psoriasis doesn't get really red since on MTX, but it has spread. My PA is almost completely in remission, but for minor neck/back pains, elbow pains now and then. Since on MTX, I have been able to cut way back on NSAIDs I was taking (diclofenanc=bad for heart, kindneys). Doc wants me to go on Enbrel due to liver issues with MTX, but I am hesitant, due to some of the Enbrel / biologics side effects. Overall, MTX literally saved my life at a time when I was in deep dispair. I wish it worked a bit better on the skin, but for PA its been great. | M | 38 | 1.5 years 15mg 1X W | 12/28/2010 | 4 | RA | M | 44 | 20 years 10mg 1X W | 3/4/2011 | 4 | Psoriasis / Psoriatic arthritis | Tiredness and occasional nausea on days of treatment. Occasional diarrhea. | It is the second time I take MTX. The first time, at higher doses, I had to stop due to liver damage. My doctor won't put me on any other DMARDS as I have had chemotherapy too recently. I now take MTX 3 x 2.5mg per week (Friday morning, Friday night and Saturday morning). I feel very tired on Friday afternoon/evening and Saturday most of the day, but feel much better on Sunday and the rest of the week. The PA is almost completely gone (I can exercise, and went back to bicycling and hiking), and the swollen joints do not come back unless I exagerate with the exercise. The psoriasis is down to a minimun, but won't go away completely. All in all, I am satisfied with the drug, as I can walk an have a normal life. I just need to plan for quiet Fridays and Saturdays! | M | 48 | 4 months 2.5mg 3X W | 8/12/2011 | 4 | Rheumatoid Arthritis | Dizziness, Mood swings | Other than the side effects this has worked extremely well for my RA. I take 25 MG on Fridays | M | 18 | 2 years | 12/10/2005 | 3 | Rheumatoid Arthritis | Extreme fatigue, headaches | I'm taking prednisone, enbrel and methotrexate. After going from 7.5mg to 15mg of mtx I am constantly tired. It starts to get better the day before taking my next dose... My doctor agrees that the fatigue is 99.9% from the mtx and wants me to stick it out a few more weeks to see if my body adjusts. If not we'll switch to something else. He thinks the headaches are most likely from the enbrel however. I take the mtx on saturday and enbrel on sunday and I usually get the headaches on Monday or Tuesday. | M | 28 | 4 months | 3/20/2006 | 3 | Finger joint stiffness. two finger | None so far. | I also have mild psoriasis and starting to see minor improvement. Less plaque formation. | M | 63 | 3 weeks 15mg 1X W | 3/2/2012 | 3 | RA | severe stomach pain, nausea, fatigue, night sweats/chills, bruising, weakness, very tired, anorexia. | my 11y/o son started this drug 2 months ago and his quality of life has diminshed significantly. He is so sick most of the week and won't eat. Has lost 7 pounds in 6 weeks. Once he feels better, it is time for another injection. He has had improvement of the edema and pain in the joints. | M | 11 | 60 days .5mg IM 1X W | 8/19/2011 | 3 | Behcets | For the first 5 or 6 months ON METHOTREXATE- nothing. In the past 7-8 months I have found my memory has become very poor, my brain seems to be foggy, a loss of sharpness, very tired all the time, irritability, stomach problems come and go, weight gain- nothing seems to show correlation between this drug and weight gain, but it's the only negative change in my intake - diet and excercise are better now then 2 years ago, yet I have increased in weight since. | Methotrexate does the job in suppressing my behcets problems. But has a few side effects that are causing different probelms. | M | 30 | 16 months 15 1X M | 10/26/2011 | 3 | Polymyalgia rheumatica, Sjogren's | at first it was making me feel worse than before, but now I am feeling much better. I take it Tuesday mornings and often need to sleep much of the day, but it has been worth it to me, thus far. I still have pain, but I can tell I am now doing better. | This is a very hard drug to take. It makes many people quite sick. I was sick taking it for the first month. If anything, my depression from chronic illness has lessened. I feel like I can now see some light at the end of the tunnel. I am not sure if improvement will keep up, but I am hoping it will! | M | 60 | 2 months 15mg 1X W | 8/29/2010 | 3 | Sarcoidosis | diagnosed with sarc. jan '06. symptomatic diagnosis with elevated ACE, clear chest x-ray. started on prednisone and switched over to methotrexate after a few months. i don't notice a huge change in the way i'm feeling taking methotrexate vs. prednisone; both severely reduced my symptoms (edema in legs, overall achiness, muscle weakness, tight curling/cramping of hands, joint pain), however i still don't feel "normal" (i.e. pre-sarcoid symptoms). Hard to say if current state is due to mtx. side-effects, or just original symptoms peeking through. I'm working on alternatives that will allow me to come off prescription drugs entirely... i'm looking for a solution, not a cover-up of symptoms... | M | 23 | 5 months | 8/13/2006 |