Drug Ratings for METHOTREXATE SODIUMAverage Rating: 3.4 (359 Ratings)
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Results are sorted by Date Rating Was Added from most recent to oldest Key to Ratings: 1=LOW (I would not recommend taking this medicine.) |
| RATING | REASON | SIDE EFFECTS FOR METHOTREXATE SO | COMMENTS | SEX | AGE | DURATION/ DOSAGE | DATE ADDED |
  | F M | | | | |||
| 2 | psoriatic arthritis | I feel sick all the time ,constant sore throat,memory loss and confusion I feel tired bad tempered ,I feel chesty and weezey in the morning my period is all over the place and a small amount of weight loss and to top it I keep getting Candida | F | 41 | 2 months 17.5mg | 5/12/2013 | 2 | RA/UVEITIS | IRRITABLE, TIRED, FOGGY, HEADACHES (MOST DAYS) | I WAS DX WITH RA WHEN I WAS 17 YRS OLD BUT HAVE MANAGEABLE JOINT SYMPTOMS. I TAKE MDX FOR UVEITIS (RA IN YOUR EYE) AND HAVE NOT SEEN IMPROVEMENT WITH MDX USE, EVEN WITH A STEADY INCREASE IN DOSAGE. EVEN WITH 20MG I HAVE RECENTLY HAD THE WORSE FLARE UP IN YEARS. I AM CURRENTLY LOOKING FOR ALTERNATIVE NATURAL REMEDIES THAT DON'T HURT ME TO HEAL ME | F | 27 | 18 months 20 1X W | 8/25/2012 | 5 | Crohn's Disease | No side effects besides some upper back pain. I felt a huge improvement in my health after just 2 weeks and all of my symptoms have disappeared. I was very anemic and couldn't put on any weight, had bloody diarrhea and rectal pain, night sweats, skin problems, arthritis, eye inflammation, and absolutely no energy. The folic acid that I take keeps away the mouths sores. | F | 25 | 3 months 25 mg | 6/10/2012 | 5 | Rheumatoid Arthritis | Terrible, terrible nausea for 2 days after dose, diarrhoea, tiredness BUT cures my arthritis and allows me to live an active life free from pain. Side effects mean I struggle to keep taking MTX consistently, when I do my arthritis is cured. | F | 23 | 11 years 20mg 1X W | 6/8/2012 | 5 | RA | very slight nausea the first few doses, but none after that. | I think MTX gets a bad rap. Never had a problem with this drug; been taking it since 2007. Along with Enbrel injections and folic acid to reduce (in my case, eliminate) any side effects, my RA is effectively controlled. | F | 49 | 1X W | 3/18/2012 | 4 | Palmoplantar Pustulosis | As yet, I have not suffered any side effects whatsoever. My Dermotologist did precribe me 5mg of Folic Acid TO BE TAKEN AT THE SAME TIME to help with any side effects. I know this goes against the thought of not taking it at the same time but I beleive that, although it may diminish the effectiveness of the MTX to a certain extent, the fact that I have not had side effects means that I can carryon taking it. However,early days! Since taking the tabs (7) days the itching has stopped and my hands and feet have dried up considerably. | F | 48 | 7 days 10mg 1X W | 3/11/2012 | 3 | Finger joint stiffness. two finger | None so far. | I also have mild psoriasis and starting to see minor improvement. Less plaque formation. | M | 63 | 3 weeks 15mg 1X W | 3/2/2012 | 3 | RA | I take my 4 pills (10 mg in total) on Monday. For the next 48 hours after, I feel exhausted, head feels heavy and I feel really bloated. I have been having trouble sleeping and been very moody also. The symptoms for my RA have drastically improved but I just feel crappy for 3 days out of 7. Now I have to increase to 15 mg. starting my next dose. I hope it doesn't worsen the side effects. | F | 40 | 30 days 10 1X M | 2/29/2012 | 2 | PA | INCREASED MIGRAINES ANS AFTER 4TH DOSAGE, NAUSEA THAT KEPT INSTANTLY COMING BACK. | I THINK IT RUINED MY LIVER AND DOESN'T SEEM TO HELP MUCH, I HAD TO TAKE PREDNISONE HERE AND THERE TO KEEP UP WITH JOINT PAIN. (AS FOR PSORIASIS IT DIDN'T HELP A TINY BIT). | F | 27 | 4 weeks 2.5 MG 1X W | 2/26/2012 | 4 | JRA | Tiredness, mood changes, foggy state of mind | F | 16 | 3 months 25 | 1/23/2012 | 5 | Seronegetive RA | loose stools at times | For about 1 month my ankles and joints hurt so bad I couldn't wear heels and it hurt to walk. I went to the rheumatologist and he started me on methotrexate 10mg/week and prednisone 10mg/day. I ended up getting off the prednisone after a year and instantly after I started the meds my joints felt great and I was able to be active again. Last year I was in numerous races, bike rides & ski events all because of the methotrexate. I'm very thankful for the increased knowledge the medical world has about RA. Hope someday they will find the true reason behind this disease. | F | 23 | 1.5 years 10mg 1X W | 1/18/2012 | 5 | Rheumatoid | within 24 hours horrible migraine, tired, can't remember things, can't form the words I need to say, hot flashes, weight loss (good thing for me) | the benefits far outweigh the side effects I experience. the folic acid appears to be helping with the side effects but still have to take pain pills for the migraine for about 2 days. | F | 46 | 60 days 15 mg 1X W | 12/27/2011 | 2 | RA | Hair loss, Fatigue, Nausea, and diarrhea. | I did the the injection once a week. And my doctor told me the side effects but at the time I was willing to try anything. My hair was falling out so bad that I had to wear hats all the time, and I am not a hat wearer. I also was in the "Meth Fog" that is when you are so tired that you sleep your whole weekend away and had no idea. My doc recommend that I take more folic acid to help. That did not help I stayed on it and tried for 6 months and did not feel any better joint wise. I know that everyone is different but explore your options. I now take 2 tablespoons of Apple cider vinegar with 1 tablespoon of Honey with 8 oz of water 2 times a day and for the joints works way better and not the extreme side effects. And best of all I still have my hair!! and I am not sleeping my life away! | F | 29 | 6 months 0.6 ml 1X W | 11/1/2011 | 3 | Behcets | For the first 5 or 6 months ON METHOTREXATE- nothing. In the past 7-8 months I have found my memory has become very poor, my brain seems to be foggy, a loss of sharpness, very tired all the time, irritability, stomach problems come and go, weight gain- nothing seems to show correlation between this drug and weight gain, but it's the only negative change in my intake - diet and excercise are better now then 2 years ago, yet I have increased in weight since. | Methotrexate does the job in suppressing my behcets problems. But has a few side effects that are causing different probelms. | M | 30 | 16 months 15 1X M | 10/26/2011 | 4 | psoriatic arthritis | Hair loss, fatigue, low immunity against colds,sore throats etc, weight loss, nausea. | I can walk now without too much pain. i was pretty much housebound before i started this treatment. apart from catching colds and sore throats the side effects so far haven't been too bad. I have lost a stone in 6 weeks. | F | 37 | 6 weeks 20mg 1X W | 10/8/2011 | 4 | RA | Nausea, diarrhea, headaches, just general feeling of malaise. | Diagnosed 4 months ago, take once a week feel horrible for about 2 days and then I slowly start to come out of it just in time to start all over again. Admittedly has been working for me. Still hurt and am stiff all over in morning but at least am walking without dragging one leg now. Cant take anything else because of other stomach problems. Next increase will go to injections. I take folic acid doesnt help really. Take vicoden and cymbalta for pain. | F | 42 | 4 days 15 mg 1X W | 9/10/2011 | 3 | RA | severe stomach pain, nausea, fatigue, night sweats/chills, bruising, weakness, very tired, anorexia. | my 11y/o son started this drug 2 months ago and his quality of life has diminshed significantly. He is so sick most of the week and won't eat. Has lost 7 pounds in 6 weeks. Once he feels better, it is time for another injection. He has had improvement of the edema and pain in the joints. | M | 11 | 60 days .5mg IM 1X W | 8/19/2011 | 3 | Ankylosing Spondylitis | Very tired, very weak, mental fog, loss of memory, night sweats. Hot flashes and acne. (went thru menopause 20 yrs.ago!) Panic attacks. Very irritable sometimes. | Seems too early to judge drug yet. Adjusting schedule to cope with tiredness; groceries, chores, friends, etc. Am taking less Vicodin,etc; however still lot's of pain in back, hips, knees, hands... | F | 60 | 5 weeks 25 MG 1X W | 8/17/2011 | 4 | Psoriasis / Psoriatic arthritis | Tiredness and occasional nausea on days of treatment. Occasional diarrhea. | It is the second time I take MTX. The first time, at higher doses, I had to stop due to liver damage. My doctor won't put me on any other DMARDS as I have had chemotherapy too recently. I now take MTX 3 x 2.5mg per week (Friday morning, Friday night and Saturday morning). I feel very tired on Friday afternoon/evening and Saturday most of the day, but feel much better on Sunday and the rest of the week. The PA is almost completely gone (I can exercise, and went back to bicycling and hiking), and the swollen joints do not come back unless I exagerate with the exercise. The psoriasis is down to a minimun, but won't go away completely. All in all, I am satisfied with the drug, as I can walk an have a normal life. I just need to plan for quiet Fridays and Saturdays! | M | 48 | 4 months 2.5mg 3X W | 8/12/2011 | 3 | RA | Fatigue/lethargy, mouth ulcers, lack of concentration, loss of appetite, bloating, sweats, awake in the night every night. | take every saturday and folic acid 5mg on sunday. by sunday night the swollen mouth is there without fail - boy it hurts. didn't realise what i was suffering because of these meds. i just want to sit and cry some days for no reason, so agree with the PMT comments. on the plus side, i can walk again, i can sit here and type. on the downside, constant frown with weariness, lack of concentration now starting to badly effect work. | F | 45 | 5 months 20mg 1X W | 8/2/2011 | 3 | Inflammatory plaque-type Morphea | Nothing yet so I hope it stays this way | My doctor said that it takes time before you can see any results BUT some of my morphea patches look a lot lighter! So I hope it will only get better from now on | F | 22 | 2 weeks 7,5 MG 1X W | 6/14/2011 | 3 | RA | Took MTX for a couple of years for Rheumatoid Arthritis without any noticeable effects, then stopped for about six months after I was also diagnosed with Crohn's and had emergency surgery. Since resuming MTX, I feel very tired and "foggy" most of the time and have increasingly bad short-term memory loss (I also take Remicade, Prednisone (5 mg/day) and Plaquenil, so it could be due to a combo of these drugs). | This drug has helped a great deal with joint pain, especially in combination with Remicade, but the tiredness and fuzzy-brained feeling is bad enough that it would be impossible for me to have a full-time job. | F | 32 | 3 years 15 1X W | 4/26/2011 | 3 | psoriasis, psoriatic arthritis | dizzy, nauseaus, migraine | took methotrexate a few months ago for 5 weeks and eyes became dry and very inflamed. Got worse with each week and could not put in contact lenses. Doctors said it was not from drug but I stopped it and symtoms went away instantly. Now on it again for two week and withing hours of taking it last night I have a horrible headache and had a migraine aura last night. | F | 57 | 2 weeks 15mg 1X W | 4/21/2011 | 4 | first 4 weeks: extreme fatigue, dizziness, nausia, stomach pain next 2-3 days after Fri night dose week 5 : fatigue, diziness, stomach pain only next day after Fri night dose Menstral cycle disruption: for the first time in many years, my cycle was completely disrupted. The menstral fluid extremely low. Lingering spotting. Frequent virginal discharge. Loss of sex drive: before starting the medication, I had rather high sex drive and noticed that I have none now. | I take 15mg/week of MTX, 1mg/day Folic acid everyday, as prescribed. Feel I have somewhat more hair falling but I have a lot of hair to the extent I reduce the amount in hairsalon, so it does not concern me. (I am a Japanse female living in US) I was diagnosed with RA several month ago and was on SSZ but switching to MTX. I still have low/high (depends on the day) pain in my joints but my stiffness feels much lower. Hoping it will improve... I don't like this menstral cycle disturbance and extremely low menstral flow... I am scared if I am going to have an early menoposal / ovarian failure. But, still better than potetial disabled joints. By the way, I read that the menstral cycle disruption is a VERY COMMON KNOWN side affects -- from a Japanese rheomatologist conference's presentation. They said that doctors should inform this prior to a RX so that the patient would not get shocked. However, the doctors in US seem not to talk about this. Have not gotten my first post-MTX blood test yes (next week) so I cannot tell how my liver doing with this or over many years. Although I will have to give this medicine a chance for a while (it has been only 5 weeks) to see stronger effect on my joints (they still hurt but not severe), I already started to feel my fatigue level decreasing. Not sure of course if this is due to MTX. | F | 45 | 5 weeks 15 mg 1X W | 4/17/2011 | 4 | Multicentric Reticulohistiocytosis | Nausea the 2nd and 3rd day after taking it, also very tired on the 2nd and 3rd day. Fingertips and toes very cold. Weight loss. | I also have ulcerative colitis. Since I have been on the methotrexate, I have noticed an improvement with the U.C. I also have not had any cardiac or pulmonary issues (first time since 2009) So I definately think it is working. I did have a kidney stone a few weeks ago, but my GP did not think it had anything to do with the Methotrexate. | F | 40 | 2 months 12.5 mg 1X W | 4/5/2011 | 2 | RA | My main side effect while taking the oral methotrexate is bloating. The bloating is horrible and seems to be getting worse. Because of my sensitivities to meds, I was started out on 2.5MG once a week for 4 weeks then went up to two pills once a week. I'm on week 8 and will be begging for the injection. My bloating is so bad that I cry and the bloating is visible. I look like I'm pregnant it is that bad. | The longer I am on the med, the worse it gets. I take it Saturday evening. As the week goes on, it lessens but then Saturday comes and I have to start all over again. I was started out on the lowest possible dose because of sensitivities. I am not even at a 'normal' dose so I will be begging for the injections. It is hard to tell if it is doing anything for the RA because of the pain from bloating. | F | 33 | 8 weeks 2.5MG 2X W | 3/31/2011 | 2 | Severe fatigue, vertigo, fuzzy thinking, depression, generally not feeling well. | I was on methotrexate for the a year with no improvement in bone deterioration of wrists. Dr upped it from 4tablets to 6. Then I had liver problems. We then tried Embrell, Humira, Simponi, Simponi with Methotrexate. All with no improvement. Now I am back to only Methotrexate. Doctor upped it to 5 a week and I began having Diarhea, Vertigo and worsening fatigue. I am considering not taking it this week and calling the doctor. | F | 71 | 4 months 10 MG 1X W | 3/18/2011 | 3 | sarcoidosis | Tired, gasy, bloated....only the day of & a couple days after | F | 38 | 1 days 2.5 4X D | 3/17/2011 | 4 | RA | M | 44 | 20 years 10mg 1X W | 3/4/2011 | 3 | Rheumatoid Arthritis | Nausea off and on, hair loss but, that is better with the folic acid, dizziness. | I initially took injectable and that gave me more nausea and more hair loss and I didn't notice any decrease in symptoms. Now I take oral in combination with Remicade. Not sure if it really helps but, I am told it works in conjunction with the Remicade. | F | 38 | 2 years 12.5 mg 1X W | 3/2/2011 | 2 | Crohn's | extreme fatigue, lowered immune system/increase in cold or flu symptoms after I take it (sore throat, congestion, etc.), dry eyes, headache | It's amazing to read all of the comments because I've been feeling sicker lately and I thought it was from the Miralax I've been taking but maybe it's actually the methotrexate... or a combo of both? Maybe taking the Miralax decreases the amount of water available in my body (since it pulls it to the colon) which makes me feel the methotrexate side effects more. I'm not sure, but either way, I've been feeling pretty awful these past couple months. Maybe my body is finally reacting to the methotrexate? Or, maybe this is all just part of the Crohn's. Idk. Has anyone else had an increase in side effects/noticed a change over time or when taken with other meds? | F | 29 | 6 years 10 mg 1X W | 2/24/2011 | 1 | RA | liver poison ('toxicity') and related rashes, elevated blood pressure; Note: If you send me a question leave me your e-mail address or I cannot respond | I wished after my hospital trip that I had known what a powerful anti-oxidant coffee is and can cleanse the liver. However I have now discovered some natural cures can work better that any drug, which the body tries to reject as poison; such as honey and vinegar and vitamen B 100 complex (with niacinamide) which can be researched on the internet, such as Dr Saul's site doctoryourself.com or his book Fire Your Doctor, excellent advice. Everything is curable, 'just say no to drugs' (Nancy Reagan). | M | 55 | 30 days 2.5 6X D | 2/3/2011 History | 4 | Psoriatic Arthritis | I have not experienced any noticable side effects as of yet | I have noticed that after the 4th dose, my symptoms of the disease began to subside slowly. | F | 49 | 7 weeks 12.5 1X W | 1/21/2011 | 4 | Skin and joints | Initially on the tablets, last 6 months via injection. I found taking the dose right before bedtime helps tremendously with side effects. Have recently got the dry mouth (always in the night) and find the folic acid helps with the tiredness. | Having dealt with this condition for 26 years its the best thing I have ever tried that works. | F | 37 | 3 years 20mg 1X D | 1/20/2011 | 4 | Psoriasis, PA | Mouth sores are not fun. I find that acitic foods help trigger them on top of MTX. I have had some consistent high liver reading, my Rhumy keeps track of that monthly. A few minor, minor PA flares, nothing like not being able to walk, or tie shoes like before. Some difficulty with memory, time and sensory perception, find it difficult to summon the right words sometimes, a problem I never used to have. Makes my Sundays (day after I take the 3 2-pill doeses) a bit slow and tired. | My Psoriasis doesn't get really red since on MTX, but it has spread. My PA is almost completely in remission, but for minor neck/back pains, elbow pains now and then. Since on MTX, I have been able to cut way back on NSAIDs I was taking (diclofenanc=bad for heart, kindneys). Doc wants me to go on Enbrel due to liver issues with MTX, but I am hesitant, due to some of the Enbrel / biologics side effects. Overall, MTX literally saved my life at a time when I was in deep dispair. I wish it worked a bit better on the skin, but for PA its been great. | M | 38 | 1.5 years 15mg 1X W | 12/28/2010 | 2 | RA | Nausea,fever,severe joint pain, dry cough/heavy chest,depression. This all happens exactly 5 days after dose. | For 4 weeks I have was taking MTX orally. Due to side effects I was given injectables. I take my 20 mg. dose on Sunday nights. I have slight nausea and fatigue Monday and Tuesday. Wednesday and Thursday are GREAT, no joint pain, nausea and fatigue much better. However, every Friday for last 5 weeks I get a low grade fever 99.9-100.7(norm for me is 97.1-97.8) I feel terrible: super sore joints, heavy chest,dry cough,fever, nausea. By Monday morning I only have the slight nausea and moderate fatigue. Then my week starts all over again. I called the Dr. today but they are closed on Fridays. I called the Pharmacist and they said this is not typical and to go to a urgent care. does anyone have any ideas?? I really wish these Dr.'s would pay more attention to people on these dangerous medications!! | M | 34 | 5 weeks 20mg 1X W | 12/10/2010 | 2 | Rheumatoid Arthritis | nausea, diarrhea, migraine, fatigue, vision problems, mouth sores, vertigo | Splitting dose between 2 days has helped naseua. Dr upped folic acid from 1mg/d to 3 mg/d. Dentist called in Peridex mouth rinse which took the mouth sores away w/in a day. Also weaning off of 5mg/d Prednisone. Will give it a little more time. Found that taking anything with aspirin or salycilicate (like Pepto Bismal) causes severe interaction w/ MTX giving me nausea and diarrhea. I don't like it because it tough on your liver and interacts with too many things. Jury is still out on whether or not it's helping. Still having plenty of joint pain. | F | 48 | 5 weeks 15 1X W | 11/28/2010 | 4 | colitis arthritis/ra | TIREDNESS!!! Im in a fog most of the time. Extreme blues two days after taking. Recently hot flushes...could be early menopause. Some nausea | I call these pills the beastie pills. But my life has certainly changed dramatically since taking, couldn't walk more than ten metres, couldn't stand for more than 1 minute. Now no swelling, pain minimal and am able to work again and go up stairs! For me the benefits outweigh the side effects. Recently I have been having more pain so will have to see rheumatologist again in two weeks and perhaps upping dosage. But compared to how I was 6 months ago, I am a different person. I was in a wheelchair when I had to go out! | F | 45 | 4 months 10 1X W | 11/20/2010 | 1 | Psoriatic Arthritis | Extreme nausea, chills, diaherra, weakness. Lasts for 3 and 1/2 days after dose. Can barely walk or bathe myself. | This is nonsense. I'm stopping. I'll try the injection, but that is it. This is not worth it. | M | 48 | 3 weeks 10MG 1X W | 11/14/2010 | 4 | Autoimmune Optic Neuritis | When taking a higher dosage (25 mg) injected, some hair loss. Since switching to oral methotrexate, hair loss has stopped. General feeling of fatigue the day of taking it. I've never had an upset stomach from this medication. Some mild depression, however it could be associated with the prednisone I am also taking. Hot flashes occur, but may be due to hormonal changes as well. | In general, this is a well tolerated drug for me which has helped to maintain the sight I still have left. You need to have your blood checked to make sure it is not affecting your liver (about every 2-3 months). | F | 50 | 2.5 years 15mg 1X W | 11/6/2010 | 2 | RA | very low white blood cell count, recurrent infections | Took for 1 month and got strep throat, treated then restarted. After using for 6 weeks again got strep throat. After treatment of strep, still was not feeling well, was admitted in hospital had gotten pnemonia. White blood cell count was very low due to methotrexate. (My husband has been on methotrexate for 1 year and no side effects, and has kept arthritis at bay with Enbrel.) | F | 37 | 6 weeks 1X D | 11/4/2010 | 4 | RA | Nausea and vomiting, headache, itching, mild hair loss, sadness and weight loss. | My pain has decreased since starting to take Methotrexate. I also take Plaquenil. I feel I am trading one problem for another because the side effects are hard to handle at times. | F | 51 | 4 months 10 mg 2X W | 11/2/2010 | 3 | SLE, APS, MCTD | Stomach pain & bloating, nausea, severe headaches, diarrhea, sever lethargy | I've only been on this a few weeks. I can't tell if my pain is less or that I've got so much else going on I don't pay attention to the pain I'm "used to" Feel like crap all week. Was hoping to feel bad & then have it taper to feeling better every day - not so for me. Also, medication sensitive... | F | 45 | 2 weeks 7.5 1X O | 10/2/2010 | 5 | RA | I DO HAVE A BIT OF MEMORY LOSS AT TIMES AND HOT FLASHES MORE THAN BEFORE. | I TAKE METHOTREXATE ONE TIME PER WEEK AND PREDNAZONE DAILY, THIS HAS CHANGED MY LIFE SO MUCH,I AM NOW DOING THE THINGS I LOVE TO DO SUCH AS GARDENING AND I CAN DO MOST ANYTHING I HAD DONE BEFORE, I AM HAPPY. | F | 56 | 16 weeks 4 PILLS 1X W | 9/28/2010 | 3 | RA | I just started on this and feel very fatigued...like my muscles are just exhausted. 30 minutes on the elliptical felt like an eternity. I also get hot flashes (more than usual), sweat more, and feel out of it--especially the day after I take it. And this is weird, I feel like I want to cry out of the blue. No RA flares though...so that's good. | F | 43 | 2 weeks 7.5mg 1X W | 9/24/2010 | 2 | Rheumatoid Arthritis | Experienced nausea, vomiting, diarrhea and extreme fatigue for approximately 2 days after taking these medications. | The doctor upped me to 8 per week but the side effects were immediate and severe and I cut myself back to 6. I take my meds on Tuesday and by Sunday night I am actually dreading what I refer to as "bad medicine" day. The only reason that I have continued is because the rheumatologist told me it works great in conjunction with a Biologic like Humira which I will be starting by the end of the month. I actually really want off this stuff, it's horrible, but am afraid to stop it because the progressive joint damage is worse. | F | 45 | 5 months 15 mg 1X W | 9/22/2010 | 2 | RA | Diarhea, weight loss, and fatigue. Never helped the RA but was due to me also having Ebstien Bar Virus (EBV) which does not go well with MTX. Was also on Humira same time. Stopped both. | Afterwards, started taking Suflasalizine and Plaquinel which help some, then started Orencia and has help a lot. Went from a 8 pain level, out of 10, to between a 2 and 3. Makes a big difference. | M | 48 | 6 months 10mg 2X D | 9/17/2010 | 4 | psoriasis | Tiredness, mood swings, lower immune system so caught everything going around especially off my kids, muscle weakness and sometimes flu like symptoms. | It did help me so I would definitely use it again if I had another severe flare up. | F | 38 | 4 months 15mg 1X W | 9/14/2010 | 3 | Polymyalgia rheumatica, Sjogren's | at first it was making me feel worse than before, but now I am feeling much better. I take it Tuesday mornings and often need to sleep much of the day, but it has been worth it to me, thus far. I still have pain, but I can tell I am now doing better. | This is a very hard drug to take. It makes many people quite sick. I was sick taking it for the first month. If anything, my depression from chronic illness has lessened. I feel like I can now see some light at the end of the tunnel. I am not sure if improvement will keep up, but I am hoping it will! | M | 60 | 2 months 15mg 1X W | 8/29/2010 | 4 | RA | Mild nausea, which goes away after sipping ice cold aloe juice. Nausea seems less of a problem each week. | Have had RA joint pain in fairly frequent flares since May 2009, and was diagnosed with RA in Feb. 2010; RF, ANA, and CPP all positive. Pain was severe (7-10 on 1-10 scale) in shoulders, wrists, and hands, especially. After 3wks on MTX, flares can't seem to get much thunder - frequency, duration, swelling, and redness of flares are down 50%+, pain 3-4 at worst. I take Indomethacin 50mg if there is any inflammation to minimize erosion, but don't need it for pain anymore. Vicodin was required for relief from shoulder flares before, now untouched for several weeks. I have more energy than before. I think the pain and disease process were the cause of my extreme fatigue the past year. I'm hoping for remission. Everyone reading with AI diseases: have your Vitamin D level checked. A lot of us are deficient and don't know it. I was. | F | 50 | 2 months 7.5mg 1X W | 8/21/2010 | 5 | rheumatoid arthritis | still tired-often stay in bed on Saturdays after taking meds:5 pills Fri. night and 5 on Sat. am,some nausea, weakness. Just increased to this dosage in July. | In May was completely off of predisone taking only Methotrexate, but in June started having some recurrent pain, hips, hands, shoulders, feet. Methotrexate dosage to 25 mg in July. Pain still present, but not unbearable...still a miracle drug for me, compared to before methotrexate. | F | 48 | 7 months 25mg 1X W | 7/28/2010 History | 5 | sero-negative R/A | no side effects | Did not work as well for me w/o Arava 20 mg daily. Blood labs have always been fine. Some gastro problems from time to time. Tried once to get off both drugs and flared terribly. The two must work together for me. | F | 65 | 15 years 15 mg 1X W | 7/23/2010 | 4 | psoriasis / pa | Ridiculous fatigue, fever, night sweats, headache, nausea and upset stomach | I still feel somewhat tired and get headaches, but the other initial side effects have gone away. Was depressed because my skin was so bad, and now it has improved greatly and I have less pain in my joints but I feel even more depressed. WTF? Also I have vertigo and some lymph nodes that are slightly enlarged and never go down. On the bright side, I'll be able to wear shorts and a tank top when I kill myself! It's a great drug but there's a lot of robbing Peter to pay Paul involved. | F | 37 | 2 months 10 mg 1X W | 7/11/2010 | 5 | RA | Fatigue, upset stomach, mouth sores, elevated liver enzymes | F | 40 | 1 years 10 MG 1X W | 7/8/2010 | 4 | mixed connective tissue disorder | Take on a Saturday afternoon. Wake up middle of the night with a bad headache. Sleep most of Sunday, feel "spacey" all day and feel like I'm coming out of the fog by Sunday night. Am going to begin to take it Saturday AM and see if I get more of my Sunday back. Hate missing a day out of a weekend. | Has helped greatly with foot joint pain. Took 4 weeks to notice the change. | F | 55 | 20 1X W | 7/4/2010 | 4 | palmo-plantar-pustulosis and PA | At higher dosage, I had dry mouth, queasiness, tiredness | Dosage is actually in two units per week: 3 tablets (2.5 mg each) on Tuesday, and 2 tablets on Saturday. Folic acid (1 mg) every day. I also gave up most gluten food, follow the no-alcohol requirement, and minimal sun-exposure. I have low vitamin D levels and am supplementing to build that up. The MTX was a big help with the palmo-plantar-pustulosis form of psoriasis and PA, but I got several flu-like diseases in winter, despite inoculations. | F | 59 | 16 months 6.125 2X W | 6/25/2010 | 4 | SARCOIDOSIS | severe hot flashes, depression is worse, severe sweating severe migraines | I have had Sarcoidosis for 9 years. Was put on the MTX a year ago for severe joint and bone and muscle pain associated with Sarcoid. I have been on pain killers for almost 20 years now. I was told the MTX would cause severe nausea when first starting it but I had bad migraines instead. It has really helped with my joint and bone muscle pain but the severe hot flashes are really really bad. I have to have a fan blowing on me 24/7. Have another Doctor appoint next month . Need to tell them to get me off the MTX. Having a really hard time handling it any more. | F | 54 | 1 years 15mg 1X W | 6/22/2010 | 2 | psoriasis | vision problems, headaches and sinus pain, extreme fatigue, depression, anxiety | I really wanted this drug to work as my psoriasis has never been worse. But I'd rather have psoriasis than be on this drug! I saw numerous doctors about my headaches and vision problems that started within days of taking my first dose. The doctors all said something else was causing it..not the methotrexate. I've been on several drugs to treat my symptoms, including antibiotics, and migraine medication...I even had a sinus x-ray. I quit the drug a week ago, and my mood has improved and the headaches aren't as frequent. Everyone reacts to drugs differently and I wish I would have followed my gut instead of listening to the doctors. I'm so glad to have my suspicions backed up by others who've experienced similar side effects. | F | 39 | 5 weeks 2.5 mg 1X W | 5/4/2010 | 1 | psoriasis | nausea, stomach pain and diarrhea | I am sick of being sick. I never want to see this drug again. | F | 41 | 2 weeks 10mg 1X W | 5/4/2010 | 1 | RA | Throbbing pain in joints, hot flashes, chills, headaches and dizziness, forgetfulness, anxiety, bad dreams, depression, fatigue.By the third week my lymph nodes were tender, I had sore throat and sinus pain without mucus and felt very tired and ill. | My RA has been mild. I had never been as miserable and ill from the illness as I was from the medication. My quality of life plummeted. The cognitive problems and depression were really hard to deal with. After I stopped taking it, I felt much better. | F | 57 | 5 weeks 10mg 1X W | 5/1/2010 |