PRISTIQ Reviews (DESVENLAFAXINE SUCCINATE)

Average Rating: 2.8 (628 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

PRISTIQ  (DESVENLAFAXINE SUCCINATE):  Desvenlafaxine is used to treat depression. It may improve your mood, feelings of well-being, and energy level. Desvenlafaxine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). It works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2008-02-29 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by Satisfaction lowest to highest.

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR PRISTIQCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Anxiety Massive hot flushes accompanied by panic attacks, excessive salivation, aggression,wierd dreams,low tolerance to alchohol,altered smell and taste - food tastes disgusting, ear lobes tingling, aching legs and arms Withdrawal is terrible. Cramps in fingers and toes, feeling jittery, massive headaches, severe anxiety with constant feeling of dread. A feeling that I am dying. F 53 4 months
200MG 1X day
3/26/2011
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 1  Depression agoraphobia, right arm numbness, brain zaps, suicidal thoughts,insomnia, no sex drive,increased appetite, craving sweets, weight gain, blurred vision, foggy head, intense dreams, lower back pain, racing thoughts The first two weeks of taking this drug, I felt like it was really helping. After that, it has gotten progressively worse. I feel like I'm losing it and I'm getting off this stuff as soon as possible. I am convinced that none of us truly know how much harm these prescriptions are doing to us long term. I feel like this has really screwed up my brain and my body. This stuff is poison, I would strongly recommend that no one take this and try to find a holistic approach to treatment. F 33 2 months
50 mg 1X day
3/21/2011
 1  Major Depression Had been on Effexor 375mg for 3 years, then titrated off. Later, depression and anxiety returned. Doctor insisted Pristiq was exactly the same but better. Started at 100mg. Two days later rise in anxiety plus agoraphobia (new) had me bedridden. In response, doctor raised to 250mg, insisting this wasn’t due to Pristiq. After 3 months disagreeing, demanded Effexor. The anxiety subsided and the agoraphobia diminished. Was then able to get out of bed. As with all medications that deal with brain chemistry, everyone’s experience is going to be different. In my case, these side-effects were visible in two days, and though highly regarded in the medical community, it was that particular doctors arrogance that extended the suffering. See Wikipedia for Pristiq, for good info on trials. Scroll to Clinical efficacy section. BTW Immediately changed doctors. M 57 3 months
275 1X day
3/16/2011
 1  Depression Crazy anxiety. Crawling out of skin feeling. Tried all the antidepressants, thought I would give this one a shot. Increased anxiety like mad! After trying 25 antidepressants, my doctor put me on 5 mcg's of Cytomel. After 15 years of depression, it went away in one day with Cytomel. It was like someone turned on the life switch. My thyroid tests were and are still normal.'I don't think big pharma has depression quite figured out yet. Try Cytomel!!! Read the testimonials on here, they are the same as mine. Start low and go slow (5 mcg's - 10 mcg's). No more than 10 mcg's per day.'You will feel like a dead plant come back to life! No generics! M 40 14 days
30 1X day
3/6/2011
 1  Anxiety I had blurred vision, dry mouth, tense jaw, insomnia. I could not eat. It was absolutely horrible for me. I only took it for a week due to the overwhelming side effects it caused me. F 28 1 weeks
50 mg. 1X day
2/28/2011
 1  Major Depression Terrible headache/pressure across forehead, neck pain and stiffness, lower back pain and stiffness, periods of increased heart rate/palpatations, hot/cold flashes, feeling incredibly anxious/jittery but outside myself at the same time, insomnia (couldnt sleep more than 3 hours a night) On my 9th day of this medication, I took a nice little trip to the ER because I thought I was gonna DIE! My heart was racing, I was short of breath, anxiety level out the roof...in other words, I was having a panic attack. ER doc said some people do well on this med and some just dont...guess that's me! He said I was getting a norepinephrine overload which caused me to feel way too "speedy", unable to relax, ect. which after days led to the panic attack. I'm tapering the Pristiq down over 10 days then starting Effexor 75mg BID, which I've taken before with ZERO problems. F 31 9 days
50 mg 1X day
2/25/2011
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 1  Major depressive disorder/ GAD Nausea, terrible stomach pains, shakes and tremors, brain fog, fatigue, loss of appetite I've taken MANY different SSRI's and SSNRI's over the years and this one, by far, has had the WORST side effects of any I've taken. I can barely function at all on this stuff. I feel like a toxic zombie. I can handle side effects. Like I said, I've been on many but none have been this bad and had this many side effects all at once. After today, I'm not taking anymore and am contacting my doctor about it. This stuff sucks! M 33 7 days
50MG 1X day
2/24/2011
 1  Severe depressive disorder Sweating, nausea, decresed appatite, sexual disfunction, distrubing dreams, sucidal thoughts Currently taking with Seroquel and Hypnodorm for sleep disorder. Feeling very on edge and very anxious all the time. Work is becoming harder to complete and I've been pushing myself away from everyone. M 35 4 weeks
100 1X day
12/20/2010
 1  Depression At first, depression worsened, feelings of sadness, crying, moodiness, agitation. Those symptoms eased, except for sadness and crying, but then my ears started ringing (typically toward evening and night) - sounds like constant chirping or a faucet running at a low flow. Just awful. Have been on Zoloft (Sertraline for approximately 13 years). Doctor recommended going off Zoloft because of ED issues, and prescribed Pristiq. M 54 7 weeks
50MG 1X day
12/18/2010
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 1  Depression & Anxiety Extreme fatigue, increased depression, ANXIETY attacks, heart racing, mental fogginess, loss of motivation to do anything, inability to concentrate, weight gain, no sex drive, horrific withdrawl symptoms Worked well until about 6 months... then completely had the opposite effect!!!!! Increased anxiety and loss of energy/motivation to do anything! I switching back to cymbalta. Would not recommend :( F 25 6 months
50 1X day
12/3/2010
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 1  depression Drug stopped working after about 6 months. Experienced extreme agitation, anxiety, irritability. Had to get off of it. Withdrawal pretty severe. In addition, during use of drug, I had extreme swets in the morning when I took it. F 51 6 months
50mg 1X day
11/29/2010
 1  depression/anxiety constant agitation, lack of sex drive, mood swings, weight gain and symptoms of depression got ALOT worse. The withdrawal symptoms are the worst part, nausea, halluciantions, dizzyness, the list goes on. I'm on day 3 of withdrawing and i feel worse than i ever did before i took pristiq, i've had thought of self harm and suicide and am actually contemplating having myself addmited to hospital for my familys and my own safety, right now i am all sorts of crazy, the worst part is my idiotic doctor told me there were no withdrawal symptoms. DO NOT TAKE PRISTIQ! This drug is anything but pristiq, it might help with some symptoms of anxiety or depression but the side effects and withdrawal symptoms are not worth taking it. Pristiq took away my anxiety, i didn't have one panic attack while i was on it but my depression got so much worse than it had ever been before and i would get so angry alot of the time for no reason at all and with no warning, this drug has made my mental health so so so much worse than it was before i started taking it. Pristiq was the 1st antidepresant i had been on and it will be the last, there is no way in hell i'm going to take these pills that the doctors obviosly know nothing about, i'm not a guinea pig! Stay away from pristiq it will not make you better or sane, it will make you sicker and crazy as all heck! F 22 3 months
50mg 1X day
11/27/2010
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 1  situational depression Brain zaps, neck pain, fainting...(led to being hospitalized for two days with a massive amount of costly tests), hallucinations, anxiety provoking dreams, insomnia, joint pain, headaches, nausea, day and night time sweats...then the chills, memory loss, irritability. These were all side effects that I experienced while on Pristiq...Currently all of these side effects have been magnified by a zillion since I quit taking the drug cold turkey 14 days ago. I stopped after I was released from the hospital; after being admitted for having hallucinations and fainting. The medical staff were not able to determine the cause...; however...all the medical staff said it could NOT be the Pristiq! Well...I used my own judgement in determining that the probable cause WAS the Pristiq; thus, I quit taking it cold turkey the day after I was released from the hospital. I am now going thru continuing withdrawals...and looking forward to the day that I feel like "myself" again...I can deal wit This drug is POISON! Do not take it! F 57 10 months
50 mg 1X day
11/24/2010
 1  major depression night sweats, extream dry mouth, still depressed, loss of appatite dont start this drug M 40 45 days
50 mg 1X day
11/18/2010
 1  Depression During it's use, I could not easily distinguish any, since I was taking two other drugs for on the same days (2x Adderall for AM & noon, and 1x Clonazepam for late PM). But after I quit taking it (about only 20 days later), I experienced a major-heavy withdrawl that induced even heavier feelings of depression, anger, and distress than I ever had before. (I really can't recall the amount, but I think it was 30mg). Withdrawing from Pristiq was VERY BAD. Pristiq didn't do much for me within the 20 days that I took it, so I just stopped cold-turkey. Bad idea! About 1 day after I stopped taking Pristiq, I could not help but to feel deep despair along a worsened form of my depression. Contributions of these bad feelings were mostly because of an unwanted divorce that occurred 4 months prior to starting Pristiq. The physical withdrawl was deep crying for nearly 30mins straight, a need to curl up in the fetal position, and body trembling. During withdrawls (which recurred on 3 more days) were incidents of sudden screaming out at the top of my lungs that were of: grief, anger, despair, remorse, anguish, among others... It's scary to know that such a drug had forced these emotions and feelings out from inside of me in such an unusually powerful and quite disturbing way. I advise NOT to take Pristiq if your depression is not that bad, and to try something safer that has more history. It's better to try something that's safe and proven effective, than taking a substance that has the potential to make an already bad situation 10x worse, and that can potentially induce or increase suicidal thoughts or motives. +Your better off temporarily very sad, then forever dead. !++++ Seek safer alternatives for God's sake! M 29 20 days
30mg 1X day
11/8/2010
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 1  depression **THIS DRUG IS DANGEROUS!!** I have been taking SSRI meds for 16 years, and after 'plateau' is reached, I switch...Prozac, Paxil, Zoloft, then Lexapro. No problems, other than weight gain (50lbs!). I took Pristiq for exactly 30 days. On the 3oth day I had a meltdown at work: hallucinations, panic attack, uncontrollable crying, suicidal thoughts, soaring blood pressure...I could go on. Suffice it to say I ended up in the ER for 30 hours while I stabalized. My kidneys shut down, I was extremely consitpated, and by blood pressure got up to 204/110. I had 2 IVs, Xanex, and water. It took a week for me to feel 'normal' again (today). I'm back on Lexapro and am on a mission to let everyone know how very dangerous this drug is. Some people, of course, have no problems, and I'll admit, the first two weeks I felt euphoric. But when the crap hit the fan, it hit hard! Be careful. Read every post you can before you take this. And beware the withdrawal symptoms! Horrible drug. F 61 30 days
50mg 1X day
11/1/2010
 1  Depression and anxiety Extreme agitation, sleeplessness, irritability, decreased appetite, nausea. I feel like I'm coming down from amphetamines on this drug, but without the high that came first. F 25 7 days
50mg 1X day
10/26/2010
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 1  Depression, anxiety,ocd Greatly increased anxiety, nausea,vomiting,weakness confusion restless, diarrhea,headache, neck pain First week as weaning of Paxil 75mg/day. Mild side effects. Week two side effects started couldn't eat anxiety started setting in, weakness and fatague with some part time nausia. BY WEEK THREE Vomiting felt like I was dying couldn't sleep,couldn't hold anything on stomach. Very weak Anxiety very high,, thoughts of suicide. Very restless.Could only go from bed to couch(to lay down). Off now 3 days and back on Paxil 1st day of 75mg still weak held down some food yesterday, but still don't feel like eating. I think maybe I should have been in the hospital. Had made peace with my Maker. Terrible for me. Still don't know how this is going to end up!!!! Worst experiance of my life!!!! And I've been through some shit!!! M 58 3 weeks
50 1X day
10/9/2010
 1  Neck Pain, Anxiety/Depression It didn't work for me: Day 1 (ON): Within two hours: My head felt like it was on fire. I was extremely nauseated, anxiety became 100 times worse. My neck pain is gone Day 2 (ON): My head still feels like it is on fire. My neck pain is gone. Depression is magnified 100 times. Anxiety 100 times. Nauseated beyond belief. I am shaking like crazy. Day 3 (ON): My head still feels like it is on fire. My neck pain is gone. Depression is magnified 100 times. Anxiety 100 times. Nauseated beyond belief. I am shaking like crazy. My neck is back. I cannot feel my legs. Day 4 (OFF): My head still feels like it is on fire. My neck pain is magnified. Depression is magnified 100 times. Anxiety 100 times. Nauseated beyond belief. I am shaking like crazy. My neck is back. I cannot feel my legs. Day 5 (OFF): My head still feels like it is on fire. My neck pain is back to normal. Depression is magnified 10 times. Anxiety 10 times. Nauseated beyond belief. I am shaking like cr M 33 3 days
50 1X day
9/30/2010
 1  Depression/Anxiety/OCD I only lasted 2 days on this drug, the side effects were horrible. I tried 50MG first night, couldn't sleep for hours. Went down to 25MG second night, but side effects were still awful. Stopping the drug. Severe nausea/gastro distress, inability to eat, food tasted weird. Headache, altered mental status, very spacy and out of it. Was hard to drive. Couldn't think properly, cognitive impairment. Disoriented, confusion. Increased Anxiety/Depression. Feelings of terror, despair, hopelessness. Not sleeping or sleeping as well, waking up too soon wired and anxious. Exhaustion, inability to focus and concentrate. Bleary feeling, mind feels very uncomfortable. Agitated, jittery feeling. Very nervous, have to keep doing things. Heart beating hard, dizziness. Difficult to function on this drug. These side effects are so severe, scared me and caused panic. Revved up feeling, talking rapidly. Jaw clenching. Also-face turning red, and skin broke out on neck. Very stressed and scared. Also experienced diarrhea, muscle twitching and tremors, shakiness, short term memory loss/forgetfulness. Felt like I was going crazy. This drug hit me like a sledge hammer! Just overall extremely uncomfortable side effects, causing suffering. Terrifying going through this. Only took for 2 days it was so bad. Hoping it wears off soon, but severe effect mentally and physically. Some minor benefits, but not worth the excrutiating side effects. This drug may be helpful for some, but I don't think I can tolerate the SNRI class of medications. F 50 2 days
50/25MG 1X day
9/25/2010

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