CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by Gender males first.

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4   less libido but did not eliminate it completely (Viagra can offset) I have been on quite a few anti-depressants over the last ten years or so. Some made me emotionally flat-line but this one doesn't and I felt more relaxed. More side effects going OFF Cymbalta or even missing one dose, though not terrible for me personally unlikely others here described. For me just dreaming constantly and more significantly do feel quite dizzy/light-headed, but then any time I have tried to stop any other anti-depressant I have had same reactions. I have been off Cymbalta for a few days and other than one crying episode I don't feel bad emotionally, just dizzy/light-headed. Unfortunately cost is very high and was just laid off due to merger at my company so no insurance for now, but think I will have to go back on in the short term as dizzyness/light-headedness is too strong to quit cold turkey. Next time will try tapering dose off and see if that works better... M 36 2 years
4/2/2008
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 4  Depression, Anxiety weight gain, excessive sleepiness, heartburn Was on welbutrin and lexapro before, and cymbalta is much more effective with much less side effects. It hasn't 'cured' my depression, but I feel much better on it then off it. The side effects aren't great, but pretty mild. I have gained some weight, but I was pretty skinny to start and watching my diet has stopped any excess gain. The sleepiness is a bigger problem, make sure to take this at night, but I still can sleep 10hr and be tired the next day. The heartburn has just started cropping up, seems if I have an empty stomach when I take it I get heartburn. So take it before bed, but soon after dinner. Though its not recommend to drink with this drug, I have had no problem with weekend drinking aside from the expected effects of the alcohol. M 20 1 years
3/10/2008
 4  Depression, Nuropathic pain mainly at first dizzyness, but after about a month or two if you miss a dose I feel very detached, acting on impulses, good or bad, some symptoms of insomia but not sure if it is this drug due to how many I'm on! Helped out with minor aches and pains but I'm also taking Lyrica 75mg twice daily and Ibuprofern 800mg 3 times a day, and on Oxycodone 5/325 4 to 6 times a day along with 90mg of Cymbalta a day. I'm trying to adjust my medicines so I can get the best results, I might have to add Nurotin to my list! but has taken care of my Depression problems for the most part, maybe a flare up now and again. M 19 4 months
1/8/2008
 4  Depression Insomnia the first few days, stomach upset (also went away), a little bit of that "I drank too much coffee" feeling. Delayed orgasm (actually a good thing for me...). Can't drink alcohol without feeling a little sick (which is also probably a good thing for me... I'll probably lose weight just from not drinking.) I've been taking this for about two weeks now, and so far so good. I think the key is taking a very small dosage. I actually opened up the 60mg tabs, and just dip my finger into the beads and take about 10-15 of them (probably about 10mg). It works great. Sex drive is back, orgasm is delayed and better, no noticable weight gain/loss, but it has made me enjoy excercise again. Eliminated my anxiety issues when talking to people, and I am new person at work. Actually optimistic about my future! It has helped me deal with ADD symptoms also. I have been taking for a short time, and I am worried about withdrawals, but so far so good. I took 60mg the first day and that was a BAD IDEA... couldn't sleep, jittery, upset stomach, etc. My advice would be to start with a very, very low dose and work your way up. Just thought I would post a positive about this drug, because it is working for me. M 25 14 days
12/10/2007
 4   depression and anxiety Only thing i have noticed is the constipation, otherwise nothing else. Been taking paxil for about 5 years and was not satisfied with the results. made the transaction from paxil to cymbalta without a hitch.Getting away from paxil also improved my sex life. M 54 11 months
11/25/2007
 4  Depression, Anxiety Loose stools, gas, some fatigue soon after dose. If I miss a dose-irritability with long and vivid dreams. This medication definitely stabilizes me, but I'm concerned by how quickly my mood goes out of control with brain zaps when I go even 36 hours without a dose. Withdrawal is much worse than the condition I'm treating! M 38 1 years
11/26/2007
 4  depression, obsessive thought some fatigue, some brief episodes of heart fibrulation, decreased sex drive, slightly less appetite. I'm pretty happy with this drug. My depression has lifted a lot and the obsessive thinking about my breakup has diminished greatly. I'm feeling much more muyself. I would say my feelings are slightly muted, but in the normal range. M 51 60 days
7/15/2007
 4  Anxiety, IBS, Migraines ESD, somewhat sedating - controlled by taking at bedtime This drug has been very effective for me. ESD is bothersome. My nuero-psych is recommending adding Neurontin then tapering off Cymbalta. M 50 4 years
10/23/2007
 4  Major depression The med simply worked. I took three weeks to get to 60 MG, stayed on it three months and then took three weeks at a reduced rate to exit. The only reason I came off was "noise" in my head similar to an electric arc from a welding machine. Is this what others are calling "Brain Zaps"? Ren M 71 4 months
11/11/2007
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 4  Bpd 1, SAD, GAD, PTSD, Depression NO SEX DRIVE! it's like the mind is there but there is no response. Often restless and have plenty of trouble sleeping. I was on Xanax for many years and had to detox. Soon I found myself on Cymbalta. It has done quite well for my anxiety and depression. M 23 4 weeks
10/31/2007
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 4  Anxiety wired like I was on speed, at first constipation, now occasional diarreha. Feel "jittery" in the mornings, ( I take at night with ativan) occasional anxiety, but ativan nips that in the bud. Ive tried lexapro with lame results still had terrible anxiety, then zoloft which actually made the anxiety worse, then finally tried cymbalta. Started on 30mg for a weekthen to 60mg. So far its been OK. The best so far. Its definately not without its side effects. I cant stay still for very long, or I get "figitty" and have to move. But the anxiety is alot better. Ive only been on it about a month, 30mg one week and 60mg for three. Go back to the doc next week and see whats next. M 29 32 days
8/20/2007
 4  peripherial neuropathy I have been taking this drug in conjunction with Lyrica and lexapro for 4 months now. I am now able to see thru the nighyt comfortably and have had only one noticeable side effect - loss of libido. The pain was gone almost immediately. I am now wondering what if any withdrawals i will have when i get off of it. After reading the postings i wonder. But then again drugs effect everyone differently has gave my life back to me. My neuroligist made sure i took it with lyrica. Tried lyrica alone and the effects were not the same M 51 4 months
8/29/2007
 4  Major depression tiredness and sleepiness at first that went away but I am unable to have an orgasm but can ejaculate I would like to stay on this as it is helpful but won't stay on it due to the sexual side effects, if you are a male and have been on it and the sexual side effects have gone away please let me know how long it took M 38 1 months
7/12/2007
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 4  ansiedad y depresion la primera semana leve somnolencia y poca ansiedad y eso si, problemas con el estomago y disminuyo la libido y retarda la eyaculación. LLevo 24 días de tomarlo, en México es muy caro el antidepresivo pero es con el que he notado mejores beneficios, me quito la fatiga el desgano y el desanimo, aunque aveces tengo poca ansiedad esta si disminuyo, espero que en otro par de semanas ya note un efecto al 100%. Por el momento puedo decir que vale la pena tomarlo, pocos efectos secundarios comparados con otros que tome, mi autoestima y seguridad volvieron y sobre todo la fatiga que era lo que mas problemas me causaba esta desapareciendo, M 27 24 days
8/24/2007
 4  Generalized Anxiety Disorder Ejaculatory discomfort, increased appetite and craving for carbohydrates. Very positive results so far. M 53 1.5 months
6/29/2007
 4  Depression, Anxiety Initial insomnia, weight loss, On it for 4 months now,and occasionally sweat profusely, and shake, but all in all, this medicine has worked wonders M 38 4 months
9/25/2007
 4  Depression, Social Anxiety Not sleeping, chills and fever, inability to drink alcohol This drug works wonders, can feel it working immediately. This is the best I have felt in many years. I didnt realize how bad I was. All the anxiety and doom and gloom have just dissappeared. This is a very powerful drug and anyone that takes it needs to decide what is important, the drug works but it is a seriously strong drug and has many many crazy side effects. I only sleep a few hours a night, have chills, and feel like I am on speed or extacy, but wow, i feel so much happier. My family and friends have all noticed how happier I am. It works, but the questions is, are you ready to deal with a drug this powerful? M 39 30 days
7/31/2007
 4  Depression Insomnia, dry mouth, constipation, nausea I had a really rough year last year which included a fmaily member dying, getting out of a bad relationship, and almost getting kicked out of school. My doctor put me on 30mg for a week then bumped me up to 60mg which I've been on for 2 months. It has worked wonders for me. The best time for me to take it is around 5pm with a good meal. This gets rid of nausea and lessens the insomnia and dry mouth. I take a stool softener to help with the constipation. I get to taper down to 30mg in about 3 weeks then eventually get back to normal life M 22 60 days
4/9/2007
 4  Severe Depression Complete loss of sex drive; nightmares if I miss one tablet together with electric shock sensation M 35 450 days
6/3/2007
 4  Nerve Transduction Issues NA Has worked with Lyrica in prevention of problems. M 38 6 months
4/27/2007
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