CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  Anxiety/Depression Dry mouth, non existent sex drive, feeling hot. This drug works fine for me, I take a 60mg capsule once a day, does good at keeping the anxiety and depression at bay, I take it alongside buspar. Keep in mind, people react to drugs different, cymbalta works good for some and terrible for others, the only way you will know for sure is by trying it yourself, another word of advice, don't miss a dose of this, the withdrawal symptoms are terrible. M 23 2 months
60 MG 1X day
1/15/2022
 4  Anxiety and depression This is a good drug and works rapidly to treat symptoms of anxiety, depression and panic attacks. I would recommend it. I don’t trust any other antidepressants following bad experiences with them. It does cause a bit of weight gain, but that is a minor issue given how effective the drug is. I’m grateful this drug exists. M 44 2 years
120mg
7/11/2021
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 4  Depression, anger and anxiety 3 days of feeling nauseous, tired and depersonalized followed by improvement on the 4th day and feeling like my old self after that. Working wonderfully for the conditions prescribed for. I was afraid of taking this or any other antidepressants, this is my first experience with any such medication. M 47 8 days
20 1X day
9/27/2020
 4  Depression, Anxiety, Chronic Pain Gained over 50 pounds in about a year, sexual dysfunction, nausea early on I had been having severe depression/anxiety, panic attacks, chest pains and other chronic pain, and full-body tingles at night. Despite its physical side effects, Cymbalta eased these symptoms almost immediately and greatly stabilized and improved my quality of life. I'm a few weeks into the weaning-off process and haven't yet experienced any noticeable withdrawal symptoms. M 33 1.5 years
90 1X day
5/27/2020
 4  Dysthimia Weight gain It worked great for me M 30 1 years
30mg
6/1/2020
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 4  Depressed mood & chronic pain. Some negligible tingling in my extremities just as the pain relief benefits set in. Typical sexual side effects everyone has heard about. Helps mood. I respond to antidepressants the same day I take them, so I have never had to take it on a regular basis, only as needed. M 40 1 years
30 mg 1X day
3/16/2019
 4  Depression Sick constipation M 47 0 days
60
5/24/2019
 4  Chronic Pain Withdrawal symptoms when missed dosage. Unexpected mood enhancement. M 30 2 years
20 MG
6/2/2019
 4  Depression I started taking cymbalta some 5 yrs ago , @ 60mgs daily , with some good results however over the last 6 moths having been having son difficulties with life in general & pain associated with diabetes, hence dosage increased to 120 mga daily divided dose , this has help me in general attitude to life & getting pain free mojo back again , so far all good , allow sufficient time /rest to take effect, cheers pjf M 70 5 years
120
3/4/2017
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 4  Osteoarthritis Brief nausea upon waking, also mild dizziness - both passed after the first week. Occasional headaches. I started taking this for serious pain in my hands due to osteoarthritis. I take 60MG just before going to bed around 10:00PM; my hands do get sore towards the early evening, but not nearly as bad as it was. The negative side effects mostly subsided after a couple of weeks of use. It does help me feel more calm, and my thoughts are actually a bit clearer. I also lost some weight due to not eating compulsively. M 51 45 days
60MG 1X day
10/11/2017
 4  extreme back pain,and depression Initially had many side effects but almost none after 3 months. Has really helped me a lot with both issues but not completely so I'm increasing to maximum dosage today to 60 mg. Has been a life saver. I don't care if this drug is addictive because without it I probably would be dead and just hope I'll have access to it for the rest of my life. I am 66 years old. M 66 3 months
20 2X day
11/12/2015
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 4  Depression Overall, I just feel normal. If I missa dose--dizziness and freaky dreams, which used to skeeve me out, but kinda find them interesting, now, in a way. Stil wonder about long term use tho. M 62 10 years
60 mg
9/22/2016
 4  Major depression Weight gain and fluctuation The drug works well. It does slow metabolism. You initially lose some weight.. Then if you don't watch food intake and carbs... You will gain weight over a period of years. It also fluctuates up or down even if you hardly eat but eat starch and do not sweat or excersise moderately. The long term effects, if you do not maintain a low food intake and SOME excersise will most often cause a gain of 3 to 10 pounds M 62 7 years
60
7/3/2015
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 4  Depression, anxiety disorder If i take it everyday i dont experience very many side effects,some short term memory loss, weight gain,trouble concentratin, if i miss a dose i get very easily agitated, dizzy, brain zaps, nervousness, Cymbalta works great for my depression and anxiety but it does leave me feeling very lazy and its hard to get excited about things. M 38 7 months
30 MG
9/29/2015
 4  Depression,social anxiety Sexual dysfunction, somnolence, fatigue, insomnia, loose stool. Worked amazingly well for anxiety and depression when combined with clonazepam. I felt better than I had felt in years. Sad to say the side effects were just too much to bear. I have 2 other close relatives on Cymbalta and they are having a good response. I wonder if response to this med. depends upon genetics. Stopping wasn't too much of a problem, but I was quickly put on another antidepressant which may have helped. M 54 3 years
60 1X day
12/28/2014
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 4  Depression Lots of side effects but it works. Now the weight issue. I lost weight at the start (some 7 years ago). Last few yes regained 7 lb and almost impossible to get it off even with dieting. If you take this drug for a long time.. Without continuos excersise, you will gain some weight. Also causes restless legs and some insomnia. Am off now and on a month of viibryd. Good effects but also, I put on 2 pounds overnight without eating more than 1000 calories a day. Next stop.. Wellbutrin Good drug; lots of weird side effects M 62 1 years
60
1/10/2015
 4  Anxiety & Depression Started immediatly on 60mg per day to deal with depression and anxiety - Key negative side effect is LOSS..... Loss of focus and attention (got into 2 small accidents after 35 years with clean driving record); lose stuff like keys, pens and stuff, loss of memory, ideas and words; Loss of sex drive (no desire for it anymore). Most of the loss is quite mild but does cause a concern - I don't and to be on ths forever - HOWEVER..... on the positive side, I sleep well don't cry at the drop of a hat, I can work full time again and my relationships are back on track again. Cymbalta and 3 month rest have helped me greatly. I've just dropped to 30mg per day - I can say I am feeling a lot better since being on Cymbalta - I'm not anxious and I'm able to put things behind me that would really set me off before. It's not a wonder drug (just read at some of the other comments) but it has done an amazing job with me. I'm looking to be off Cymbalta soon and hopefully the effect lasts, and I'm worried about withdrawl. M 52 6 months
12/6/2009
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 4  Maintenance for depression I tolerate Cymbalta really well. It works for anxiety much better than the SSRI's like Prozac, Paxil, and Zoloft. And I don't know what everyone is talking about, 30 days worth of the 60 milligrams is only $120, so Cymbalta is not that expensive without insurance. I guess I also get some mild sexual side effects, but not bad....the molecule that Cymbalta is based on is closely related to the molecule that Prozac is based on, and I tolerate Prozac very well so that explains why I do so well with Cymbalta. This drug has an action like Effexor but with a much more calming, soothing affect. The only thing that you have to watch is the short half-life which means that if you miss just one dose you will experience withdrawal symptoms like dizziness, nausea, and electric-shock sensations. But don't let these horror stories scare you...this drug is known for working quickly among the antidepressants and for working when many other medicines have failed. Cymbalta has really improved the quality of my sleep and the quality of my life, actually. I'm a high-anxiety kind of person by nature and this drug has really allowed me to relax and enjoy my life a lot more. Definately give this drug a try, especially if you have depression with anxiety and the SSRI's like Prozac, Paxil, and Zoloft don't really adequately treat all of your symptoms. M 27 2 months
12/3/2009
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 4  stress mild constipation M 38 2 weeks
11/16/2009
 4  Major Depression/ Dysautonomia Vivid dreams, waking up at night some times, will sweat a little more, loss of appetite I am taking 20 mg once a day for depression and dysautonomia. My mood has improved already, to early to tell on the dysautonomia (or re-balancing of the autonomic nervous system)I have been experiencing neurocardiogenic syncope for years which did not stop fully with a pacemaker and cardiac meds so we are trying cymbalta. I have noticed no change in libido but orgasm takes a little longer which my wife seems to like! A welcome side effect is that 30 years of migraine and chronic daily headache has stopped since starting cymbalta I hope the drug is the cause, time will tell as nothing else has ever worked for me. I have found with my cardiac meds a loss of appetite as with the cymbalta, so I eat 5 or 6 small meals through out the day which helps me to be healthier and keeps my weight normal. eg: healthy protein bars/yogurt/nuts/peanut butter sandwich and lots of fluids M 41 20 days
10/21/2009

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