CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by Gender males first.

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  severe clinical depression none worthy of mention I was beyond depressed due to my wife of 15 years filing for a divorce. At age 50 and with 3 kids, 4,12,14, I was devastated and almost suicidal. I tried Lexapro with no success. Switched to Cymbalta and after 3 weeks, it was almost miraculous how much better I felt. Not happy-mind you- but light years of improvement and coping with my sadness. Remarkable product, and I mean that sincerely. It was a life saver for me. M 50 4 weeks
10/5/2006
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 5  Diabetic Neuropathy & Depression Difficult to orgasm, sleepiness Cymbalta started relieving the pain almost immediately, I am much more functional and need less opiods for 'breakthrough' pain. I've been on Cymbalt for 4 weeks now and it has been my 'cure'. I got my life back! M 37 4 weeks
3/3/2007
 5  Anxiety/Depression Slight weight gain. Sweat profusely when barely doing anything. Get brain zaps if a daily dose is missed. Until about 3 years ago, everything was fine, but then I hit a wall. I was extremely depressed and anxious all the time. This drug has been awesome so far. I had tried several different antidepressants to no avail. After a week or so on Cymbalta, I felt like I did before the depression/anxiety hit. After reading several posts/websites, I am worried about the effectiveness wearing off and the subsequent withdrawal symptoms if I have to come off of it. So far, though, it has been a life saver. M 36 14 months
4/21/2007
 5  depression/anxiety Dry mouth...sleepy...and those arent to bad. Took a while to work i have been on alot of different ssri's and cymbalta is by far working the best. I have been on 60 mg for about 2 months now and im feeling a whole lot better. My anxiety has decreased and i am in an overall better mood! It took awhile to work and to be able to feel the positive affects...but hang in there and get through the first couple of months M 21 2 months
6/3/2007
 5  Depression, GAD First week- nausea, dizziness, tired, sleeplessness, decreased appetite. After that, delayed ejaculation, sleeplessness, teeth grinding. All side effects are now gone except teeth grinding (bruxism), but that is being treated with a low dosage of klonopin. Its a powerful medication. You'll feel that the second you take your first dose. The beginning side effects are rough, take a week off from work to get used to the effects. They'll eventually go away however. Its helped me tremendously. I have always suffered from depression and anxiety, and this drug takes the edge off of both those. It doesn't turn me into an emotional zombie, and I can perform my job right up to par. I'm a Mensa member, and I don't feel like this drug diminishes my intellectual capacity whatsoever. After 8 months of using this drug, I'm very happy with it. I'll check in later after another 6 months or so of using this powerful drug. M 25 8 months
6/28/2007
 5  Depression, GAD nausea, diarrhea, constipation, agitation, sexual side effects (only the first 3 weeks) Immediately after I took the first dose I noticed that this is a STRONG drug. I tried many antidepressants (SSRIs, tricyclics, NaSSA, MAOI) but none of them killed the depression and especially the anxiety like Cymbalta did. After 10 years of suffering, I am free of any anxiety finally! I experience life like I did before I got the illness. I feel JOY again in my everyday tasks. But I understand why this drug has so many negative ratings. That’s due to its potency. I dosed in VERY slowly, by opening 60mg capsules and splitting the pellets in six parts, being careful not to damage the pellets. Even with 10mg I needed a sleep aid for the initial 3 days. Starting with 60mg is definately too hard in side effects concerns. That's too much in the beginning. Now after 30 days I am at my final dose of 60mg, feeling so good like I never did before and side effects free. They subsided pretty fast. M 30 30 days
9/2/2007
 5  DEPRESSION & IBS NAUSEA, MILD VOMITING, SWEATING, DIZZINESS, FATIGUE, WEIGHT-GAIN, INSOMNIA ALL THESE WENT AWAY AFTER 3-4 DAYS I WAS IN A MILD DEPRESSION FOR 20 YEARS! I HAVE A NERVOUS STOMACH THE ONLY THING THAT HELPED ME LIVE NORMALLY WAS SMOKING MARIJUANA. I HAVE BEEN PRESCRIBED PAXIL, (MADE ME FEEL INSANE!!) & WELLBUTRIN SR (DID NOT DO A THING) I WAS PRESCRIBED 30MG CYMBALTA 1 MONTH AGO & IT HAS CHANGED MY LIFE!!! ( I WAS IN A MAJOR DEPRESSION, SELF-MEDICATING WITH BOOZE & COKE) -IM BEING HONEST. -ANYWAYS I HAVENT HAD A DRINK OR A LINE IN 32 DAYS!! MY OBSESSION TO USE COCAINE IS GONE!!!!! THIS IS INCREDIBLE! I FEEL SO GOOD. I SWITCHED TO THE 60 MG DOSE 2 DAYS AGO & THE BEGINNING UNPLEASNT SIDE EFFECTS ARE RETURNING AGAIN, SMOKING POT REALLY HELPS WITH THE NAUSEA. I FELT THE 30MG DOSE LEVELLING OUT AT A PLATEAU ABOUT 2 WEEKS AGO. I WANTED TO SEE IF THE 60MG DOSE WOULD FILL THAT VOID IN MY HEAD. I THINK IT WILL DO THE TRICK. I LOVE CYMBALTA, IT HAS TAKEN AWAY THE VOICES & FEARS IN MY HEAD WHEN I WAKE UP & ALSO MY CONSTIPATION & DIAHREA IS DECREASED BY ABOUT 75%. THIS MAKE MY M 35 32 days
7/29/2007
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 5  Drop Foot,chronic back and leg pain none Cymbalta replaced Nurontin due to nite leg pain and chronic back pain,its wonderful. Ive been disabled 17 years and this drug is a God Send I take it in conjunction with Duragesic. M 49 1.5 years
6/7/2007
 5  Drug resistant depression / anxiety Not many. Suddenly stopping can cause jitters and loss of sleep. Likewise, starting a high dose without ramping up can cause the same thing. These effects go away in 1-3 days. I sometimes supplement with Lexapro 20mg if my depression or anxiety increases for more than a couple of weeks. After 2-3 months with the Lexapro, I cut back to just Cymbalta, which has worked better than anything else I've ever tried, with fewer side effects. M 25 3 years
8/1/2007
 5  Depression, Anxiety First week - Nausea, dizziness, no appetite. First month - sleeplessness. After that, just teeth grinding. I take a low dose of klonapin for that. Sexually, I'm stronger then ever. I know there are a lot of nay sayers out there. I work with my doctor and trust him very much. I've suffered from GAD for quite a long time, and this drug works wonders. Things that I would obsess over before no longer are a concern. The only issues I have, not really side effects, is that its a little harder to get out of bed in the morning, and some constipation. They are not side effects that ruin my life or change it in anyway, so I didn't mention them. M 24 1 years
9/6/2007
 5  RA and CHRONIC myofacial pain I took 30 mg first day, felt wierd and didn't sleep much. Now take 15 mg (sprinkled over applesauce)in morning. Doing great. Pain is minimal, mood is great!! Fatigue is gone!! So far this has completely changed my life. I have suffered pain and fatigue from my autoimmune disorders for 2 years. Nothing has worked. I first refused anti-depressents but, now I wish I had been on this sooner. I love my life again. I feel like my old "MEGA-MOM" self again!! M 40 2 weeks
10/18/2007
 5  GAD and depression none M 57 30 days
11/23/2007
 5   at the end, although i'm not 100 percent sure that this is because of the cymbalta and not the depakote or seroquel, VERY erratic behavior, perhaps what was the start of my first mixed bipolar episode. either way, my depression was killed. i cannot overemphasize how elated i feel to have no depression since it was sooo incredibly deep. i had previously tried effexor XR, wellbutrin, lexapro, and celexa to NO AVAIL whatsoever. cymbalta kicks tail. M 20 9 months
11/27/2007
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 5  Depression ,Anxiety,ADD None I've been on about every SSRI available over the last 11 years with Zolft and Wellbutrin being my favorites until I started taking Cymbalta a week ago. So Far I really haven't had an real side effects to speak of. I'll update this post in the future if their are any changes. M 59 8 days
12/5/2007
 5  Bipolar Dissorder Good concertation You have to take them every 4 hours. M 24 4 months
12/28/2007
 5  back pain, minor depression Urination difficult: weak flow, frequent stops. Often quite cold on one side of my body. (Only I can feel it.) After taking this drug for over one year, it continues to be extremely helpful for both chronic pain and minor depression. M 62 1 years
1/14/2008
 5  severe depression Dizziness/disorientation when I missed a dose. It helped me a great deal along with a number of lifestyle changes, and I (thankfully) had very few or no side effects. I'm glad I took it. M 21 13 months
1/27/2008
 5  Depression A little tiredness at first but went away eventually. I have been on Zoloft then Paxil for about 4 years. My doctor told me about Cymbalta and I decided to try it. I really like it. It makes any worry go away where you basically "Don't Care." Where some things used to bother me I now say..."So What!" I noticed this as a few weeks went by on Cymbalta. If you decide to try Cymbalta give it a little time to work. It is a powerful med more so than Zoloft or Paxil. I am looking to be on Cymbalta for a long time. It's one medication that I actually could tell it was working correctly. M 34 2 months
2/2/2008
 5   Not of any significants. I you are having problems with insomnia have your Dr. prescribe some Trazadone. It's available on the $4.00 prescription plan at most pharmacies. M 58 3 months
2/12/2008
 5  Depression/GAD Sad all the time. No interest in anything no motivation I have been this way for as long as I can remember. I just thought it was my personality. But as my marriage has been getting worse partly because of the depresion I looked for answers. I tried prozac & Zoloft nothing happened. Then I went to a new Shrink and he wanted me to do a clinical trial of Cymbalta at 120 mg the first two days were very hard but I think It was because I was coming off pain killers. I now feel great very upbeat playing with my kids like I never did before. I am enjoying my life. I am scared that it won't last but I will take this feeling for as long as I can. The trial is for 1 year I will try to keep you informed on how it's going. M 32 7 days
2/11/2008

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