CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  Neuropathy Diarrhea, nausea, loss of appetite My neurologist prescribed this for my neuropathy in my feet after I tried various other drugs and none of them helped. The first time I took cymbalta, I had severe diarrhea and nausea and for about a week with same side effects. AFter going off of it for about a week, I realized how much it had helped me the short time I was on it as the severe pain in my toes returned. I tried it again after my dr. encouraged me to stick with it 2 weeks. After just about 2 weeks the side effects disappeared and I haven't felt this good in a long time. It has helped me tremendously and all side effects have gone. F 61 30 days
2/12/2008
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 5  depression anxiety minor headaches, extreme horniness, weight loss, happiness , clear thoughts, motivation. helping me tremendously. I recommend trying it and staying on it. F 37 90 days
3/14/2008
 5  depression was very sick at the beginging, it kicked in after 14 days,started on 30mgs I upped it to 60mg after 1.5 years... Gave me back my life.was on it 3 years.I came off it cold turkey when I found out I was pregnant, had a miscarriage..took 8 weeks to get back to normal came down with a bang. Lost weight on this drug F 40 3 days
3/15/2008
 5  Depression, Fybromyalgia First two weeks headache, dizzy, nausea, no appetite....switched to taking it at bedtime and most side effects went away. (Because I slept through them.) A little foggy at times; yawning. I was hesitant to take this med because of some of the negative things I read about. I do not take any other meds. I knew there would be a period of adjustment and some side effects and was prepared for the worst. I was on Lexapro a few years ago and the adjustment period was a painful 7 or 8 weeks. Within 2 weeks on Cymbalta, I feel better than I ever really expected. The side effects were initially uncomfortable but experimenting with the time I took the dose helped tons! I don't think I'll need a stronger dose than the 30mg. I can understand why a higher dose could make you feel whacked-out. The number of people who try it for a few days and give up are suprising. I recently learned that consuming more than a a few cocktails while on it can cause some pain. Two glasses of wine are probably my maximum from this point forward. I am motivated to get back to the gym and work out....which can only help me further. I wish everyone the best who needs to take an anti-depressant.....don't be F 34 6 weeks
2/28/2008
 5  Depression and pain Little nauseaus first couple of days. I already had all the gastro symptoms and hot flashes others have mentioned. Unfortunately, those symptoms have not improved. I am experiencing hair loss and am wondering what the cause may be-could be Cymbalta, could be my age/hormones, a vitamin I might need, winter. 30 mg worked initially then abruptly seemed to stop working after about 6 weeks/now on 60 mg. I am happy to say I have not felt this good for years and years. Fibro pain greatly reduced, energy up, sleep and dreaming wonderful after many years of not much of either. I am very enthused and interested in my life again. Coming off Cymbalta does sound scary, but I am trying to just enjoy feeling well for now, will cross that bridge down the road. I am trying some different approaches to the thinning hair and hope I can solve it. F 61 3 months
2/29/2008
 5  FIBROMYALGIA I DID NOT HAVE ANY SIDE EFFECTS UNTIL I MISSED 3 DAYS OF MEDS. THEN I BECAME HIGHLY IRRITATED AND IRATE BUT ONCE I STARTED THE MED BACK I FEEL GREAT. I REALLLY LIKE THIS MEDICATION IT SUPRESSES MY APPETITE AND HELPS WITH MY FIBROMYALGIA PAIN AND DEPRESSION. GREAT MED. I JUST WITH IT DID NOT COST SO MUCH. F 42 1.5 days
2/28/2008
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 5  depression was on this before and had weight loss i was on cymbalta a couple of years ago and thought i could live without it boy was i wrong. my moods changed i didn't care if i ever got out of bed and i was down right miserable! if you stop taking this the withdrawal is awful. my doctor decided to put me on lexapro because when i get feeling better i think that i don't need anything and lexapro didn't have withdrawal effects, but i gained 35 pounds on it. when i was on cymbalta before i was able to lose weight and not feel hungry all the time. i don't think i will ever stop using cymbalta again. looking back when i was on cymbalta before it was the happiest i have been in about 10 years. in the past i have been on several medications and nothing worked as well as cymbalta F 43 2 days
2/1/2008
 5  Peripheral Neuropathy Initial side effect were "racing thoughts," restless legs, vivid dreams (no nightmares) and frequent urination. All side effects completely resolved in 2 or 3 weeks! This med is the only med that relieves the pain & numbness of neuropathy for me. I've tried Trileptal, Elavil, Lyrica, Neurontin & a couple others which never helped me at all. It's a really expensive med (over $300.00 a month), but I purchase Cymbalta overseas for a lot less & write it off as a deduction on my taxes at the end of the year. I'm sorry to hear so many folks have such a problem with this med....it's been a Godsend to me! F 60 4 months
3/25/2008
 5  ocd, anxiety, mild depression First three days nausea, mild trembling feeling, no appetite. After about five days all of these completely disappeared. I have been on every anti-anxiety drug available over the last 12 years and I NEVER stay on them because I usually always gain A LOT of weight within a couple of months, and two, I am unable to orgasm. I workout 4 - 5 times a week hard, watch my diet, and every other drug has always made me gain. Paxcil was the worst. Cymbalta has been literally a miracle drug for me. For the first two weeks I had to take xanax every now and then until the cymbalta built up in my system to fight the anxiety. I have been on it now for five weeks and feel great. My mood is better, the anxiety is gone. I have my appetite back, but have not gained any weight at all. For the first two weeks I could not orgasm, but that has also gone away. I could not be happier. I am on a drug that makes me feel great, my moods are evened out, no weight gain, and I can enjoy sex! Good luck to you all! F 36 6 weeks
3/28/2008
 5  depression. ADD. OCD none horribly expensive. MY copay was $400.00 after ins. for 90days. Having to quit it for the cost too much now that pay percentage not small copay F 59 3 years
3/10/2008
 5  Depression Less appetite, but unfortunately that side effect subsided after about 1 year. I love this med! My depression is fairly mild overall, but it allows me to function while not becoming an emotional drone. Just wish it wasn't so expensive...can't wait for a generic to come out. F 35 2 years
3/21/2008
 5  anxiety Initially because I was very anxious before my treatment started it made me feel extremely anxious for 7-8 days. But I am so glad I stuck it out because I am now calm and feel "normal" for the first time in a long time. F 45 64 days
11/9/2007
 5  Chronic Depression, OCD, Anxiety The first week I had flu-like symptoms and felt somewhat detached from myself. Symptoms improved each day. I have tried them all. This medicine is a blessing for me. It's the best I have felt since grade school. I am enjoying life again. I have energy and motivation. Since I have chronic depression, I will not go off EVER! I'm ok with that since I feel so good. F 39 2 years
11/8/2007
 5  Depression and hypomania. Bi-polar Tired, wich could come from my depression. I hade a depression and was on SSRI and Lithium when I suddenly got hypomanic. My MD changed the SSRI and started me on cymbalta and increased xanor. It took me 5-6 days to come down from my hypomania. This is an observation from someone who only used the medicin one week. F 43 7 days
11/14/2007
 5  PTSD, Major Depression, Anxiety Moderate to severe dry mouth and dry eyes, occasional constipation or gastric symptoms. No longer to enjoy the occasional glass of wine or champagne (can't tolerate any alcohol since starting Cymbalta) b/c it makes me too drowsy. After discussing this drug at great length with my Pdoc, reviewing the research, looking at brain scans etc, we decided this was my best option for managing PTSD symptoms associated with childhood s*xual abuse. I'd been on Effexor for 2 years with decent depression management, however it exacerbated my anxiety, caused sleeplessness & foggy-headedness. Since switching to Cymbalta, my depression & anxiety are very well managed. I do not feel drugged or cloudy. I just feel like my self (something I never expected to return fully). I'm skeptical of some online reviews of withdrawal & SE's. The research done for med is better than most by far! Talk to your doc. In my experience, missing a dose has not caused any major issues other than headache or dizziness. I take 60 mg per day. My main SE is fairly intense dry mouth & dry eyes. I don't like it. But overall, I'm so happy with Cymbalta, that I simply treat those SE's and deal with it. Every so often I get a bout of consti F 39 2.5 years
11/2/2007
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 5  depression and anxiety initially I could not sleep while taking it. After the first week though, I improved in this area. It has raised my blood pressure, but because it helps so much it is worth taking another pill to control the bp. If you can get through the first week on it, it is worth it. F 52 8 weeks
11/2/2007
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 5  leg pain, insomnia, depression mild nausea, loss of appetite, rare occasions of slight dizziness, clenching of teeth & related headaches, sleeplessness at first I LOVE Cymbalta! Within an hour of taking the very first pill, I felt 1000 times better! Since then I've started dieting and exercising which I'd never cared to do before - resulting in weight loss of 10 lbs so far. I'm much more able to deal with my emotions, and can communicate more effectively. I'm able to put things into perspective better, and have really seen a difference in myself lately. I don't know how I ever lived without this drug - it's amazing! F 28 6 weeks
11/7/2007
 5  anxiety/depression weight loss, insomnia (all went away after two weeks) I have tried about fiver other anit-depressants and they all made me CRAZY. I couldn't handle the side effects. After just a couple of days on 30mg of Cymbalta I notice a difference. I felt human again, although I had to reduce dosage to 20mg. I had trouble sleeping but not with the 20mg. My doctor told me I can even open the pill and split the 20mg in half which I'm cosnidering. I haven't had a single panic or anxiety attack or bouts with deperession in over a month since taking it. It is a life saver for me. F 43 2 months
11/9/2007
 5  Fibro Constipation, but since I have IBS, better than the alternative! Brain Zaps if I forget to take it Had been in pain for 15 years prior to drug trial and I have never felt better in my life. my only problem is the high cost of the medication F 38 2 years
8/25/2007
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 5  Depression Absolutely None!! But I am loosing weight.. The first night that I took the 30mg I was very sick...but I had to do something. I didn't take another dose for two days. I am now taking 60mg and things are great. It seemed like everything was unraveling quickly and I had to make a change fast. It worked..I feel like I can deal with stress; I can focus and concentrate again. I am also loosing weight!! F 37 2 months
8/26/2007
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