CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  depression anxiety sweating, constipation F 46 3 days
5/21/2008
 5  depression On 60 mg, took away depression, took away anger 'Lizzie Borden' complex. On 120 mg 11 months later, depression has lifted and general anxiety has decreased overall, but I feel like I am always 'shaking' and 'cannot breathe', and I cannot sleep any longer than 3 hours per night. I have been taking Cymbalta (60 mg once a day) since late December 2007. I was amazed at how quickly it began to lift my mood. It also greatly lessened what I have heard called the 'Lizzy Borden' complex ( extreme anger and outbursts). I am bi-polar, and have also taken Lamictal 100 mg once per day on and off in the past. In the past two weeks however, my mood really dropped, and I was feeling suicidal. The doctor then put me back on Lamictal and told me to stay on it, and raised my Cymbalta level to 120 mg. I started taking the higher dose this past Monday (11-3-08). Today is Sunday, 11-9-08. In the past three nights, I have been experiencing insomnia. I am really, really shaky, nervous, a bit tense and I feel like I am having heart palpitations. The other night I had a very strange dream that my husband was married to my mother and he was 'dating' me, although he wasn't supposed to. I was also pregnant in the dream! Kind of freaked me out. F 39 11 months
11/9/2008
 5  depression and anxiety No side effects which is just awesome! Finally an anti-depressant that helps my depression. I was always so suicidal before I started Cymbalta. I have been on over 40 different psych meds and this is the one that has helped me the most. Thanks Cymbalta! F 11 months
11/7/2008
 5  anxiety, migraines, depression happiness I loved it. I no longer had a negative outlook on life and actually looked forward to socializing with people (which used to make me slightly nervous).PLEASE REMEMBER THAT THIS SITE IS BIASED! READING REVIEWS HERE SHOULD NOT DISCOURAGE YOU FROM TAKING A DRUG, JUST PREPARE YOU FOR THE POSSIBLE SIDE EFFECTS! F 18 1 years
4/25/2008
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 5  Severe depression Extremely gassy, drowsy, vivid/violent dreams, awake while asleep. I've been on Cymbalta for over six months now, besides being overly gassy, tired all the time, odd sleeping pattern, and vivid/violent dreams, I really don't have any side effects. On my first dose, I got sick to my stomach, but the sickness could have been from something I ate, since by day three, I felt much better. For the first few weeks, I'd have muscle spasms that would go away if I ate salt, these have since gone away. The most major complaint I have, is that on it's own, Cymbalta causes me to be awake when I'm asleep. However, with 25 mg of Tradozone, this is solved. I was diagnosed with depression at five years old, and have been on three other medications besides Cymbalta. It's really the only one that has worked for me. The first I was on (can't remember the name), gave me bad nightmares. Zoloft, didn't really work, but I also couldn't go past the initial starting dosage without going manic. The 10 mg of Prozac didn't do much for me, but when I was upped to 20, I went F 20 6 months
4/18/2008
 5  chronic depression Mood swings....maybe once a week on average. Since I've suffered from Chronic Depression for 18 years, I can deal with the mood swings by talking myself out of them....or riding them out by taking a nap or being alone. I know they are temporary. Combined with monthly cognitive behavioral therapy every 4-6 weeks (or as needed), regular exercise, healthy eating, and writing in my diary, Cymbalta has improved my mood and outlook and life! F 36 5 months
4/19/2008
 5  depression Hard to say becasue I take quite a bit of medication. I had to quit taking my Cymbalta when I got pregnant and never experienced any of the withdrawl people talk about here. It has done wonders for me and within hours of having the baby I asked to be put back on it. Depending on your chemical imbalance, this may not be the drug for you. It is for me becasue none of the other worked quite as effectively. I am more than wiling to make that $50 co-pay each month for the peace of mind that I will not suffer a major relapse into depression F 31 3 years
4/14/2008
 5  neuropathic pain Initially, I experienced anhedonia, but it passed with time. Excellent results, minimal and bearable side effects. Noticable difference in pain level by mid-afternoon if I forget the morning dose. F 55 2 years
11/25/2008
 5  Anxiety due to Chronic Pain (RA) Have been taking this drug for about 4 years. I have had no side effects until recently-last 3 months. Can't sleep or sleep too much. Little bit of blurred vision. Otherwise drug helped me tremendously through those rough earlier years. I think everyone's body is different. It has a different chemistry for each drug we put into our body. I have to say that I started out with 60mg for the first 1yr and then dropped down to 30mg and this drug really helped me. I actually handled my pain better and life was more manageable for me. However, the last 3-6 months I have noticed sleep problems that I can't relate to anything else other than this drug. I feel I am ready to wean off this drug anyways as I am dealing well with my disease alot better, but am afraid of the side effects of withdrawls. I noticed before that if I missed a dose, my body recognized it by the dizziness or the brain zap, so I hope it goes well. My doctor says to try taking every other day to start with. I pray it works well! F 42 4 years
12/22/2008
 5  Depression, anxiety, self harm For first two weeks dry mouth, restless legs, yawning that I couldn't control, feeling sedated but unable to sleep, blurry/jumpy vision, tingling feeling over skin. Now I yawn a lot and feel a bit drugged up and constipated, sleeping isn't so easy but I'm ok. This has helped all of my symptoms lots, I've found myself feeling clearer headed despite being a bit sedated, and in a way I'm grateful for feeling a bit sedated as I need to calm down. I feel optomistic and happy, plus I wake up in the morning and don't have an overarching sense of misery. F 27 26 days
1/13/2008
 5  Unexplained pain and anxiety The only side effect is decreased libido when taken in the morning. I began taking it at night which caused extreme sleepiness during the day, so I switched to taking it in the morning and all is well :) After having several MRIs and being in physical therapy for two years, the cymbalta cured my unexplained back pain within a few days of starting it. Switching from zoloft was an easy transition and I have more energy than with the zoloft. It seems a lot of what people experience with this is patient-specific as it works well for some and not for others...there are also many psychosomatic issues to consider as well when reading these comments. F 35 2 years
1/10/2008
 5  Bi-Polar rapid cycling; Severe Depr Upper ab cramps; weight gain; wake up 3 times per night I am a psychologist. I started taking anti-Depressants in the 1980's. The psychiatrist (#4) finally said all the anti-Depressants that I had taken made me become bi-polar. What I have noticed through my work as a psychologist and my history of taking this type of medication: is that psychiatrists want you to take the "normal Therapeutic" dose (e.g., 60mg of Cymbalta) right away. Caution: I recommend to everyone that when starting a new medication – Start Slow; increase slowly over a long period of time; and when it comes time to decrease or discontinue, Decrease slowly over a long period of time. Start at a very low dose (e.g., 20mg or 30mg of Cymbalta) for several months; access the effects; then increase the dose a little at a time. It took me 3 years to get to my current dose of DEPAKOTE ER. The 1st small dose (30mg) of Cymbalta: I could feel my brain actually change. I increased the dose to 40mg 5 months later. Then I increased the dose to Cy F 48 8 months
1/23/2008
 5  anxiety/depression/lower back pain dry mouth, some jitteriness i have taken cymbalta for the past one week. it has really helped me with my depression and anxiety. it has also helped to alleviate the lower back pain that i was having constantly due to nerve pain. i would definitely give cymbalta a try and when it is time to ween yourself off you just have to reduce your dosage yourself over a period of time..... F 29 7 days
1/15/2008
 5  Anxiety Severe nausea for the first 2 weeks (totally subsided after that), very vivid and long dreams, some stomach discomfort (does not happen very often), extreme night sweats for the first 2 months, cold sweats I have been very anxious about different aspects of mine and my families lives. I always wondered "what if something happens?" I eventually became moody and would get upset with my hubby and kids for no reason at all. I was moody, picked arguments, was angry and just so tense, nothing like myself at all. I started feeling relief after 3 days of taking the meds. I started on 30 mg/day and worked up to 60 mg/day. This has helped me immensely and the effects that it has had on my life were worth the side-effects for the first couple of months. Now, I only experience cold sweats every now and then and something I can only describe as a hot flash. I am back to my old self, which is fabulous. I'm happy and not the "worry wart" that drove my very optimistic husband crazy. I have much more patience with people, especially with my kids. My back pain has mostly subsided as I am no longer always tensed up. I feel that it really depends on the person in which effects y F 30 3 months
1/15/2008
 5  pain and depression because of it constipation taken care of with proper diet sleep disorders I have tken numerus medications and therapies before but none has helped me this much F 50 4 months
12/29/2007
 5  Moderate Depression 1st week major insomnia, nausea and vertigo, since then night sweats, vivid dreams, trouble waking up, loss of appetite If you can make it through the first week then keep with this! The major side effects rapidly diminish after week 1, and are mostly gone by week 3. This is the first medication to truly work for my depression. I can actually go to class, read and work on my hobbies, as opposed to watching TV for hours on end. The vivid dreams were interesting to begin with, but do get tiring. After about two months they diminish slightly. The night sweating is really annoying, I have to change my sheets often and febreeze heavily inbetween. The loss of appetite comes and goes, so don't buy much in the way of fresh produce because each day is up in the air as to whether or not you'l want to eat. F 20 3 months
1/15/2008
 5  Severe depression mild nausea, insomnia, lack of concentration. Compared to the horrible darkness of deep depression, this medication and even with the side effects is a lifesaver. I am able to get out of bed and function. I am no longer angry and I have been able to do things around that house that only a few months ago seemed hopeless. I still have to push myself every day to not go back to bed but I know Cymbalta has made a very significant difference and I will not stop taking it any time soon. One other comment- this is a very potent drug. I have read postings where people state they are taking it for mild pain or stress....this strikes me as odd. why does a M.D. prescribe this for anything other than severe depression? I would advise people not to take it for anything else - it is a very potent drug. Any side effects for me are better than the blackness of depression. F 42 2 months
1/2/2008
 5  Pain/Anxiety/Depression Excessive Yawning & Sleeplessness (at 1st) - Weight Loss - Constipation/Diarrhea - Vivid Dreams - Food doesn't have much taste AMAZING!!! I didn't know i could ever feel so good again. Just days after starting the medicine, I could tell a difference in my anxiety & patience levels. However, i considered getting off due to excessive yawning & sleeplessness. After reading this website, i decided to try to work through those side effects. I'm SOOO glad I did. I am happier than I have been in a long time. I spent a lot of time in prayer over taking any type of antidepressant - i'm grateful God made people smart enough to make such a drug, and had my dr prescribe it. I use to go to the bathroom 15-20 times a day because of anxiety - now i can go an hour or more without having to go. I feel like i actually have my life back! Try to work through any side effects you are having (3-4 wks) it will be well worth it - besides i was more afraid of the side effects for coming off. Good luck F 35 10 weeks
1/2/2008
 5  Depression & anxiety Tummy hurt for the first day but none since then. When my doc first recommended Cymbalta I read a lot of mixed reviews, most coming from this site. I was terrified to try it but basically at the end of my rope. My depression and anxiety were making life hell for both my husband and me, and after trying or being on several anti-depressants in the past, I decided to give Cymbalta a try DESPITE the reviews I read. I first took 30 mg and felt better but began having side effects (no orgasm). Doc decreased dosage to 20 mg a day and it has changed my life! I am finally back to ME, the real me, 100%. Absolutely no depression, no anxiety, no panic attacks. I went from being a pessimist to an optimist in two weeks. My husband and I haven't had an argument since I started taking it. I feel great! Just 20 mg has made such a difference in my life I felt I needed to come back onto this board and share my story. Any time someone comments on how I've changed, I'm never shy to say, "Thanks Cymbalta!" It's great to be happy and l F 37 7 months
11/22/2007
 5  Depression, anxiety, panic Very vivid dreams, if I miss a dose I have these weird sparks in my brain, dry mouth sometimes. I have tried effexor XR and lexapro these drugs changed me for the worst! Quit them over 3 years ago refused to take anything. My depression got really bad so my Dr. had me try Cymbalta 30mg. It worked for about a month.then i felt it quit working went up to 60 mg. 60mg makes me sleepy so, I take my dose before bed and the next day things are great! My sex drive is also good. The only bad thing I have experienced is if i forget a dose the night before the next day my brain has these weird sparks! i love Cymbalta but after reading comments i am very affraid to come off! F 29 4 months
2/21/2008

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