CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  Major Depression Night sweats -- especially during my period. Itchy palms. Occasional dizziness. No other side effects to speak of. I have taken Cymbalta now for three years and it's changed my life. I've had fantastic results. I can navigate challenges professionally and personally that I could not have managed nearly as well before due to chronic depression. Other than some uncomfortable night sweats during my period, side effects for me have been negligible. I had previously used Prozac and Wellbutrin. The former killed my libido. The latter simply did not work. With Cymbalta, I am liberated from depression for the first time in my life -- in my 40s. I feel very lucky to have found it. F 47 3 years
8/17/2008
 5  depression/anxiety Sweating, nausea at first, headaches if I missed a dose I've read all the negative and positive. Cymbalta, like other antidepressants, does not work for everyone but I have had a great experience. I was on it for about 3 months and had to go off. Had NO difficulty with discontinuing the med other than headaches the first few days. I feel more able to focus, less anxiety, and increased sense of wellbeing when taking it. I restarted the med a few months ago and other than a few days of nausea, had no adjustment problems. I would highly recommend Cymbalta. Positive benefit - decreased appetite helped me lose and keep off 15 pounds. F 39 9 months
8/18/2008
 5  Depression Some night sweats, initial nausea-only lasted a few days. This drug has changed my life, and the turnaround was immediate. I went from years of depression and had tried Paxil, Wellbutrin, and a number of other drugs that I simply could not tolerate. My doctor augments this with 25 mg of Traozodone for sleep. I sleep for the first time in 30 years and wake up feeling great. I am positive, optomistic and am never "Blue". I can have a sad moment over something that is truly sad. I don't ever sweat the small stuff and am doing great. I highly recommend this. For the first time I am living, loving, and enjoying life--not just sitting at the sidelines watching it go by. F 45 6 months
8/24/2008
 5  Fibromyalgia extreme sweating from morning to night; blurred vision at times. Either jittery feeling or tired feeling depending on time of day taken. Taken in a.m., hungry after six hours; taken in p.m. appetite depressed next day, so usually try and take in p.m. I am one of the extremely lucky ones, I guess: I can still cry at sad things and I have much STRONGER orgasms! No loss of libido. The main thing is after only about five days the pain from fibromyalgia--toes, feet, neck--ALL GONE! I only take 30 mg a day and sometime only every other day. F 57 3 months
8/23/2008
 5  Pain/Depression First week... Nausea, sleepiness, and a disconnected feeling. All people react differently to all medications. I decided to try Cymbalta after suffering from chronic pain, which has caused insomnia for many years. The lack of sleep began to affect my day to day mood and life. I was severely depressed and tired all the time. I roughly saw 2-3 hours of sleep a night while taking Ambien to sleep. Since I started Cymbalta, I have had one night of no sleep. The remaining nights have been 6 - 8 hours of restful sleep, even with two nightly trips to restroom. It's amazing how important sleep is to your mood. I became a much happier person in life and to be with. This drug has not stopped my pain, but it is much easier to deal with pain when I'm rested and have a positive outlook. To explain the side effects, the first week I was very nauseated and sleepy. I had a sort of fog surrounding me that went away as I got used to the medication. Remember you will not experience the side effects repeatedly if you remember to take the dose at the same t F 37 2 months
8/28/2008
 5  Very severe depression. Headache, severe dizziness, which went away after taking the medication for a couple of weeks gradually increasing the dosage. This medication saved my life. Literally. The depression was so bad that I couldn't go on much longer. I was taking Wellbutrin and I must have built up a tolerance to it or something. F 55 6 months
8/29/2008
 5  depression & anxiety When first starting... Goosebumps and chills intermittently, fatigue and sleepiness, slight intermittent feeling of dizziness, urinary hesitancy, decreased appetite with slight weight loss. I started taking Cymbalta in March "08". It has been a success story for me. I feel very well and am enjoying life. My experiences with side effects are minimal and were only when first starting and adjusting to it. Goosebumps and chills intermittently, fatigue and sleepiness, slight intermittent feeling of dizziness, urinary hesitancy, decreased appetite with slight weight loss. None of these symptoms were distressing and abated after about 6-8 weeks. Now it's just a daily med I take and is no big deal. I have missed a dose occasionally and have not had any problems but I never would allow myself to miss two days doses as I know what paxil did to me with that experience. It has helped me so much that I don't contemplate going off of it. It doesn't make me feel addicted like paxil did. Why try stopping what has made such a positive difference to my health and well-being?...just to be miserable? Blessings to all of you. F 52
7/25/2008
 5  bipolar/anxiety/depression 60 mg at bedtime. Thankfully no sexual side effects, no weight gain, some teeth grinding which I wouldn't have even mentioned or thought was from this med, but saw someone else listed it too. I take this along with 100mg lamictal for bipolar /depression/anxiety. I am very pleased with that med combination. I started at 30mg, but 60mg works better. My doctor suggested taking it at nite to subdue any feeling of tiredness. I feel clear and alert for the most part. I have a more positive attitude towards life. I am not constantly worrying and the "mouse on the wheel in my brain" seems to have slowed down a bit. It is difficult to compare yourself to others when you read these because we are all different, but if you are not happy with what you are taking, I would suggest giving it a try. I may never feel like a "normal" person, but I am very content right now. F 41 9 months
7/5/2008
 5  Migraines, mild anxiety, Nausea the fist day, and after doubleing doses. Extreme drowsiness1-2hours after taking it. climax more difficult, waking up after 6 hours of sleep, constipation 1st 3 weeks-better with fiber foods, weight loss forst 3 weeks-appetite back to normal after that. Increased threshhold for pain(good thing) Week 1 improvement, after 3rd week felt great. No more migraines, except self induced(too much wine), anxiety still not completely gone but sooo much better. I have motivation again and more self confidence. I feel like I'm back to the old me....before i had any problems-emotional and migraines. I recommend trying it for migraines- it has changed my life. i was having 3-4 migraines a week, now none/very rare. F 30 7 weeks
6/19/2008
 5  back pain and depression Sweating,night sweats and crazy dreams I feel that this medication helped me tremendously as I have had depression for 50 years, I am a new and happy lady. F 65 15 months
6/22/2008
 5  PAIN F 50 20 weeks
12/30/2008
 5  depression Only increased sweating. No other side effects I really like this drug. I'm not big on drugs but needed something to help with depression. Other drugs did nothing for me. F 48 13 months
12/22/2008
 5  Rheumatoid Arthritis and Fibromyalg I experienced many of the side effects others have written about here. I read the comments of others who had pressed thru the adjustment stage and found that my side effects subsided just as they said it would. Had I not been encouraged by others' comments to keep taking the drug I would have given up. I would highly encourage you to keep taking the medication and don't give up. I now have no side effects whatsoever and this drug has improved my pain dramatically. I think this drug is wonderful and it has helped with the pain of RA and fibromyalgia. After a few weeks, the dreams went away, the headaches went away, and the other side effects are a distant memory now. I've been on Cymbalta for over a year now and highly recommend it. F 53 18 months
12/24/2008
 5  Depression nausea, ongoing; arm and leg tremors that lasted about 3 weeks, then went away Cymbalta has stablized my moods. A surprising and good side effect was that it eliminated nerve pain in my neck, which I had suffered from for thirty five years. I have been very pleased with Cymbalta, but I wish I knew more about long term usage. F 54 2 years
1/14/2009
 5  Fibromyalgia/Depression I experienced no side effects whatsoever. Started taking about 2 months ago. Haven't felt this good in years. It has taken away the Fibro pain by at least 80%. Also feel like me again. Cheerful, happy, motivated, energized. Also started sleeping soundly again, so deeply that I am actually dreaming again. I have not experienced any side effects at all, have no more "Fibro fog", am finding myself getting alot more accomplished in my day. And just feel really good. I started taking 30mg once a day every morning, doctor was going to move me up to 60mg but feel it is unnecessary as I am doing great with current dosage. Would recommend doing your research, asking lots of questions, pay attention to yourself, having a good support system, and taking good care of yourself. Everyone is different, what works for some, might not work for others. Good luck to everyone out there. F 33 2 months
1/22/2009
 5  Extreme Depression/General Anxiety Diarrea, hot and cold, dizziness, this has been a real God-send for me ---- It has worked tremendously. My moodswings, raging, suicidal thoughts and tendancies have pretty much disappeared. The side effects are worth the benefits. I hope this works for others as well. F 35 9 weeks
1/23/2009
 5  depression/mood swings Initially dry mouth, extreme sleepiness, some nausea READ THIS!!! Guess I am the ideal patient. LOVE this drug. After 7 weeks side effects are GONE. My life has been transformed. No more crying jags, or self-involvement. Best part of this is my self-esteem problems disappeared. No longer hate myself and because of my attitude change I have stuck with my diet/exercise program and have lost almost 10 pounds. Life-changing. F 48 7 weeks
2/4/2009
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 5  Anxiety Dry mouth, constipation, tiredness, dry eyes and also losing eyelashes......not sure if the eyelash loss is connected or not- but I've only noticed this happening since I've been on this medication (I lose several eyelashes daily) This drug has really helped me with my anxiety. I dont have the racing thoughts or that "racing feeling" in my chest that I constantly had. No more anxiety attacks YAY! My life has improved tremendously since I've been on this drug. I have not experienced any negative side affects.....all the side effects I have/am experiencing are tolerable. Though I am concerned about this eyelash loss.....I will be asking my DR about that! I dont want to end up with NO eyelashes! F 27 1.5 months
2/2/2009
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 5  depression constipation, brain fog, slowed response, insomnia, weight loss Cymbalta has worked better for me than any other anti-depressant. Yeah, it has some crappy side effects, but you have to weigh the costs and benefits for yourself. I went off it for a few months and started feeling very, very depressed again. I started it back and had to take a higher dose than I had originally, but it is still working. F 33 2 years
1/30/2009
 5  Depression/Anxiety For the first 2 weeks I experienced nausea, dizziness, loss of appetite and dry mouth. These slowly went away over time though and after 2 weeks they were pretty much gone. I just kept telling myself that after my body adjusts it will be worth it and I was right. Remember to hang in there and give it a chance! THIS MEDICATION GAVE ME MY LIFE BACK! It took almost a month to fully kick in but the difference I notice in myself is absolutely amazing. I can concentrate again and the dark cloud that has been constantly chocking me for the last 4 years is completely gone! I went from someone who had turned off all her emotions to someone who can laugh and be passionate about life again. Honestly, give this a fair chance. The side effects might be brutal at first but they DO go away and from then on it's all up-hill from there! As far as I'm concerned the hardest part was going to my doctor and telling him I thought I needed help. I WOULD LOVE TO OFFER SUPPORT OR ADVICE TO ANYONE WHO WANTS IT SO PLEASE FEEL FREE TO SEND ME AN EMAIL! :) F 23 1.5 months
1/25/2009
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