CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  General Anxiety Disorder I experienced every bad side effect that is advertised within 2 hrs of first dose. Didn't sleep for two days. Couldn't go too work. Horrible experience. Almost had my wife take me to ER that night, it was soooo BAD! M 44 1 days
60mg 1X day
7/28/2021
 1  Pain Awful to wean off of, terrible side effects headache, nausea, craving for something to eat, or another pill to alleviate the symptoms. So glad I'm off of it, yet it took two month's to feel better. It did work for nerve pain but the side effects are not worth it... M 50 2 months
20 1X day
12/24/2020
 1  Depression, Anxiety, Derealization The brain zaps are unbearable, just showering and brushing my teeth is exhausting, no joy in things I used to love, no friends because they think I'm insane.can't work a real job because of the fatigue even with insane amounts of caffeine. I'm like an angry zombie I got on this to be helped not crushed. If you have depression or anxiety PLEASE look at holistic ways FIRST. I wish I knew diet and exercise and drinking enough water can help with symptoms M 24 4 years
60 1X day
5/27/2022
 1  Low Back Pain Extreme dizziness, sweating, tremors, teeth chattering, general malaise. I only took ONE PILL at bedtime, and woke up with horrible symptoms that checked off at least half the list for serotonin syndrome. Doctor tried to tell me Cymbalta cannot cause serotonin syndrome. I said it's right in the list of side effects FROM THE MANUFACTURER. Doctors do NOT know everything! M 65 1 days
30mg 1X day
10/22/2022
 5  Fibromyalgia At first I felt some shocks in my nerves. That went away and I have no further side effects. PSA!!! This needs to be evaluated for chronic back pain. I've had debilitating back pain and nerve pain down my legs for 8 years. It was disabling. After increasing my does to 60 mg I've gotten my life back and my pain is virtually gone! I rarely have pain, and if I do it's limited to a local spot on my back and is completely tolerable. I hope it can help other people suffering from this. F 40 3 years
60mg 1X day
11/7/2022
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 5  Anxiety and depression No side effects. Works quickly Gives me serenity F 59 4 years
60mg 1X day
12/9/2022
 5  Fibromyalgia Extreme sleepiness and dry mouth/eyes with dizziness the first several weeks until I adjusted. Fibromyalgia symptoms are much less frequent and nerve pain decreased dramatically after the first day. My depression symptoms are also greatly diminished. However, I have developed RLS that's driving me crazy! F 48 18 months
30mg 2X day
9/24/2023
 5  anxiety it turned my anxiety into depression it has less of an effect on libido and when mixed with alcohol than SSRIs F 21 2 years
30mg 1X day
9/29/2020
 5  Chronic Muscle/Skeletal Pain No side effects This is unbelievably effective for my chronic pain of 25+ years. After trying everything (NSAIDs, Opioids, Plaquenil, Prozac, Amiltriptaline, Gabapentin and no relief, I'm nearly in disbelief that I have zero pain most nights, sleep better, and can participate in most activities. Honestly, it's like a life saver! My pain was constant, intense and debilitating - and it's basically gone. Cymbalta began working for me right away. By the time I upped to the 60 mg dose after 2 weeks at 30 mg - I was lying in bed at night amazed at not feeling pain. F 55 6 months
60 1X day
10/11/2020
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 5  Chronic pain fatigue Warm feeling and yawning without being tired..stomach gurgling I was happily surprised within 3 hours of the first dose my pain had greatly improved. So far I was able to fall asleep in under an hour. No grogginess or feelings of no rest these last 3 days! My mood seems even better also. Decreased appetite is a plus as well. F 33 3 days
60mg day 1X day
1/11/2021
Email
 5  Anxiety, Depression, Nerve pain Had no side effects and feel more like myself than I have in years!!! Scares me to see all the dissatisfaction with this drug when it seems to be helping me so much. F 61 13 days
60mg. 1X day
7/18/2021
Email
 5  Depression No side effects When the generic form came out, after 2 weeks I had extreme vertigo. Stopped the generic and went back to Cymbalta. I have not had any problem since. Helped me tremendously. Depression has been with me since I was a child. I found out later in life it runs in my family (mother and her sisters) It changed my life. F 74 15 years
60MG 1X day
2/20/2022
 5  depression, anxiety insomnia , sexual side effects, cant cry, weight gain This is a miracle drug i highly recommend it, it works different for everyone so dont listen to the extreme side effects some people say they get....i feel so calm now, no bad thoughts anymore, no more mood swings and crying for any reason...i feel happy and content...i cant cry anymore which i miss, but atleast i got my mind back and living my life... F 44 3 months
30 mg
1/2/2017
 5  Fibromyalgia & slight depression Occasional nauseous occasional diarrhea I take this med at bedtime. I have had incredible relief from fibro pain. Spirits have lifted, less moody. Finally sleeping throughout the night. F 63 2 months
30
1/20/2017
 5  Pinched nerve Lower back - anxiety Had to take pain pills before I saw the commercial for this Med - a life saver I was taking opioids for pinched nerve in lower back & going to the pain clinic once a month before I saw the commercial for this med - as soon as I saw it - I went to the Dr to ask about it - have not had to take a pain pill since :-) I can still feel the pressure sometimes in back back from the pinched nerve (when it's really cold) but I dint feel the pain anymore. Stopped the pain on the 1st day . I was taking Zoloft - with horrible side effects - was able to swap straight from the Zoloft to the Cymbalta without weaning . Helps anxiety , gives me energy . Once the generic came out , it did have to up the dose 30 Mgs a day but had to do the same thing when the generic for Zoloft came out . I think this med was made especially for me :-) F 49 5 years
90 1X day
4/14/2017
Email
 5  Fibromyalgia I had to stop using it because I was diagnosed with Bipolar and was taking to other medications that had Serotonin in them causing be Serotonin Storm. It was fine before taking two other medications with Serotonin in them. Cymbalta worked great for Fibromyalgia. It was nice to be able to swim again because my skin wasn't sensitive to the cold. I was disappointed when I had to quit taking it. But I had to make a choice which was worse the Bipolar or Fibromyalgia. F 54 4 years
3 mg 1X day
11/10/2017
 5  Depressed High blood pressure F 0 days
30
5/1/2017
 5  Hip pain Day 1 I was a little nausea, day 2 some diarrhea but no hip pain! Day 3 no pain and no side effects! I love this medication! I did not want to be put on opioid pain pills. I'm back in my yard working again. I'm picking blackberries again and I put in a grapevine trellis. I'm living life again! F 52 90 days
20 mg 2X day
7/26/2017
Email
 5  Nerve pain, depression Nothing really noticeable for me. As far as I'm concerned it saved me! I feel like me again! Helped with my pain and depression F 1 years
90 mg
3/19/2018
 5  Depression, anxiety This drug changed my life. I'm more relaxed and optimistic for the first time. I wish I'd tried medication a decade ago. My partner noticed the change, and even my dog seems happier around me. At first I had trouble concentrating and extreme exhaustion, but I switched to taking it at night and now I sleep really well and feel well-rested and positive in the morning. Keep in mind lots of people only come on here because they're having the negative side effects, probably most people dont bother to rate who are satisfied with it. I was scared to take any meds at first especially after reading negative reviews - so just know it can help!! F 32 2 months
60 mg 1X day
7/6/2020

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