CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by Gender males first.

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  Anxiety Complete loss of libido and sexual function. Total impotence. The impotence and loss of sex drive turned out to be permanent. Even one year off the drug, nothing has come back. I can't have a girlfriend any more. See here for more details: ssri-side-effects.com M 30 6 weeks
1/2/2007
 5  Severe Depression Near complete relief from 20 years of depression after just a few weeks at 60mg. Prior to Cymbalta I could not find joy in anything. Tried Paxil, Wellbutrin, Zoloft, Effexor and Lexapro before finding Cymbalta. Nothing before had worked and after only a few weeks I'm feeling much, much better - thoughts of suicide have disappeared completely. With this drug I have experienced loss of appetite, night tremors, sleeplessness, dizziness, blurred vision, headache, fatigue, and difficulty with orgasm, but all to such a minor degree that they do not outweigh the benefits. My head is so clear of negative thoughts I can't believe what I have been missing all these years. If you've tried all of the other depression meds with no relief then give Cymbalta a chance. I didn't even realize the extent of the physical pain I was in until after a few weeks on this medication. Now considering an increase to 90mg daily to see if additional relief is possible. Insurance will cover to 120mg daily w M 45 6 weeks
1/2/2007
 5  panic disorder, depression sudden sweats particularly between my legs? (kinda gross but tolerable, 1-2/day), occasional hot flashes (~15 minutes each, 1-2/day), no change in sex drive, slightly delayed orgasms, amazingly powerful orgasms, increased thirst, occasional middle insomnia, ocassional muscle twitches (particularly at night), amazingly vivid dreams, and bizarreness warning--> I occasionally ejaculate (4-5 times) while having a bowel movement (without orgasm, freaky!) This drug cured my depression and eliminated the panic attacks I was suffering with. Certainly an interesting set of side effects, I don't mind at all, I feel and act so much better, my wife is much happier. I am scheduled to stay on cymbalta for 26 weeks than taper off (slowly). Warning: one day I missed a dose and the evil symptoms returned within 12-16 hours, this was early in the treatment cycle but indicates that some people will have trouble coming off this quickly. Good luck to all. M 44 12 weeks
3/6/2007
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 5  Extreme Anxiety & Panic Attacks Sort of makes food, especially my beloved coffee, tast bland and uninteresting. Mild loss of appetite, which is welcomed. Mild weight loss. Markedly reduced my craving for sugar. No real nausea. Using low (10mg.) dose of Cialis to counteract the sexual side effects. Cialis highly effective. Modest delay of orgasm although they seem to be more intense when achieved. I guess that's a fair trade. First couple weeks experienced some sleep disturbance, which is resolving. Doctor helped me through that rough spot with Ambien CR. Fast acting. For me it is the only drug in its class which has virtually obliterated my anxiety and panic attacks. I would say 95% positive benefits vs. 5% negative side effects. All other things being equal I will stay on it. Celexa, Lexapro, Welbuterin did nothing compared to this. Only Serzone, which is no longer available, was better than Cymbalta. M 40 4 weeks
9/11/2006
 5  Chronic Pain from MS Would make me feel sleepy and dizzy mostly during the first few hours after ingestion. Loss of appetite, mild sweating. Cymbalta is great. It helped relieve some of the pain and made me MUCH less irritable from the other medications I am currently taking. Dosage schedule is 30mg 1x daily. M 33 1 weeks
2/9/2007
 5  Major Depression, Anxiety Dry mouth (at my optimal dosage). I tweak my dosage to get the optimal results. 20 mg leaves me feeling too fatigued in the morning, while 30 mg has me tapping my feet with excess nervous energy and with less than optimum concentration and mental focus. To reduce the dosage, I twist open a 30 mg capsule and remove about a dozen of the time-release pellets, then re-assemble the capsule to leave just the right dose for me. It's amazing that just a few milligrams can make such a difference, but it does for me. I'm very happy with Cymbalta. M 49 8 months
10/23/2007
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 5  ADHD, Asperger's, Depression None, but I switched to this from Strattera which is like the SNRI found in Cymbalta, and there was a lot of agitation the first six weeks on that. Cymbalta is the very first anti-depressant to help me, and I've been through most of them, including the MAOI's. I wish this drug had been around 20 years ago ! M 49 5 months
2/17/2006
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 5  neuropathic pain - low back I am a doctor and I can tell you....BE VERY VERY CAREFUL WITH THIS DANGEROUS DRUG!!! Began on 30 mg and had insomnia, nervousness and anxiety. Went to the therapeutic dose of 60 mg to help my back pain AND I HAD A PSYCHOTIC EPISODE THAT ALMOST PUT ME IN THE ER. By now I'm sure you know a college girl killed herself during the drug trials. It can happen. This is not just an SSRI. It alters THREE neurotransmitters and for some - that's a serious problem. I flushed $120 worth down the toilet after one horrible night. This is a SCARY drug and should be re-examined by the FDA. See if your Doc knows the details of this drug before you take it. Sure, it may help some, but it is dangerous with others. Question is, how do you find this out? Are you willing to be test subject? This drug should be pulled and re-studied to be safe. When you start, have a friend or spouse alerted to potential bizzarr behavior and perhaps the ability to get to a hospital. M 52 5 days
4/14/2006
 5  Depression/Anxiety slight dizzyness/nausea at first, then jittery/agitation continuously, occasional sweating. As far as sex goes, i'm not sure what's wrong with everyone here, but I've had so much energy and sex drive has easly gone up 10x. Orgasm is delayed, which my wife prefers anyway, and when I finally do finish, the orgasm feels twice as powerful as it normally did before taking this medicine. Lovin' it. Especially, if u smoke marijuana. Lots more energy now, require less sleep, less tired in the morning, don't worry about things I can't change. Overall, I'm much happier. It takes awhile to adjust to the side effects, but they subside. M 25 5 days
4/24/2006
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 5  depression and diabetic neuropathy I was prescribed the drug by my Cardiologist who examined me in hospital for persistent chest and arm pains which he demonstrated were not cardiac related but most probably due to Diabetic Neuropathy.I have been afflicted by Type 2 diabetes for about 20 years. The Cymbalta was prescribed to replace a daily dose of Effexor XR 150mg.and he gave me a 3 week sample supply which worked very well indeed. However when I presented his prescription at my usual drug store they could not fill it due to refusal by my insurance carrier, Blue Cross of Pennsylvania, Personal choice,to pay for it. They declared Cymbalta to be an " unsupported experimental drug" unproven in value for my situation, in spite of my personal trial experience which is why they refused to pay for it. My Cardiologist Dr. Ramesh Adiraju prepared and submitted an appeal which Blue Cross again rejected. Their refusal is still open to further appeal,can you possibly suggest any supporting evidence I can present to them? M 69 21 days
10/28/2006
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 5  Neuropathic Pain due to Cervical di The only side effects were minor weight gain and some dizzyness if I missed a dosage. Slightly edgy for the first week but that went away quickly. Absolutely Fantastic. Got me through an incredibally difficult time. Before Cymbalta I tried Anti inflamatories, Steroids and on occasion, Vicodin for the pain which was severe at points. I was significantly limted for 6 months before trying Cymbalta. None of them worked. Cymbalta took about one month to build up to concentration and reduced the Nerve pain to the point i could easily resume regular activities. I'm just now reducing dosage 10 months after starting and having no side effects. M 40 10 months
4/4/2007
 5  Depression Cymbalta has cured my life-long depression, and eliminated my constant fatigue and irritability. Prozac did nothing for me, and I could only tolerate Wellbutrin for 1-2 weeks. Cymbalta increases norepinephrine (along with serotonin), and I started having greater energy after only a day or two. I started at 20 mg for the first 2 months, and just increased to 30 mg 2 weeks ago. The only side effects I notice are a dry mouth (have to be more careful with dental hygene--I had 2 cavities while on Prozac), and that lately someone remarked (twice) that I am smiling a lot. :-) I have felt almost "too happy" the last week or so. But after a lifetime of depression, there's nothing wrong with that. Cymbalta has changed my life, as my doctor and my counselor would agree, and my best friend tells me. I'm apparently growing new neurons in my hippocampus, and it has given me the mental focus and clear-headedness that I so desperately needed working on my Master's degree. I've read some negative comments about coming off of it, but with the overwhelmingly positive changes it's made in my life, I would be willing to stay on it for the rest of my life if I needed to. But maybe with my lower dose (30 mg instead of 60 mg), it won't be as bad. I'm not worried about it. I hardly worry about anything anymore. ;-) My life is going just great now, the way it was always supposed to. M 49 3 months
5/9/2007
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 5  Depression Mild loss of appetite, more intense orgasms. Lost 5lbs in 3 weeks. I was on Prozac for 3 years prior. I can feel the difference after only 3 weeks. Nothing really specific, just better at handling stress and I don't "mope around" as much. Don't feel as blue. M 37 3 weeks
11/2/2006
 5  Major Depression Sexual side effects: some difficulty getting and keeping erection, significant difficulty achieving orgasm. I've tried a variety of anti-depressants, and Cymbalta has been by far the most effective for me. I feel happy and productive for the first time in several years. The sexual stuff is bothering me, though. I have a new girlfriend and want to be great in bed. Viagra solves the erection issue, but the no orgasm is really a drag. Not sure what to do about that.... M 47 4 months
6/25/2006
 5  Social Anxiety and minor depression increased sex drive, more tired for the first few months and that went away around the 3rd month. Cymbalta has really helped with my general anxiety. Being in public is a lot easier now. It really works with depression and a lot of people have mentioned that it still allows you to feel emotions which is a plus. For the first 8 weeks I felt like a zombie but it went away. It takes time to adjust to these medications. Some people have a harder adjustment than others. The social anxiety is still there, but honestly unless you want to be a drugged up zombie who has no emotions I would reccommend counciling and learning how to relax when with people or in public. Part of it really is phychological. but the cymbalta is a great tool for helping me to concur the depression and the social anxiety. At first I noticed I was a little antisocial on the medication but I stuck it out and by about the 10th week that all went away. My muscle tension that was always with me...its gone.....but at first it actually induced anxiety and depression for me. that was for about a month. when I thoug M 20 3 months
1/18/2007
 5  Social Anxiety and minor depression increased sex drive, more tired for the first few months and that went away around the 3rd month. 60mg Cymbalta has really helped with my general anxiety. Being in public is a lot easier now. It really works with depression and a lot of people have mentioned that it still allows you to feel emotions which is a plus. For the first 8 weeks I felt like a zombie but it went away. It takes time to adjust to these medications. Some people have a harder adjustment than others. The social anxiety is still there, but honestly unless you want to be a drugged up zombie who has no emotions I would reccommend counciling and learning how to relax when with people or in public. Part of it really is phychological. but the cymbalta is a great tool for helping me to concur the depression and the social anxiety. At first I noticed I was a little antisocial on the medication but I stuck it out and by about the 10th week that all went away. My muscle tension that was always with me...its gone.....but at first it actually induced anxiety and depression for me. that was for about a month. when I thoug M 20 3 months
1/18/2007
 5  Anxiety and Depression Delayed ejaculation, vivid dreams. I currently take 40 mg. of Cymbalta a day. At first I had some minor sexual side effects (no problems with erection, but I did have delayed ejaculation), but those side effects disappeared after a few months. The only side effect that I have now is extremely realistic/vivid dreams. The best comparison I can make about the dreams, is if a "normal" dream is like watching a dvd on a 13 inch screen, then a dream on Cymbalta is like going to see an IMAX movie. The dreams aren't bad though... just more interesting. Plus, I'm better able to remember my dreams after I wake up. M 32 6 months
1/13/2007
 5  Anxiety and Depression Delayed ejaculation, vivid dreams. I currently take 40 mg. of Cymbalta a day. It has GREATLY reduced my level of anxiety and depression. At first I had some minor sexual side effects (no problems with erection, but I did have delayed ejaculation), but those side effects disappeared after a few months. The only side effect that I have now is extremely realistic/vivid dreams. The best comparison I can make about the dreams, is if a "normal" dream is like watching a dvd on a 13 inch screen, then a dream on Cymbalta is like going to see an IMAX movie. The dreams aren't bad though... just more interesting. Plus, I'm better able to remember my dreams after I wake up. M 32 6 months
1/13/2007
 5  Depression Mild Constipation(went away after 3 weeks) decreased libido (still in effect). Increased sweats (went away after 4 weeks). I now blackout when drinking hard alcohol (never happened before), also prone to emotional outbursts and crying when drinking hard alcohol. Okay with beer. I like this drug alot, most of the side-effects have gone away, except for decreased libido (but not really a problem since mine was over-active before) and the fact I can no longer drink hard alcohol. Has helped tremendously in getting rid of persistent negative thoughts. Most symptoms of depression are gone, some still remain, but i've only been on it for 4 months so far. M 25 4 months
3/21/2007
 5  EXTREME HEALTH ANXIETY / DEPRESSION THE ONLY SIDE EFFECTS I EXPERIENCED WAS PROBLEMS REACHING ORGASM. I WAS HAVING CHEST PAINS, MY BREATHING WAS SO MESSED UP THAT I WAS HYPERVENTALATING ALL THE TIME NOT TO MENTION PANIC ATTACKS. THOUGHT I WAS GOING TO DIE UNTIL I STARTED TAKING CYBALTA. TRIED TAKING EFFEXOR, BUSPAR, ZOLOFT, TRAZADONE, XANAX AND NONE OF THEM WORKED UNTIL I STARTED TAKING CYBALTA. WITHIN 4 DAYS IT STARTING WORKING. CHEST PAINS STARTED TO GO AWAY, MY BREATHING RETURNED TO NORMAL, WASNT CONSTANTLY WORRYING ABOUT MY HEALTH AND NOW AFTER 3 WEEKS OF TAKING IT I FEEL GREAT. M 29 3 weeks
6/23/2005

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