CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Depression & Anxiety On 30mg, none. On 60mg, mild constipation and delayed orgasm. The delayed orgasm was similar to Effexor, but without impotance. Effexor 150mg was effective but pooped out. I switched to Pristiq which was not effective so I stopped it. I then commenced 30mg Cymbalta for two weeks and then increased to 60mg for three weeks. Being an SNRI like Effexor, I was expecting it to be effective, but it's been underwhelming. Nortriptyline is next on the menu. Wish me luck. M 33 5 weeks
7/2/2009
 1  depresion, and rage loss of delayed orgasm, and then complete loss of sexual appetite, now can't even get it up even with partner. increase in appetite, never been on anti depressants before, and never will again, more depressing to be on this stuff than off. more sucicidal thoughts than ever, numb to life, tingling in extremities, fogginess, always feel hot. coming off was bad for a bit made raging more often until it cleared the system. not worth it M 28
7/5/2009
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 1  Nerve Pain Sleep Apnea, constant sweating, constant thirst, intense dreams, psychadelic feelings at night, emotionless person now. I am on 60mg of cymbalta which I am taking for nerve pain. This is my second rating now that I have been on this medicine a little longer. I am dropping my rating from a 3 to 1. If I am lucky I can keep my marriage. I wont go into all the problems since these can be found in my other entry. Just my latest problem which is sleep apnea. For those not in the know this is when you stop breathing at night. You never get into a deep REM sleep. You brain is starved of oxygen, you get no rest, and you go through life exhausted. This is a new problem for me and I suspect the cymbalta. I have never snored in my life and my wife of 13 years now is constantly awakened by me. After being hooked up to sensors I found out that I stop breathing up to 51 times per hour. I cannot make it through the day without napping... which does not go over well at work. I am trying to get off cymbalta now. I realize now I am an emotionless zombie and this has brought great strain on my marriage. My wife wishes to file for a seperation. :( M 40 11 months
6/22/2009
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 1  Mild depression Confussion, inactivated, nausia, dizziness, eventually increased depression, unfocused, not able to concentrate. Nasty withdrawal brain zaps going on and on! Headaches. Loss of appetite Dont ever think about taking this drug unless perhaps you are ready to kill yourself! In any case, try everything else first. This drug may ruin your ability to maintain your friends, familiy, and work. It is difficult to understand that this drug is legal. At first it seemed to work VERY well for me but eventually dragged me down into a much deeper depression from all the inactivating depression-like side effects. Very sneaky bastard! M 34 1 years
6/21/2009
 1  nerve pain snored alot more, extreme sweating, felt like i was in the clouds, violent rage against family this is the worst drug i have ever taken. hard time getting to sleep at night. had this weird feeling about myself. thought it was just from the back pain. then one day i dont remember anything that happened. i went into a violent rage and went after my girlfriend and her son. i will not go into detail but will say that cymbalta turned me into a monster. i stopped taking it cold turkey. the side effects from stopping was not that bad only for 3 days for me M 35 2 months
7/21/2009
 1  minor depression and arthritis Severe nausea and Severe muscle pain over entire body. Unable to walk or eat. Only with help was I able to use a porta potty. I became hot then cold , then hot again. Room was spinning and could not even get out of bed. Doctor wanted me to continue . I could not. M 89 2 days
8/10/2009
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 1  Depression/Anxiety Vivid dreams, odd bowel movements, decrease in sweating, weight gain, insomnia, electric shocks in neck, no sex drive. I have been on Cymbalta for about 2 months now. The first 2 weeks were ok, I was on 30mg, with only minor sleep pattern changes which I expected. When I was upped to 60 mg, everything started. I began having really vivid dreams, not scary, just odd. I began to have diarrhea one day and constipation the next. I am normally a sweaty person, but I rarely sweat at all, but when I do, it is profuse. I have gained 10 pounds, which I can deal with, but it isn't good for my wallet by having to buy new clothes. I now cannot sleep, either from the dreams or just not feeling tired, but may fall asleep during the day. The worst thing is the electric shocks going from my head through my neck and the lack of libido. M 24 2 months
7/27/2009
 1  Mild Anxiety Extreme sweating & insomnia, suicidal thoughts, racing heartbeat, panic attacks, aggressiveness. I went to my doctor several months ago in search of something to calm me down after my life sort of exploded with all sorts of issues at once- cut in pay (economic downturn with company), barely affording massive mortgage, family member sent to prison for her drug addition/possession, and now dealing with lawyers and massive bills in addition to everything else. I first started out on Paxil, which ended horrifically. I became incredibly numb to emotion all the time coupled with extreme nausea and lost interest in just about everything and became depressed even though I wasn't depressed in the first place. After 2 months, I couldn't take it anymore and went back to the doc hoping for something else. He then switched me to prozac. This is when sweating really started happening: Non-stop, day and night, regardless of my movement I sweated profusely. I had to stand in front of a fan in the morning with every window open in the house while getting ready for work after my shower, even though it was 50 degrees outside in San Francisco fog. Two months after prozac, I felt significantly more anxious, more aggressive, started fights with co-workers over nothing, barely slept... basically way worse then before I took any damn pills in the first place. Finally, I went back to the doc again and he switched me to cymbalta. Having been on this for a few weeks I am now convinced there is not a single anti-depressant my body can handle. Cymbalta not only increased my already inces M 24 4 weeks
7/27/2009
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 1  depression, anxiety, body aches. Huge fits of anger, mood swings, extreme fatigue, extreme depression, impossible to sleep, vertigo, stomach problems, unable to interact with people. THIS DRUG IS A NIGHTMARE AND SHOULD NOT BE ON THE MARKET! I am currently phasing cymbalta out. Getting off it alone has been hellish not to mention being on it for 6 months. The longer I was on it the worse I got. On many occasions I thought I was losing my mind, and have been unable to function. Ive missed months of work this year because of it. Im lucky I own my own business with my parents and was able to still get paid. I feel sorry for those who aren't so lucky, as I would be without a job and friends thanks to this. THIS DRUG CAN SERIOUSLY RUIN YOUR LIFE! What really gets me is that I was taking it for general depression and anxiety, not the end of the world stuff, I could function fine. It completely turned my life on end and nearly sunk me! I am considering contacting an attorney to see if there are any lawsuits going on this. If not I may start my own. Looking at the forum shows Im not the only one having serious trouble with it. My family and I are very worried about any long term harm it can do... M 39 6 months
8/24/2009
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 1  Depression, Anxiety Could not urinate for two days. Absolutely went from good sex drive to none whatsoever. No orgasm for a month after taking it. Side effects were much worse that what I was trying to treat. My depression became worse that before the med was started. Anxiety increased a lot. My work involves traveling with others and could not uninate for two days. Developed urinary track infection. DRUG SHOULD BE OUTLAWED. I tried to continue taking after one month of Dr samples. Guess what ,Blue Cross denied prescription and had to quit cold turkey. Depression continued to worsen and am lucky to be here today. Stay away from this drug. A patent drug being pushed to Drs by phamacuticals regardless of the results. I will be suprised if you see this drug around in five years. Thank God I made it off and still alive. M 54 30 days
9/30/2009
 1  Intractable Depression Need to sleep 10-20 hours / Exhausted / Wild nightmarish dreams / Teeth grinding, jaw clenching, tongue biting (seizures) / Urinary retention / Severe diarrhea / No motivation, social isolation, lack of any feeling / Severe Irritability / Inability to function / Don't care about anyone or anything / Chemical Castration / Dry mouth / Tingling and numbness in limbs, painful feet / Extreme Fatigue / Memory Loss / Vomiting / Carb Craving / High Blood Sugars and others as previously listed by other posters I have suffered from severe depression for many years following the onset of diabetes and loss of career. I have tried most of the usual antidepressants on the market with no improvement to my depression. Approximately 4 months ago my psychiatric nurse put me on Cymbalta, starting with a 30mg dose (have since increased through 60, 90 and 120mg). There was no benefit to my depression at all And the worst side effect has been the desire to sleep 10 - 20 hours a day and then total apathy about everything and anything. Have been stuck for weeks in a completely flat emotional state...letting everything go including my diabetes. I recently became ill and nauseated...causing me to stop taking my meds...including Cymbalta. I am now suffering with the worst of withdrawal symptoms as frequently stated throughout these postings. I am afraid I will have to be hospitalized. If I had known about any of these terrible side-effects, I would never have agreed to take Cymbalta. I believe it is a very dangerous drug. I believe it should be withdrawn and re-evaluated. I believe a class action lawsuit is in order here. Good luck to everyone taking this med. M 50 4 months
9/12/2009
 1  depression related to chronic pain extreme dizziness, diarrhea, extreme "brain zaps" trying to come off the drug very difficult coming off the drug. Very expensive...$300.00 without insurance. M 51 1 years
10/18/2009
 1  Pain, Fibromyalgia, Depression A plethora, (especially libido suppression none of which were therapeutic. It did nothing for anxiety, and it tended to make me much more emotional than was appropriate at any given time. Also, I cannot really tell if it had a better effect on depression. The withdrawal side effects are absolutely mind boggling and I don’t believe most physicians are aware of the extreme dizziness, mood swings, etc. that correspond with cessation from this drug. If they did they would think twice about dispensing it. I was taking Zoloft and switched because it allegedly was supposed to help with pain and have fewer side effects than Zoloft. However, the pain didn’t decrease at all and the side effects were just as profound as with any other SSRI. I realize it has been a Godsend to others, however, I wonder if these people had tried other SSRI’s first in conjunction with other forms of pain management (even the mildest of prescription pain-killers like Ultram would be a much more effective choice). I wish I hadn’t started this medication, and I also believe that the representative from the manufacturer didn’t convey the real truth about this drug to my physician. I tried to go off this drug several times; however I am a technician and could not afford to make even the smallest error. I am now taking several months off from work, (thanks to this drug) and I’m taking advantage of this time to quit this abhorrent “Medication”. I have spoken with several people who have taken MOA anti-depressants for years, and who (briefly) switched to this drug only to find it much less effective and with intolerable side effects then they were used to. Be very careful with this drug, and consider other options for pain management, and/or depression first, it’s not worth it. Personally, I believe the sole purpose of this drug is to generate money for the manufacturer, and that because of its side effects and lack of effectiveness it’s not as expensive as M 52 3 years
1/5/2010
 1  Back Pain, Depression Cymbalta has the same adverse side effects of the other SSRI medications and then some. In fact, because of Cymbalta’s adverse emotional reactions, the inherent inability to get an erection or orgasm that is more the norm in other SSRI medications appears to be even worse with this one. If that weren’t enough, it increases anxiety and thus has less value as an anti-depressant. Yet what was even more profound, I found that I was in a state of emotional upset at all times but wasn’t aware of it until I stopped the medication 6 days ago. Bizarre sensations of profound guilt and regret about incidents from the past (childhood to adult), were constantly re-lived and extremely inflated to say the least. I found myself on the verge of tears at all times. To add to the constant emotional upset, I can now attribute Cymbalta to frustrating memory lapses and a dramatic compromise in my cognitive abilities which I had mistakenly blamed on my pain medication. This drug caused me t I have severe and chronic lower back pain with Fibromyalgia which resulted in my developing depression. Consequently, I was placed on anti-depressants to counteract the side effects of pain medication, and also because the constant pain sucked the life out of me. Initially I was on Effexor (YIKES!), but had to stop this drug after only a few days. Subsequently I was placed on Zoloft for several years, then Celexa for several more, and finally Cymbalta in an effort to decrease the SSRI side effects the first two medications had. Each time I switched drugs I had to stop completely to start the other. I had no adverse withdrawal side effects from either Zoloft or Celexa; however Cymbalta was a different story. I had tried several times before to quit Cymbalta but because of the extreme withdrawal side effects, I was forced to stay on it. The evidence for me is irrefutable; Cymbalta has absolutely no redeeming value when compared to any other type of SSRI anti-depressant. In Fact, I believe it should either be removed from the market or be deemed a controlled substance, not because patients would be inclined to abuse this drug, but that physicians are in an effort to improve mood and block pain without having to dispense pain medication. Even the most innocuous of prescribed pain medication has vastly more therapeutic value, simply because Cymbalta has none. DO NOT TAKE THIS DRUG, IT IS DANGEROUS. Cymbalta is a living nightmare, avoid it. M 42 14 months
1/6/2010
 1  Depression At first things were great, then about 6 weeks into the treatment I experienced electric shocks that would shoot from the front of my head, down my spine and out both hands. This would typically happen early in the day, right after I took my daily dose. If I missed a day, then the shocks would occur throughout the day. I also found that it was difficult to urinate completely and when I tried to force a greater flow, it would not increase. My level of agression had greatly increased and I was very intolerant of minor irritations, with explosive outbursts. I decided to stop the medication to make sure that my prostate wasn't in trouble and to make things better for those that were living with me, and the week of withdrawl was horrible. I was not able to concentrate, I don't remember much of what I did, nor why I did it. It was pretty much a lost week, but things are back to "normal". I have been taking Welbutrin for 3 months with no side effects and things are back on an even keel. M 54 8 weeks
12/13/2009
 1  depression/ anxiety Flu-Like Symptoms (Alternating between cold chills and hot sweats, sore throat, body fatigue), headaches, insomia. There were brief moments when I felt good but the bad outweighed the good... I swear this med is a virus in a pill. Upon calling my doctor, she said these flu-symptom side effects are quite common at start-up in a lot of people but I couldn't take it anymore. M 29 4 days
11/3/2009
 1  ANXIETY WEIGHT GAIN, BRAIN ZAPS, BRIEF THOUGHTS OF SUICIDE THIS DRUG SHOULD BE REMOVED FROM THE MARKET AS IT DESTROYS THE LIVER! M 39 1 years
11/7/2009
 1  depression anxiety It worked well for about 2 yrs. Then the deppresion started creeping back• from month to month.stomach pains and gas was the normal while taking cymbalta. Memory loss became worse and couldn't finish sentences while in conversation. I didn't realize the cymbalta was causing these isuues. Finally got doctor to change my antideppresant cause I was down and out all the time. Well the new med. And trying to ween off cybalta sent me over the edge. I stopped all mess. And have been slowly getting back to normal. Cymbalta caused me more harm than good. Been off the drug 3 months now and its been a rough withdrawal. Leave this dangerous drug alone... While getting of 60 Mg. Daily of cymbalta my anxiety had me vibrating. Had to get on blood pressure medicine for few months. M 43 6 years
60 mg.
12/27/2014
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 1  depression Horrible. Totally horse tranq knocked out for 12hrs within 2hrs of tasking it couldn't focus on anything laid down and stayed there all day apart from running to the toilet with diarrhoea a few times. Could sleep later without restless legs then slept for another 12hrs. One of the worst meds I've been on. M 49 1 days
60mg
9/27/2014
 1  fibromyalga Did not help with pain. Made me feel like a zombie. Had shocks going through my brain. Been off for a year and still having withdrawal symptoms. Still have the shocks in my head and shakes. M 56 1 years
30
1/16/2015

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