CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  major depression nausea, sleeping too much, inability to orgasm, near complete loss of sex drive, random irritability, food and drink taste different, weight loss, no appetite, dizziness and feelings of hypoglycemia STAY AWAY i am afraid to wean off of it :( M 28 45 days
5/9/2007
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 1  Major Depression pain anxiety None, never took it due to this web site..looks like a horror show....very expensive...just a money maker for Lilly Should be off the market before someone dies M 60
4/11/2007
 1  anxiety, depression massive yawning, hyper anxiety, trouble staying asleep I've been depressed on and off for years, but after a series of stressful life events early last year the anxiety really started. Tried effexor (no!), paxil and remeron, then psych put me on wellbutrin and now he's added cymbalta. I'm trying to hang in there with the WB/cymbalta combo but the constant feeling I'm on speed and inability to sleep (I take ambien) may force me to give up. Any suggestions? M 44 14 days
6/21/2007
 1  depression, pain First day - speed like effects tension, hyper, upset stomach second day - really tense like being wired, constipation third day - more of the same, some sleep issues weird dreams forth day - felt hyper tensive (and I have low blood pressure and exercise) fifth day - hyper tension getting worse, stomach still in knots sixth day -woke up at 2:00 am heart racing, heart palpitations stopped taking the drug It worked on my depression on about day two instead of the 2 weeks the doctor said, very effective that way, but the blood pressure increase is horrible, I would monitor your heart rate and blood pressure constantly. I do not recommend this drug too many side effects. Like being on speed only worse. M 38 6 days
6/24/2007
 1  depression/pain Worked great at first then sucker-punched me by significantly worstening the depression; induced suicide ideation; terrible, 24/7 headache that nothing touches; sweating, sweating and more sweating all the time; induced body aches; 100's and 100's of "brain zaps" and blackouts all day long; blurred vision; anxiety x10 worse than before use of the drug; complete zombie-like state -- interested in absolutely nothing; trashed my spirituality; weight gain; no sleep in a long, long time, even with ambien. This drug robbed me of a year of my life and replaced it with intolerable sickness. Took therapeutic dose for six months and then spent another six months of pure hell weaning and withdrawing, and its still there. Never before have I have been so sick, and it has been a long time since I quit its use. I FEEL SO DECEIVED BY THIS DRUG. I WILL LET OTHERS USE THE APPROPRIATE ADJECTIVES TO CHARACTERIZE JUST HOW HORRIBLE THIS STUFF IS; THERE ARE JUST NO WORDS STRONG ENOUGH FOR ME TO EXPRESS MY DISDAIN FOR WHAT IT HAS DONE. I'VE TRIED DESCRIBING IT AS RAT POISON, BUT NOW FEEL LIKE APOLOGIZING TO THE RATS. IT IS ABSOLUTELY NOT WORTH THE GAMBLE TO TRY THIS DRUG BECAUSE YOU HAVE A GOOD CHANCE OF BECOMING ILL LIKE YOU HAVE NEVER BEFORE EXPERIENCED IF YOU QUIT USING IT, WHICH IS LIKELY, BECAUSE IT FIRST QUITS YOU AND YOU INSTINCTIVELY KNOW THAT IF YOU CONTINUE ITS USE YOU WILL SURELY DIE. M 52 6 days
10/6/2006
 1  Depression Shaky hands depression worse, sexual side effects M 50 1 years
3/7/2007
 1  anxiety and depression I felt physically ill during the first 3 weeks at 60 mg on this med. While that subsided, I then felt a progressive feeling of being in a general stupor. Lethargy, significant effects on short-term memory to the point it was affecting my ability to work efficiently. I finally took myself off and have been experiencing significant dizziness to the point of being concerned about driving. For a mild depression, I would not recommend. M 42 4 months
5/5/2005
 1  Neurocardiogenic Syncope, Depressio Premature ejaculation, loss of sex drive, restless leg, zombie effect, sleepiness, loss of conscience, apathy, some kind of daltonism as I started seeing thing in other colors, lack of interest at work, home, family, entertainment. A total failure. I'm taking the 30mg pill and I have tried to quit twice... a horrible ordeal. The first time I stayed clean for one week (I couldn't get up of bed at the end); the second time I only lasted 2 days. READ the side effects and the withdrawal symptoms. Best of luck to those trying to quit. M 34 1 years
7/30/2007
 1  Depression Nausea, Insomnia, Constipation, Crying, Dry Mouth, Sexual, "Speeding", Worsening Depression, Thoughts of Suicide, Jaw Clenching, Heart Racing This is the most frightening experience I have ever had with an anti-depressant. I have a very high tolerance for drugs, and I have been on meds almost consistently for thirteen years, trying almost everything possible. Never have I had such side effects, nor have I ever felt as "drugged" as I did on Cymbalta: nervous and speeding. The side effects were almost immediate. Rarely do I ever think of suicide, but after two days the thought was almost constant. I woke up after three hours sleep each of the four nights, and could not get back to sleep. I was "speeding" the whole time, but felt no relief or, for that matter, a single positive effect. I would rather be depressed than feel like this--at least depression is predictable and I know it will end. I see that it worked well for some, but I would never take this drug again. The user comments for withdrawal were enough to stop me after four days. M 46 4 days
9/3/2007
 1  mild depression heart symptoms, palpitations, vascular rash on extremities, etc. extreme anxiety, brain zaps, loss of thought in midsentence, or changing the subject in midsentence. wanting out of my wonderful 23 year marriage for no apparent reason. I did not want out before cymbalta and do not want out after coming off of it. grandiose ideas regardng my business and financial situation and I am usually VERY frugal. This nearly cost me my life, marriage, children, business etc. I am lucky my wife noticed that this was not the man she was married to for 23 years and had the Dr. take me off the meds whether he liked it or I liked it. I thought everything was FINE, great...just like a frat boy and I am the biggest nerd..like Fred Rogers normally. This is a bad bad drug. Do not make any life decisions on this drug as you may not be yourself on it. My 11 year old daughter asked my wife if something had inhabited my body. It was the body snatcher called Cymbalta. M 44 1 years
10/29/2007
 1  Neuropathy/feet I only took one 30mg pill today and that was enough for me flush all the pills down the toilet. I had cramps, nausea, felt like vomiting, I was tired, had a head ache and could not focus. I want to thank everybody on this message board for posting their comments, experiences AND STRONG WARNINGS about this stuff. I have been suffering from worsening foot pain for about 4 - 5 years now. I figured it was sports related so I cut down on high impact sports. I went to a foot and ankle specialist who diagnosed me with tendinitis of the achilles and tibialis tendons about a year ago. I went to PT , did Yoga and have shoe inserts, but none of that helped with the pain. In fact the pain seems to be getting worse. Recently, on my quest to find a solution I went to a neurologist who diagnosed me w/ "small fiber painful peripheral neuropathology.” Anyway, the doctor thought I might benefit from Cymbalta and he gave me a free 3 week course. Based on my reaction to one dose (30mg) and fears I have about messing with my brain chemistry (heightened by what folks have posted here), I flushed it all down the toilet. Cynbalta may work for a few, but it looks like Cymbalta M 43 1 days
8/18/2007
 1  depression poor sleep FOr the 1st 3 months, I thought this was a miracle drug. I felt better than I ever had in my life. However, it gradually suppresses the 3rd, 4th, and 5th levels of sleep. That's the deep, good kind. You will wake up feeling for sleepy than when you went to bed, and all you'll think about all day is sleeping. I slept through the last 3 months. Wake up (3 alarm clocks) go to work, come home go to sleep. But the sleep you get is not good, and your body will DEMAND that you go back to sleep. But the drug won't let you get GOOD sleep (you'll sleep 18 hours at a time though). M 40 6 months
10/28/2008
 1  Depresion Horrible thoughts and night dreams. I went from depressed to nuts! This is the worst drug ever! I got off it as soon as possible. Physicians are crazy for perscribing this medication. M 21 2 weeks
1/30/2008
 1  fibromyalgia/anxiety after only one dose of 20 mg,i vomited and had diareah,then hallucinations,and my thorat was numb and had trouble breathing,was instructed to to ER from doctors nurse I have never felt so detached ever from one dose of a medication in my life! This was a scarey experience,i had a severe allergic reaction to it,weirdly,it did help a little with my pain,but not worth it for all the other side effects from hell. use caution!! M 42 1 days
2/14/2008
 1  antisocial & social anxiety nausea, lethargy, awkward feeling I don't really know the extent of my depression or if I'm depressed at all. I'm far from suicidal. I'm a bit meloncholy from time to time but I keep a regular regimen of excercise cycling and lifting weights. I play golf and enjoy my job. Despite all this I went to the doctor and asked for help. I feel antisocial and have a hard time relating to a lot of people. I need a couple of drinks to loosen up in social settings. I also have a difficult time sleeping through the night. I am begininning to realize this is just who I am and that I have plenty of positive attributes as well. I do have $14,000 of credit card debt which I'm chiseling away at and just broke up with my girlfriend of three years. She's living with a new guy within just two months of our split. I think these matters have weighed on me a bit. The doctor recommended Cymbalta. Today is the sixth day on the drug. The nausea is awful and I'm sick of yawning. Last night I sat in a chair in the living room and stared out the wi M 34 6 days
2/12/2008
 1  depression All the bad side effects started after about 2 weeks. Started on 60mg. I have been on it 6 months. WORST DRUG ON THE MARKET TODAY. NO ONE SHOULD BE PRESCRIBED THIS MEDICATION. M 35 6 months
2/19/2008
 1  depression & neurothy weight gain big time. Loss of appitite and weight gain, dry mouth,bad dreames,night sweats,joint pain,cramps,constipation,. M 54 7 years
3/5/2008
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 1  Depression This is the worst drug I have ever taken. Lost interest in everything. More depressed,weight gain,ringing in my ears. DO NOT TAKE THIS DRUG! Very hard to get off of. M 42 2 years
12/13/2007
 1  neuropathy in feet from chemo Took 30 mg. for 30 days felt a little side effects with headaches and not being able to urinate. Doc increased after 30 to 60mg. I was sick, throwing up, no sex life, constipation, severe headaches, night sweats, body tremors. Went off the drug and felt all this 100 x fold, now back on it but splitting 30 in 1/2. This is worse than chemotherapy. DO NOT TAKE THIS DRUG!!! Why can't they make a drug you can take without the side effects worse than the original problem. M 48 60 days
1/10/2008
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 1  depression,anxiety,ocd profuse sweating, suicidal thoughts when withdrawing. took for 2 years.helped with depression. had to wean off due to profuse abnormal sweating. weaned off and 4 months later had serious relapse causing suicidal tendencies which required hospitalization. definitely caused by stopping usage of cymbalta M 2 years
12/15/2008
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