CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Neck and Shoulder Pain/Depression Cymbalta did not work for me. It raised my liver enzymes. The FDA has issued a black box warning for this. This happened to me. I hope that you and your Dr. are careful and monitor your liver enzymes. Cymbalta did not work for me. It raised my liver enzymes. The FDA has issued a black box warning for this. This happened to me. I hope that you and your Dr. are careful and monitor your liver enzymes. M 33 60 days
60 1X day
9/16/2010
Patient History
 1  Back pain & Depression Chills , Severe sweats , headache , muscle spasms( entire body would jerk uncontrollable !) B.P. raised ! Nausea ! Insomnia ! M 50 2 days
30mg 1X day
9/4/2010
 1  neuropathy Severe confusion,anxiety,constant yawning, For the first two years of taking this drug the side effects where nothing i couldn't live with, because it help with the leg and arm pain from my neuropathy. But soon after my wife notice changes in my mood and i started having trouble finding words i wanted to say, as if i where in the first stages of alzheimer's. I stopped the drug and it took over a month for everything to return to normal. This Drug is dangerous. M 51 3 years
30MG 2X day
9/7/2010
Email
 1  Firbomyalgia I was a total zambee.(sp) Walking around with no emotion at all. Felt like I wanted to just lay down and stare at the walls. Wanted to cry, but didn't have it in me. Only one pill and I was out of it for 4 days. Not a good drug!!! Through all of the samples I received in the trash!! M 50 1 days
30mg 1X day
11/16/2010
Email
 1  Fibromyalgia Initially: Hyper, dizzy, disoriented. Later that day: Panic attacks, hypervigilance, insomnia, heart palpitations, chest pain, intense muscle spasms, loss of motor control, slurring or speech, severe hand and leg tremors. I understand that it takes some time to adjust to Cymbalta, and I have read some of the other comments about how if you've only taken it for a short time you are not qualified to truly review the drug, but I have to ask: If a drug requires that much suffering to adjust to it, should you really be taking it? At what point are you clearly just reacting to the drug? My body clearly did NOT want this. The day started out ok. I took the Cymbalta at 9am and went to a meeting. By lunchtime, my co-workers were making comments that I "had too much coffee". I was indeed hyper but couldn't control it. I was annoying to MYSELF! But, I did feel quite happy. I was a little dizzy but nothing I couldn't handle, and I did manage to drive myself home. By 7pm, I started having crazy thoughts- like suicidal. I have NEVER had any sort or mental illness and I've never had any issues with clinical depression, and here I was having suicidal thoughts and panic attacks. My husband returned home and looked at me strangely and asked me what I was "on". I told him I didn't feel right and he asked if I was drunk and said I was slurring. Soon after, my hands and legs started shaking and I couldn't control it. A friend of mine brought me to the ER and they kept me for observation and said I was having a severe reaction to the Cymbalta. Needless to say I didn't take any more pills!I think every person is truly unique and your mileage may vary, but use your head: your doc doesn't know ever M 36 1 days
20mg 1X day
10/22/2010
Email
 1  Pain Caused a lot of problems. M 33 2 years
60 1X day
2/20/2011
Patient History
 1  Depression and Pain Weight gain, crying, agitated, more pain, daily headaches, suicidal!!! Hated it!!!!!!!!!!! M 47 10 days
60mg 1X day
3/10/2011
Email
 1  Cronic back pain then sadness MUD BUT all brown water nasty 1 dose vomiting really vivid dreams pain in my grown thoughts of killing hurting someone who pisssed me off in the past I am aware of it tho but this stuff OMG is a amplifier for RAGE but I'm stuck on the stool or vomiting then I'm fine 10 hours later from first dose please be carefull with this stuff Welbutrin 300xl of Zoloft is better for me I'm just lucky to be a cripple I don't want go to jail over this drug(CYMBALTA).doc told me to take it 30mg before bed for a week I could not make it thru the first night it makes me have RAGE. I have pain from a car accident when I was 13yo had surgery @21 disc discectomy made chronic 10 to a 4 to 9 pain scale and pain is my life the jerk ran the red light me and my uncle were the only two hurt I need some relief but this drug made things worst. I need something to help me forget. like California or Colorado medical Maryjane M 33 1 days
30 1X day
4/9/2011
Email
 1  depression Withdrawal is completely incapacitating, complete loss of sexual desire, nausea, headache. This is the most addicting worse medicine anyone could be placed on. If you've been prescribed Cymbalta, please do not take or get off as soon as possible. M 55 2 years
60mg 1X day
4/9/2011
Email
 1  Bipolar mania None but could have exasperated the symptoms from the two other drugs I was taking during that time. Used for around a month and a half in conjunction with Geodon and Saphris. Didn't seem to do nothing for me so my doctor pulled me off the drug. I believe the dosage is correct. M 26 40 days
30 1X day
3/20/2011
 1  Severe depression Loss of appetite, constipation, tiredness, loss of emotional capabilities aka zombie, general numbness, lack of sexual interest when I finally stopped taking this stuff after losing five years of my life to it, I now have joint pain that makes it difficult to do anything. I am very frustrated that this stuff has permanent consequences in joint pain which I have never experienced before. M 42 5 years
60 1X day
5/18/2011
 1  Depression, Anxiety, Stress, Pain Everyone imaginable. Loss of appetite, metal taste in mouth, weightloss, headache, disoriented. Worst medication to date for me. I couldn't believe the side effects and how harsh they were. I felt horrible, my mouth tasted like metal and I could not sleep for days. I was hoping it would eventually go away so I continued to take it and after the 6th day of the same intense side effects I finally had to just chunk them in the trash. Was wondering if anyone else had this bad of effects but that they did go away after a certain amount of time. I have been on wellbutrin before and the side effects were bad but did wear off after about a mont M 33 6 days
30 mg 1X day
6/27/2011
Email
 1  Bipolar II Agitated, often risky behaviors, uninhibited behavioral choices, spent more money than I made, was put on Depakote also, to counter the Cymbalta, total catastrophy Stopped taking both after 5 years, feel great now, I think I was mis-diagnosed, and was put on these drugs because, (I think) the doc got incentives from the drug companies. M 54 5 years
120 mg 1X day
5/7/2011
Email
 1  Depression Lack of emotion, night sweats, high blood pressure. Beware starting this drug because it will alter your brain. I have been having withdrawals and I completely stopped taking it 3 months ago. I had to ween off of it over a period of about six mos. with the help of a holistic doctor. I believe that the supplements that she gave me helped decrease the severity of the withdrawals. Now after being off, I have nightmares almost every night. It seems to pull the hidden fears out during your sleep and turn them into nightmares. I have never had a problem with this before and read about the night terrors that others have had. Also, I get angry very easily and feel irritable a lot. I started out with Lexapro about 8 years ago for depression and that stopped working, so my doc put me on Cymbalta. Every time I went for my physical, I asked him about going off of antidepressants, and his reply was "if it's not broken, why fix it." I believe that the doctors now are getting kickbacks from the pharmaceutical industry to get people started on these addictive drugs. They don't warn you ahead of time what a horrible experience it is when you don't want to be on drugs any longer. My depression was mild-moderate, and I wish that I had never gone on any drugs at all. I see a holistic doctor now and she is able to help me with my moods with natural supplements. I am hoping that the nightmares will eventually go away. I feel like I have permanent brain damage from this drug. Consider yourself warned if you have been advise M 51 5 years
30 mg 1X day
8/5/2011
Email
 1   Mind racing, brain sparks, talking without thinking, over aggression, aggition, sleeplesness, and loss of appetite (extreme weight loss)!!!!!!! M 30 8 months
60 1X day
8/2/2011
Email
 1  Chronic LBP Complete loss of sexual interest and ability. Sleep 16-20 hours per day and when up absolutely no motivation. Felt as though I was sleep walking. Severe depression as a result of no life whatsoever. Worked about the same as any anti-depressant has for me. No discernible help with pain and the side effects are terrible. Talk about completely sucking any life that's left out of a person. As miserable to quit taking as narcotics, no fun. M 52 1 months
30mg 1X day
10/7/2011
Email
 1  sleepless headache, constipation; But all drugs are poisoness eventually, I have gone to nutrition for total cures; as Nancey Reagan said 'just say no to drugs'! If you have sleeping trouble/ depression, fibromyalgia or almost anything else including RA and MS, you should go with vitamins and minerals - mega B, C, and apple -cidar vinegar; it's mostly at doctoryourself.com; but I'm outta space, you can e-mail me. M 56 5 days
20 mg 1X day
8/31/2011
Email
 1  Bipolar depression TOTAL FLAT EFFECT I was so absolutely flat I had no emotions WHATSOEVER. No feelings of depression, love, hate, anger, NOTHING. No sense of humor, no laughter, which still persists to this day 5 yrs later I can not laugh or smile. I see something funny and cognitively say "hey that was funny". But I can't laugh. I would love to be able to laugh. I did not care abt anything. I did not grieve for my fathers passing, I rationalized it that he was in terrible pain, when he was the most influential person in my life. M 60 2 months
Donremembe 2X day
10/24/2011
Email
 1  for pain i have chronic fatigue syndrome and i think i have fibro. having a lot of muscle pain. took cymbalta at 10:30 am. it's now 5 pm and i'm extremely, nauseas, tired, irritable and running to the bathroom. i will not take it again. M 70 1 days
1X day
10/29/2011
 1  Depression Irritability, sleeplessness. NEVER, NEVER take this drug. I made a suicide attempt while on it and it is my opinion it was the cause that pushed me over the edge. M 47 1 years
1X day
12/7/2011
Email

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