CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  depression Off feelings throughout my body, sensitivity to sounds, light and touch sensations. Others have referred to them as 'brain zaps'. Irritability and the desire to have an angry outburst are increased. M 31 9 months
4/11/2007
 2  Depression Couldn't really notice this medicine having any effect I didn't feel bad but didn't feel good either. Strange thing is, shortly after I stopped taking it (abruptly), I felt much better. I felt good although not like myself. I'm not sure if the medicine actually started working or if I was just having strange withdrawal symptoms. I felt sort of electric shocks going through my body every once in a while, and I had strange episodes of simultaneous violent and happy feelings. I started taking it again and had a seizure due to combining it with tramadol. (You shouldn't take tramadol with any SSRI as far as I understand now). M
4/13/2007
 2  motor peripheral neuropathy took 60 mg dose after breakfast, then the horror begins; severe chest pain at first, sat down wrote a goodbye note, well the chest pain passed then was cold sweats, chills, sick feeling all day, finally was able to eat something, tried to sleep it off. No Good, head felt like it had a gyroscope gone crazy inside, was not able to sleep the entire night, wanted to go outside and run around in circles, but was unable to due to foot/ankle pain swelling etc. I guess I just can't tolerate Cymbalta or another possibility it was stored at improper temparature. a sample bottle that was by my PC Physician, Now after 2 years I am going to try Lyrica, I hope the chest pain doesn't return. M 50 1 days
3/13/2007
 2  General Anxiety Disorder Very delayed or inability to orgasm. However, no erection problems. Some loss of sexual desire. Dull headache all day long. Maybe some teeth grinding and sleep interference. I want to get off of these brain altering drugs and control my general anxiety by exercise, will and therapy but my wife insists I stay on it to keep our marriage intact. I'll be talking to my doctor shortly about options. M 49 5 weeks
2/22/2007
 2  depression, nerve pain night sweats, nausea, increasing apathy, short-term memory loss. Sleep disturbances. Because it is a relatively new drug I did not want to take it at all. My luck with anti-depressants has been poor. However, my doctor (a very young family practice M.D.) swore by it and I accepted his recommendation. Started @ 30 mg. and had sleep problems immediately. Either too much or too little. After almost5 months on the drug (the last 4 @60mg.) I now want OFF of it. I have progressed from mood swings to to ONE mood --the basically "I don't care" mood and want to sleep all the time. My pain level is worse because of spending so much time in bed, but I feel exhausted all the time. I feel as if I am living under a blanket with no real feelings. I would NOT recommend this drug to anyone. I do not think there is enough study on it to do so, and with my own experience being more negative, I just could not do so in good conscience. Not even in the "try it" maybe it will be good for you category. M 59 5 months
4/20/2006
 2  Anxiety/Depression drowsy, feeling lethargic; inability to reach orgasm. Feeling like I'm have an out of body experience; clenching jaw and teeth a night; jittery; dribbling when I uninate; loosing time (an X-File sort of thing); Generally just feeling weird like I'm catching the flu. Confused. Do I stay on it? Switch to something else? This is only my 4th day, and I have all of these side-effects. My Psychiatrist one time put me on Buspar when I was going through a difficult divorce. After a few weeks, I was at a friends house and started using a punching bag and it felt great! A few days later, I was putting holes in our walls at the house. What was next my family? Medicine scares me, I don't want to go back to those feelings. Do you have any advise? M 41 4 days
4/23/2007
 2  clinical depression nausea, headache, severe sweating, feel more depressed M 42 2 months
2/6/2007
 2  depression anxiety tired sometimes , minor weight gain ,night sweats , vivid dreams i tried cymbalta to replace effexor and have found that effexor was much more effective for both anxiety and depression. Has anyone else experienced this ? im willin to deal with the effexor side effects to replace cymbalta... M 33 2 months
1/1/2006
Email
 2  Chronic Severe Depression, PTSD Extreme fatigue, nausea, flatulance, feeling of pressure inside my head, extreme lethargy, loss of interest in sex, diahrea, my limbs feel like they're made of lead. All I want to do is sleep. Oddly, despite the side effects, my mood seems to be very stable, my anxiety is down, my back pain is down. I would not, however, say that my mood has lifted, just that the mood swings are less severe. After reading other people's experiences on here, I'm going to stick it out and see if the side effects go away. M 42 10 days
5/15/2006
 2  depression, anxiety vivid dreams, decreased appetite, fatigue wasted my time with this medication, did not help depression in anyway, caused increased fatigue which only made mood worse, cymbalta is nothing "novel" just another SNRI antidpressant M 31 3 months
60 1X day
4/30/2013
 2  Mild Depression/Anxiety Nausea, brief hot flashes, pressure in head, diarhhea, increased feelings of worthlessness/suicidal thoughts, insomnia, extreme fatigue in the afternoon, delayed orgasm. Cymbalta seems to have alot of side effects that work opposite to its claims. I felt these almost immediately. Decided to stop. Although I did feel a tad better emotionally...I'm not sure if that's just because I was preoccupied by its side effects. M 35 4 days
1/10/2006
 2  Anxiety, Depression Several sexual side effects (40 mg+) Completely ineffective anti-depressant/anti-anxiety medication, I had to be tapered immediately down from 60 mg to about 30 mg, very soon thereafter to almost none. I do not intend on continuing taking cymbalta. Other than its complete lack of effectiveness, the sexual side effects (similar to ones experienced with Effexor XR, also a popular "SSNRI") were absolutely severe and intolerable. I've been on many SSRI's and other meds with a high chance of sexual side effects, and only, possibly, effexor, was worse than cymbalta in this area. M 22 5 months
8/17/2006
 2  GAD Weight loss and increased anxiety I stayed on cymbalta longer than I should. It did nothing for my GAD and actually made it worse. I only stayed on the medicine because it helped me lose weight. Unlike others - I had no problem getting off. I went from 60 to 30 to 0 with no side effects at all. M 35 1 years
60 1X day
6/25/2012
Email
 2  Bipolar II Emotially numb, no sex drive, chronic fatigue. I was on this for about a year and didn't notice the effects until about 6 months in. They progressively got worse to the point where I was pretty much indifferent about everything. Extreme side effects for such a low dose. M 43 1 years
30 1X day
10/7/2011
Email
 2  Depression, anxiety, lack of energy Anger, hostility, aggressiveness, agitation, suicidal thoughts, odd behavior. Psychiatrist changed me from Paxil to Cymbalta to treat norepinephrine levels to increase my low level of energy that was significantly affecting my quality of life. Paxil only treats serotonin so Cymbalta was an obvious choice because it is used to treat both serotonin and norepinephrine. A VERY BAD choice for me. I was hospitalized with what I call an "anger stimulated adrenaline rush." I actually slammed my head through a wall and had thoughts of unimaginable evil rage during the outburst. TOTALLY out of character for me! The feeling of anger was so intense I had a small heart attack (documented) and have to take heart related drugs, now. My Cymbalta experience caused me embarrassment, a big hospital bill and a heart attack. ACT EARLY IF YOU HAVE SIDE EFFECTS! Don’t wait for them to worsen like I did. M 55 30 days
60 MG 1X day
7/30/2011
Email
 2  Sever depression Cymbalta made my nervousness and depression worse! I have taken many, many drugs and this one was a doozy. Stay away from Cymbalta. Or don't. I love this site. The fact is that this is a first line antidepressant/all around drug for those with suspected Bipolar disorder. It shouldn't be. M 26 4 weeks
20mg 1X day
8/25/2011
 2  MDD Complete absolute loss of sexual desire/function. Emotional blunting (not necessarily bad). EXTREME LETHARGY. Had to stop taking this as I was requiring 12 hours of sleep at night and also taking several naps during the day. Burned thru all of my vacation trying to acclimate. Had to quit or lose my job. Even cutting capsules and taking 10 mg a day caused me to fall asleep at work. Stopped suicidal ideation. Stopped almost all ideation of any sort hah. Probably only good if you are suicidal and don't need to hold down a job. Discontinuation syndrome wasnt that terrible. Email for more if you want, but this about covers it. M 37 6 weeks
40mg 1X day
2/23/2011
Email
 2   M 56 3 days
1X day
3/15/2011
 2  Bipolar - mania At first really helped with my "lowest-lows" but then the brain zaps, ruminating thoughts, loss of sex drive, gained 15 lbs and I excercise and eat well religiously, high blood pressure, heavy sweating, zone out sometimes. Weirdest side effect-- The insatiable desire to drink alcohol! I've been a social drinker 3-4 a week, but then I started drinking everynight. I would drink an entire 750 ml of wine and get up the next morning and go to work with a slight headache and then think of it all day. I went to every other day for about 10 days and then stopped taking it about 5 days ago. Still can't sleep, racing thoughts, horrible dizziness/brain zaps, bloating (holding water) heavy sweating. But have stopped drinking completly and blodd pressure is going down. Hope the weight comes off soon. I think my bi polar ad Cymbalta don't mix. Tried prozac and lexapro too. No more anti-depressants for me. I'll stick to the lamictal... M 37 2 years
60 mg 1X day
3/17/2011
 2  Anxiety, depression Chest pain, heart palpitations, rapid heart rate, high blood pressure, nausea. Was taken to the ER for major chest pain, admitted overnight for observation and spent tens of thousands of $'s on heart scans, etc. Stopped taking and switched to another similar medication. Experienced constant nausea, dizziness, heart palpitations, "brain zaps" (feeling of an electrical pulse in my head when I turn my head or move my eyes), constant ringing in my ears, mood swings, irritability, increased anxiety and much more. Would not recommend this medication to anybody! Have felt awful for 2 weeks so far and have been told by others that these symptoms may last for months to come. M 32 9 months
60 MG 1X day
10/18/2010

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