CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  mild depression difficulty sleeping, sweating all hours of the day, no sex drive at all, decreased appetite, does not do well with alcohol, get extreme headaches with two drinks, mentally in a fog...sometimes I think I'd be better off depressed..... M 54 40 days
11/23/2007
 3  Major Depression None yet! Haven't started... I have to say, after reading this site's and others about Cymbalta, I'm a bit freaked out in switching from Zoloft. BUT... I gotta say this... I would like to know what other medications those who have some of the horror stories here are on. I'm no doctor, but it seems like there are some combinations that would explain much of the issues above. Also, it seems as though this drug isn't a great treatment for anything other than depression/axiety. I know Lilly wants to get the old market penetration, but GEEZ... don't use a shovel when you need a screwdriver! If I have any of the issues I've read here, you bet I'll be back to let you know... M 43 0 days
12/3/2007
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 3  depression Day 2 of using it: slightly queasy, a bit light headed, a bit of jaw clenching. Day 2 of using it: mood swings, seems to magnify emotions either way, not the best for me. M 52 2 days
12/14/2007
 3  Depression Anxiety Constipation (cured with metamucil), longer to reach orgasm, nausea gone after the first three days. Overall so far better tolerated than other drug I dont feel like I am doped up or in a daze the first few days I did but it went away. My anxiety has decreased not much of a change in depression but it has just been two weeks at 30 mgs. I will post again in two weeks M 30 14 days
12/12/2007
 3  Depression Jaw Clenching, Severe sweating, sleplessness unless I take something else for sleep. 7 days on 30mg now on 60mg. Jaw clenching, the sweating is almost unbearable when I sleep, if I sleep. Chest pain. M 32 10 days
1/5/2008
 3  depression Made me gain a quick 15 pounds. I work out daily and did not change my calorie intake. Switched to wellbutrin and have allread lost 8 pnds with out trying. It works well for some but not me M 31 6 months
4/8/2008
 3  Anxiety Heartburn this med is ok...I am in much better mood...Benefits outweight any side effects in my opinion. M 43 6 months
4/8/2008
 3  Anxiety and Depression Light Headedness, constipation, slight bloating, slight sexual decrease--but much less than SSRIs. I was taking 40 mg total (2 x 20mg) in the AM. I had come off of 100mg. of Zoloft. I found the cymbalta effective for my depression. I'm currently reducing dose to 20mg and then off Cymbalta as I've been on antidepressants for about 4 years and have lost insurance coverage, so the cost of a psychiatratist and paying out of pocket will only generate anxiety and depression --($240/month!) I would return to the medication immediately, if my health insurance status stabilizes or if I show marked symptomology. 20mg (lower dose) for titrating off is not effective for depression. Noting withdrawal syndrome, anxiety --, increased in the am and going away post dose by around 2pm. So 7am to 2pm is the killer time (5 hours of zaps and such). The manufacturer should consider dosages that are in 10mg and/or 5mg capsules. Titration 40 to 20 to ? is not possible in current forms. As most people are noting withdrawal symptoms that are equal to or worse than Zoloft, Paxil, Prozac etc, the "gett M 42 120 days
4/2/2008
 3  Depression, GAD, fibromyalgia vivid dreams, decreased sexual function, muscle and joint pain After taking Prozac for almost 3 years, I switched to Cymbalta 3 weeks ago. it was an easy transition. I stopped the prozac and immediately started on 30mg cymbalta for 1 week and now 60mg everyday. I noticed within a few days I was sleeping better, despite the vidid dreams. During the day, I feel more happy and excited. I still have muscle and joint pain and it may actually be worse since starting the cymbalta. The pain does slow me down, but I feel so good mentally that I don't think about it. Maybe after a while the pains will lessen. There are definitely frustrating sexual side effects (worse than prozac). After 3 years of prozac not working for my anxiety and depression, I'm pleased with cymbalta. M 28 3 weeks
12/4/2008
 3  depresion anxiety blurred vision sweating on 60 mg has helped with depression but still working on anxiety i am starting to go up to 90 mg today M 53 2 months
1/9/2009
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 3  Depression Loss of libido. Migraines and brain zaps. Inability to orgasm (exception-masturbation). Penile insensitivity. I switched to Cymbalta after I started feeling depressed again while on Zoloft (1 year). Cymbalta worked wonders for me for the first 10 months I took it. However, after around 11 months of use I started to experience brain zaps and migraines on a weekly basis, and especially if I delayed taking it (sleeping in had it's consequences). I didn't notice a loss in sexual sensitivity at first because I'd already been experiencing it on Zoloft. In the past 5 months I have gone from having trouble orgasming (unless it was masturbation) to not being able to orgasm unless I was masturbating. Now I'm having trouble even when I'm masturbating. This seems, in part, to be due to the fact that my penis is no longer very sensitive to stimulation. My libido in the past 2 months has dropped considerably as well. 18 is not the age to be losing it. I can atest to it's effectiveness as an anti-depressant. It still works as one for me, but the trade off in side-effects has become unbal M 18 1.5 years
2/4/2009
 3  Nerve Pain, Fatigue CTD Extreme weight loss, chronic fatigue, frequent night urination, no appetite, sleeplessness,nausea, headaches, constipation, difficulty swallowing, night sweats,wouth sores. Have taken Cymbalta about about 5 months,has helped with nerve pain associated with cdt, cant go to sleep or stay asleep problems with frequent urination 4-5 times a night, when I do go to sleep cant wake up, or could sleep for ever, feel exhasted no energy 24x7 , no appetite lost 10 lbs that I couldnt afford to lose. Its possible the weight lose is attrubuting to the fatigue but dont think so. M 52 5 months
2/8/2009
 3  depression lethargy, increased need for sleep, extreme night sweats, daytime sweating, vivid dreams with violent behavior upon waking I have struggled with depression for 30 years without seeking couseling or medication. After severe period of anxiety and depression, got very good initial results from 60mg. after no help from Lexapro. Assumed extra need for sleep was just "catching up" from sleep deprivation over previous months. Now getting worried because the vivid and often pleasant dreams have twice ended with me striking my wife who was cuddled up close to me. Last night I dreamt Will Farrell was clowning around in his typical movie character and throwing things around the RV in which I was actually sleeping. In the dream I jokingly threatened to punch him if he did not stop throwing stuff around. I asked if he preferred a right or a left. He chose a left and I struck him. My wife's outcry woke me as I had just knocked her on top of her head, jamming my own left thumb severely. This is not me! I adore my wife and would never hurt her. This behavior has to be caused by Cymbalta. Reading many other comme M 58 2 months
2/21/2009
 3  Depression Teeth Grinding, 4-6 hour crash where you can almost pass out on your feet, sweating, Chronic Hives, servere weight gain 25pds, miss a dose get servere headaches and enter into an almost drunken fog. I have gone from Effexor to Cymbalta and I am much more pleased with the Cymabalta. Sexaul side effects are more mild, Consentration is easier, and I am able to control racing thoughts. The Sweating is not as bad as it was with effexor either. I have had hives while on both medications so no advantage there. The one thing I really do dislike is the crash. I am taking Cytomel to help with energy and didn't realize that was a potential side effect until comeing to look at this page. Literally you will be fine them five minutes later you can not keep you eyes open or your head up. The weight gain has been something I experienced on effexor but not nearly to the extent that I have on Cymbalta. With Effexor I was able to make a few modifications to my diet and was able to ge to my original weight pretty quick with Cymbalta no matter how strict I am the weight just doesnt seem to wat to come off. M 33 6 months
5/30/2008
 3  mild depression Just started it. will report back. Paxil makes me SOOOO TIRED. Need energy. Have been taking provigil for the "ssri apathy" and it works but has it's own tolerance building issues, etc. M 53 1 days
3/13/2009
 3  depression, fibromyalgia increased sesitivity to cold weather, tired, yawning, foggy mind, confused, no worry even when I should be. I have been on Cymbalta for three weeks and my mood is better and I am happier. I take 30Mg in the morning and will increase if I stay with this med. At night I sleep well now and waking up is extremely difficult. It has not improved on the fibro fog or pain. Pain in my legs is worse than before. I am also taking 10mg of Amitripline at night. M 49 20 days
4/7/2009
 3  Depression Lack of Energy, Sometimes I get anti-social and moody and tired all day It has caused my depression to get to a tolerable level, where most of the time I am not depressed anymore, but I don't know if its the Cymbalta or it mixed with my other medications (Methadone, Roxicodone for Severe Chronic Pain, Klonopin Wafer 2 mg for Anxiety and Inderal ER 60 & Lyrica 150mg for essential tremor and nerve pain), but since I added it to these other medications I have not had any energy at all and I feel like I am asleep all day and just want to lay in bed M 26 29 days
5/19/2009
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 3  neurological pain & depression Dizziness/Nausea/Vomiting/Diarrhea Cymbalta has been the only pain medication that has helped to relieve severe neurological pain I have had for almost 7 years. Unfortunately the side effects were so bad after 6 weeks that I had to stop using it. What good is the relief of the neurological pain if your head is stuck over the toilet most of the day because of the nausea? For the last week I took Cymbalta, I had chronic diarrhea. The other major size effect was the dizziness. The last day I took it my world was literally spinning around me. I was laying down trying to watch TV and it was like chasing the TV all over the wall to try and see the image. When I first took the med I had an episode where I was crashing into the walls trying to make it to my bedroom because of how dizzy the Cymbalta made me. It worked wonders for the pain though, and I really feel bad that I cannot continue on it because of the side effects I experienced. I would rather cope with the neurological pain than live through the side effects. M 52 6 weeks
6/5/2009
 3  norepinephrine reuptake Nausea, loss of appetite, severe pressure in head It is hard to determine whether or not this is helping due to the side effects. I have noticed that it takes the edge of a bit and I don't seem so overwhelmed with adrenaline all the time. M 27
6/6/2009
 3  fibromialgia dry mouth, feel "floaty", if that makes any sense... also had the feeling of a knot in my throat, or something that kinda made me feel nauseous i have been taking 30mg once daily for my fibromialgia pain... after about an hour of taking my first pill, i started feeling "floaty"... don't know how else to describe it. i also had very bad dry mouth, no matter how much water i drank. after about the 4th day, i stopped feeling floaty and do not get dry mouth anymore. it seems to be helping BARELY with my pain... i think i need to be on a higher dose. i think i will give it about another week so it has time to build up in my system, and if it's still not helping that much, i will ask my doctor for a higher dose. M 27 1 weeks
6/8/2009
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