CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  Depression I experienced erectile dysfunction, delayed urination, and an increase in yawning. M 34 4 weeks
12/18/2006
 3  depression I definatly get real nausious. I am having strong flu like symtoms but I am coming off of effexor and that has always been hardcore. I have been on effexor for 11 years and it has help me funtion and provide for my family, but I have been really tired and have to contantly fight weight gain. I have noticed that I have a little more energy and more mental clarity in the short time that I have been on Cymbalta. I'm going to stick it out and give this new drug several months before making a decision. God bless M 35 11 days
6/3/2006
 3  depression first week or so, major tremors after it was taken (the first time I took it it shook uncontrollably for 3-4 hours, this effect faded after each sucessive dose), sweating, restlessness, anxiety, fatigue, nausea, harder to reach orgasm the first antidepressant I've taken that actually seems to be helping somewhat, at least in combination with other meds, after prozac, celexa, wellbutrin, etc it was a relief to have something that seemed to cause some improvement, although the side effects nearly caused me to quit before there were any beneficial effects M 20 30 days
11/2/2006
 3  Moderate depression CYMBALTA PATIENTS: This is a serious medication. My side effects were sexual disfunction, including anorgasmia and partial loss of pleasurable sensation and stimulation of erect penis; jitters, jaw clenching, teeth grinding, and a sense of being slightly dazed. Having said that, I actually felt emotionally very well in the days immediatley following discontinuing this medication. My doc prescribed Cymbalta 30mg/day for moderate depression. Within two days of taking Cymbalta, I immediately noticed onset of sexual dysfunction, including anorgasmia and partial loss of pleasureable sensation and stimulation of erect penis. The sexual side effects alone were reason enough for me to immediately discontinue using Cymbalta. SSRI's and SSNRI's are known to cause long-term or permanent sexual dysfunction for some patients. Note: Not all patients have the same side effects profile with Cymbalta; I am merely speaking of my personal experience. M 45 2 days
7/10/2006
 3  depression / physical aches &pains Inability to orgasm. Noticable dry mouth. Sleepy and groggy. A dramatic decrease in appetite. Frquent urge to urinate. Mild constipation I went to the doctor complaining of lethargy and bodily aches and mild depresion. I began taking 30mg, and then after 1 week moved up to 60mg of Cymbalta. I immediately lost ANY ability to reach orgasm. Belive me I've tried, to the point of exhaustion. After years of a good and active sex life this was not acceptable. I've never went this long without an orgasm since I was 12 years old. Went back to the doctor and he perscribed Wellbutrin SR ( 150mg ) to take in addition to the Cymbalta to counter the side effect. This is the first time I have ever been on any kind of depression medication, so I remain a little uncomfortable taking both of these pills. Only been on the Wellbutin a few days but am having the same ejaculatory problem, hope with time it will come back. I do think I feel a little less depressed overall, and the body aches have gone away completely. I am also losing weight (2lbs. in the first 10 days alone) which is a plus.I eat a 1/4 of what I used to before the Cymbalta. M 42 21 days
1/16/2007
 3  Depression Horrible loss of libido. I find that keeping an extra pair of underwear in the car a benefit. Never take for granted that it’s gas. I probably have 10 pit stops to the bathroom a day. Horrible diarrhea. My depression went away but my relationships and my laundry suffered. M 32 1.5 years
7/21/2006
 3  Major Depression Serious side effects, very unpleasant starting the drug, even more unpleasant stopping the drug!!! I am having a VERY hard time coming off the drug...I can't even move my eyes from side without becoming dizzy! I have never had so many unpleasant side effects from any drug i have taken. I would like to hear from other people on how to come off this drug...is it just with time? I have recently stopped wellbutrin as well, maybe too much too quick? Please if anyone can recomend some other medicine that is working for them...email me! If anyone just wants to chat about all this crap...plz email me! The drug was effective on my anxiety and did elevate my depression, BUT it in my case made everything OK...you and i both know EVERYTHING IS NOT OK!!! It is not ok to let the house go without cleaning to the point i will not let anyone in! It is not OK to just simply ignore anything that needs your attention, it is not ok to just to curl up and sleep through the weekend! I mean excessive sleep is one problem i want overcome, But with this drug, it's ok...Hell most everything is ok!!! This probably has it's place in some peoples treatment, but with me, it's not a good thing. M 48 6 months
1/21/2007
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 3  Major Depression, Social Phobia,GAD INTENSE HOT FLASHES, PROFUSE SWEATING, particularly severe with stress and when too hungry - can get to the point of soaking, dripping sweat, soaked clothes, bed, chair, car seat, total embarrassment, happens worst at most inappropriate times. No one seems to understand why this happens, so embarrassing, even family mystified. It seems only a VERY TOXIC drug would have this side effect. Now, after 9 months, constant dull (sinus) headache, constant insomnia, caffeine intolerant (1 cup coffee = heart pounding, headache, agitation, uncomfortable for rest of day), 3 months ago weight started increasing, now 40 pounds heavier! Isolating, fuzzy headed, poorer concentration now 9 months after switching to Cymbalta, time to switch back or on to another SSNRI/SNRI or hopefully, maybe, something better!?! Effexor was on a similar uncomfort scale to Cymbalta for me, increased blood pressure, hot flashes/heat, sweating. Cymbalta, however, has decreased ability to orgasm much less than Effexor or Zoloft, Paxil caused much worse (totally intolerable) headaches. Cymbalta has helped with depression, but I've had better success with much less, unpleasant side effects from other medications, and soon I will be switching back. PLEASE - be careful with Cymbalta and all other SSNRIs/SSRIs, report all side effects, withdraw VERY SLOWLY - dizziness, "brain zaps", blackouts are inevitable result of withdrawing too quickly from all of this class, ONE MUST SHAVE PILLS DOWN BY CRUMBS IN DECREASING DOSE OVER LONG PERIOD OF TIME WHEN WITHDRAWING, A MG. AT A TIME - IF THIS IS NOT FOLLOWED CLOSELY, DANGEROUS AND UNPLEASANT WITHDRAWAL SYNDROME (SEROTONIN SYNDROME) RESULTS, AS SO MANY OF US HAVE REPORTED AND ARE FAMILIAR WITH!!! Please be careful, good luck, and good health. M 36 9 months
1/6/2007
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 3  anxiety restless sleeping / logs of waking / vivid dreams / trouble staying still / exhaustion during daytime M 40 30 days
4/18/2007
 3  Severe Depression Mild weight gain, excessive sweating, lethargy - if I forget to take a dose I feel like there is electricity running from my brain down my arms It has been just OK. In the beginning it was really good but about 3 months in it started being less effective. I didn't have the weight gain like I did on Zoloft. I'm worried about withdrawal when I stop taking it because if I forget to take it for a day I feel completely out of it. And I have major "brain zaps". I so wish I could take Wellbutrin (I'm allergic to it) because that drug was the best one for depression! M 29 9 months
10/17/2006
 3  Depression and Anxiety Nighttime sweats some sleepiness during day I have taken many antidepressents over the years (prozac, paxil, wellbutrin, lexapro). Am currently on 60mg cmbalta (up from 30mg first two weeks) and am weening off 40 mg prozac). No major effects yet. Am hoping this will address my ongoing depression and anxiety (since October). M 39 14 days
2/28/2007
 3  depression hair loss and weight loss M 6 months
2/12/2007
 3  anxiety, migraines, back pain dizziness, headache, increased sweating, vivid dreams, jaw clenching, freezing cold after I went from 30mg to 60mg, can't sleep at night for more than 2 hours, helped with the back pain for the first 2 weeks on 30mg then the pain came back moved up to 60mg for 2 weeks and had more headaches and lack of sleep This is the only medicine I took for 1 month. This worked GREAT for the first 2 weeks at 30mg, then it just stopped working, moved up to 60mg for 2 weeks and felt worse, can't deal with the lack of sleep since I have 2 small children to take care of. Going through withdrawals for 2 days, very dizzy, headache, feel cold then hot, angry (which isn't normal for me). :~( M 30 1 months
7/15/2007
 3  Leg Paim (MS) At first loss of appetite, fatigue, sleepy, and after a few weeks I felt like I had a lump in my throat, swallowing all the time and burping , had to clear my throat all the time, seemed to open my sinus completely open felt like I had water in my ears, and ears ringing. Plus a few other minor things. I am glad that I found this web site, when I went to the Doctor a told him about my throat and how I was always have to keep swallowing which caused me to burp alot and clear my throat, He said I never heard of that before. I told him about this site because he seemed dumbfounded about things I had told him. Most side affects subsided except for the throat problem, worked great for my legs almost to the point of no pain but I could not stand the throat problem. I wish I could keep taking it because I cant seem to find something else and keep my mind on my work. M 45 4 months
5/15/2007
 3  Depression Kind of like a lsd trip so far, dilated pupils, confusion, sensitivity to noises, light trails, sleep loss, Jaw clenching, short attention span, sweating, small hallucinations M 20 3 days
5/24/2007
 3  severe depression NAUSEA, horrible, horrible stomach issues , cold sweats and jitters. all of this happened starting the 1st day of treatment.Hope they will go away soon. M 2 days
10/17/2007
 3  Pain/Nerve Damage Weight Loss (40lbs.). Loss of appetite. Abdominal pain. Diariaha. Headaches. Dizziness. Nausa. Very recluse. No social life. Pain/Nerve damage symptoms reduced. Very calm/mello. M 49 2 months
11/8/2007
 3  Headaches ocassional somnolence but what corries me really is I cant orgasm. I have a lot of sexual appetite but can't orgasm. Soes it go away?If anybody has gotten the sexual side effects and they have gone away please let me know. Or is it the only solution to change medication? M 34 3 days
8/20/2007
 3  Depression and anxiety Initially, I had constipation. When I tried to get off of it the first time, I had severe electro-shock tingling in my head, and thought I would go crazy. I have had suicidal thoughts too from time to time. I would use caution when using this drug or even when your doctor recommends it. My withdrawl symptoms where so severe that I am scared to stop taking it. M 37 6 months
10/4/2007
 3  depression M 12 days
10/31/2008

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