CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  Muscle pain in my neck. Headache's, dry mouth This drug will cause you to gain weight and keep it. I gained 20 lbs. and sometimes I'll only eat one regular meal a day, two at the most with no snacks. I'm going to wean myself off of this drug because of the cost. ($160 a month) This is a drug that you have to wean off slowly because of the withdraws (ringing in ears, and it makes you feel weird) M 44 5 years
60 1X day
10/22/2011
 3  depression weight gain , insomnia tired of pills M 43 60 days
30mg 1X day
10/19/2011
 3  Depression Emotionally Numb, Aggression, No Concentration, No Motivation, Excessive Hunger, Weight Gain Starting was tough, 1st 2 weeks were morning doses. Yawning constantly, Moving eyes caused a sensation I can describe only as a brain shock. Yawns were almost climactic, felt like I had run a marathon. The shakes and nightmares were horrible. Night doses helped, except the sexual problems, keeping aroused was almost impossible. 6 Months: Things settled I thought 'I Love Cymbalta',Something finally worked. 12+ Months: Started to notice how I just 'Couldn't be bothered' to do so many things. I was a Gym Junkie, extremely fit and energetic. The desire to eat now rules me, I have gained so much weight and i cant stop. 2 Years: I have changed. Home life fine, wife and I doing great but I am getting horrible mood swings where I just snap, aggression kicks in and I make no sense. I don't hurt anyone other than myself, but I need to smash something and scream. I have no regard for my wife's feelings. This is NOT me, it is scaring me and is getting more frequent. My concentration is getting worse which is making my work suffer (software developer), I am so tried though mostly sleep well, I don't seem to care about anything and thinking things I shouldn't. Cymbalta? I think so, I always felt like I handed over a little bit of control when I started taking it and now I think it is taking more. It gripped me like no other drugs had, and I have been on many. I want off this drug and have made the appointment with my Dr to hopefully get this under way but I am terrified. M 32 2.5 years
60 MG 1X day
10/23/2011
Email
 3  Anxiety Some sleep disturbance the first week, weight loss I was surprised that there were so few side effects with this medication (I reacted horribly to Effexor). I am not sure I am getting much relief from the anxiety but I am going to keep trying for a few more months. An added benefit has been that it seems to have increased my metabolism. I have lost weight but maintained by normal appetite M 35 3 months
60mg 1X day
1/3/2012
Email
 3  Clinical Depression - PTSD Nausea, brain-zaps, ED, extreme malaise and apathy, debilitating tiredness, muscle and joint pain, memory and concentration issues... Traded the dreaded Effexor for alleged wonder drug, Cymbalta. Since they of the same ilk, the transfer wasn't too bad. Actually worked okay for the first 9 months (hey, doctors don't have a clue how all these drugs work but they dole them out to millions of us guinea pigs every day) , then everything turned bad: I became so depressed that I wrote my goodbye letters and picked out a spot to park my car where I wouldn't be disturbed once I stuck the hose from the exhaust into the window; I had trouble concentrating on driving and had a rear-end collision; having never been a great sleeper, I began waking up 30-50 times per night so I was constantly exhausted; lost the little that was left of my libido; experienced extreme pain in my muscles and joints... Tried changing the dosage and experienced the worst depression in years... I was looking forward to ending the pain through suicide, I experienced fits of rage at nothing in particular (except my desperation)... it was a full on Dr. Jekyll and Mr. Hyde transformation and very, very scary... I'm now at 120 MG A DAY OF THIS S%*T... THIS STUFF IS EVIL... but so are all the other dozen AD's I've tried over the last 30 years.... is the cure worse than the disease... that is something each of us has to decide for ourselves… M 60 1 years
60MG 2X day
12/12/2011
Email
 3  Rage/Anger/Inpulse Control Bear in mind that i have been taking Remeron for 11 years, and had to add Cymbalta 2 years ago because I had been experiencing rage/anger (my dr. called it 'impulse control'). It worked for the rage. Get occasional dry mouth, and have had palpitations for over a year. Also began having difficulty sleeping, but I don't know if it's because of the Cymbalta or not. Hmmmm. My memory has gotten really, really bad. Need a change (from Remeron + Cymbalta), or maybe from my other medications (too many to list). M 53 2 years
30/60 1X day
5/28/2012
Email
 3  Clinical Depression Increased Blood Pressure. Took water pill for years for BP. Due to Cymbalta, I had to take Lisinopril too. 9 months on Cymbalta along with 1 month with Lisinopril meant dizziness and still BP that was too high. When standing up my BP would drop quite a bit which caused dizziness. Cymbalta seemed to work otherwise, but high BP had to go. I quit Lisinopril and am weaning from Cymbalta to Prozac. Never tried Prozac before. M 53 9 months
60 MG
6/16/2012
Email
 3  back pain WEIGHT GAIN!! sweats I have been taken cymbalta for back pain, 30 mg did nothing for me however the 60 mg helped for about 2 months. I gained about 20 pounds!!! Horrible!! The fat on my stomach sure can not be good for my back!! I wanted off of it. So I decided to stop. BAD IDEA! DO NOT GO COLD TURKEY! I was so sick the 3rd day off of it, felt like I had the flu. I immediately took it again and called my doctor. My doctor brought me down to 30 mg every day for 2 weeks and then every other day. The only side effect now is heart palpitations, which is just annoying. I still sweat like crazy. Hoping that will go away soon and hopefully I can loose this weight I gained! M 53 7 months
60 mg 1X day
7/27/2012
 3   About a week into Cymbalta, I stopped ejaculating. i still have a fairly active libidio and can achieve several erections in one night, but after hours of stimulation, nothing, nada, zilch. it was prescribed for nerve pain, whici has abated some, but not nearly enough to make this worthwhile. M 62 1 months
10mg 1X day
6/23/2012
Email
 3  depression Gave me midnight insomnia. Would fall asleep for a few hours, the stay awake anywhere from 1-4 hours. After 6 years I got off the insomnia. In less than a month, I developed insomnia for the past year. I am convinced it was caused by this drug. M 58 6 years
60 1X day
10/8/2013
 3  Chronic pain Side effects include - Periodic sweats Severe muscle twitches - 200 - 500 +/day-night 24/7 Did not help with pain...helped with depression feelings very well but side effects were too much. M 50 90 days
3o mg 1X day
2/20/2013
 3  Chronic pain Headaches, dizzyness and sleepiness Very difficult to come off- lots of unpleasant withdrawal effects even when reducing by 10% every 2 weeks M 25 12 months
60mg 1X day
1/3/2013
 3  Depression, Anxiety, fibromyalgia M 52 3 weeks
30mg 1X day
2/20/2013
Email

Patient History
 3  anxiety jittery, rigors, loss of appetite, dry mouth M 7 days
8/27/2005
 3  Depression After 10 months, I've gained about 20 lbs and am feeling emotionally flat and unmotivated. I don't feel extremely depressed but don't feel particularly happy about anything, either. I don't think it's related, but I started having blood pressure problems (for the first time in my life) a few months after starting. I've been on antidepressants for years and can't seem to find something that will remain effective for more than a few years. I feel a little jealous of all of the responders who have had more success with the medication. I'd be interested in hearing from anyone who has had similar experiences. M 53 10 months
5/3/2006
 3  Neuropathic pain Sleepiness during the day (I will fall asleep easily if I sit down during the day), yawning all the time, very vivid dreams, leg jerks, dry mouth/ bad taste during night, upset stomach (bloating/flatulance/bouts of diarrhea), difficulty reaching orgasm, but *much* more intense and longer lasting than previously when it happens. Am in two minds whethenr or not to continue - it really helps my pain a lot, but the side effects are quite severe. Worst is the constant sleepiness - keep nodding off all the time. I do sleep much better at night now - even though I keep waking, I used to sleep really poorly so this is an improvement (but I always wake with a horrible taste in my mouth). For the first month couldn't get an orgasm at all but after 4 weeks could manage it with a lot of effort. Now its easier and, after the effort, it lasts much longer than before and is an all over body feeling. Feels a bit tantric actually. My partner enjoys the extra length of time it takes too - though can be pretty exhausting after an hour so sex happens less then before since it needs plenty of time. Would actually really miss this now. Did stop briefly taking it because of the sleepiness but the pain came back big time. Am just hoping the side-effects will lessen in time. If not, will have to decide if the good outweighs the bad. M 46 3 months
12/12/2006
 3  BiBolar II Depression None - Maybe more Tired Rate it at a 3 M 64 180 days
4/1/2007
 3  depression , anxiety I have only been on it 2 days and I have this funny feeling in my head. I feel these weird brain sensations. Almost like needles poking my brain. I am also on concerta, but am trying the cymbalta for depression. These are the weirdest side effects I have ever fealty. Almost feel like electricity is tuning through my body and I am real jittery. Will this go away? Has anyone else experienced this? Let me give you a brief history of the meds I have taken. I started having panicky attacks at the age of 18 and tried all the ssri's and was put on ativan as needed. The whole benzo road was a nightmare getting off, so I decided to just deal with the depression. Around 2003 my Dad was dying of cancer so I was put on valium and effexor. On top of that I was doing some heavy drinking and taking a lot of opiates. I became heavily addicted to opiates and finally tapered down with my doctor and have been off for 2 weeks. Now I feel like my life is wasted. When I was on the opiates I wasn't depressed but everything around me was falling apart. My doctor has me on concerta (which helps me focus at work), klonopin 1mg as needed for anxiety, bisoprolol (blood pressure) and now the cymbalta for depression. I just don't know if this is a good combo. The reason for getting off the opiates was to feel better, and now I just don't know what I feel. I just hope the cymbalta works because the side eff M 26 2 days
4/5/2007
 3  Severe depression and anxiety First day (30mg) sent my anxiety through the roof, had my first and only panic attack. That tapered off over 2 weeks, then has improved for the most part since then. Still having trouble sleeping well through the night (early wakening, vivid strange or scary dreams). First couple weeks I was sleeping 3-4 hours, but usually had plenty of energy through the day. Occassional dry mouth. Trouble reaching orgasm, somewhat painful orgasm. Has helped the depression, though I'm down the last few days. It's not the cure-all, I definitely need to be more careful with lifestyle, over-doing it, and keeping on my psychotherapy. First drug I've taken. Can't decide if I will really "get over" depression. M 35 6 weeks
2/23/2006
 3  depression/anxiety After being on Lexapro for about 6 months, am now taking Cymbalta. Have noticed significant weight gains, 30 pounds in about 3 months but eating habits have not changed and working out twice as much as I used to due to increased energy. About ready to get off of Cymbalta if weight stays on. Anyone else have this problem? M 42 4 days
12/5/2006

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