CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  Fibromyalgia Pain Sexual Side Effects such as inability to orgasm or have sex for prolonged periods of time. Weight gain at first which subsided over time. Pronounced hair loss. I was virile until I started Cymbalta. Erections were rock hard and hair was thinning, but was not bad. Two year later, It's hard to achieve an orgasm or even become erect at times. It's hard to ween off Cymbalta, as well. I take this with Lyrica to help with nerve damage. Both work well when combined for the pain. Sex drive is still there, but I need to take Cialis or Viagra to be a rock star in the bedroom again. M 43 2 years
30 MG 1X day
2/6/2010
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 4  anxiety and depression Like most drugs of this type, there are side effects when first starting such as insomnia, tired feeling, sweating, and these can be bothersome. Believe me they do go away after a week and it is definatly worth hanging in there. I was on this med for 2 years and foolishly decided to stop. Without noticing, I fell back into a major depression. See additional comments. I just restarted Cymbalta after being off of it for 6 months. I started using 60mg per day almost 2 years ago for anxiety and slight depression. Wow I had no idea how well it was helping me until I stopped taking it. Within a month, I went into a severe depression. I tried starting Cymbalta again, but developed annoying side effects. I tried 6 other SSRIs and had the same trouble. I thought I was going crazy. My Dr could not figure it out. He knows me and was shocked that I had become so severly depressed and intolorant to everything. I had always taken Xanax as needed for Panic, and even Xanax stopped working. Anyway, Dr prescribed Lyrica which is rather new for depression, and although it slowly helped, I developed a rash from it even at a low dose. He next tried Lamictal, and after tapering up for over a month, at 150mg per day I was feeling slightly motivated to leave the house, but the med made me short tempered, nasty, did not help anxiety and the crazy side effects like acne, weight gain, mouth sores etc. were not worth the benefit. The worst part of Lamictal was how manic it made me. I think Lamictal is probably great for Bi-Polar disorder, but I am not bi-polar. Anyway, Out of desperation, I decided to force myself to deal with the side effects of starting the Cymbalta again. The first night was hell not sleeping, stomach ache, dizzyness blah blah. I am so happy to report that after a couple of days telling myself, Just deal with it, I am starting to feel great again M 41 5 days
30 mg 1X day
2/28/2010
 3  Neuropathy Side effects included dry mouth, weird dreams, total personality change from grouch to happy all the time. Until recently did not realize that my sex drive increased almost to an addiction. For the neuropathy I had to change to the 60mg per day because the insurance woul not pay for 2 30 mg. The 2 30mg were working pretty good but the 1 60mg was not working as well. Doctor changed me to 2 60mg a day and that put me over the edge. My sex drive was making me become a nymph and I ended up having sex in my office. Got caught and fired. Be cautious if you are starting this pill about the hidden side effect of thinking you can do anything. The happy feeling all the time was great but now after all these years of working to loose a job and damage you mariage is not worth it. It did help the pain in my feet. Currently being weened off of it. M 64 370 days
30 2X day
2/17/2010
 3  Anxiety nausea, slight headache and sweating. I understand this is just the first day. I wasn't sure I could deal with the nausea but it seems to be getting better as the day goes by. I have noticed a great deal of alertness with me throughout the day and full of energy hopefully this will continue. I will respond back after a few more days. VERY worried about Weight Gain! M 39 1 days
30 1X day
3/5/2010
 3  FM/CFD/fibromyositis/dystonia hallucinations, loss of appetite, night sweats, night terrors, horrible after taste, etc... Eventually subsided. (Thank God!) Doctors haven't really figured out what type of pain disorder I have. However, Cymbalta has been helpful. At first, it was a NIGHTMARE! Getting used to it was difficult. I stopped taking this medicine 4 times, when my doctor told me I had to take for at least three months in order to effectively rule it out as ineffective. Took it for a while, and it proved to be helpful. Last time I visited Johns Hopkins, the dr. decided to increase from 60 mg to 120. Now that I'm used it, the side effects have subsided. M 30 1.5 years
60 mg 2X day
5/19/2010
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 3  anxiety/depression anxiety, drowsiness, insomnia, chills, loss of appetite, sweating, cloudiness, memory loss Over the last 6 months I've experienced the separation of my parents after 38 years, life-threatening surgery for my mother, first death of a family member and extreme job dissatisfaction. The collection of these events have made me pretty depressed and anxious. My relationship with my fiance has really taken a blow as a result of these occurences. I began seeing a therapist a couple months ago, but I wasn't feeling the effectiveness. I decided to reach out to my physician for information regarding medication treatment. He prescribed Cymbalta, which I've been on for the last 4 days. It's been pretty horrible, thus far. I've been anxious at times, paranoid, very drowsie, sleeping for no more than 3 hours per night, loss of appetite, sweating, very cloudy thinking, forgetfulness. I'm toughing it out for another couple days, in hopes that my symptoms improve. Wish me luck! M 28 4 days
30 MG 1X day
6/11/2010
 3  depression dry mouth,insomnia,anxiety it only somewhat works,i still need to take buspar to help relieve residual anxiety M 38 5 years
120mg 1X day
4/19/2010
 3  Depression and anxiety Decrease in Lidido, Difficulty in ejaculation; Increase in sweatiness I wish they could develop an anti-depressant for men that doesn't strip your libido, or make it difficult to orgasm. That is my BIGGEST complaint with Cymbalta. Despite it being one of the newest on the market, this side effect is something that the makers of Cymbalta can't seem to eliminate from their product. On the positive, Cymbalta has helped me with my anxiety. I no longer get butterflies in my stomach. It has helped my depression about 60%. Would I recommend it to another man? Depends how much they value their sex drive. M 43 1.2 years
60 MG 1X day
5/4/2010
 3  Nerve Pain extreme anger, hate, and rage, nightmares, daily suicidal thoughts i have to take it, i don't have any other choice at the moment, and i'd rather be hateful than live with all the shooting nerve pain through my body. M 31 8 months
60mg 1X day
4/16/2010
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 3  depression, GAD, DOC. HUGE costipation, somnolence, loss of libido. it seems to be uneffective to me. I completely had to change med to stay well al least of my real state. i don't recommend it. M 23 1 months
60 mg 2X day
4/21/2010
 3  Neuropathy Acute loss of interest in sex, inability to reach climax - no sensitivity, mild constipation, dry mouth, uncontrollable yawning Seems to help some with neuropathy, although it doesn't completely ease the pain and burning sensation. The first time I tried it, I got very nauseated and stopped taking it, but decided months later to take it with food and didn't have that problem again. Will probably stop taking it and go back to neurontin because of sexual side effects. M 65 3 weeks
30 mg 1X day
6/16/2010
 3  depression at first none felt great after approx i week got this foggy feeling, always tired, have a not care to do any thing attitude this is my second time on this first time quit cold turkey not to may problems other than those silly brain zaps. this will be my second and last time taking after one day i feel 100% better hopefully tommorw will be the same M 43 30 days
30mg 1X day
7/10/2010
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 3  Major depression I get brain buzzes, headaches, and cannot sleep. Major Depression has been helped but still have anxiety and panic attacks and days when I feel just simply not motivated. Not sure on this one M 42 6 months
120 1X day
7/13/2010
 3  Depression - extremely suicidal Inabailty to orgasm, insomnia, migraine headaches, jaw clenching, feeling 'wired' and speedy. I found the drug very effective at lifting my mood and removing depression. I also found it made me feel more empathetic and connected to people, something i had not felt for a very long time. I found that once the initial start up dose of 30mg was increased to 60 mg, I suffered from migraines for a period of time. Eventually these went away. Also i found it very difficult to orgasm. This actually became worse the longer I was on the medication, and in some ways the only way to have orgasm was to stop taking the medication for a day, then wait till the next day to have orgasm. I also began to find it really hard to sleep, and also felt too racy and speedy. I have recently stopped taking cymbalta - even though the +ve on mood and disposition were very good, I found not being able to orgasm, sleep etc were making me want to stop taking the drug. Since stopping, I definately am struggling again with mood, and disposition... I may try another type of anti_depressant... I'm not sure yet though. M 35 5 days
60 1X day
8/28/2010
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 3  GAO Nausea, dry mouth, loss of appetite Has already started helping with my anxiety. Involved in very stressful situation last night and felt very calm throughout. I weighed myself and have already lost one pound in just 2 days from loss of appetite. It's the weekend though, so I'm concerned about the nausea during work hours. M 39 3 days
30 1X day
8/22/2010
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 3  Fibromyalgia Nausea, yawning, and sweating. The first two side effects went away after 2 weeks. Chronic pain from FM went away within 2 weeks. My doctor tapered me off from 90mg to 0mg within 2 weeks. The first day completely without Cymbalta was the day when hell opened up for me. I am a happy, laid-back and healthy person (besides FM), but I felt as if I was posessed by something evil and insane. It was the worst thing I ever experienced in my life. My doctor said I might get brain zaps, but what I experienced was waayy beyond that. A constant feeling of absolute horror and severe anxiety. Terrifying nightmares. If I would have known that, I would never have started taking Cymbalta. M 40 2 years
60+30mg 2X day
11/9/2010
 3  severe depressive episode ringing in ears, constipation, apathy, reduced libido went cold turkey for a week....was HELL, need to be on it now because am suicidal, if i get through this not looking forward to withdrawal M 37 5 months
60 2X day
9/15/2010
 3  nueropathy & depression severe bouts of short term memory loss, inability to think of words , near total loss of libido, bouts of sudden onset sweating, frequent urination the "have to go NOW! kind. recent dramatic weight gain, wired lethargy if that makes any sense, developed high blood pressure since starting cymbalta too.... plus more but that's enough, right? Cymbalta works amazingly well for my at times crippling nueropathy. It also helped greatly as I began to suffer from depression which I'm not inclined is Cymbalta induced (why would it work well in treating the same thing it caused?) I am prone to ever increasing instances of an inability to think of a word or name that in the past would have rolled off my tongue with ease (now I'm often resorting to ridiculous sounding multi word phrases in place of the word or name. I'm at this site now looking for something that might replace cymbalta before I morph totally into some pathetically forgetful, sweat drenched, morbidly obease cymbalta victim that even my wife can't love anymore! Oh and for anyone interested I am also on daily pain meds (methadone), also NSAID as needed, Provigil for years because I get so lethargic I tend to do nothing, BP med now, and the wonder cure my doc recently instructed me to try for HORRIBLE cramping (legs and feet mostly) MAGNESIUM and Calcium w/vit D suppliments. This worked immediately for not just myself but also my wife and motherlaw that also suffer from these ...try it if you have the problem! Now I don't dare forget taking it every day! Seems if I do I WILL have a major cramp episode ..did everyone but us know about this? I can't believe such a simple fix has not been common knowlege! I guess there are differnt causes for cramping so it probably does not work for squat for some ...but 3 for 3 sugggests there is a BIG percentage of suffere M 56 3.5 years
60 1X day
11/7/2010
 3  Major depression Loss of interest in sex, severe memory loss, inability to ejaculate, need to urinate frequently and immediately, nervous leg, severe withdrawal when I forget to take a dose on time I'm on a combination of meds - Cymbalta, Abilify, Seroquel, & NAC for depression, Vyvance for ADD, and Metformin, Simvastatin, Fenofibrate, & Diovan for the diabetes from the meds I've taken over the years & the blood pressure is caused by the Cymbalta. I think the meds work okay, but quite frankly, I'm prepared to say that they aren't all that great. Since my suicide attempt in late '09 I've started using MMJ and I go in for regular shock treatments every 8 weeks. Now those two things have been very effective. I've given up alcohol (I never drank that much), and the benzo's the psychiatrists were prescribing, and I don't take/need pain killers anymore I don't live in agony any more and I rarely think of suicide. I've been chronically depressed since I was a teen and it has worsened over time. I told you all of that to tell you this. I'm afraid to stop taking the anti-depressant cocktail I take even though I doubt that it is that effective. Even one day without Cymbalta brings on pretty severe depressive symptoms. Some of that may be because I'm on such a high dose although I've been on as high as 180mg a day for a few years. If I had it to do all over again, when it seemed clear that medications were only marginally effective I would have added MMJ and if it didn't improve, I would have gone to ECT (the PC term for shock treatments) much earlier. If nothing seems to be working for you, consider ECT and MMJ. There is hope. Really. M 53 6 years
120 MG 1X day
2/20/2011
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 3  Depression Oversleep, flat, unemotional feeling. No weight difference. A few nausea spells initially with vomiting. After initial side effects, not much I don't know how to feel about this drug. It is my first anti-depressent. I started taking it for a month and I felt great; but i needed to sleep way too much. I went off it, and felt fine for a while, but then hit a low as I had never had before. I am back on it now, and it seems to be working in a sense. But I don't feel much of anything at all. Cognitively better, sleeping too much can be a problem. Tough to gauge. M 20 4 months
60 1X day
4/5/2011

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