CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  Depression / Anxiety Flat affect, drowsey, sweating often through the day and loss of libido. I have been depressed for many years and only recently looked for help. I have been on just about every med since trying to deal with it. I am now on 90 mg of Cybalta, 300 mg Welbutrin, and Zanax prn. They tell me the welbutrin helps with the lidido and it seems to. I do laugh more and have more fun. I still have no interest in socializing. It has been less than 2 months, so I will wait a couple months to see how it works. M 49 45 days
8/21/2005
 4  depression the usual: initial sweating and sexual difficulties/innabilities. One thing I havent read much about that cymbalta definetly caused/aggrevated was difficulty to urinate! It literally cut my frequency down to 4 times a day - even when i felt 'somewhat full' I couldnt go without difficulty. THIS WAS HUGELY IMPROVED WITH WELBUTRIN XL. Ask your doctor about combining Welbutrin XL with cymbalta. Within two days - I could use the restroom like normal and sexual drive/ability to 'O' was almost normal (still difficult but nowhere NEAR how it was). Am on 120mg cymbalta and 300 welbutrin XL. I cannot emphasize what a side-effect improvement adding the welbutrin was!! M 31 6 months
10/25/2006
 4  Depression/ Bi Polar DO The first month was terrible. Nausea and loss of appetite to the point where I ate almost nothing for 3 weeks. I slept most of the month. Gradually things got progressively better. This is a great medication minus the withdrawl symptoms (sweating,brain zaps, dizzyness). It has definitely changed my life for the better. I was very suicidal before and now it's an almost irrelevant contemplation. Like any medication, it takes some getting used to. I read some comments on this page and have had some similar side effects. Increased sex drive, hypomania, vivid dreams, increased orgasm (oh yeah!!!), i have become more aggressive than I was in the past. The bad part about this drug is the lack of creativity in my work being replaced with compulsiveness, i'm very verbally and could be physically agressive, i have to watch my behavior a lot of the time. night sweats (actually waking up drenched some nights), if i miss a dose the effects are very noticable,...i missed it for three or 4 It's Jan 29th now and I'm married, holding a steady job, i moved across the country, quit smoking, no drugs, rarely suicidal and most importantly very happy with my life and choice to stay on cymbalta. My advice is to tough it out during the first month. It can be hard and might be even harder for you than in my experience. You won't regret it. M 23 6 months
1/29/2007
 4  Depression/Anxiety Difficulty in reaching orgasm, a wierd sensation like that feeling you get just before you hit the top part of the first hill of roller coaster, sleeplessness, major decrease in appetite. I've been on a lot of different medications, and I was diagnosed with depression at a very early age. I took Cymbalta some time ago and it scared me because of the wierd feeling. But I'm going to try again. I guess maybe the wierd feeling is what most people feel normally. I'm not sure because I've never really been "not" depressed or anxious before. We'll see how it goes this time. M 29 2 weeks
1/3/2006
 4  Scizo-Effective Disorder This Is My Second Day On Cymbalta, But Yesterday I Could Not Go To Work Because I Was So Tired And Sick. I Have Not Had Any Mood-Swings, Depression, Or Stress Though. I Would Reccomend It M 24 2 days
5/17/2006
 4  IBS Felt really strange when starting Cymbaltia. Had major withdrawal when I stopped. Took for a year and it seemed to cure my IBS. M 34 1 weeks
5/24/2006
 4  depression, anxiety, panic Loss of libido, ringing/twitching in ears I felt very good, like myself again. No worrying all the time. Dr. took me off of it because of the side effects. Bad headache for two days after stopping it. M 39 1 months
12/11/2005
 4  depression, pain sweating, sexual dysfunction, insomnia, weight up, able to breathe better, pain way down, mood up, sex terrible 3+ months. to alleviate the sex side effects, have tried viagra, holidays, many others ... not much help M 60 120 days
12/18/2005
 4  Depression If I miss a dose I get dizzy. Sexual Side effect. Difficulty getting / keeping an erection. Dificlty obtaining orgasm. Worst symtom is hot flashes and night sweats. Has helped me better than Wellbutrin, Paxil, or Lexapro. Sexual Side effects are tolerable but the hot flashes and night sweats are REALLY annoying! But I tolerate because it helps the most with depression. M 40 1.5 years
8/16/2006
 4  Nerve pain in Back (Trigger Point) Loss of sex drive was the most pronounced side effect. Tired in the first 2 weeks, insomnia and dizzyness. Otherwise felt great. Have gone on/off the drug 3 times and not experienced significant problems. Very positive impact on pain - I have had chronic back pain for over 10years, this is the only thing that has worked. Positive change in overall attitude and stress. Only downside is the sex drive. M 33 3 weeks
11/7/2006
 4  Depression Worked pretty good. Made me rather irritable but when i combined it with tryptophan, my irritability went away. Only SSRI that didn't give me sexual side effects. (20-30 mg)After about 2 months on it though, i started developing this weird feeling in my head. Like a pressurized feeling. Anybody else have this side effect? I was pretty satisfied with its effectiveness and side effect profile. It also seems to work excellenty when combined with Tryptophan. M 21 3 months
9/12/2005
 4  depression headaches and nausea almost gone now This is my second entry. I am coming off of effexor and and now down to 150 mg effexor and 40 mg of cymbalta. I notice my mood is ok, my thoughts are clear and most of all I am not as tired which is the main reason I wanted to get off effexor. M 35 17 days
6/9/2006
 4  Concentration, slight depression Hypomania. Slight bladder pain when running. Higher heart rate when running. Exstreme loss of apetite (probably due to hypomania). Good for me, because I have Zyprexa and I gained 20kg) It is great, but I am slightly hypomanic, so that maybe doesnt count. It is a strong drug for major depresive disorder I am probably going to take just 15mg (split the capsule and fill another one). I can finally feel like a normal human being not thinking I am very bad and have no qualities whatsoever. I stabilise with Omega 3 in the evening to fall a sleep and of course Zyprexa. Allmost no side effects whatsoever. I am actually bipolar with psychosis and I dont want to take moodstabilasers, because I cant read when taking them. Good luck to all. M 24 6 days
9/18/2007
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 4  fibromyalgia & mild depression first week. On first day, burning down legs and feet so hot on bottom felt like fire. Nervous feeling in heart/chest area or upper stomach like getting ready for a navy jet launch. mood elevated. energy elevated. pain in gut on taking for an hour. i hope that pain is less, it seems so. M 60 7 days
8/2/2006
 4   Suffering major depression and severe insomnia. Within a week I was sleeping well again as it reduced my anxiety and panic attacks and took the edge off the depression.Side effects were low libido and uncontrollable body twitches at night and when resting. The Cymbalta really helped.It took me from wanting to die, or thinking that I would cut my legs off if it would ease my depression. I have now gone pretty much cold turkey after 5 years on it because I am not sure if I am still in a depressive frame of mind.Unfortunately issues causing the depression are still there.Withdrawal symptoms are headaches, dizziness, and crying at the drop of a hat. M 50 5 years
60 1X day
1/13/2013
 4  anxiety, pain, depression Heavy GI illness for 2 weeks, helps with anxiety and depression. Still dealing with chronic pain. Find that it takes 2-3 days to recover after a workout. I taker 30mg in am then 60mg @ night. Tried 60mg in morning and couldn't keep my eyes open. M 39 2 years
90mg
12/4/2012
 4  Depression and Anxiety I had insomnia problems before Cymbalta, the insomnia is maybe a bit worse now but I seem to have more energy during the day. I've tried a lot of different anti-depressants over the past 15 years (Prozac, Effexor, etc, etc) and for me Cymbalta has been the best one. After 2 years at 60mg my depression has just started getting a bit worse again so I'm thinking of aasking the Doc to increase my dosage to 90mg per day M 52 2 years
60mg 1X day
1/1/2013
 4  chronic lowback pain I started on 30mg 1x per day and felt very tired at first. After I got used to it I went to 60mg.Had some sexual side effects at first but they subsided. After 2 lower back surgeries for herniated discs I was in constant pain. Cymbalta helps take the edge off and reduces any nerve pain.Also makes me less afraid to go out and live my life and to stop focusing on my back so much. M 41 3 months
60mg 1X day
5/3/2012
 4  LBP (Lower Back Pain) Dry Mouth, Night Sweats Been taking Cymbalta for 2 weeks, started @30mg 1st week then @60 now. Back pain went from 6-8 level to 1-3 level. Very happy about that, am able to function in all areas. Concerned about the long time effects concerning sexual reactions. I already take 3 blood pressure pills (for 11 yrs) to keep my #'s low. prior to Cymbalta M 43 2 weeks
60mg 1X day
3/22/2012
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 4  Low back pain and depression I have not had any side effects and hope I won't. So far it has lessen my low back pain and made me more connected with life. Started 30 mg for 15 days before going to 60mg and it has worked fine. M 30 3 weeks
30mg/60mg
1/30/2012
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