ZONEGRAN Reviews (ZONISAMIDE)

Average Rating: 2.9 (90 Ratings)

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 ANTICONVULSANTS

 Type: Rx Drug

  

ZONEGRAN  (ZONISAMIDE):  Zonisamide is used with other medications to prevent and control seizures (epilepsy). Zonisamide is a sulfonamide anticonvulsant and a carbonic anhydrase inhibitor. It is unknown how zonisamide works to prevent seizures.   FDA Approval Date: 2000-03-27 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on ZONEGRAN: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR ZONEGRANCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  Migraines The only side effect I'm having is very vivid dreams. I wish I would have the lack of appetite/weight loss, but never have had that effect from this drug (this is not my first time taking it). Working for my migraines - right now, at least. Better than the Ajovy I was taking before, and the Trokendi before that. F 51 45 days
100mg 1X day
9/4/2022
 5  Epilepsy increased thirst, chapped lips, peeling skin, drowsiness, short term memory loss, stuttering, jerking of the limbs. Helped a great deal!!! No more seizures since I started taking it!! F 16 2 years
100 MG
1/30/2016
 5  Migraines Tinglingly and numness in hands and face causes an itchy feeling, Periodic loss of appetite or weird cravings, hot flashes/fevers , insomnia/weird dream,and somedays my brain doesn't think quite as well as it did I feel like a dingbat I was having 4-5 migraines a week I have had two since starting this med finally some relief the migraines I did Have were caused by very stressful days the day prior F 21 3 months
1/21/2016
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 5  Migraines slight loss of appetite, improved mood, less tired, less irritable, less headaches, less neck pain I feel like this drug has been a Godsend for me, my severe episodic migraines and chronic daily headaches were interfering with my life and work to the point that I was fearful I may have to go on disability. I was laying in the bed most all the time so tired and depressed fearful of another attack even when I didn't have a full blown headache. I took Topamax but had to unpleasant side effects. Zonegran and meloxicam have really made a difference for me. F 42 7 days
100MG 1X day
5/11/2015
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 5  Migraines So far so good. I have a little eye pain which is manageable but none of the crazy side effects I had with Topamax. Topamax caused tingling in feet so bad I couldnt walk, terrible memory recall to the point that it was affecting my job and just plain fuzziness in the brain. I also did not lose weight like a lot of people do so that is not a side effect that everyone experiences. I havent lost any weight with zonegran either but it is a low dose. I am also interested that a previous poster commented that it was helping her migraines on the right side. I also get all of my headaches on the right side and it appears to be helping so far. Just wondering if there is a coorelation. F 41 1 weeks
25
5/4/2015
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 5  Seizures I can function on this medication , my hair don't fall out, My speech is not bad , I am not confused.. I was even able to take it while pregnant and my babies are healthy F 38 5 years
200 mg
4/24/2015
 5  Myoclonic Epilepsy Extreme weight loss (20+lbs) in a short amount of time, loss of appetite, extreme nausea (particularly in am), irritability. These have gone away now that I have fully adjusted to the medicine. This took me approximately 1 year, but everyone is different. The nausea still shows up once in awhile but is bearable. Now all I notice is trouble recalling words (takes a little longer to find the right word). THIS DRUG IS NOT FOR EVERYONE! I was diagnosed with epilepsy when I was 8 years old and was extremely lucky to have an excellent neurologist/pharmacist team to help me find the perfect drug for me, which even still took 10 years. I have tried Keppra, which did not control the seizures, I have also tried Depakote, which the side effects were outrageous. This drug takes time to adjust to and find the correct dosage as any other drug, the difference is for me was the nausea. I can only assume it was because of the rapid weight loss that was occurring. I should mention one of the side effects of Depakote for me (the previous drug before zonegran) was weight gain, so I was approximately 40lbs overweight so weight loss was not an issue. *If you do not have extra weight to lose, this is not a good drug for you* It was the rapid drop that made it so difficult. This only lasted for about 3 months for me (until we found the correct dosage). One thing I wish someone had told me is to make sure to eat a healthy snack about 1hr- 2hrs before bed such as fruit. Also carry snacks such as granola bars or nuts. I never wanted to eat, but new if I ate even a few almonds it would make my nausea 10x easier to deal with. My nausea only lasted until I became acclimated with the drug (approximately 6m), my weight loss plateaued shortly after that. I have been the same weight since. I am a little concerned about the delay to recall the correct words. But as this is my only real side effect, for F 28 10 years
300mg 2x D
2/18/2015
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 5  Juvenile Myoclonic Epilepsy Increase in thirst, minor slurring of speech at times, weight loss, decreased appetite, occasional hot flashes. M 11 1 months
125mg
4/19/2014
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 5  Epilepsy I've been on this for 4 years now with minimal side effects and seizure free. I maintain a VERY healthy diet to keep the fatigue, headaches, and brain fog to a minimum but I also make sure I get plenty of rest as well. The odd thing is, I only just started loosing my appetite and lost 20 lbs. not sure if it's the RX. I also recently went off BC, so it could be a combo. But it's the weirdest thing! I've been on Keppra and Lamictal before and they both affected me poorly in the personality dept, so I'll take what Zonegran throws my way any day! F 29 4 years
300mg
4/3/2014
Email
 5  migraines Sleepiness, sometimes forget words, not sure if that is from medication. F 58 4 years
400 mg
8/6/2013
 5  epilepsy First few weeks insomia, hair loss , weight loss butt after few weeks all came back to normal I did not have any episode in 3 years. Love it. And now Im 6 month preggo. F 32 3 years
300mg 1X day
3/11/2010
 5  epilepsy dry mouth, tiredness, dizziness, weight loss, gum problems no seizures since taking this drug; 100mg in morning and 100mg in evening; dizziness disappeared after a few weeks; lost 30 lbs and have kept it off for over a year without any trouble just have a smaller appetite; play tennis everyday so obviously got over tiredness and sleep like a rock; drink 64 oz of water plus per day and have since starting this drug; very happy; glad my doc encouraged me to stick with it... F 48 16 months
11/14/2008
 5  migraines none Take 100mg every other night, can do this because this med has very long half life. Also makes it very affordable as a generic. Took a full 3 months to work for me but after trying Depakote, Lamictal, Topamax, Elavil with no help and many side effects love this medicine. Have been on it for 4 years and has given me my life back. I still have some symptoms from migraines and migrane syndrone but they are 80% better. My neurologist said making me 50% better would be a success. F 50 4 years
10/8/2008
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 5  migraine weight loss, increased thirst I am on 100mg every night. I have not had any side effects except for weight loss. This is the only med that has kept my migraines under control! F 27 1 months
3/18/2007
 5  Migraine 200mg at night. I took this drug before I went to bed. I had to sleep with the light on just until I fell asleep because of extreme hallucinations that haunted me. The hallucinations were so real too. I saw monks hovering over me... It felt like a salvia trip sort of. Besides this it works SOO GOOD for migraines preventative treatment. It works similar to Topamax just without the nasty, unbearable side effects. Topamax made me stupid, cold hands feet, speech problems, waking dreams and sleep paralysis. This works soo good for migraines without the nasty side effects. It made me lose a ton of weight too. I gained it back when I stopped taking it for a bit but that could be because of a few other reasons though. F 24 1.5 years
3/6/2007
 5  Epilepsy I feel dehydrated, which isn't so bad it makes me drink more water which is good for you and I have the muchies. Other than that I feel good, I have energy, I'm very clear headed. I like this stuff and so far no seizures, I hope it keeps up! F 34 1 months
2/23/2007
 5  Mixed Bipolar II/ADD None, except maybe a slowing of my thoughts. I've been taking 50 miligrams for quite some time. I didn't experience the weight loss that I thought I would, but it has really helped my mood and my organization! F 17 6 months
12/12/2005
 5  migraine on 50 mg at bedtime , Iam experiencing some trouble falling asleep.Itake it 4 hours before sleep and this helped relieve my insomnia.. really working great for migraines, and nothing else has, as a preventative.I have been on it one month.I usually experience daily headaches and take imitrex for them. I have only had 2 headaches since on zonegran. F 49 30 days
6/4/2005
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 4  Daily tension headaches I feel stupid, mental processing slowed way down and Memory loss. M 15 86 days
200mg 1X day
8/26/2020
Email
 4  Migraines/seizures Blurry vision, depression, brain fog But no migraines and has controlled seizures and my hair stopped falling out like it was on Topomax, it was falling out in clumps!! So I’m grateful for that Why is it I can’t ever have the good side effects like weight loss! Lol F 41 45 days
100
11/8/2019
  

ZONEGRAN  (ZONISAMIDE):  Zonisamide is used with other medications to prevent and control seizures (epilepsy). Zonisamide is a sulfonamide anticonvulsant and a carbonic anhydrase inhibitor. It is unknown how zonisamide works to prevent seizures.   FDA Approval Date: 2000-03-27 (Sources: U.S. Centers for Medicare Services, FDA)

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