ZONEGRAN Reviews (ZONISAMIDE)

Average Rating: 2.9 (90 Ratings)

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 ANTICONVULSANTS

 Type: Rx Drug

  

ZONEGRAN  (ZONISAMIDE):  Zonisamide is used with other medications to prevent and control seizures (epilepsy). Zonisamide is a sulfonamide anticonvulsant and a carbonic anhydrase inhibitor. It is unknown how zonisamide works to prevent seizures.   FDA Approval Date: 2000-03-27 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by Age from youngest to oldest (reviews with no age reported listed first).

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on ZONEGRAN: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR ZONEGRANCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  seizures Memory loss Stuttering incapable of speech dizziness angry depressed crying stomach aches diarrhea unable to eat no ambition to do anything this is a medication from hell I felt this way 24 hours a day for over2 years and was still having seizures all the doctors did was increase it milligram by milligram now I'm going through the side effects of coming off of it the same thing all over again if they offer you this run like hell find a new doctor they probably own a stock to all of you coming off of it I wish you well God bless The horrible medication they should take off the market it is almost like an illegal drug that drag you into it put you through hell to go on it and off of it this is the horriblest thing I've ever been on to everyone on it good luck I wish you well god bless you all F 1 days
600
3/2/2016
Email
 3  chronic daily headache minimal weight loss; Kidney Stone Was so disappointed! Took this drug for 2 months. At the onset it didn't seem to help, but after approximately 2-3 weeks my daily headaches were gone when nothing else had worked. HOWEVER, be sure to heed the warnings to drink alot of water so that you don't develop kidney stones - apparently I didn't drink enough because I developed a kidney stone. I discontinued the drug so that I won't have to go through that pain again! F 4 2 months
4/25/2008
 2  Epilepsy Extreme sleepiness ....very difficult to find words....slow thought processing.... has not yet helped with seizures going to continue for a while longer to see if side effects go away and things get better F 5 3 weeks
60 2X day
10/29/2013
Email
 1  Epilepsy Horrible vomiting which caused metabolic acidosis. The metabolic acidosis was almost not reversible and my son almost died. My son almost died from this drug. I found a 24 page document at the FDA that said the #1 problem with this drug (in adults during clinical trials) in the GI tract was vomiting. It was not mentioned in the PDR or the package insert. I found it on my own and told the doctor we needed to wean from it to see if the vomiting decreased. It did. My son almost didn't make it. This is not a benign drug. M 5 11 months
8/17/2005
 4  Epilepsy some loss of appetite, some fatigue, takes longer to take tests in school, some difficulty with math problems F 7 4 months
7/11/2005
 1  seizure My 8-year-old son starting taking Zonegran at 11:00 P.M. last Saturday. At 11:30 P.M. the next day he started becoming dizzy and disoriented. A half hour later, he fell to the ground and had a grand mal seizure. This lasted about 6-8 minutes. In the hospital ER, he had a severe headache and abdominal pains. My neurologist was not convinced it was the drug, but we disagree. My son at age 8 has never had a seizure without a fever--which places him as atypical, and this one was in the absence of a fever; however, he did have a fever the following day. M 8 1 days
25 mg 1X day
9/4/2013
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 5  Juvenile Myoclonic Epilepsy Increase in thirst, minor slurring of speech at times, weight loss, decreased appetite, occasional hot flashes. M 11 1 months
125mg
4/19/2014
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 4  Daily tension headaches I feel stupid, mental processing slowed way down and Memory loss. M 15 86 days
200mg 1X day
8/26/2020
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 1  Migraine Prevention Major weight loss, no appetite ,irritability, agitation, extreme sleepiness and tiredness, can't concentrate. Uti with kidney stones. M 15 2 months
75mg
1/9/2020
 5  Epilepsy increased thirst, chapped lips, peeling skin, drowsiness, short term memory loss, stuttering, jerking of the limbs. Helped a great deal!!! No more seizures since I started taking it!! F 16 2 years
100 MG
1/30/2016
 5  Mixed Bipolar II/ADD None, except maybe a slowing of my thoughts. I've been taking 50 miligrams for quite some time. I didn't experience the weight loss that I thought I would, but it has really helped my mood and my organization! F 17 6 months
12/12/2005
 1  rsd pain they just took me up to 500 mg aday i dont like it but what to do for pain they will not give out pain medswe will see how this go F 18 9 months
500mg
11/12/2012
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 3  epilepsy memory is just trash now this used to work great for me but after 3 years of working it just stopped and i had 3 seizures on it F 20 3 years
500 1X day
10/6/2020
 2  Epilepsy Weight loss for the first 3 months, consistent expressive aphasia (can't get the words out) and recall memory problems that became worse as dosage was increased. Skin rash at 500 mg/d. Ultimately didn't control the seizures so discontinued it. M 20 9 months
7/11/2006
Email
 5  Migraines Tinglingly and numness in hands and face causes an itchy feeling, Periodic loss of appetite or weird cravings, hot flashes/fevers , insomnia/weird dream,and somedays my brain doesn't think quite as well as it did I feel like a dingbat I was having 4-5 migraines a week I have had two since starting this med finally some relief the migraines I did Have were caused by very stressful days the day prior F 21 3 months
1/21/2016
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 3  Partial Epliepsy None really Started to take in 2004 after control with Depakote and Tegretol XR peaked. Helped for a while but has not totally cured the seizures; still occur approximately twice a month. M 21 5.5 years
200 Mg 2X day
2/28/2010
 2  headaches & seizures I was never hungry, It was very difficult to study concencentrate, and remember pretty much anything. Within 3 weeks after I went off it the first time I had my second seizure. I was on it for 5 months for my headaches, and it didn't help, so my neurologist switched me to another medication, when I had my 2nd seizure. I went back on it, and while I didn't have my siezures I had all of the same side effects, so it wasn't worth it. F 21 10 months
11/18/2008
 1  Epilepsy Slower mental processing; inability to find specific words in context, couldn't keep up in a long conversation with one person, forget my train of thought, reading became harder, an overall understanding what was going on or explain anything was hard. It helped stop my partial complex seizures but at the cost of slower mental processing. I will be going back to Lamictal. the switch occurred because we did not know that the other medicine I was on was a seizure stimulant so now hopefully I will be right back to where I was before zonegran came into my life and disrupted things. VERY dissatisfied. F 21 1 years
200 2X day
9/7/2015
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 2  Psuedo Tumor Headache EXTREME fatigue, slowed motor and cognitive function - forgetting words and the like, feelings of extreme panic after I take it, sleep paralysis/ horrible dreams. Haven't noticed any positives yet since it's only been 4 days, but at the rate the negative side effects are coming I don't think i'll make to a week. Worried the side effects will end up causing a schizo-effective episode. F 22 4 days
100mg 2X day
8/18/2013
Email
 4  migraines insomnia!!! (anxiety and nervousness when I got to 100 mgs, but both stabilized after a week) I have tried a lot of drugs, and zonegran has been the only one to get rid of both my killer migraines and those irritating little headaches. I don't sleep as much (or as well) as I used to, but I'll deal with that if I can be almost migraine free! F 23 3 months
5/19/2006
  

ZONEGRAN  (ZONISAMIDE):  Zonisamide is used with other medications to prevent and control seizures (epilepsy). Zonisamide is a sulfonamide anticonvulsant and a carbonic anhydrase inhibitor. It is unknown how zonisamide works to prevent seizures.   FDA Approval Date: 2000-03-27 (Sources: U.S. Centers for Medicare Services, FDA)

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