ZONEGRAN Reviews (ZONISAMIDE)

Average Rating: 2.9 (90 Ratings)

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 ANTICONVULSANTS

 Type: Rx Drug

  

ZONEGRAN  (ZONISAMIDE):  Zonisamide is used with other medications to prevent and control seizures (epilepsy). Zonisamide is a sulfonamide anticonvulsant and a carbonic anhydrase inhibitor. It is unknown how zonisamide works to prevent seizures.   FDA Approval Date: 2000-03-27 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by length of time drug was taken from shortest to longest duration (reviews with no time reported listed first).

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on ZONEGRAN: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR ZONEGRANCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  epilepsy since ive been on this med ive had loads of side effects like confusion, memory crap, processes info not as quickly/accurately, agitation, loss of consentration, cognitive slowness- mind seems to be elsewhere, forgets what im going to say when its in my head for a minute then its gone, less engaged in activities, feel like im in my own little world, someones speaking to me goes in one ear and out the other, weird thoughts and suisidal thoughts also im getting loads of abnormal/vivid dreams and they're really weird,sorry nothing to do with zonegran, im also on loads of other meds too, these have been working since ive been on them as i have grandmal sz and complex partial sz and the last grandmal i had was 14th august last year and last cp was on 9th february this year they come in clusters M 25
150mg 1X day
3/20/2019
Email
 3  neurological pain bad insomnia constpation M 39 30 times
3/8/2004
 1  seizure My 8-year-old son starting taking Zonegran at 11:00 P.M. last Saturday. At 11:30 P.M. the next day he started becoming dizzy and disoriented. A half hour later, he fell to the ground and had a grand mal seizure. This lasted about 6-8 minutes. In the hospital ER, he had a severe headache and abdominal pains. My neurologist was not convinced it was the drug, but we disagree. My son at age 8 has never had a seizure without a fever--which places him as atypical, and this one was in the absence of a fever; however, he did have a fever the following day. M 8 1 days
25 mg 1X day
9/4/2013
Email
 1  seizures Memory loss Stuttering incapable of speech dizziness angry depressed crying stomach aches diarrhea unable to eat no ambition to do anything this is a medication from hell I felt this way 24 hours a day for over2 years and was still having seizures all the doctors did was increase it milligram by milligram now I'm going through the side effects of coming off of it the same thing all over again if they offer you this run like hell find a new doctor they probably own a stock to all of you coming off of it I wish you well God bless The horrible medication they should take off the market it is almost like an illegal drug that drag you into it put you through hell to go on it and off of it this is the horriblest thing I've ever been on to everyone on it good luck I wish you well god bless you all F 1 days
600
3/2/2016
Email
 2  Psuedo Tumor Headache EXTREME fatigue, slowed motor and cognitive function - forgetting words and the like, feelings of extreme panic after I take it, sleep paralysis/ horrible dreams. Haven't noticed any positives yet since it's only been 4 days, but at the rate the negative side effects are coming I don't think i'll make to a week. Worried the side effects will end up causing a schizo-effective episode. F 22 4 days
100mg 2X day
8/18/2013
Email
 1  bipolar 2 Super anxious to the point of tears, hair falling out, very tired. Took this to replace Topamax, which worked wonders for me, but made my hair fall out. This does the same, but without the mood stabilizing effects. F 33 5 days
25mg 1X day
2/9/2010
 5  Migraines slight loss of appetite, improved mood, less tired, less irritable, less headaches, less neck pain I feel like this drug has been a Godsend for me, my severe episodic migraines and chronic daily headaches were interfering with my life and work to the point that I was fearful I may have to go on disability. I was laying in the bed most all the time so tired and depressed fearful of another attack even when I didn't have a full blown headache. I took Topamax but had to unpleasant side effects. Zonegran and meloxicam have really made a difference for me. F 42 7 days
100MG 1X day
5/11/2015
Email
 1  Migraines Worst drug I have had. Sent my heart rate through the roof, almost passed out in the shower multiple times, no appetite, very agitated, anxious and not effective. And started having involuntary movements in my hands, shaking. Continue to have very severe migraines It did not effect my depression but I am already medicated for that F 26 14 days
50mg 1X day
11/23/2020
Email
 2  High CSF pressure Left arm weakness and slight left leg weakness M 57 21 days
9/24/2009
 5  migraine on 50 mg at bedtime , Iam experiencing some trouble falling asleep.Itake it 4 hours before sleep and this helped relieve my insomnia.. really working great for migraines, and nothing else has, as a preventative.I have been on it one month.I usually experience daily headaches and take imitrex for them. I have only had 2 headaches since on zonegran. F 49 30 days
6/4/2005
Email
 4  migraine insomina and very hyper at first abdominal pain F 40 30 days
100 1X day
3/4/2016
 3  to prevent migraines so tired i was falling asleep at my desk. this never improved in the month taking it. i couldn't drink enough caffeine to wake myself up, so much caffeine it was creating digestion problems. as time went on i became more and more anxious on top of the grogginess, and some past anxiety disorders came up like phobias. i got really jumpy and was concerned i would have a panic attack. i haven't had these issues for 18 years but it was starting to come back. i would so much rather have a constant migraine than have the mental health issues i used to have and panic attacks. my doctor agreed i should stop taking it immediately. i've been off for 3 days but i'm still feeling tired and jumpy. i hope the anxiety goes away so i'm not preoccupied with past phobias (spiders, bugs). this sucks. unfortunately it is the only drug i've found so far that helps with my extreme light sensitivity, but i prefer light sensitivity, migraines, or any physical problem over anxiety disorders. F 35 30 days
25mg 1X day
8/11/2011
 5  Migraines The only side effect I'm having is very vivid dreams. I wish I would have the lack of appetite/weight loss, but never have had that effect from this drug (this is not my first time taking it). Working for my migraines - right now, at least. Better than the Ajovy I was taking before, and the Trokendi before that. F 51 45 days
100mg 1X day
9/4/2022
 4  Migraines/seizures Blurry vision, depression, brain fog But no migraines and has controlled seizures and my hair stopped falling out like it was on Topomax, it was falling out in clumps!! So I’m grateful for that Why is it I can’t ever have the good side effects like weight loss! Lol F 41 45 days
100
11/8/2019
 4  Daily tension headaches I feel stupid, mental processing slowed way down and Memory loss. M 15 86 days
200mg 1X day
8/26/2020
Email
 5  Migraines So far so good. I have a little eye pain which is manageable but none of the crazy side effects I had with Topamax. Topamax caused tingling in feet so bad I couldnt walk, terrible memory recall to the point that it was affecting my job and just plain fuzziness in the brain. I also did not lose weight like a lot of people do so that is not a side effect that everyone experiences. I havent lost any weight with zonegran either but it is a low dose. I am also interested that a previous poster commented that it was helping her migraines on the right side. I also get all of my headaches on the right side and it appears to be helping so far. Just wondering if there is a coorelation. F 41 1 weeks
25
5/4/2015
Email
 1  Bipolar II Extreme depression, nausea, loss of appetite, vivid, terrifying dreams, confusion, feeling of being very slowed down, felt like I was dying. Only took it for a week; the side effects were unbearable. F 37 1 weeks
4/20/2004
 4  chroic migraine preventative Just started this drug. Was taking Propranolol as a migraine preventative for about a year and a half which had stopped working for me and which I believe had caused a deep depression. Was reluctant to start zonisamide/zonegran because i thought it might work like Topamax which was a horrible experience - tingly hands, foggy thinking. So far Zonisamide is working well on keeping the chronic migraine pain on the right side of my head away and I my energy is beginning to come back. I am starting to feel normal again -- I also have a smaller appetite which I am going to take advantage of and really fix my eating habits. I hope this drug will continue to be effective for the chronic migraine pain. So far so good. F 46 2 weeks
100mg 1X day
4/26/2015
 3  Migraines Only slightly lethargic if I don't keep busy. I'm also feeling a slight ache in the back of my head, but I don't now if it's related to our drastic weather/barometric pressure change here lately or not. I was on Topamax for over 3 months and couldn't take the side effects. Two major ones being daily sinus pain/problems and sexual side effects. I started taking 100 mg the 1st week at night and now I am taking 200 mg also at night. F 33 2 weeks
6/28/2005
 2  mood stabilization Constipation, constipation, constipation. I only took it for about two weeks when the side effect got to me, so I don't know about any benefits the drug may have had. F 25 2 weeks
1/15/2007
  

ZONEGRAN  (ZONISAMIDE):  Zonisamide is used with other medications to prevent and control seizures (epilepsy). Zonisamide is a sulfonamide anticonvulsant and a carbonic anhydrase inhibitor. It is unknown how zonisamide works to prevent seizures.   FDA Approval Date: 2000-03-27 (Sources: U.S. Centers for Medicare Services, FDA)

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