ZONEGRAN Reviews (ZONISAMIDE)

Average Rating: 2.9 (90 Ratings)

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 ANTICONVULSANTS

 Type: Rx Drug

  

ZONEGRAN  (ZONISAMIDE):  Zonisamide is used with other medications to prevent and control seizures (epilepsy). Zonisamide is a sulfonamide anticonvulsant and a carbonic anhydrase inhibitor. It is unknown how zonisamide works to prevent seizures.   FDA Approval Date: 2000-03-27 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on ZONEGRAN: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR ZONEGRANCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Migraines Worst drug I have had. Sent my heart rate through the roof, almost passed out in the shower multiple times, no appetite, very agitated, anxious and not effective. And started having involuntary movements in my hands, shaking. Continue to have very severe migraines It did not effect my depression but I am already medicated for that F 26 14 days
50mg 1X day
11/23/2020
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 1  Severe migraines Severe mood swings deeply depressed Barry manic anxiety through the roof panic attacks loss of interest all I wanna do is stay in my bed very negative thoughts wanting to commit suicide .everything tastes weird Very shaky don't want to get out of my bed lethargic My migraines have stopped for the most part and I'm thankful for that but my mental status but I have to go through it's not worth it risking my life is not worth it it was probably one of my darkest parts of my life very very sad F 24 2 months
200mg 2X day
10/10/2020
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 1  Migraine Prevention Major weight loss, no appetite ,irritability, agitation, extreme sleepiness and tiredness, can't concentrate. Uti with kidney stones. M 15 2 months
75mg
1/9/2020
 1  Seizures Just don t stop seizures. Take 500 mg. Don t work F 60 3 years
100mg
6/1/2018
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 1  Chronic back pain Severe Anxiety, Depression(not normally depressed) Suicidal, Panic Attacks(never had before). Muscle tightness I'd be really careful starting this medication. It made me into someone I wasn't normally and almost committed suicide. Anxiety/Panic went away almost immediately when I stopped taking zonegran. My whole body relaxed when I stopped taking the medication. I tried this medication for chronic back pain from lumbar back fusion and cervical neck degenerative disk disease. F 42 3 months
100mg
5/19/2016
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 1  seizures Can't taste food it all tastes the same will it come back after time??? ;( feeling emotional but still early days may not be the Zonegran for emotions don't know! F 45 2 months
200mg
4/16/2016
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 1  seizures Memory loss Stuttering incapable of speech dizziness angry depressed crying stomach aches diarrhea unable to eat no ambition to do anything this is a medication from hell I felt this way 24 hours a day for over2 years and was still having seizures all the doctors did was increase it milligram by milligram now I'm going through the side effects of coming off of it the same thing all over again if they offer you this run like hell find a new doctor they probably own a stock to all of you coming off of it I wish you well God bless The horrible medication they should take off the market it is almost like an illegal drug that drag you into it put you through hell to go on it and off of it this is the horriblest thing I've ever been on to everyone on it good luck I wish you well god bless you all F 1 days
600
3/2/2016
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 1  Epilepsy Slower mental processing; inability to find specific words in context, couldn't keep up in a long conversation with one person, forget my train of thought, reading became harder, an overall understanding what was going on or explain anything was hard. It helped stop my partial complex seizures but at the cost of slower mental processing. I will be going back to Lamictal. the switch occurred because we did not know that the other medicine I was on was a seizure stimulant so now hopefully I will be right back to where I was before zonegran came into my life and disrupted things. VERY dissatisfied. F 21 1 years
200 2X day
9/7/2015
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 1  Migraines Weight loss, complete loss of appetite. Eating made me physically ill. Lack of food increased my migraines. Nightmares, anxiety, irritability, no energy, depression. F 35 2 months
300 mg
7/15/2015
 1  Epilepsy Weight loss, irritability, expressive aphasia, inability to focus or comprehend what others are saying at times, Sleepiness, Loss of appetite, depression I felt like I was going to just wither away and die if I continued taking this medicine. There was no hope if I continued it...it wasn't helping with my seizures regardless...I have absolutely nothing positive to say about this drug! It did nothing but make me look like a skeleton. F 29 7 weeks
400 mg 1X day
8/30/2014
Email
 1  seizure My 8-year-old son starting taking Zonegran at 11:00 P.M. last Saturday. At 11:30 P.M. the next day he started becoming dizzy and disoriented. A half hour later, he fell to the ground and had a grand mal seizure. This lasted about 6-8 minutes. In the hospital ER, he had a severe headache and abdominal pains. My neurologist was not convinced it was the drug, but we disagree. My son at age 8 has never had a seizure without a fever--which places him as atypical, and this one was in the absence of a fever; however, he did have a fever the following day. M 8 1 days
25 mg 1X day
9/4/2013
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 1  Weight loss, insomnia Have all but lost my sense of smell and taste. At first things tasted or smelled funny. Then I couldn't smell or taste at all. I am tapering down now since I have lost the weight and do sleep at night, I hate to think the sense of smell is lost for good! Prescribed Zonegran when I came off of Elavil. Needed to loose 20-30 lbs and sleep at night. I did loose the weight and have been able to sleep. But have a lot of anxiety and terrible problems with smell and taste. F 56 1 years
300 mg 1X day
6/22/2013
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 1  rsd pain they just took me up to 500 mg aday i dont like it but what to do for pain they will not give out pain medswe will see how this go F 18 9 months
500mg
11/12/2012
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 1  Migraine Prevention Increased Anxiety, Agitation, Difficulty Falling Asleep, Just Felt WEIRD. I was supposed to increase my dose by 25mg a week until I reached 100mg. At 50 mg, I began to feel agitated, edgy and snappy which is NOT like me at all. I already take Celexa for anxiety, and haven't had issues in some time. I had a mild panic attack today, and am stopping this medicine ASAP. Not much change with my migraines, and I hate the way I feel. F 31 2 weeks
50 mg 1X day
7/31/2011
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 1  bipolar 2 Super anxious to the point of tears, hair falling out, very tired. Took this to replace Topamax, which worked wonders for me, but made my hair fall out. This does the same, but without the mood stabilizing effects. F 33 5 days
25mg 1X day
2/9/2010
 1  Headache prevention Severe anxiety which led to rapid heartrate and high blood pressure. Was taking 100 mg/night, and the two days I tried 200 mg/night led to obsessive anxiety bordering on paranoia. Even 100 mg proved to be too much and I had to stop taking it. It also caused some mental "dopiness", i.e. I couldn't think what I was doing or trying to say. (A lot of "um, um" moments.) Unfortunately, it also did nothing for preventing my headaches. Even if it had, though, I could not have continued taking it. I was well on my way to a heart attack, stroke, or possibly even a nervous breakdown. F 38 2 weeks
10/23/2009
 1  migraines ~!~!~!~!~ANXIETY~!~!~!~!~!~irritability would be putting it mildly! I snapped at my daughter for calling my son a nickname I have called him in the past (so the name SHOULDN'T have bothered me, and in retrospect DIDN'T). I was so stressed about everything, and while I live a VERY stressful life as a single mom and fulltime student, things were exagerated, and I couldn't eat, or sleep and I was visibly shaking from the stress!!! AHHHH! I understand my symptoms are rare, I decided to switch taking the pills from at night to the morning (because originally I had heard they would make me sleepy so I took them at night, when I couldn't sleep I wanted to try to take them in the morning, because it was out of routine I FORGOT to take them that morning... and by that afternoon ALL that stress started to MELT away and I could feel my body untense, and my whole body hurt... because for the past month and some my entire body had been TENSED UP, and then and there I decided I WOULD NOT take those pills EVER AGAIN!!! As far as the headaches/migraines go... it worked... but it was NOT WORTH IT to feel like THAT! If no migraines makes me a horribly irritable stressed out freak attack, then I'd rather have the migraines thank you (and anyone who's ever had migraines knows that's pretty durn bad to say that)! F 29 3 months
3/3/2009
 1  Epilepsy Horrible vomiting which caused metabolic acidosis. The metabolic acidosis was almost not reversible and my son almost died. My son almost died from this drug. I found a 24 page document at the FDA that said the #1 problem with this drug (in adults during clinical trials) in the GI tract was vomiting. It was not mentioned in the PDR or the package insert. I found it on my own and told the doctor we needed to wean from it to see if the vomiting decreased. It did. My son almost didn't make it. This is not a benign drug. M 5 11 months
8/17/2005
 1  epilepsy Zonegran made me extremely nervous, moody and confused. Plus I broke out with a horrible rash all over my body! As I was getting off the medicine, the rash was coming back again. Plus it gave me horrendous headaches. It was like I had swallowed a monster! It should be destroyed!!!!!! F 38 9 weeks
10/9/2004
 1  Mania Depression, rash, sore throat, insomnia I believe more research should be done on this medication before being prescribed for mood disorders. F 52 6 weeks
8/12/2004
  

ZONEGRAN  (ZONISAMIDE):  Zonisamide is used with other medications to prevent and control seizures (epilepsy). Zonisamide is a sulfonamide anticonvulsant and a carbonic anhydrase inhibitor. It is unknown how zonisamide works to prevent seizures.   FDA Approval Date: 2000-03-27 (Sources: U.S. Centers for Medicare Services, FDA)

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