ZONEGRAN Reviews (ZONISAMIDE)

Average Rating: 2.9 (90 Ratings)

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 ANTICONVULSANTS

 Type: Rx Drug

  

ZONEGRAN  (ZONISAMIDE):  Zonisamide is used with other medications to prevent and control seizures (epilepsy). Zonisamide is a sulfonamide anticonvulsant and a carbonic anhydrase inhibitor. It is unknown how zonisamide works to prevent seizures.   FDA Approval Date: 2000-03-27 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on ZONEGRAN: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR ZONEGRANCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  neurological pain bad insomnia constpation M 39 30 times
3/8/2004
 1  Bipolar II Extreme depression, nausea, loss of appetite, vivid, terrifying dreams, confusion, feeling of being very slowed down, felt like I was dying. Only took it for a week; the side effects were unbearable. F 37 1 weeks
4/20/2004
 1  Mania Depression, rash, sore throat, insomnia I believe more research should be done on this medication before being prescribed for mood disorders. F 52 6 weeks
8/12/2004
 4  Migraines Significant weight loss (30 lbs), some blurred vision and difficulty concentrating These side effects are mild condidering how much the medicine has helped my migraines. I consider them a fair trade-off. I have been on similar meds (Topomax) that I had much worse side effects from. F 24 11 months
10/3/2004
 1  epilepsy Zonegran made me extremely nervous, moody and confused. Plus I broke out with a horrible rash all over my body! As I was getting off the medicine, the rash was coming back again. Plus it gave me horrendous headaches. It was like I had swallowed a monster! It should be destroyed!!!!!! F 38 9 weeks
10/9/2004
 3  migraines narcolepsy, apathy,slowness of thoughts .it was very hard to make the decision to stop taking zonegran because it was the only thing that ever helped my migraines. But I could no longer deal with the loss of my mental functions, and falling asleep at inappropriate times ( i.e. on the job! ) However I must add that I may consider going back on this M 42 12 months
2/4/2005
 2  To decrease neck pain weight loss, mental slowing, difficulty concentrating, irritability, anxiety, speech problems, depression, I was seeing things that didn't exist and was ready to end my life. I was hospitalized, weened off of Zonegran and slowly regained my physical and mental health. Started with a dose of 100mg day first month, 200mg a day the second and 300mg a day the third. It did control the pain, but there was no way I could continue taking this med. F 43 3 months
3/25/2005
 5  migraine on 50 mg at bedtime , Iam experiencing some trouble falling asleep.Itake it 4 hours before sleep and this helped relieve my insomnia.. really working great for migraines, and nothing else has, as a preventative.I have been on it one month.I usually experience daily headaches and take imitrex for them. I have only had 2 headaches since on zonegran. F 49 30 days
6/4/2005
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 3  Migraines Only slightly lethargic if I don't keep busy. I'm also feeling a slight ache in the back of my head, but I don't now if it's related to our drastic weather/barometric pressure change here lately or not. I was on Topamax for over 3 months and couldn't take the side effects. Two major ones being daily sinus pain/problems and sexual side effects. I started taking 100 mg the 1st week at night and now I am taking 200 mg also at night. F 33 2 weeks
6/28/2005
 4  Epilepsy some loss of appetite, some fatigue, takes longer to take tests in school, some difficulty with math problems F 7 4 months
7/11/2005
 1  Epilepsy Horrible vomiting which caused metabolic acidosis. The metabolic acidosis was almost not reversible and my son almost died. My son almost died from this drug. I found a 24 page document at the FDA that said the #1 problem with this drug (in adults during clinical trials) in the GI tract was vomiting. It was not mentioned in the PDR or the package insert. I found it on my own and told the doctor we needed to wean from it to see if the vomiting decreased. It did. My son almost didn't make it. This is not a benign drug. M 5 11 months
8/17/2005
 2  epilepsy Extreme loss of appetite and my head felt heavy all the time. Ultimately, Zonegran really didn't control my seizures, but just left me feeling like I was in a dull fog all the time. I had to take a nap every afternoon. F 30 2 months
9/27/2005
 5  Mixed Bipolar II/ADD None, except maybe a slowing of my thoughts. I've been taking 50 miligrams for quite some time. I didn't experience the weight loss that I thought I would, but it has really helped my mood and my organization! F 17 6 months
12/12/2005
 4  migraine prevention very sleepy a couple hours after taking, (not a problem since I take it in the evening) present nausea may be related to the drug reduced my number of migraine days from 15 to only 5 per month. I'd have rated it a 5 if I wasn't suspicious that the mild intermittant nausea I've had for awhile now might not be related to the zonegran. But I'd rather have occasional mild nausea than migraines! F 52 8 months
4/14/2006
 4  migraines insomnia!!! (anxiety and nervousness when I got to 100 mgs, but both stabilized after a week) I have tried a lot of drugs, and zonegran has been the only one to get rid of both my killer migraines and those irritating little headaches. I don't sleep as much (or as well) as I used to, but I'll deal with that if I can be almost migraine free! F 23 3 months
5/19/2006
 2  Epilepsy Weight loss for the first 3 months, consistent expressive aphasia (can't get the words out) and recall memory problems that became worse as dosage was increased. Skin rash at 500 mg/d. Ultimately didn't control the seizures so discontinued it. M 20 9 months
7/11/2006
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 3  bipolar disorder At a higher dose I was uncoordinated and fell, but this went away when the dose was lowered. I have also lost some weight F 48 3 years
10/3/2006
 2  mood stabilization Constipation, constipation, constipation. I only took it for about two weeks when the side effect got to me, so I don't know about any benefits the drug may have had. F 25 2 weeks
1/15/2007
 5  Epilepsy I feel dehydrated, which isn't so bad it makes me drink more water which is good for you and I have the muchies. Other than that I feel good, I have energy, I'm very clear headed. I like this stuff and so far no seizures, I hope it keeps up! F 34 1 months
2/23/2007
 5  Migraine 200mg at night. I took this drug before I went to bed. I had to sleep with the light on just until I fell asleep because of extreme hallucinations that haunted me. The hallucinations were so real too. I saw monks hovering over me... It felt like a salvia trip sort of. Besides this it works SOO GOOD for migraines preventative treatment. It works similar to Topamax just without the nasty, unbearable side effects. Topamax made me stupid, cold hands feet, speech problems, waking dreams and sleep paralysis. This works soo good for migraines without the nasty side effects. It made me lose a ton of weight too. I gained it back when I stopped taking it for a bit but that could be because of a few other reasons though. F 24 1.5 years
3/6/2007
  

ZONEGRAN  (ZONISAMIDE):  Zonisamide is used with other medications to prevent and control seizures (epilepsy). Zonisamide is a sulfonamide anticonvulsant and a carbonic anhydrase inhibitor. It is unknown how zonisamide works to prevent seizures.   FDA Approval Date: 2000-03-27 (Sources: U.S. Centers for Medicare Services, FDA)

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