LUPRON DEPOT-3 Reviews (LEUPROLIDE ACETATE)

Average Rating: 2.6 (110 Ratings)

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 ANTERIOR PITUITARY HYPOTHALMIC FUNCTION ANTINEOPLASTICS

 Type: Rx Drug

  

LUPRON DEPOT-3  (LEUPROLIDE ACETATE):  Leuprolide is used to stop early puberty (precocious puberty) in children. It helps to delay sexual development (such as growth of the breasts/testicles) and the start of menstrual periods. It also helps slow down early bone growth to increase the likelihood of reaching normal adult height. Leuprolide works by decreasing the amount of sex hormones that a child's body makes (estrogen in girls, testosterone in boys).   FDA Approval Date: 1997-03-07 (Sources: U.S. Centers for Medicare Services, FDA)

  

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More on LUPRON DEPOT-3: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR LUPRON DEPOT-3COMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  Endometriosis and ovarian cysts After I was diagnosed with level 4 endometriosis, my pain was so bad I could barley get out of bed most days I would just lay there and cry from the pain, I had a laparoscopy to remove lesions, I was told it would help me be pain free for years, 8 weeks after my first surgery my pain was back and worse then ever, my doctor recommended hysterectomy and an oophorectomy (since I already had children and was unable to have anymore anyway) I was pain free for awhile after my surgery and when my pain came back I wasn't sure if I was imagining the pain or if I could still really have endometriosis... I had another surgery and still did that's when my doctor recommended me on this shot since it won't seem to go away. I was fairly skinny 105 lbs and in great shape, after I took this shot I started packing on the pounds, was extremely moody, I had terrible hot flashes, night sweats so bad I would have to shower in the middle of the night, and I was either starving or could go days without eating. When I started my second round of lupron after another surgery my symptoms were a 100 times worse I started getting really bad insomnia and nightmares I maybe slept between 1 & 3 hours a night. This is the last time I will take this shot I would rather live with the debilitating pain then have the side effects from this shot. F 22 9 times
3.75 mg
8/11/2014
 5  Endo Hot Flashes Heavy Sleeping Or Sleeping A Lot No Period Appetite Increase And No Painful Sexual Intercourse F 24 6 months
3.75
7/27/2014
Email
 5  adenomyosis I am taking lupron for adenomyosis and i have had hot flashes 3-4 times a week at nights a mild headache a few times.with breakthrough bleeding 2 times in the second month....but overall it has been wonderful F 44 3 months
11.25
4/7/2014
Email
 5  Stage 4 Endometriosis I didn't have any major side effects, 2 mild hot flashes (one at ovulation and one the day before my period). I think since I had such severe endo and such severe symptoms the relief is that much more noticeable. I have been on the shot for 1 month. It has been awesome. I have been less bloated, had less stomach pain, and now have my period which doesn't hurt at all (where I would normally have to take 8-12 Advil each day for the first 2-3 days) and I have not bleeding nearly as much (normally 12 tampons first 1-2 days now just 2/day.) F 28 1 months
3.5 1X M
4/29/2013
Email
 5  Endometriosis and ivf Lump and redness at injection sight for 2-3 weeks after injection Joint pain in fingers toes and ankles especially Hot flushes Very anxious and depressed Palpitations Dizzy ness Headaches Well worth all side effects But I u fortunately still had very regular periods on time F 30 3 months
11.25 1X O
1/2/2013
Email
 5  Fibroids Mood swings , migraines , hot flashes were severe the first 2 months but have tappered of since.my 3 softball size fibroids that put strain on my heart and lungs forming a pluresy mass . Drs gave me 7 yrs to live & a full hysterectomy was my only option. After 5 mths of 3.75 treatments my fibroids are gone except for one that has shrunk from 10 in to 6cm. I've never be happier with my results and the Luperon Depot is worth enduring any side affect .Hopefully I will still have a chance at getting pregnant...best of luck to you all F 42 7 months
3.75
2/4/2012
Email
 5  Continuous bleeding and pain Hot flashes, painful injection site I started the lupron injections four months ago after suffering continuous heavy bleeding and pain for about 18 months. I was scared to try this therapy, but my doctor made me feel more comfortable about it after talking with her. I have had hot flashes and night sweats, but the bleeding has stopped and the pain is more manageable. My doctor said it's this therapy or a hysterectomy. (This was my 4th opinion). Since I have been unsuccessful in staying pregnant and do not have any children, she recommended this therapy to give me a chance at having a child before a hysterectomy. So far, I do feel much better. Sure, there are are days where I feel horrible, but it's so much better than it feeling bad everyday. My doctor gave me a low dose of Lexapro to help with the hot flashes and night sweats and it has made a huge difference. I would recommend this to someone who may be in my situation. F 26 4 months
3.75 1X M
3/20/2011
 5  Stage 3 Endo/12.6 cm mass, rt ovary Hot flashes, night sweats, constant fatigue, loss of period, vaginal dryness, decreased libido, memory and concentration issues, heart palpitations, depression, mood swings, muscle and joint pain, bloating, weight gain > 60 lbs (1st round), mild acne, nightmares I took 7 rounds of monthly Lupron in 2002 for Stage 4 ENDO after lap with adhesions all over my organs, including a mass on my diaphragm. I experienced severe side-effects, but the results were astounding I was able to get pregnant in 2007 and had a healthy,beautiful child. I had no pain or complications until getting pregnant in 2010 with my daughter. I developed a 12.6 cm endometrioma on my rt ovary and had to be monitored very closely during my pregnancy. I lost my daughter in my 3rd trimester to a cord accident and am now on my 2nd 6-month round of Lupron to attempt to avoid surgery and get pregnant again before I lose my reproductive organs for good. 2nd time, milder symptoms, but new and worsening memory and concentration issues are worrisome. I am also having muscle and joint pain and heart palpitations that I did not have last time that I attributed to age until reading this site. Lupron has been a miracle drug for me,aside from the side-effects, and I hope this 2nd round passes quickly and does its job. This drug is not for the faint of heart, but in my case, it has been my saving grace. F 29 6 months
3.75 MG 1X M
3/16/2011
 5  Endometriosis Bleeding, temperature changes I have had only great results from the 3 month Lupron shot I received. I did get a lengthy 2 week period of bleeding, and then the extra pain about 3 weeks after the shot was administered, but since then feel better than ever. My mood has actually improved. I used to be hot all the time, and now am more on the cold side and feel regulated. I am taking add-back therapy so that may be a helper. I am due for my second 3 monh shot at the end of the month, and am hoping that the results stay the same! F 3
1X day
3/10/2011
Email
 5  prostate cancer physical & mental exhaustion, loss of stamina, loss of concentration, hot sweats, raised liver functions & mild nausea,high blood pressure, high glucose level, raised cholestrol; increased appetite early on and periodically, bone thinning (first posted below on 4/2/08) - now finished Tx: this drug is like being on mild chemo, especially after the first 12 mos. BUT it seems to have worked for me. each man experiences it differently, but i do think it is harder the younger the patient, based on my support group experience.exercise is a great mitigator - i missed very few days - and resistance ex. is v. important - google RoAnne Segal's JCO article, 12/8/08 ascopubs.org/cgi/content/abstract/JCO.2007.15.4963v1. feel free to e-mail me for info and support. M 59 27 months
22.5 1X O
6/5/2010
Email
 5  premenopausal breast cancer After 2 yrs in combination with tamoxifen: thin eyebrows, cramping in calves, no periods (great!), but finally some severe cramping in calves and pain/swelling in am in knuckles and soles of feet. But I would do this combo again - not bad at all. Effects may be just menopausal. Used Lupron with Tamoxifen for 2 years for hormonal treatment of breast cancer. I believe Tamoxifen does stimulate the endometrium because I got my period back after chemo, 1 month after starting tamoxifen. Therefore I used Lupron for ovarian suppression to hopefully keep my estrogen down and prevent reoccurance of my breast cancer. I think it was a good decision - no cancer return so far, and quality of life was OK. F 47 21 months
4/17/2009
 5  Severe Endo Major hot flushes, hair loss form the head (not visable to others though) big spots on my cheeks a few days after every jab, irrational mood swings I have just finished a 6 month course as I had my last injection at the end on Nov 07. I also did a 6 month stint on Zoladex last year. This is to put me through temp monopause so that i don't bleed. Every time I have a period, I grow a HUGE cyst on my left ovary. I have had 4 op's in the last year and a half...don't think my body can cope with much more. They will remove my left ovary and fallopian tube next time. Even though my last injection was about 6 weeks ago, I',m still waiting for my periods to return...no sign as of yet. The Next step is possibly inserting a mirena coil but I also have a bicornuate uterus so we're not sure if this is possible....anyone out there know? F 30 6 months
1/7/2008
Email
 5  ovarian cysts and uterine fibroids insomnia first week, mild hot flashes, mild nausea For me this is a miracle drug. It shrank the cysts and fibroids in 3 months and I was able to avoid surgery to remove my uterus and ovaries. I REALLY wanted to avoid the surgery--my mother contracted a lung infection during her hysterectomy and never really recovered from it. But my grandmother died of ovarian cancer and I was scared. In my situation, the side effects are so minor compared to the alternatives. F 49 4 months
12/14/2007
 5  Endometriosis Hot Flashes, Mood Swung for the better. Sex drive increased. Felt better than ever before...now I am not sure I even want children. I love this stuff...no more periods, no more costs for kotex, no worry about timing sex, great sex, no pain, very few hot flashes...big deal! This is great ...I'd like to stay on forever! F 36 8 months
11/28/2007
 5  shrink uterine fibroid pre-surgery Mild hot flashes, period stopped, some head hair loss. Possibly fatigue in month 3, possibly sensitive teeth 4 months after injection. Received one injection rated to work for 3 months. Began taking calcium tablets to counter any bone loss. Tumor shrinkage allowed for successful hysteroscopic surgery. F 43 3 months
11/5/2007
 5  Endometriosis Hot Flashes and fatigue. I was very scared to take this drug. I am sure it affects everyone differently. I am on the add-back therapy also. I had severe hot flahes in my first 2 months but now in my fourth they have gotten much better. I also feel tired a lot of the time. I made sure to start taking a multivitamin and calcium, which I think helps. Although the two side-effects I described are bothersome...it is definitely worth it. I now realize that I didn't even know how much pain I was in until it was gone(after starting treatment.) I just always had pain and cramping so I thought it was normal. I feel good after only 4 months. I can deal with the side-effects for 6 months..if the result is less pain all of the time. F 27 4 months
6/14/2007
 5  Endometriosis Positive Side Effects - no more migraines! Weight Loss - 40 pounds! Increased sex drive! Negative Side Effects - hot flashes, waking at night, but definitely worth it due to feeling SO much better! I took it for 7 months (no period for a year), then a year later took it again for 9 months (no period for a year again). I felt fantastic! No periods, no pain, could go to the gym and exercise, lost weight, wanted to have sex, migraines went away (did have regular headaches). I felt better those months than I had in a long, long time. However, when I stopped and my estrogen levels came back up, I had severe nausea for months - as if I were pregnant. F 43 16 months
5/20/2007
 4  Fibroid tumours edmeotsios Last year of this month start getting orgasm I don't know its working haven't get an ultra sound in two years F 43 3 months
11.25 mg
5/31/2015
Email
 4  Catamenial Endometriosis - Pneumo F 37
1X M
3/4/2014
Email

Patient History
 4  Endometriosis and Ovarian Cysts MOOD SWINGS, Some abdominal pain once in awhile, Hot flashes, Tiredness, Hunger cravings, Night sweats The mood swings are the worst. I do not reccomend trying to be in a relationship if he isn't ready for to deal with this cause I have been up and down with my emotions such as crying for no reason and getting irritated at the smallest of things. I sleep with my window open every night (and it's snowing outside) because i'll wake up dying of heat. All I want to do is lay in bed and eat food. I have struggled with being tired throughout the years but this is much worse. I go to work and put my head on my desk and fight to stay awake some days. I've gained about 10 lbs since I started the injection. And that is without changing my diet. Besides all the cons I would not stop taking it. I went from curled up in bed in so much pain to being able to work out for 45 minutes and walk up stairs without crying. So far the injection has been wonderful to help with the pain. I used to have cysts that would burst often and since I started the injection I have had none and have not felt any pain from them. If you can put up with the cons than you will feel much better. A few days ago I received my second injection. My doctor is having me do one more at the end of this month and than in 3 months i'll have one more and will be done. F 25 1 months
1X M
3/7/2012
  

LUPRON DEPOT-3  (LEUPROLIDE ACETATE):  Leuprolide is used to stop early puberty (precocious puberty) in children. It helps to delay sexual development (such as growth of the breasts/testicles) and the start of menstrual periods. It also helps slow down early bone growth to increase the likelihood of reaching normal adult height. Leuprolide works by decreasing the amount of sex hormones that a child's body makes (estrogen in girls, testosterone in boys).   FDA Approval Date: 1997-03-07 (Sources: U.S. Centers for Medicare Services, FDA)

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