Drug Ratings for LUPRON DEPOT-3

Average Rating: 2.7 (99 Ratings)

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)   

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RATING  REASONSIDE EFFECTS FOR LUPRON DEPOT-3COMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
sort down sort up F  M  
 5  Endo Hot Flashes Heavy Sleeping Or Sleeping A Lot No Period Appetite Increase And No Painful Sexual Intercourse F 24 6 months
3.75
7/27/2014
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 5  adenomyosis I am taking lupron for adenomyosis and i have had hot flashes 3-4 times a week at nights a mild headache a few times.with breakthrough bleeding 2 times in the second month....but overall it has been wonderful F 44 3 months
11.25
4/7/2014
Email
 1  Endometriosis pain Severe depression, anxiety, mood swings, short term and long term memory loss, 24 hour a day sweats, aggravation, no energy or motivation, pain came back within 2 months after my last injection. Horrible experience!!! F 34 6 months
3.75
3/28/2014
Email
 4  Catamenial Endometriosis - Pneumo F 37
1X M
3/4/2014
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History
 1  Elevated PSA after prostatectomy Hot flashes, depression, energy and muscle loss, fuzzy thinking, memory loss, forgetfulness, extreme fatigue. I work full time and never had any of the above problems until after the injection that will last another three months. Google lupron petition. It is before congress to ban this horrible drug. M 72 3 months
3
7/3/2013

 1  Prostate cancer weight loss, fatigue, MDS, loss of hearing, heart attack and death. I am the wife. It is my opinion that my husband died because of the Lupron Depot injection. M 82 2 months
1X M
5/10/2013
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 5  Stage 4 Endometriosis I didn't have any major side effects, 2 mild hot flashes (one at ovulation and one the day before my period). I think since I had such severe endo and such severe symptoms the relief is that much more noticeable. I have been on the shot for 1 month. It has been awesome. I have been less bloated, had less stomach pain, and now have my period which doesn't hurt at all (where I would normally have to take 8-12 Advil each day for the first 2-3 days) and I have not bleeding nearly as much (normally 12 tampons first 1-2 days now just 2/day.) F 28 1 months
3.5 1X M
4/29/2013
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 3  Large Fibroid 10.5cm,in uterus/cerv Wake up with Headache, stiff back n ribs, flu like symptoms, feel extra tried, BUT NO mood swings or hot flushes yet. Abdomen increased in size after 1 week and was very uncomfortable, peeing every hour. By week 2, some decrease in abdomen but bleeding around normal period time. Treatment is to shrink fibroid prior to surgery, currently abdominal hysterectomy booked for July, desperately want to avoid surgery or want option for sub total not total hysterectomy. Tried Marina for six months prior but fibroid continued to grow. Hope this works as out of options. F 50 14 days
11.25mg 1X O
4/22/2013
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 5  Endometriosis and ivf Lump and redness at injection sight for 2-3 weeks after injection Joint pain in fingers toes and ankles especially Hot flushes Very anxious and depressed Palpitations Dizzy ness Headaches Well worth all side effects But I u fortunately still had very regular periods on time F 30 3 months
11.25 1X O
1/2/2013
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 3  Endometriosis Major hot flashes, weight gain (40 pounds), extreme mood swings, trouble sleeping Though i had a very hard time with the drug, and the side effects, especially going through a simulated menopause at 16, i have to say it has helped to decrease my daily pain and helped me be able to re-enroll in school. I will never take this drug again though if i can help it. F 16 5 months
? 1X M
6/27/2012
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 4  Endometriosis and Ovarian Cysts MOOD SWINGS, Some abdominal pain once in awhile, Hot flashes, Tiredness, Hunger cravings, Night sweats The mood swings are the worst. I do not reccomend trying to be in a relationship if he isn't ready for to deal with this cause I have been up and down with my emotions such as crying for no reason and getting irritated at the smallest of things. I sleep with my window open every night (and it's snowing outside) because i'll wake up dying of heat. All I want to do is lay in bed and eat food. I have struggled with being tired throughout the years but this is much worse. I go to work and put my head on my desk and fight to stay awake some days. I've gained about 10 lbs since I started the injection. And that is without changing my diet. Besides all the cons I would not stop taking it. I went from curled up in bed in so much pain to being able to work out for 45 minutes and walk up stairs without crying. So far the injection has been wonderful to help with the pain. I used to have cysts that would burst often and since I started the injection I have had none and have not felt any pain from them. If you can put up with the cons than you will feel much better. A few days ago I received my second injection. My doctor is having me do one more at the end of this month and than in 3 months i'll have one more and will be done. F 25 1 months
1X M
3/7/2012

 5  Fibroids Mood swings , migraines , hot flashes were severe the first 2 months but have tappered of since.my 3 softball size fibroids that put strain on my heart and lungs forming a pluresy mass . Drs gave me 7 yrs to live & a full hysterectomy was my only option. After 5 mths of 3.75 treatments my fibroids are gone except for one that has shrunk from 10 in to 6cm. I've never be happier with my results and the Luperon Depot is worth enduring any side affect .Hopefully I will still have a chance at getting pregnant...best of luck to you all F 42 7 months
3.75
2/4/2012
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 4  endometriosis,bleeding,cysts Hot flashes, pain in pelvis worse for first 3 months, headaches, extream cold, mood swings, weight lose, incresed labido I was on lupron for six months and was taken off for 3. I was off for only 1 month when I started getting my ovarian cysts back. They had to go in and do emergency surgery to remove a 10cm by10cm cyst from my right ovary when they went in they also found extreme endometriosis. My doctor told me that I had to go back on lupron for another 6 moths then on to birth control. Before I was on it I had extreme pain and bleeding, after 3 months all my symptoms were gone. I had some side affects that were opposite of what most women experience. I was happy to go back on it again but also worried because i am coming up to the year mark here in a while and once that happens I have to come off it. I am not looking forward to that. I dont wanna go back to the pain and the bleeding. F 21 7 months
1X M
1/3/2012
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 4  Endometriosis, cyst, bleeding, pain Hot flashes, moody, sobbing, bone loss I have been on Lupron twice for once for a year (2005) then another time for 6 months (2003). I start again today or tommorow whenever the shot comes in the mail. Lupron was a life saver for me, I went from bleeding for months and extreme pain to almost no pain at all. This time the main reason is for a cyst on both ovaries. I am trying to avoid another surgery due to me still trying to conceive. F 31 1 years
1X M
8/24/2011
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 1  Endometriosis Pain, and crazy mood swings. I had the 1 month injection given to me 2 days ago due to supposed endometriosis, aka pain that wad only getting worse, periods getting heavier and more painful, and experiencing painful intercourse for nearly a year. I just had my 2nd child 3 months ago, was on the pill, which only made my mood and periods worse. Finally an ob recommended I try this instead of "different positions and more lube and throw some Mrotin in the mix for the pain." first of all, due to a stomach condition I can't even take motrin and right now I am in so much pain, and I have been alternating between pure rage and complete hopelessness...not to mention yesterday I had the first migraine I've had in years, and fluid retention...and yet they won't do another surgery. I've already had one ovary removed due to a lot of good sized cysts, and have 2 beautiful children(and 2 miscarriages), and am so Done with dealing with this...I am feeling very lied to by the ob and would never wish this hell on anyone except maybe a serial killer or something. Please tell me it gets better or at least some advise on what to do... F 23 3 days
3.5 1X M
8/24/2011
Email
 3  Endometriosis I've taken the time to read over everyone else's experiences with this drug. You must understand going on this drug is by choice and for many different reasons. Many people have different side effects but here were mine; Headaches, Weight gain(35 pounds to date), Tiredness, Night sweats, Hot Flashes, Cold sweats, The worst leg pain I've ever experienced, loss of vision to an extent,feeling weak, overall feeling like crap. <<< I'm sure some will read these and wonder why I put myself through this, Though the side effects suck pain wise I feel much better. I first got sick when I was 15. I've had 4 surgeries to date since then. Doctor One:First one at the age of 15 to remove polyps of the uturis and a D/C. No endo found at that point. Then tried many oral birth controls ended up at the first depo P. shot. Doctor Two: Second operation at the age of 17: I remember this quite well due to it was the week of xmas, Found adhesions and cysts. No endo found at this time. Once again this second doctor said they had done what they could and put me back on b/c(birth-control) During these three years I had to drop out of public school and go to an online school, I had my period at least 3 weeks out of a month. Pain was not tolerable. Finally at age 18 I went to see a specialist for endo in Hershey Pa. Doctor 3: First thing she said is I know you have endo we need to go to the operating table as soon as possible. By July 2010 I was on the table being cut open again. For the third time with the third doctor I had a D/C, lap scope, and four new incisions. When I was brought to I knew something wasn't right. Doctors all around me and my mom crying. They had finally found endo after my battle with doctors and pain for 4 years. What was suppose to be an hour operation turned into a 5 hour operation! The endo had moved onto my lungs, appendix, bowels, bladder, ovaries, uturis, ect. At my two week check up I was told how bad my endo was, I was then told I needed to go on the lupron depot right away if I wanted any chance at one having kids and two F 19 7 months
1X O
3/22/2011

 5  Continuous bleeding and pain Hot flashes, painful injection site I started the lupron injections four months ago after suffering continuous heavy bleeding and pain for about 18 months. I was scared to try this therapy, but my doctor made me feel more comfortable about it after talking with her. I have had hot flashes and night sweats, but the bleeding has stopped and the pain is more manageable. My doctor said it's this therapy or a hysterectomy. (This was my 4th opinion). Since I have been unsuccessful in staying pregnant and do not have any children, she recommended this therapy to give me a chance at having a child before a hysterectomy. So far, I do feel much better. Sure, there are are days where I feel horrible, but it's so much better than it feeling bad everyday. My doctor gave me a low dose of Lexapro to help with the hot flashes and night sweats and it has made a huge difference. I would recommend this to someone who may be in my situation. F 26 4 months
3.75 1X M
3/20/2011

 5  Stage 3 Endo/12.6 cm mass, rt ovary Hot flashes, night sweats, constant fatigue, loss of period, vaginal dryness, decreased libido, memory and concentration issues, heart palpitations, depression, mood swings, muscle and joint pain, bloating, weight gain > 60 lbs (1st round), mild acne, nightmares I took 7 rounds of monthly Lupron in 2002 for Stage 4 ENDO after lap with adhesions all over my organs, including a mass on my diaphragm. I experienced severe side-effects, but the results were astounding I was able to get pregnant in 2007 and had a healthy,beautiful child. I had no pain or complications until getting pregnant in 2010 with my daughter. I developed a 12.6 cm endometrioma on my rt ovary and had to be monitored very closely during my pregnancy. I lost my daughter in my 3rd trimester to a cord accident and am now on my 2nd 6-month round of Lupron to attempt to avoid surgery and get pregnant again before I lose my reproductive organs for good. 2nd time, milder symptoms, but new and worsening memory and concentration issues are worrisome. I am also having muscle and joint pain and heart palpitations that I did not have last time that I attributed to age until reading this site. Lupron has been a miracle drug for me,aside from the side-effects, and I hope this 2nd round passes quickly and does its job. This drug is not for the faint of heart, but in my case, it has been my saving grace. F 29 6 months
3.75 MG 1X M
3/16/2011

 3  Endometriosis Constant backache, occasional pelvic pain and intense pressure, chills(not really chills, but always extreamly cold), hot flashes at least once an hour, weird cravings(especially at night), weird dreams, increased libido(which is the oppisite of most people on the drug),depression/INTENSE mood swings, and bad headaches I had always had painful periods, but around age 17 i started getting cramps and backaches through my entire period. After a foot surgery in october 2010( dont know if its related) i started bleeding, even though im on the pill, and i bled for 4 months. I had a laprascopy in December 2010 and was diagnosed with moderate endometriosis. But after my surgery i could barly move for weeks, i was in so much pain, i had a pelvic infection and started intense antibiotics. After finishing them i was still bleeding, not sleeping, and in a ton of pain. I usually took something to knock me out so i wouldnt have to deal with the pain. Then i got the Lupron shot. at first it worked, the bleeding and cramping stopped the first month. But this is my second month and i feel out of control. The hotflashes, cravings, dreams,headaches, and backaches are killing me. I have to finish my dosage though, so im hoping to not have to do this again. Its hell :( F 18 6 months
1X D
3/12/2011

 5  Endometriosis Bleeding, temperature changes I have had only great results from the 3 month Lupron shot I received. I did get a lengthy 2 week period of bleeding, and then the extra pain about 3 weeks after the shot was administered, but since then feel better than ever. My mood has actually improved. I used to be hot all the time, and now am more on the cold side and feel regulated. I am taking add-back therapy so that may be a helper. I am due for my second 3 monh shot at the end of the month, and am hoping that the results stay the same! F 3
1X D
3/10/2011
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 4  endometriosis constipation, 5 lb weight gain the 1st week which disappeared after the 2nd week. I feel good on Lupron so far. I have more energy and no lasting side effects but I'm only on my 1st month. I was worried to go on it after hearing all the horror stories but also realize that many women only come on the site to vent. I wanted others to know that it can help some people feel better and is not only a nightmare drug. F 40 1 days
3.75 1X M
2/15/2011
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 1  Pain, endo? Had an emergency hysterectomy after the birth of my son 19 years ago, have had trouble ever since, it's taken them this long to do anything!!! passing out with the pain, only one ovary, adhesions, leg pain, bowel problems I was great at first, even though the mood swings were awful and I was very very tired (I have narcolepsy and it seemed to make my symptoms there better too) but started getting chest pain within about 8 months and my blood pressure shot up!!..and stayed there! Massive weight gain, my hair has thinned a great deal ( I have very very long hair so it has made a big impact) The hot flushes started to get unbearable, I honestly felt that I would literally drop dead of heat exhaustion, dramatic but true! Suicidal!!!Lost all my confidence, have become a recluse..cannot lose weight no matter what I do, I'm so tired. Developed a fistula so now a colostomy is on the cards, the doctors can't tell me if it's connected or not. I just feel like a lab rat frankly so I'm not having the shot anymore, Totally fed up and have no life now. The oestrogen add back was the worst point. I was literally barking at the moon and I don't feel that I was monitored enough by the doctors. My life has ground to an abrupt halt completely and all the tiredness, hair loss, depression, it's all been for nothing. I wish I'd never been put on it. I will never go back on this drug, ever! I'm better of with nothing but my own oestrogen, at least the symptoms were only monthly rather than all the time! I don't believe that the doctors know enough to prescribe this drug to women. I studied medicine myself when I was younger and my treatment over the years has just been absolute rubbish! F 42 1 years
1X M
1/25/2011
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 1  Adenomyosis I've suffered with adenomyosis, probably for 35 years. After years of being on various low-dose types of the Pill and Depo Provera, nothing was very effective. With Lupron Depot, I had hot flashes, cold chills, and sweating all day. I since decided to have a hysterectomy. I developed pain in my neck, arm/leg joints, and hips five months after my first (and last) injection. The joint pain has been getting progressively worse. I did not have joint pain prior to taking this drug. The 11.25 dosage is to be taken every three months. Four months after the injection, I had a hysterectomy (with my ovaries remaining). I'm not in menapause and am still ovulating. Prior to surgery, I was in excellent health, with no family history of arthitis. I am very strong and was very mobile prior to surgery. I'm taking it easy, as it has only been five weeks since my surgery, but I walk and move around and eat and sleep well. But I'm surprised that the neck and joint pain started after the surgery (five months after the Lupron Depot injection). The hot flashes and sweats have been greatly reduced since I started taking sage leaf extract a couple of times a day. But I'm concerned that the drug has affected my immune system, and I hope it hasn't triggered an auto-immune response in my body. F 47 3 months
11.25 1X O
12/17/2010
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 3  Endometriosis Hot flashes and some restlessness at night I just had my third shot of Lupron. So far I am having hot flashes a few days a week. I had surgery a couple months ago and had lots of endo removed. I am on Lupron in preparation for a second surgery on my bladder. Lupron will hopefully shrink the endo that is on my bladder. It is growing in a tricky area near the ureters and will be a risky surgery that could lead to more problems (bladder problems). Really hoping the Lupron shrinks what's there. Has anyone ever have endo on their bladder? F 30 3 months
1X M
10/29/2010
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 1  Endometreosis Hot Flashes, mood swings, abdominal cramping, diarrhea, migranes, vision changes, decreased sex drive, nausea, vomiting, light-headedness, I have only been on this medication for just over 2 months, first month went fine no problems besides the hot flashes... if those were the only side effects i could deal with it. Directly following the second shot however, the side effects got extreamly worse. I foolishly didnt do any research before accepting this shot, I recomend that anyone being told that they should go on this, DO RESEARCH! Endometreosis is a very common diagnosis among women, almost 60% of women. I dont believe this drug has helped me at all. I believe it has made things worse. I have missed several day's of work because i couldnt function at all. The abdominal pain, nausea, hot flashes, dizzy spells, fainting, back aches, trouble sleeping...It felt like i had the flu for a month straight. ITS REDICULAS! i think all health care providers should definatly have an in depth conversation about the side effects with their patients they plan on giving this shot to. If the patient dosent mind having all these side effects on top of the endo-pain... go right ahead.. but personally I will never take this shot again! It hasnt helped, just made everything worse! F 23 2 months
1X M
10/18/2010

 3  endometrosis hot flashes, cold chills, migraines, nausea, difficulty urinating, constipation, painful female organs, anxiety, overwhelmed, fatigue, acne, weight gain (40 lbs), memory loss, throbbing in my right temple that makes me tired--(and probably more side effects I can't remember right now) I gave this medicine a 3 because even though I had a blue million side effects, I had severe endo and my organs were stuck together. The doctor couldn't remove it because he didn't want to damage my other organs. So I did lupron once a month for 6 months. The first 5 months, I was great on the shot with only acne and hot flashes as side effects. The 6th month however brought with it the rest of the side effects. However, the doc scheduled my surgery in October of 2005 after my last shot in August and was able to clean me out from the endo. In November I went on the shot for another 6 months due to the pelvic pain I was in while on the last month of the first 6 shots and wow, did it ever get worse. I thought it was the endo causing the pain but little did I know it was the shot. During this time side effects were worse than ever and 5 years later, I am still suffering from them. F 34 1 years
1X M
10/12/2010
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 3  Exreamly bad Endo. Exream hot flashes, memory loss, swollen hands and feet, weight gain ( over 40 pounds ),extream headakes, crying for no reason, got attached to people, really bad back pain, sleeping all the time,uncontrolable shaking, some bleeding, hurt to walk up and down steps, feeling like bugs are crawling in your skin. I am 15 years old and i have had endo. since i was 13. All the doctors i went to told me i was crazy that i was to young to have endo. i went thru 3 different doctors, and by then i was out of school and couldnt move it hurt me so bad. I had lapo. done and they found out that i had so much of it on my blader and overies that they couldnt burn it off so i got put on Lupron. I wont say it is my favorite thing, but it is helping me alot. After i got the 1st shot it was hard to deal with. I just had my 2nd shot done 2 weeks ago i am still having alot of pain. The doctors just want the endo. to get off of my blader then if i still hurt they want to do a hysterectomy. F 15 6 months
12.5 2X M
9/19/2010
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 3  Fibroids, heavy bleeding and pain Hot flushes, weight gain, joint pain especially knees, fatigue, weepy and highly emotional Stopped injections 3 month ago and periods have still not returned. Prostap stopped the severe pain and heavy bleeding completly but added a whole lot of new problems to my lifestyle. Joint pain especially bad and not good for my husband and two young children to see. Still highly emotional and tired and have a lot of excessive weight to shift so not sure would recommend really!! F 33 8 months
1X M
8/21/2010

 1  PROSTATE CANCER In 2007 I had a radical prostatectomy. In 2009 my PSA went up. Dr recommended Lupron depot. Did not inform me of possible side effects. Now I have no muscle strength, very poor endurance, hot flashes, very poor sleep, memory loss, very poor concentration, irritability, bouts of extreme depression, vision changes, and PAIN in legs. When I went back to Dr he said my PSA was lower and would not need another injection. Stated I would never take another injection. This medicine has destroyed my life. I have been a paraplegic for 23 years. My life has gone from being independent to depending on others. I cannot make transfer into my car so now will have to buy van with lift. The pain in my legs seems to be bone pain mainly is in my left femur which has had no feeling for 20+ years. Due to the muscle weakness I have fallen and fractured two bones in calf. Dislocated a finger and suffered a torn rotator cuff and head trauma. THIS MEDICINE SHOULD NEVER BE GIVEN TO A PARAPLEGIC WITHOUT AN EXPLANATION OF POSSIBLE SIDE EFFECTS! I was given the shot Sept 1, 2009 and went to my 40th class reunion on Nov 21, 2009 and barely remember any of it. M 59 1 times
? 1X O
7/16/2010
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 1  Ovarian Fibroid and Heavy Bleeding Severe weight gain, horrific hot flashes, mood swings which effected my everyday life, severe depression, joint pain and frequent, long lasting headaches. I was happy with this medication on my first go around, I used it for a little over a year and it did what it was suppose to do, decreased pain, stopped my bleeding. After losing insurance coverage I had to go off this medication for about 2 years during which the pain and bleeding returned worse than before. I was able to get back on the shot for about 1 1/2 years during which the side effects were awful. I continued the shot because of the fear of the pain in my pelvic region returning and the uncontrollable bleeding. I have been off the shot since Feb and all my old symptoms are returning. This time I do believe I will seek a surgical treatment versus Lupron Depot! F 30 1.5 years
1X M
6/6/2010
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 5  prostate cancer physical & mental exhaustion, loss of stamina, loss of concentration, hot sweats, raised liver functions & mild nausea,high blood pressure, high glucose level, raised cholestrol; increased appetite early on and periodically, bone thinning (first posted below on 4/2/08) - now finished Tx: this drug is like being on mild chemo, especially after the first 12 mos. BUT it seems to have worked for me. each man experiences it differently, but i do think it is harder the younger the patient, based on my support group experience.exercise is a great mitigator - i missed very few days - and resistance ex. is v. important - google RoAnne Segal's JCO article, 12/8/08 http://jco.ascopubs.org/cgi/content/abstract/JCO.2007.15.4963v1. feel free to e-mail me for info and support. M 59 27 months
22.5 1X O
6/5/2010
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 1  Endometriosis hot flashes & sweating bad at night, decrease in sex drive, mood swings I would never take this shot again. I took my last shot in February and have yet to have a period. My pain was not bad at all and this treatment was not worth it. My endimetrosis was discovered when i had a cyst removed. He said it was a light case but went ahead and put me on a 4 month shot. One one month and then three the next month. If i had to do it all over i would not. When should i expect a period if anyone knows? F 30 4 months
4X O
5/17/2010
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 4  Endometriosis Horrible embarrasing hot flashes, could not sleep, serious hair loss, weight gain (20 pounds), fatigue, mood swings (angry, sad), hands, legs and hips joint pain...I finished the treatment in january, just got my period back and was not painful at all, still not losing weight and Im having acne breakouts in my face and back that I didnt have even as a teenager. I feel better now that i am finished with the treatment but I gained a lot of weight....dont know yet if it was worth it. F 33 6 months
1X M
5/12/2010

 2  Uterine Fibroids & Heavy Bleeding High blood pressure. Joint pain (Knee & finger) Could hardly walk on occassions! Migraines. Depression/weepy. Palpitations. Memory loss/Forgetful Initially agreed to to have 3 x monthly PROSTAP injections, prior to my hysterectomy. Ended up having 5 as they couldn't fit me in for the op. They did help with the bleeding, no more flooding or clots, just light bleeding. F 50 5 months
1X M
4/24/2010
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 2  Uterine fibroids Briefly? Leg pain, vertigo, nausea, vomiting, fever, chills, sweats, flu-like symptoms, debilitation, fatigue I have known I've had fibroids for some 15 years now, but they (one 15cm one, plus other smaller ones) have become so problematic that my uterus was the size of a six-month pregnancy, and was pressing on my leg veins (I've had a clot), and central veins (feeling dizzy if I lay on my back for too long). I am of course a prime candidate for hysterectomy, but do not want to have one for various reasons, so was keen to try Prostap (UK name). Was given the treatment (1-month depot injection) by the nurse who said that most women are fine, without being told of the possible adverse side effects. It was only after reading the leaflet later, that I became concerned. Felt OK in the first 2 weeks of treatment, and it was like a miracle in terms of the notable uterine shrinkage. My stomach became flat again, and my legs stopped swelling up. Great! However, I then developed the excrutiating leg pain (bone pain), that kept me awak at night. Next was the vertigo attacks. Usually on rising in the morning, but so bad that I had to take time off work. Next was the worse nausea and vomiting I have experienced in my life, to the point I had to go to A&E with dehydration from it. Then came the flu-like symptoms and the hot flushes, plus the affects on sleep. As a business woman and fitness enthusiast, the treatment has totally pollaxed me. I am due for my third shot next week. The week I had the N&V, I swore I would not have any further treatment, but no have the dilema of f F 48 2 months
1X M
3/5/2010

 4  Prostate cancer I was prescribed this, which they call Prostap in the UK, as a preliminary treatment before having radiotherapy. After a few days I started to experience obsessions with certain things, and this developed into a mania over about 3 weeks. Then I had what felt like an emotional crisis, with insomnia, anxiety, extreme swings of mood (elation, weeping) and over-reaction to any emotional event. I felt I was deeply in love with one of my best friends! (Never told her) Also physical symptoms like palpitations and sweaty episodes, but these were insignificant in comparison to the mind-bending effects. After 3 months the effects are wearing off, thank god, And I am much calmer. Now I just have the effects of the radiation to suffer. It had the desired effect on my prostate cancer, but I hope I never have to have this drug on a long-term basis. M 65 3 months
11.25 mg 1X O
2/13/2010
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 3  Endometriosis Hot flashes, hair loss, depression, irritability, lack of energy, joint pain especially in knees, less frequent but more intense migraines, loss of sex drive. The pain and bleeding went away within the first week. I am anxious to see what the long term effects will be and how long it will take to be eliminated from my system. F 36 6 months
12/10/2009
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 1  Endometriosis, Heavy periods Tingling under skin, severe migrane, spots in vision, emotional meltdowns, anxiety, hot flashes, memory loss, confusion, anger, mood swings, weight gain, joint pain, strange shooting pains, loss of period, extreme fatuige, heart palpatations, rashes and skin problem, darkening of skin on face like above upper lip and under eyes, insomnia On January 25th I had a lap for endo. On February 12th I had a lupron depot shot(3month).I was told the only way to keep endo from coming back for 5 years is taking the lupron. The third week was hell.............I started to have panic/anxiety attachs. I scaring my family. Then came the hot flashes, ever 15 to 30 minutes!!!horrible. I still have not started my period and I am coming up on 6 months. I WILL TELL YOU FROM MY EXPERIENCE THIS DRUG IS EVIL AND SHOULD NOT BE USED! THE SIDE EFFECTS ARE FAR WORSE THAN WHAT YOU COULD EVER IMAGINE. MY HUSBAND AND I ARE GETTING A DIVORCE AND I BLAME IT ON THE SHOT!!! IF YOU HAVE A FAMILY DO NOT TAKE THIS MEDICINE. MY 11 YEAR OLD SON AND I ARE VERY CLOSE AND IT IS HARD FOR HIM TO UNDERSTAND THE SHOT AND WHY I AM STILL HAVING PROBLEMS. NEVER EVER TAKE THIS SHOT!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! SOME DAYS I WONDER IF I WILL EVER BE MYSELF AGAIN OR HAS IT ALTERED MY CHEMISTRY FOR GOOD???? THERE IS NOTHING THE DRS OR ANYTHING I HAVE READ ON THE INTERNET ABOUT HOW LONG IT STAYS IN YOUR SYSTEM OR HOW LONG IT WILL BE BEFORE I FEEL LIKE MY SELF AGAIN..............BE CAUTIOUS ABOUT WHAT YOU LET BE PUT IN YOUR BODY. GOOD LUCK TO ALL AND BELIEVE WHAT IS WRITTEN IN THESE COMMENTS I DID NOT AND AM PAYING THE PRICE, MY LIFE HAS BEEN STRIPPED FROM ME AND I DONT WANT THAT TO HAPPEN TO ANYONE ELSE F 30 6 months
8/3/2009

 2  15 cm fibroid & cycts SEVER MOOD SWINGS! VERY ANGRY MOST OF THE TIME , YELLING OUT OF MY NORMAL CHARACTER, EASILY PISSED OFF AND ANNOYED. HOT FLASHES EVERY DAY, HEADACHES,STILL HAVE PAIN IN OVARIES WHILE ON MEDICINE, EASILY BRUISE ALL OVER BODY, CHANGES IN SKIN COLOR I HAVE NOW SUFFERING FROM DARK BROWN SPOTS ON SKIN FACE, HANDS, ALSO THE MUSCLE PAIN THAT I AM CURRENTLY EXPERIENING ON MY ARMS AND LEGS IS TREMENDOUS I FEEL AS THOUGH I GOT HIT BY A CAR .. THIS IS REALLY BULLSHIT.. I STARTED TAKING THIS MEDICINE IN MARCH 2009 AND I JUST RECENTLY TOLD MY DOCTOR THAT I AM STOPPING TREATMENT. I HAVE TWO MORE MONTHS TO GO BUT I REFUSE TO CONTINUE. I HAVE PUT MYSELF AND MY FAMILY THROUGH HELL SO FAR. ESPECIALLY MY CHILDREN I AM 34 YEARS OLD AND I AM A MOTHER OF TWO BOYS, ONE IS 10 YEARS OLD AND THE OTHER IS 1 1/2 YEAR OLD. PLEASE THINK TWICE BEFORE STARTING TREATMENT... I DID DO MY RESEARCH ON THIS MEDICINE BUT I NEVER IN A MILLION YEARS WOULD'VE THOUGHT THAT I WOULD SUFFER FROM SO MANY OF THESE SIDE EFFECTS AND F 34 4 months
7/18/2009
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 4  Endometriosis fatigue, weight loss, unexplained crying spells, night sweats/chills I have had two months of shots, the normal side effects, and it is well worth it. The pain from the endometriosis had taken over my life and I was hospitalized twice. I had constant pain. Please know this is a personal decision and can change your life for the better ! I also do add back therapy and would highly recommend it. F 42 60 days
7/3/2009

 1  To Shrink Fibroid EXTREME HOT FLASHES, Mood Swings, Chills, Restless Sleeps, Crying, depression, and Hungry all the time. I was an outgoing, friendly, bubbly person. I would walk into a room and brighten it. I barely want to leave the house because of the HOT FLASHES! I carry a fan everywhere I go and its so embarrassing when the flashes just come out of no where. If I am emotional, which is all the time because of the shot, the FLASHES ARE WORST!! I am going through a horrible crying spell that I have no control over. I feel so sad and depressed and I have no reason to feel that way. IT SHOULD BE CALLED THE SHOT FROM HELL!!! I wish that I had listened to a friend of mine that had to go through the same thing, when she told me, "whatever you do, don't take the Lupron Shot". I am now suffering more than I was before. I had to have a Hysterectomy and my Dr. was great. I just wish I hadn't ever agreed to shrink the fibroid before surgery.I am now applying estrogen patches to level the side effects. The hot flashes are every hour instead of every 15 min. I would never recommend taking this medication to anyone, not even my worst enemy! God Bless the women and their marriages that have no option, but to take the "SHOT FROM HELL"! F 36 2 months
7/3/2009
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 5  premenopausal breast cancer After 2 yrs in combination with tamoxifen: thin eyebrows, cramping in calves, no periods (great!), but finally some severe cramping in calves and pain/swelling in am in knuckles and soles of feet. But I would do this combo again - not bad at all. Effects may be just menopausal. Used Lupron with Tamoxifen for 2 years for hormonal treatment of breast cancer. I believe Tamoxifen does stimulate the endometrium because I got my period back after chemo, 1 month after starting tamoxifen. Therefore I used Lupron for ovarian suppression to hopefully keep my estrogen down and prevent reoccurance of my breast cancer. I think it was a good decision - no cancer return so far, and quality of life was OK. F 47 21 months
4/17/2009

 3  endometriosis Freaky dreams, edgyness, acne, weight gain, headaches Laproscopy for endo 4-2008. 9 months later, started lupron. I am always wary about medicines, so I do a lot of research and consideration before starting something new. This one had me a little nervous especially b/c of the bone loss, but after discussing all my ?'s with the dr. I decided to try it. She suggested the 1 month shot to give it a try. I said that if all went well, I would continue to have them given one month at a time b/c I like to have the option of getting a medicine out of my body asap if needed. Anyway, the very first night after getting the shot, I had a very disturbing dream! These types of disturbing dreams continued for 2 solid weeks, all night, every night! After 2 weeks they began to get less disturbing, but I was still dreaming all night--feeling like I had a restless sleep. My husband said I was very edgy that whole first month and the first couple days after the shot I felt kind of crazed like a wild energy and ambition. So, I decided to not pursue any m F 37 1 months
3/13/2009

 1  guinnea pig PAIN PAIN PAIN PAIN PAIN PAIN PAIN and depression. I can barely function and live on a day by day moment by moment basis. Come to find out my dr. gave me this drug without telling me it wasn't approved by the FDA for my condition F 31 8 months
2/24/2009

 4  Endometriosis I took Lupron for 4 years off and on. I am 29 years old and was very concerned about infertility after having 2 lap's to remove adhesions and still experiencing pain. I happened to have a very good experience with Lupron but I do urge one to do tons of homework on this med and it's side effects prior to taking it. After 3 months on Lupron, I had lost 10lbs, was not experiencing as much pain, felt much less moody and unpredictable, and did not have a period through the whole course of my treatement. However, I also experienced hot flashes that were out of this world, occasional fatigue, as well as osteopenia (or bone loss) in my hips and knees (Osteopenia has since improved with regular weight bearing exercise and calcium supplements) I stopped taking Lupron about 3 months ago and luckily all my symptoms went with it. My cycle is beginning to return but is in no way "a regular monthly cycle." I am very sorry to hear about the awful effects this med has had on so many women. I have not read many positive ratings on this med and do feel very fortunate after reading all of yours. I, like most of you, did not do my homework and jumped on the Lupron wagon with my eyes wide shut. My 2 concerns were; 1. no more pain and unbearable periods but most importantly 2. Fertility protection. From what I have read these have been the concerns of most women contemplating Lupron therapy. We all must weigh out the risks and benefits of starting any new medication and it is always best to get more than one opinion especially if you do not fully trust your physician. Also, there are many holistic therapies that have been effective in treating the pain associated with endo, fibroids, as well as other repoductive disorders. My recommendation to anyone considering Lupron therapy would be to seek out alternative therapies before putting this drug (or any drug) into your body. F 29 4 years
11/10/2008

 1  wife with endometriosis hot flashes, constant bleeding, head aches, pain, mood swings, depression. my wife has endometriosis. this was the second time she had this treatment. She got a new doctor, she gave her a 3 months dose, in one shot! She has been worst, and she is constantly bleeding off and on. Right now she is in the hospital because of the bleeding and the pain. This treatment should be your last option. F 37 7 days
11/4/2008

 1  prostae cancer Hot flashes, extreme sensitivity to sun. Mania (without depression) Loss of libido. Difficulty with erections. Orgasm without ejaculation. Took 2 one-months shots. No problem. Then one three-month shot: after two months 24-hour hot flashes and recurrent bouts of mania. I don't mind about the loss of libido. I expected that. Shot was supposed to have worn off one month ago, but the effects are worse than ever, while my psa slowly climbs. I'll never have any kind of treatment for prostate cancer again. I'm not afraid to die if I have to live like this. M 64 5 months
10/28/2008
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 3  endometriosis Hot flashes, cold flashes, memory loss, sex drive better, "tired" due to hot flashes at night, emotionaly up and down, but i do feel more level headed then before...kinda weird! After 2 pelviscopy surgeries for my endometriosis, and finding out that i have another disease called endomytosis, the doctor recommended this procedure for 6 months... i wish i did a little more research on it BEFORE i decided to go through hell for 6 months. I would have to say the only major problems were my hot flashes and memory loss. I noticed that after my 2nd shot i lost alot of weight almost too much if there is such a thing. But by the 4th shot and no really change in my work out pattern i notice the weight came back on but only in my mid section, i know this might not make sense but my pain started to come back again as well. I did notice the depression was a on going battle, up and down...etc. Listen people ask me all the time would i recommend it...and the answer would be ....i don't know, it is such a complicating shot, some people have the results THEY hoped for and others don't. All i know is that physically i feel as if i am poisoning my body, i look at photos of me a M 6 months
10/25/2008
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 1  Endometriosis Insane hot flashes, mood swings (aka crying for no reason every day) I took Lupron as a last resort after, even after surgery did not provide relief, for severe endometriosis pain. I took it for 6mo. six years ago without the progesterone supplements. Although my back pain subsided during the 6 mo. my other side effects were just as bad and the pain returned as soon as I stopped the Lupron. One important thing to note is that the use of Lupron has been tied to the development of other autoimmune diseases such as rheumatoid arthritis. My cousin and I used Lupron for endo ~6 years ago and now we have both been diagnosed with RA. We are only in our early 20's and have debilitating joint pain and she has had more health complications. I would not recomend Lupron to anyone. Natural hormone replacement has been the most effective for my endo., and 2 laporoscopies. F 24 6 months
6/17/2008

 1  Endometriosis Weight gain,hot flashes and the worst mood swings, depression, nervous breakdown,and anxiety attacks My doctor stopped the treatment a month after my 3rd shot because of the anxiety attacks, depression and nervous break down, was horrible! Those episodes were causing so much problems in my life, nobody understood me, either do I. It's two month already since my last shot and I haven't have my period back but I have more hot flashes. This treatment did not work for me; the serious side effects almost kill me. Please use this drug as your last resort. F 41 3 months
6/10/2008
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 4  Prostate cancer I am taking Lupron for two years for post op Prostate Cancer and removal of prostate. I had 33 radiation treatments followed by injection of Lupron ( 3rd one ) 3 more to go. I am getting severe pain in one knee with swelling and mild and occasional pain in the other knee. Some days are better than others and Advil seems to minimze pain and I walk normal. Did some kneeling during some construction and days later ... interior meniscus of knee had acute pain. Chiropractor seemed to alleviate some symptoms but next it has moved to outside of knee in meniscus and ligaments an causing to limp and be in pain when I walk. Is this caused by LUPRON ?? M 56 1 years
6/7/2008
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 3  Pre surgery for ablation Extreme hot flashes and night sweets and headaches. Recently severe chills, don't know if it related. The cold chills started about 2 weeks ago (just after my 2nd shot) and last about 30mins to an hr, until a hot flash takes over. I am painfully cold and can't get warm no matter what I do. The headaches tend to be mostly at night as well. I also had some leg pain the fist 2 weeks but it went away so I don't know if it was related either. I have one more treatment of Lupron and then I will be very glad to be done with it. The hot flashes and night sweets are causing a major lack of sleep and is wearing me down to the point where it is getting hard to cope. At night there are more like an attack. I also have type 1 diabetes and have a hard time telling a diabetic low from a hot flash which can cause, some serious problems. I only have to have the third shot as my surgery date has been moved. I don't think I can stand to have a 4th one if they move my date again. Two to three months of the side effects will hopefully be worth it for the surgery to be effective. I have had no we F 47 2 months
4/16/2008
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 4  Prostate Cancer I have been on Lupron Depot 3 for 4 months, I had prostectomy July 2007, The only side effects I have had from Lupron are hot flashes and lower back ache. both of which are tollerable, I was very wary at having Lupron injection , I read alot of the comments on this site plus many other sites, But I must admit I really have not had any major side effects from this drug, I feel it is everyones choice as to whether you have this drug injected, Everyone reacts differently to all chemicals , I feel the positives out weigh the negatives with this drug, I suggest people should use their own discretion in decisions, Not to just take what others have to say, We are all indaviduals and God gave us the ability to think for ourselves, Use that ability in every way possible to fight what ever cancer or disease you may have. I attend a support group each month, I have found it a great way to learn, It also allows you to be able to speak about your experiances regarding Lupron , Radiation ECT. I can only speak of my experiance with this drug, Maybe it works better for males than females, But I feel one never knows unless you try it, But please dont believe all the negatives you re M 59 120 days
4/14/2008
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 3  ENDOMETRIOSIS Hot flashes, acne, mood swings... possible weight loss inhibitor. I just had my 3rd injection. So far I've had several hot flashes-- not too bad though... yet? I've been receiving accupunture to help with the mood swings, i think i have them in check. Just in the past 2 weeks I have been experiencing forehead and chin breakouts. Acne was something that I've never really had a problem with... not even in my teen years. And, as always, weight gain is a concern. I've been working out pretty consistently, but the scale isn't moving- up or down. I should also mention that I had a multiple myomectomy and a left ovarian cystectomy in 12/07. My Doc removed 21 + fibroids, while discovering that I also had severe endometriosis--hence the treatment. My doctor has prescribed a half tab of Norethindrone to help with some of the side effects. Anyone else on this same cocktail? Speaking of cocktails, I wouldn't advise drinking too much alcohol while on this treatment. "I'm just saying" F 35 2 months
4/12/2008
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 2  Endometriosis weight gain, joint pain, headaches, hot flashes, insomnia, mood swings, depression, severe lack of energy, skin problems I had a hysterectomy over a year ago for pelvic and leg pain. I was diagnosed with endometriosis at that time. My ovaries were left because the dr. felt I was too young to remove them. One year later, most of my pain and symptoms had returned. The dr. thinks this is due to my ovaries feeding more endometriosis in my pelvic wall. I have had 4 injections of lupron and my symptoms have only gotten worse, and now I have the side effects to deal with. Please do a lot of research and prayer before deciding to take this treatment. F 31 4 months
4/10/2008

 2  prostate cancer (T3a, 4+4) hot sweats, raised liver functions, high blood pressure, increased appetite, loss of stamina, bone thinning (first entered under 'lupron' but actually receiving L depot-3) typical hot sweats that seem to be decreasing with time - good since i have a 28-month program. ALT, AST and cholestrol were very high initially and have returned to top of normal; sugar higher and B.P. a problem too; also i'm always hungry. i've always had an aggressive daily exercise routine so i've confined weight gain to around 5# and believe exercise is key to L. management. it is certainly a little tougher to scull or cycle, but my yellow wristband is an inspiration. exercise also helps fight bone thinning - i learnt i had borderline osteoporosis readings in my spine from the baseline bone density scan. is anyone on a prescribed course other than 4-6 months and 28 months initially? i am concerned about becoming hormone refractory. i've been on effexor for 7 years for depression (strong genetic history) so can't tell whether it's helping with the sweats/mindset. PSA has declined from 13.1 to 0.1, so clearly the L is d M 57 5 months
4/2/2008
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 3  PCOS/Constant Bleeding/Pelvic Pain I took the 1 month shot in Jan. I stoped bleeding with in the first 3 days. 2 weeks in I felt like I was loosing my mind. I was very short temp. I started bleeding with in the end of the 2nd weeek and stoped the 3rd week. All the time having sever pelvic and lower back pain. I havent had a period since. I took a higher dose 3 month shot on march 26th and today march 29th I Blew up. My temper went through the roof, I couldnt stop crying or shaking so I ended up in the ER. My blood pressure wich is usualy lower than normal was extremly high. They ended up having to give me Adderall to calm me down. As far as what the purpose of the meds are it is working but as far as side effects. I feel why even bother. F 27 3 months
3/29/2008

 4  Prostate Cancer Hot flashes, zero libido, atrophy, weight gain. I was diagnosed with PC in 1999. Went thru: External conformal radiation 4 years later psa=7.0 Cryosurgery= no help Lupron 12/2004= the usual side effects. psa=0.26 Stopped Lupron 12/2007 I saw an article about a UCLA Med Center trial where 4,000 advanced PC men were divided into two groups 2,000 continued on Lupron 2,000 stopped Lupron and toke one 8 oz. of Pomegranate Jucie/day 4 years (as i recall) the results were that their psa was the same in each group with some in the pom juice group lower. My urologist agreed to my plan to stop Lupron and start pom juice. I started pom juice Sept 2007. PSA was 0.0.26 Checked PSA March 2008 it is now 0.10. I use the Pomegranate Juice concentrate (Sam's Club $16.00 += for 32 oz)(one oz = 8 oz of juice) so this about $0.50/day. Costco carries it also. Also available online. All the Lupron effects are slowly going away. To see the UCLA trial report search Google for "UCLA prostate Cancer pomegranate j M 79 3 years
3/23/2008
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 3  ENDOMETRIOSIS Hot Flashes, Skin problems, severe mood swings, sleep disorder This is my second time taking Lupron and started crying when my doctor told me I have to go on again.. Yes the pain is gone but the side effects are horrible, The mood swings are causing so many problems in my life, the hot flashes are embarassing, the cold sweats in the middle of the night I can't bare.. Any woman reading this should take Lupron as a last resort because the side effects seriously change your life and most people will not understand or care that it's the medicine making you act the way you do. Also Lupron is not a cure so I will of course have to take it again in about another year or so ughhhh.. F 30 3 months
3/11/2008
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 1  Endometrosis/pelvic pain All the standard (hot flashed, decreased sex drive, mental, 30lb+ weight gain) but the joint pain was the worst. 6 months off the meds before I had a medically triggered period and the joint pain only got worse. 5 years of infertility treatments, I no longer have a period and they don't know why, but think this med played a role. A year after discontinuing I was diagnosed with Rheumatoid Arthritis and every dr. thinks this medication triggered this disease. My RA is VERY sensitive to changes in estrogen levels--there is a belief RA has an estrogen link as it is more common in women. I now have 2 other auto immune diseases and have seen more than 20 dr's over 6 years at Duke, UTSW, Baylor and Northwestern. They all agree that this med did something to my system. If you have any auto immune disease in your family, do not take it!!!!! F 28 9 days
3/11/2008

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