MIFEPREX Reviews (MIFEPRISTONE)

Average Rating: 3.6 (68 Ratings)

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 ANTIPROGESTATIONAL STEROIDS

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MIFEPREX  (MIFEPRISTONE):  This medication is used to control high blood sugar in people who have a certain condition (Cushing's syndrome), and who have failed surgery or cannot have surgery to correct the condition. Cushing's syndrome is caused by the body producing too much of a certain hormone (cortisol) which can cause glucose intolerance or type 2 diabetes. Mifepristone works by blocking the effects of cortisol.   FDA Approval Date: 2000-09-28 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on MIFEPREX: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR MIFEPREXCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  terminate 7 week pregnancy I experienced no side effects after taking Mifeprex, the "first" pill which actually stops the pregnancy. I waited the necessary minimum 24 hours before taking Misoprostol (the 4 pills that dissolve in your mouth) at 10 a.m. that started the rest of the process. The bad taste of these four pills is a walk through the park with what I experienced for the next 14 hours. I was given Vicodin for pain and Phenergen for nausea. I needed both. After a severe cramp, I usually expelled a very large clot. This went on for about 6 hours. Seven hours into the procedure I started very heavy cramping, bleeding and clotting. This did not seem normal. An hour later I experienced a gush of blood and tissue as never before. Didn't make it to the toilet in time. No fun cleaning up your own abortion while you're experiencing it. I became scared and called the nurse hotline. I described everything, she assured me that the worst is over and it will die down. I had two more "visitations" I regret my decision to do a pill abortion. I am an intelligent, professional woman. Ten years ago, I had a surgical abortion (suction) to terminate a 10 week pregnancy. Yes, the pill method does allow you privacy in that you experience the abortion at home on your own terms, but here is the crux of the matter - why suffer? Why . . . suffer? Whatever method you choose, you're still in control. In both cases, the doctors and staff at the clinics I went to were very professional, supportive, thorough, compassionate and listened well. A pill abortion involves very powerful medication. Once you start, you're own your own to make decisions that really should be made by trained medical personnel. Choosing an abortion is an intensely personal decision. Take your time before agreeing to a method. I am pro-choice. Never take your legal right to an abortion for granted. The choice? Terminate a pregnancy in 10 minutes with little to no pain, or choose (potential) hours of pain and bleeding. In my opinion, the most humane (think about this) method is a surgical abortion. F 45 1 days
10/4/2009
 3  abortion This was incredibly painful (as bad as, if not worse than natural childbirth - which I have had two). It is not any cheaper nor easier to go this route. Now 10 months later I have endometrio cells outside of my uterus (possibly endometriosis) which can be from surgery or childbirth (need to go in for futher testing) - I bet it is from this procedure. Do not take this option lightly - if you can have a surgical procedure done by a reputable hospitable I would do so. I also experienced blood "gushes" a couple of days after the procedure - thank goodness I was at home - I went back to Planned Parenhood - thought I was hemorrhaging. F 42 1 days
5/3/2006
 1  abortion I had severe cramping. The pain was equal to child-birth contractions. I have 2 kids, I know what I am saying. I would never ever take these pills again. It is not worth it. F 41 1 times
11/20/2005
 4  Medical Abortion Very painful, heavy bleeding, blood pressure dropped low. Having said said that it was over quickly I was tired for a day or two. Would do it again if I had to. Feel my doctor could have told me how quickly the pain came on and how bad it would be but over in a few hours. I wasnt goingto tell my husband but I am glad I did as for a few hours it was bad. M 40 1 days
1X O
2/13/2011
 5  pregnancy termination Four weeks pregnant: One strong contraction with a gush of blood accompanied by diarrhea. No other problems. This review written 31 hours after taking misoprostol. After all the terror I suffered preparing for this ordeal (my first experience with birth control failure, religious upbringing, etc) I'm so happy. Day one I took the Mifeprex in a clinic. I asked for pain and anxiety meds. I felt great for the next two days, no side effects. After ~52 hours, I took a Vicodin, waited 30 minutes, placed the misoprostol between my cheeks and gums. One note - I only weigh 100 pounds so I took the liberty of reducing the dose from 4 to 3 pills without consulting a clinician. I was afraid of the severe pain I've heard of others experiencing. The 3 pills took an hour and a half to dissolve, which I didn't expect, therefore waited that long to take a 600 mg ibuprofen chaser. Even after that, I felt only minor lower abdominal cramps, and was so comfortable I got hungry on hour three and went out to dinner. Luckily I wore a pad because as soon as I began to eat I had to run to the bathroom as it felt like I had diarrhea. For about 10 seconds on the toilet I worried because it was really bad cramping, but it went away as fast as it came. I went home (finished my food!)waited for anything bad to happen, but there was just bleeding when I sat on the toilet. At about 11 hours, I woke up and took 2 Advil for minor cramping, and went back to sleep. I then got up and went to work this morning like a normal day. Have had clots and thick bloody discharge when I pee but minor spotting on the maxi pad, no pain. Feeling emotionally better than I have in 2 weeks. F 38 1 days
1 1X day
3/14/2011
 5  early pregnancy termination minimal nausea and fatigue with the Mifiprex, moderate, but not intolerable cramping with the misoprostol I was very nervous about taking the misoprostol based on ratings here and other sites. Here is my experience: 5 pm- took Iburofen 800mg, 6 pm- took Percocet and Zofran (nausea), 7 pm- took misoprostol, allowing to dissolve in cheeks for 45 min, 8pm- mild bleeding, 10 pm-2 am- able to sleep, mod cramping, (feeling like I had the breath knocked out of me, in a way) took 2 more Percocet and 800 mg IBP. 9 am- cramping done, still had some bleeding with clots, but not painful. Much less traumatic than I expected, very little pain. I feel tired today, but am able to be up and about. F 37 1 days
1X day
5/3/2010
 5  unplanned pregnancy The side effects.. I went to the Dr's they did blood work, urine test and then ultrasound (all within 30 minutes) and found out I was exactly 6 wks 5 days pregnant. Dr. gave me the mifeprex pill to take orally which i did. Then handed me a small bag with the 4 misoprostol tablets and told me to insert vaginally within 72 hours. Side effects w/just the oral mifefprex were nausea and sluggishness but not enough to miss work or be in pain. I noticed a slight brownish discharge about a day after taking the oral pill but had no cramping until after inserting the 4 vaginal tablets I waited to insert the vaginal tab's because I went out of town so I waited almost 2 days after taking the oral mifeprex.The Dr. told me not to wait too long after because the abortion may not work...Woke up at 3am took Tylenlo 3 and waited... 4am, inserted the vaginal tablets and just went back to sleep, woke up at 8am and got up to use the bathroom and was already heavily bleeding with clotting. I did take the Tylenol 3 before inserting the tabs but the cramps were pretty strong..The really bad cramps lasted from about 8am to 1pm that day. Had to use a pad for the next 5 days because of heavy bleeding. I only took 3 more Tylenol 3 pills throughout the 5 days and mixed it up with ibuprofen and then midol. About day 4 I noticed some heavy cramps and pain in the abdomen but also discharged more clots with may have been the last of the embryo. It's now day 6 and I am almost done with the bleeding and cramps. I'm going in to get an IUD asap. F 37 6 days
7/25/2009
 1  Terminate pregnancy It seemed to work. 5 days after taking Mifeprex, I woke up with the worst cramping and abdominal pain I had ever experienced. I called the clinic emergency number. The nurse told me additional cramping is not uncommon. I cried in pain for many hours. I knew this pain was not normal, but after talking with the nurse I thought I could suffer through it. I had some heavier bleeding, then it seemed to subside. I went on with my day. I never imagined what would happen next. I woke up at 5 am and had hemmhoraged so much blood that I went into shock and lost consciousness. After a trip to the ER, 7 bags of fluid, an overnite hospital stay, and continued bleeding for 7 weeks, I don't recommend this product. F 37 1 days
6/7/2012
 4  Abortion None. I was satisifed with how well it worked, but waiting two weeks for my follow-up apptmt. to find out if it was complete was excrutiating. Only do this if you can take the wait. Surgery was too scarey for me so if I had to I would go this route again, but I think it works best really early in pregnancy. I was only about 3 weeks preg. Also, please don't do a home preg to see if it worked. You'll drive yourself crazy. My test said positive almost two weeks after taking Mifeprex, although I wasn't preg anymore. My doc said the hormones can hang around for a while so let your doc tell you if you're still pregnant. It will keep you off the emotional rollercoaster. M 36
6/5/2006
 5  6 weeks pregnant / medical abortion I took the first pill of mifeprex in planned parenthood ct on day one felt pretty nauseous. then four others at home in cheek n gum two each side abiut 34 hrs later.. I was prepared for the worst after reading so many frightening outcomes but after disolving the four pills at 1115pm I felt nauseated so I laid down around 11:40pm. fell aslp and woke up at 2 am my husband asked if I was ok I said yes nothing is happening I feel fine I figured it didn't work. so I went back to bed and woke again at 440 had to pee still no pain no cramping nothing. I did have a bloody pad on and after peeing I felt a gush of blood than a good size clot came out and then I had cramping and it was over. no side effects just slight nauseous. I was so worked up and terrified to take the remaining four pills I was crying and ill over the whole thing. I am a mother of four this was a big accident but I feel ok. not all that much bleeding either. just do it and you will have your own experience. everyone is diff but id say try not to work yourself up by reading everyone elses experience on here. you are promted to seek medical help right away if you have certain issues. you will be ok as most have. thank you F 32 1 days
12/28/2013
 5  abortion i guess everyone is different, but i had very little pain form this. it was like a heavy period to me. i was 6 weeks 3 days. i had a little nausea the morning after taking the dose at the office, then on the 3rd day did the 4 pills vaginally to dissolve. about an hour later i had some mild cramping and passed blood clots for a few hours but that as well as the crampling stopped with in about 5 or 6 hours. it is now day 5 and i still have some light bleeding but i feel good. i was very thankful that i was about to have a medical abortion instead of surgical. do what is right for you. dont believe all the horror stories online. just talk to your doctor and i am sure they can let you talk with some REAL people who have taken it. good luck to all. i know it is scary but you will make it thru everything. F 32
1X day
5/25/2010
 5   32
3/3/2001
 4  Medical abortion, 5 weeks & 4 days Very painful for 3 hours Another story focusing on the pain- not meant to repel women from choosing this method, but to advocate for having physical and emotional support nearby, just as you might for normal labor. I was 5 weeks and 4 days pregnant on ‘day 1’. I took the Mifeprex at the doctor's office, and inserted 4 tablets of Misoprostol (vaginally) 15 hours later (within the 12-48 hour recommended window). For 1-2 hours after inserting the Misoprostol there was not much action (light cramping). Then it began- nausea, severe uterine pain on par with labor contractions, diarrhea and vomiting. I took 1 vicodin but likely vomited it before full absorbtion. This phase lasted for 3 hours. The passing of blood and clumps was expected, the high level of pain was not- it was on par with childbirth. I had no idea that this would be the case. After those 3 grueling hours I reverted to cramps (as strong as my most painful period, but manageable with a hot water bottle and 2-3 tylenol) and continued bleeding for several days. Ultimately, I feel satisfied to have chosen the medical vs. surgical version, but if I had to do this over again I’d have a midwife present. Next time someone sends me home with ‘just-in-case’ bottle of narcotics, I won’t be so naïve! F 32 1 days
200 mg 1X O
1/14/2012
 5  Medical Abortion Felt weak. Heavy, heavy , heavy bleeding At 5 weeks I took the one pill on a Friday then on Saturday exactly 24 hours after taking the first pill I took the remaining 4. Two on each side of the cheek and let it stay for 30 minutes then swallow the rest. I waited an hour then took some percocet and I felt no pain. The bleeding and bloodclots however where alot. It is day 6 and I am still bleeding but not as heavy. Other than the heavy bleeding this is way better then going to the clinic and having it sucked out. It cost more but it is worth it and especially in the comfort of my own home and help. F 31 2 days
1X day
3/11/2011
 5  3 weeks pregnant I took 1 tab orally. Then 4 buccal 2 days later....... had light bleeding for about 10 hours..... medium cramps. But definitely tolerable. F 31 1 days
4/17/2014
 5  Abortion 8 weeks Cramping, heavy bleeding, nausea and diarrhea The first pill wasn't bad,the four I took the next day is what did it...I was in so much pain but I toughed it out.Just glad it's all over with F 31 1 days
1X day
2/18/2021
 1  Termination Extreme nausea, intense shaking, fever, excruciating pain. The most intense pain I've ever felt after taking the 4 tablets 48hrs after the 1st dose. I do not recommend this product, the pain is horrific - almost unbearable. I'm not writing this to scare people, just to warn them of the potential for pain taking this medication. I highly recommend strong pain killers, and having a support person with you. F 31 3 days
Unsure 1X day
12/18/2022
 1   I began a horrendous infection in my uterus after takin those pills. In the end I spent a week in the hospital on 3 of the most potent anti-biotics available, as well as some heavy-duty narcotic pain killers. If I were supervised in the hospital and given anti-biotics, nothing might have happened. I have constant sharp pains in my abdomen and have been told the scar tissue left over from the infection may now keep me from becoming pregnant in the future... F 31 1 days
11/20/2005
 1  Medical abortion Vomiting. Diarrhea. Chills. Uncontrollable shaking. F 31 1 days
1 pill
11/7/2012
 4  To end an 8 week, 6 day pregnancy Hardly any cramping but unpredictable blood flow for 2 weeks now I was expecting the worst side effects per the clinician at Planned Parenthood - not from online sources. After taking the first pill at the clinic I felt nothing the rest of the day. After 24 hours I placed the 4 pills between my teeth and cheeks as instructed and waited. This wasn't a horrible ordeal. After 2 hours I thought it didn't work because I still felt nothing THEN came the gush. The passing of the "lemon sized clot" (as predicted by PPH) was a little shocking as was seeing all of the matter pass but from then on the bleeding was off and on. Tomorrow will be 2 weeks and the bleeding hasn't stopped but I guess that's expected. The only bad part of this experience (physically) is the unpredictable flow - today alone I had to change my tampon 20 minutes after insertion then nothing the rest of the day. I have had very little cramping - maybe a 3 on a 1 to 10 scale - and no headaches, nausea or vomiting... Everyone is different. I wouldn't base how u decide to term your pregnancy on other people's experiences. I do wonder if the women that had horrible cramps with using Mifeprex, have bad cramps regularly with their period. I very rarely ever have cramps. F 30
1X day
5/2/2010
  

MIFEPREX  (MIFEPRISTONE):  This medication is used to control high blood sugar in people who have a certain condition (Cushing's syndrome), and who have failed surgery or cannot have surgery to correct the condition. Cushing's syndrome is caused by the body producing too much of a certain hormone (cortisol) which can cause glucose intolerance or type 2 diabetes. Mifepristone works by blocking the effects of cortisol.   FDA Approval Date: 2000-09-28 (Sources: U.S. Centers for Medicare Services, FDA)

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