MIRAPEX Reviews (PRAMIPEXOLE DIHYDROCHLORIDE)

Average Rating: 2.8 (431 Ratings)

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 EXTRAPYRAMIDAL MOVEMENT DISORDERS

 Type: Rx Drug

  

MIRAPEX  (PRAMIPEXOLE DIHYDROCHLORIDE):  Pramipexole is used alone or with other medications to treat Parkinson's disease. It can improve your ability to move and decrease shakiness (tremor), stiffness, slowed movement, and unsteadiness. It may also decrease the number of episodes of not being able to move ("on-off syndrome"). This medication is also used to treat a certain medical condition (restless legs syndrome - RLS) that causes an unusual urge to move the legs. Symptoms usually occur at night along with uncomfortable/unpleasant feelings in the legs. This medication can decrease these symptoms and thereby improve sleep. Pramipexole is a dopamine agonist that works by helping to restore the balance of a certain natural substance (dopamine) in the brain.   FDA Approval Date: 1997-07-01 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR MIRAPEXCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Parkinsons My mother has been taking Levodopa for 4 years, but since she was given also Mirapex, in April 2011, experienced extreme fatigue, too much sleep even during the day, personality changes, vivid dreams, allucinations. Now she's trying to come off it, following a neuro doc's advice and is going through hell, she cannot sleep at all, she's got panic attacks and is very much distressed. Angry with the GP who prescribed it to her saying it would help... Awful medicine due to side effects and extreme difficulty to stop it: no benefits for the patient, as far as I could see. I hope it will be removed from the market. Wonder why the doctors keep on prescribing it, without warning of what kind of medicine is this: highly addictive and with no evident improvement for the Parkinsons' sufferer. F 89 14 months
1X day
8/12/2012
Email
 1  Parkinson's Disease Taken by my 88 year old father. Developed insomnia - awakening at 3:00am, compulsive eating - upset his diabetes control, compulsive repetitive behaviors, severe swelling in feet and ankles, hallucinations and irrational behavior. This was a nightmare!!!! He never did work up to a maximum dose, his symptoms and behavior got so bizarre, we insisted the neurologist wean him off this drug. He is still recovering from the damage done by three months of Mirapex! M 88 90 days
6/13/2008
 2  Restless legs It doesn't stop my restless legs, even though my doctor said to take it with Sinement 25/100mg, it still doesn't help me.My doctor told me this week when I'm finished with the script. to not take it anymore, when something isn't helping me there's no reason to continue taking it.So - when I finish the bottle of mirapex, I won't renew the script,& try something else. I haven't been able to sleep more than 1 to 3 hours nightly, & that's not good for me. Sorry it just doesn't work. Goodbye F 85 6 months
1.5
9/9/2012
 2  Parkinson's I am writing for my husband, who was taking Mirapex for Parkinson's and RLS. He soon began having blood pressure drops, causing him to fall into a deep sleep to the point of my having to call 911 to revive him and take him to the hospital. After several days, they released him, with no explanation as to what was happening. His cardiologist could not regulate the highs and lows of his blood pressure, since he was experiencing both to the extreme, so one medication was counter-acting the other. He was beginning to fall asleep in his food every time he ate. His Parkinson's doctor put him on Mirapex ER once a day, hoping that would better regulate the meds, as he wasn't good at taking it properly. Until then, he was still able to be out doing some things around the farm. When his BP dropped one morning to 49/32, I phoned and told his doctor that the Mirapex seemed to be dropping it too low and he immediately took him of all Mirapex. For the next 2 weeks, he was falling into a deep s When I checked the warnings on the Prescription print-outs, there it was. Not the BP part, but the falling asleep part. I can't believe that not only the doctors, but myself as his caregiver, had missed that for so long. It could have killed him. He is doing well now, except for the RLS, which came back with a vengeance. He is on Neurontin for that, but it isn't controlling it during the night.I would only recommend this drug if ALL the warnings were conveyed to the patient by the doctor and that the doctor was monitoring all of them faithfully. I cannot believe that our PCP, our Cardiologist and our Neurologist all knew what was going on with him and that he was taking Mirapex, but not one of them connected the two or the gravity of his situation. M 85 5 years
25 3X day
9/4/2010
 3  restless legs sleepiness, tired I've tried every drug on the market, & mirapex costs more money, but doesn't do the job any better. F 82 400 days
11/10/2009
 1   swollen ankles, painfull joints, weight gain am always hungry I want to get off mirapex. Iam having some luck with smaller, earlier evening meals, no caffiene or alcohol,chocolates. also easy to digest foods help.I am convinced my rls is food related M 81 2 years
1X day
12/11/2011
Email
 5  Restless Legs Mirapex has been like a miracle for me as I have suffered from RLS for years butI have developed leg pain(outside of legs from hip to knee)which even pain killers don't relieve. This happens after several hours in bed.Am wondering if anyone else has had this effect. F 80 2 years
4/28/2005
 1  /restkess leg I became incontinent, was drowsy in day time, than finally became itching over parts of my body On quiting it I was no longer incontinent. But it was hell coming off the drug. Laying down would cause my legs to twitch constantly and feel very irriated. I was unable to sleep more than 1 hour a night. It is now almost 2 months and the side effects of quitting are easing off. That is the most horrible drug. F 80 5 months
9/10/2007
 5  to hope it would stop aching legs Only brief nausea the first week of starting on mirapex. I have been taking mirapex for over 10 years. For me it was a life saver. With a very ill husband and maybe three hours sleep a night I was living in a sleepless daze. I was reading everything on line and in magazines when I ran across an article about mirapex helping rls. My arthritis dr. had received information from Mayo Clinic and prescribed it for me and it has helped me from day one. I never take it during the day and drive because of falling asleep side effects. So far it has helped me during the day until late in the afternoon and may have to increase to four .125mg pills instead of three .125mg in the evening two hours before bedtime. I now know I have had fibromyalgia since childhood and never had restless legs. I moved my legs because they ached not because of a creepy crawly feeling. F 79 10 years
1/4/2007
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 1  parkinson hallucinations....seeing things memory lost completing this about my mother....drug is dangerous F 79 2 years
2/1/2007
 1  parkinsons Fell asleep without warning x2.1st time while on the phone--thought I had a seizure. Heart studies normal.2nd time,3 yrs. later fell asleep while walking--head hit cement hard.Trauma cost $30,000 to repair. I stopped taking Mirapex after last fall.I am afraid to take any meds.$30,000 of dental repair and permanent scars.Again my heart studies were normal.I have a slight tremor but I sleep better off of Mirapex. F 79 4 years
.25 mgm 3X day
9/27/2011
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 4  RLS daytime sleepiness F 78 6 months
11/8/2005
 5  RLS I have noticed an increased interest in sex especially for a 77 year old man Th benefits of Mirapex completely relieving my RLS syptoms far outweighs any negative side effects. M 77 5 years
2 MG 1X day
3/25/2010
Email
 5  RLS None whatsoever has been completely effective from virtually the first day M 73 10 years
2/25/2009
 4  rls none M 73 3 years
3/29/2009
 3  Parkinson's Disease Sleepiness (often fall asleep at the computer), nausea,ankle edema, constipation, joint pain. I've been on mirapex for about a year now and I really don't see much difference. My biggest problem with the PD seems to be my typing and hand writing. The mirapex hasn't seemed to help this at all. F 73
4/23/2004
 1  PD My husband (73) has had PD for 15 years. The neurologist prescribed Mirapex. It was the worse thing the doctor could have prescribed. He became a sexual monster. The longer my husband was on Mirapex the worse the symtons became. He became very sexual aggressive and I feared for my life as he started raping me several times during the night. I could tell that he did not know what he was doing as his eyes were blank. It also made him confused and forgetfull. He could not remember what he did to me. After the medication stopped he was like a new person. When he took the medication he would have freezing spells and had many falls. He no longer shakes and walks much better no more freezing spells and he is much happier and alert. He also sleeps much better during the night. M 73 3 years
3/29/2009
 1  parkinsons my grandfather has parkinsons right now and he has been on mirapex for 8 years and he recently came off of it for various reasons. He is now experiencing panic attacks and has worse health issues. I would never recommend this drug to anyone. I have watched him become progressively worse and it is awful. M 73 8 years
5/29/2009
 5  Restless legs and muscle spasm Slight nausea for 1st few weeks This has made a huge difference too my quality of life. Night time restlessness and jerking spasms of arms legs and sometime whole body sometimes quite violent . Within a day of starting these decreased and after gradually increasing dose are Gone completely. M 72 2 days
0.75mg 1X day
7/16/2022
Email
 3  RLS No real side effects for 9 or so yrs, worked well but I steadily had to have dose increased from . 25 mg daily to present 2 mg daily as RLS rolled over the meds. Now I'm sure Mirapex has augmented since RLS NOW affects one or two legs at a time, going into thighs, happens anytime day or nite, can last 20 min. or all nite (lately all nite), have more and more leg jerks and my tricks (like hot water on my legs from shower or laying down for awhile) do not work. I've, of course, developed a horrible sleep pattern of absolutely no sleep or if I'm lucky 3-4 hours per day. Becoming scared to drive, afraid of nodding off like I have when talking with people. I'm being switched to Requip but am not expecting much. My sister takes Requip for mild RLS symptoms, nothing like mine. To finish up, I hate RLS with a passion ... It steadily gets worse and control is near to impossible the longer it goes on. Unless yr doctor has had personal experience with this condition, I don't think they ge F 72 11 years
1 mg 2X day
1/19/2015
  

MIRAPEX  (PRAMIPEXOLE DIHYDROCHLORIDE):  Pramipexole is used alone or with other medications to treat Parkinson's disease. It can improve your ability to move and decrease shakiness (tremor), stiffness, slowed movement, and unsteadiness. It may also decrease the number of episodes of not being able to move ("on-off syndrome"). This medication is also used to treat a certain medical condition (restless legs syndrome - RLS) that causes an unusual urge to move the legs. Symptoms usually occur at night along with uncomfortable/unpleasant feelings in the legs. This medication can decrease these symptoms and thereby improve sleep. Pramipexole is a dopamine agonist that works by helping to restore the balance of a certain natural substance (dopamine) in the brain.   FDA Approval Date: 1997-07-01 (Sources: U.S. Centers for Medicare Services, FDA)

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