ZYPREXA Reviews (OLANZAPINE)

Average Rating: 2.5 (585 Ratings)

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 ANTIPSYCHOTICS ANTIMANICS

 Type: Rx Drug

  

ZYPREXA  (OLANZAPINE):  Olanzapine is used to treat certain mental/mood conditions (such as schizophrenia, bipolar disorder). It may also be used in combination with other medication to treat depression. This medication can help to decrease hallucinations and help you to think more clearly and positively about yourself, feel less agitated, and take a more active part in everyday life. Olanzapine belongs to a class of drugs called atypical antipsychotics. It works by helping to restore the balance of certain natural substances in the brain. Talk to the doctor about the risks and benefits of treatment (especially when used by teenagers). See also Precautions section.   FDA Approval Date: 1997-09-09 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR ZYPREXACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  sexual harassment Horrible. Made me feel dead. Suicidal. Weight gain. Obsessive thoughts completely out of character. Ruined relationships. Isolated me. Changed personality completely and not for the better. No joy. No creativity. No sex. pure poison F 59 6 months
20 1X day
5/9/2022
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 5  Bipolar 2/Cyclic Depression Weight gain. Also, after 5 years at 2.5 mg/day, I'm just now starting to experience some toe and ankle movements that may be precursors to tardive dyskinesia. I'm not looking forward to the withdrawal process (Google "Zyprexa withdrawal" for more anecdotal information). This is a *wonderful* medication if you need it. It gives me the deepest, best sleep I've ever had and has eliminated agitated, irritable states and the horrible anger and homicidal thoughts that went with them. On the other hand, please read about the side effects, which can be serious. I've read that average weight gain while taking Zyprexa is 40 pounds in the first year. It appears to contribute to the onset of diabetes in some people (as would the added weight). I am concerned I might be in the early stages of TD, so I will talk to my doctor and begin slowly cutting back on my dosage to see if the movements and restless legs disappear or at least improve. For short-term use, it's a miracle. M 58 5 years
8/5/2008
 5  PSYCHOTIC EPISODE/SHIZOPHRENIA WEIGHT GAIN I had a very good experience with Zyprexa. It got rid of my psychotic symptoms rather quickly. However, now it is time to come off and I have to taper slowly for a few months. F 58 1.5 years
2.5 1X day
1/20/2016
 3  Schizophrenia Increase in tremor, confusion Calming effect F 58 15 days
5mg
1/13/2020
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 3  Bipolar Disorder Weight gain and constant hunger. I gained about 40 pounds and just could not stop eating. Also felt very boring and flat...no personality at all. I just stopped a few days ago and already my appetite is back to its normal level and I feel better. The Zyprexa definitely helped with my racing thoughts but the side effects are just too awful. I have problems with depression and nothing depresses me more than being fat. F 58 365 days
8/1/2006
 1  Mood disorder My very normal 17 year old son smoked a lot of marijuana two years ago this December. Somehow it triggered a psychotic state in him. A few days later I took him to a psychiatric hospital and the doctors gave him zyprexa. He became very groggy and felt very hopeless. Two weeks later he took his own life. The zyprexa at no time seemed to help my son feel any better or think any clearer. It made him feel very tired and low energy, which in turn increased his feelings of wanting to commit suicide. F 58 2 weeks
12/16/2008
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 1  Psychosis I put on a huge amount of weight with Zyprexa. I felt like a zombie. I got high cholesterol extreme tiredness low white blood cells extremely itchy skin and thyroid problems. It is very hard to get off. To help withdrawal I reduced the dose gradually over a year. I took Zyrtec and three herbal sleep remedies which really helped. F 58 15 years
5 mg 1X day
1/18/2022
 3  Depression & Anxiety Extreme weight gain; out of control appetite! Couldn't get enough to eat. All I thought about was food constantly. Dr. put me on Zyprexa 2.5 mg once per day. I read the reviews about weight gain but didn't think it would happen to me. Thought I would be one of the few exceptions to the rule and I would not experience weight gain. Boy was I wrong! I am a 4'10" woman and I went from 114 lbs to 124 lbs in 2 weeks. My appetite increased until I was out of control. All I could think of was eating. I also have an eating disorder and the weight gain made it worse! However, in all fairness, it is an overall good drug and I really liked it; made me feel calm; helped my anxiety and depression, and helped me sleep, but I couldn't deal with the extreme weight gain. Dr took me off Zyprexa and put me on Abilify. 3rd day off Zyprexa and so far no withdrawal symptoms. This is a good drug if you can deal with the weight gain. It really helped me, but I believe Abilify will be better for me as it doesn't normally cause weight gain. F 57 1 months
2.5 mg 1X day
7/27/2013
 1  schizo/paranoid/depression I did not like the drug at all.No sex drive and did not help me at all.Slept at lot and lo ebbed.I stopped taking it and woke up at 4:00am with cold sweats,clastaphobia,anxiety bad.I spent all day walking,went back to hospital for suicidal problems. I explored caves alot.I would not give it to my worst enemy but then again what a form of torture. M 57 10 months
1/15/2009
 5  manic with auditory hallucinations Weight gain, dizziness I had a severe long term manic episode that occurred over a period of several years, treated with Lithium [did not work] then I started to hear voices, and I finally found a psychiatrist who prescribed Zyprexa. I have often had dizzy moments, although they don't last more than a second or two. At my last annual checkup the doctor said I had slightly high cholesterol. I have gone from 110 pounds [weighed this all my life] to 185 pounds today. Granted, I went into menopause during my second year on this drug, but that can't be the only reason for this increase in weight. I have had no mood problems since I started on Zyprexa, but I am tired of gaining 5 to 10 pounds every year. I am trying an exercise plan with smarter eating habits, but I do plan to tell my doctor I've had enough of this drug and that I want to try something else. F 56 10 years
5 1X day
3/8/2010
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 1  bipolar - severe My face swelled up, my scalp split open and my hair fell out. I had to wear a wig for 6 weeks while it grew back. Weight gain ++++ even in a month. This is the worst anti psychotic I have ever been on and I've been on most. The side effects were horrendous. F 56 1 months
10mgs 1X day
3/20/2012
 1  bipolar/manic/insomnia EXTREME WEIGHT GAIN! 70 pounds in five months on 15 mg at night. Slept like a log for 12 hours. Lethargy during the day--foggy days but I did sleep. Drug caused me to eat all of the time. Went from 140 to 210. Craved sweets. Breathing problems from elevated weight. Doctor thought that the adverse weight gain was outweighed by the benefit of sleep. Could not control an obsessive need to eat. Psychologically my self-image drom the weight gain made me go cold turkey off the drug. Lost 10 pounds in five days. Increased anxiety with no source for it. Getting 7 1/2 hours of sleep off the drug but take 4mg of xanax xr and150 mg of effexor xr at bedtime too. Do not recommend this drug. Went from a size 10 to a size 22. Taking B-12 to increase energy level. F 56 5 months
3/31/2007
 4  anxiety disorders irritability first few days M 55 15 days
11/20/2002
 4  Sleeplessness, PTSD, Anxiety,Depres Hungry-Crave Sweets Nothing else was working for the sleeplessness until this medication. I sleep better and don't have terrible mood swings. M 55 5 years
10/7/2005
 3  Bipolar 1 Huge weight gain, constant hunger mainly carb cravings, sleepiness I absolutely hate this medication. I was taking it for about 3 years and it only had a mild affect on my mood. The Doc then took me off it and I lost 20kgs of the weight I had gained in 3 months. I then had a manic episode and he once again prescribed Zyprexa at a lower dose. While I haven't regained the weight I have stopped losing (I still have lots to lose from gaining while on Zyprexa in the first place) F 55 3 years
7.5 mg 2X day
9/15/2011
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 3  PTSD witnessed Awful Event. Anxiety Am not very happy taking Meds and so have a low tolerance to most drugs even a basic Pain med but felt highly Anxious and wired all the time so Dr Recommend it . From Day one take at night, I feel hungry all the time the next afternoon . Usually eat normally Lunch and Dinner, all cooked at home..I feel extremely hungry have eaten alot more than usual, trying to make that salad and fruit, weigh 59 kg at the moment, am conscious of the other reviews of weight gain. Don't feel any better mentally yet but I will give it a go for a few weeks. F 55 4 days
2.5mg day 1X day
11/16/2023
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 4  Stress Feel great M 54 10 days
12/27/2016
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 3  Bipolar Major weight gain (40lbs). Worst was being a zombie, confused, in a constant fog. Cognition deficits. It severely affected my job performance. Fortunately, my boss knew of my condition and was supportive...but I need to think crisply. Started out at a low dose, but it was escalated when I was having severe depressive/suicidal episodes. Doctor took me off it about 4 months ago as my mood had stabilized. I've lost 25lbs and continuing gradually to lose. No longer in a fog. Basically all the side effects reversed after I quit, but I needed it at the time. F 54 2 years
5-15mg 1X day
10/31/2014
Email
 3  depression, borderline PD To be on a medication so long it was hard to tell what was me and what was the medication when I went off it I realized the sleepiness and laziness were side effects. Also I had weight gain, high cholesterol, high triglycerides, and high glucose. Heat intolerance which made me sick when I ran 5K races on warm days. Withdrawal: increased anxiety, muscle tension, heightened sensitivity to stimuli, aggitation. These mimiced the symptoms I went on the medication for. But the withdrawal was complete in two weeks. Now I am very glad I am off of it. Zyprexa is a mixed blessing. When my life was unstable and my depression was more severe it was a life saver. It gave me boundaries. When others were upset I didnot have to be upset with them. So I was much less sensitive to perceived rejection. I am fortunate I now have a stable job and my kids have grown up well. So I don't need it to function. When I went off it I did so because of the metabolic side effects. I was surprised to experience the anxiety and tension. And equally surprised when they went away after two weeks. I have discoverd I am not lazy or sleepy or hungry all the time. That was the zyprexa not me. However if my life fell apart by getting fired or someone dying and I became suicidal and unable to function I would probably go back on it F 54 8 years
12/9/2006
 2  anxiety gained 50 pounds in a year and developed high cholesterol Concerned about diabetes F 54 12 days
6/26/2007

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